Macromolecular crowding compacts unfolded apoflavodoxin and causes severe aggregation of the off-pathway intermediate during apoflavodoxin folding

Journal of Biological Chemistry

Volumn 283, Issue 41, 2008, Pages 27383-27394

  Engel, Ruchira ^a,c   Westphal, Adrie H ^a   Huberts, Daphne H E W ^a   Nabuurs, Sanne M ^a   Lindhoud, Simon ^a   Visser, Antonie J W G ^b   Van Mierlo, Carlo P M ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COMPACTION; CYTOLOGY; DEXTRAN; ENERGY TRANSFER; ESCHERICHIA COLI; FLUID DYNAMICS; FLUORESCENCE SPECTROSCOPY; GLUCOSE; MACROMOLECULES; MOLECULAR SPECTROSCOPY;

CD SPECTROSCOPIES; CONFORMATIONAL SPACES; FLUORESCENCE CORRELATION SPECTROSCOPIES; FOLDING INTERMEDIATES; GUANIDINE HYDROCHLORIDES; HIGH YIELDS; HYDRODYNAMIC RADIUSES; IN CELLS; IN VITRO; IN-VIVO; MACROMOLECULAR CROWDING; MOLTEN GLOBULES; NATIVE FORMS; OPTICAL SPECTROSCOPIC TECHNIQUES; PROTEIN STABILITIES; PROTEIN VOLUMES; RESONANCE ENERGIES; SECONDARY STRUCTURES;

PROTEIN FOLDING;

APOFLAVODOXIN; APOPROTEIN; FLAVODOXIN; PROTEIN DNAK; UNCLASSIFIED DRUG; DNAK PROTEIN, E COLI; ESCHERICHIA COLI PROTEIN; HEAT SHOCK PROTEIN 70; RECOMBINANT PROTEIN;

ARTICLE; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; ESCHERICHIA COLI; FLUORESCENCE CORRELATION SPECTROSCOPY; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; ULTRAVIOLET SPECTROSCOPY; AZOTOBACTER VINELANDII; CHEMISTRY; GENETICS; METABOLISM;

ESCHERICHIA COLI;

APOPROTEINS; AZOTOBACTER VINELANDII; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FLAVODOXIN; HSP70 HEAT-SHOCK PROTEINS; PROTEIN FOLDING; RECOMBINANT PROTEINS;

EID: 55549084888     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802393200     Document Type: Article

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