The effects of protein stabilizers on aggregation induced by multiple-stresses

Yakugaku Zasshi

Volumn 123, Issue 11, 2003, Pages 957-961

  Arakawa, Tsutomu ^a   Dix, Daniel B ^b   Chang, Byeong S ^c  

^a ALLIANCE PROTEIN LABORATORIES   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

^c Integrity Biosolution   (United States)

Author keywords

Agitation; Detergents; Formulation; Proteins; Storage; Stress

Indexed keywords

AMINO ACID; ARGININE; CILIARY NEUROTROPHIC FACTOR; DETERGENT; LYSINE; ORGANIC SOLVENT; POLYSORBATE 20; PROPYLENE GLYCOL; STABILIZING AGENT; SUCROSE; DRUG; PHARMACEUTICAL VEHICLES AND ADDITIVES; POLYSORBATE; PROTEIN;

AGITATION; EXPOSURE; MECHANICAL STRESS; PROTEIN AGGREGATION; PROTEIN STABILITY; REVIEW; SHIPPING; STORAGE; TEMPERATURE; THERMAL EXPOSURE; CHEMISTRY; DRUG STABILITY; DRUG STORAGE; HEAT; PROTEIN DENATURATION; PROTEIN FOLDING;

ADJUVANTS, PHARMACEUTIC; CHEMISTRY, PHARMACEUTICAL; CILIARY NEUROTROPHIC FACTOR; DETERGENTS; DRUG STABILITY; DRUG STORAGE; HEAT; LYSINE; PHARMACEUTICAL PREPARATIONS; POLYSORBATES; PROPYLENE GLYCOL; PROTEIN DENATURATION; PROTEIN FOLDING; PROTEINS; STRESS, MECHANICAL; SUCROSE; TEMPERATURE;

EID: 1542644843     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi.123.957     Document Type: Review

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