Effects of pH and arginine on the solubility and stability of a therapeutic protein (fibroblast growth factor 20): Relationship between solubility and stability

Current Pharmaceutical Biotechnology

Volumn 10, Issue 6, 2009, Pages 609-625

  Maity, Haripada ^a   Karkaria, Cyrus ^a   Davagnino, Juan ^a  

^a CURAGEN CORPORATION   (United States)

Author keywords

Aggregation; Arginine; Circular dichroism; Cold denaturation; Differential scanning calorimetry; Fibroblast growth factor; Fluorescence; Folding unfolding; Linderstrom Lange's smeared model; PI; Protein solubility; Protein stability; Salting out; Thermodynamics

Indexed keywords

ARGININE; BUFFER; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 20; GUANIDINE; POLYSORBATE 80; SULFATE; UNCLASSIFIED DRUG;

ANION EXCHANGE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BINDING; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; MELTING POINT; PH; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN DEPLETION; THERMOSTABILITY;

ARGININE; FIBROBLAST GROWTH FACTORS; HYDROGEN-ION CONCENTRATION; PROTEIN DENATURATION; SOLUBILITY;

EID: 71749097016     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920109789069297     Document Type: Article

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