The effect of the reconstitution medium on aggregation of lyophilized recombinant interleukin-2 and ribonuclease A

Pharmaceutical Research

Volumn 13, Issue 4, 1996, Pages 643-646

  Zhang, Mei Z ^a   Pikal, Katherine ^a   Nguyen, Thai ^a   Arakawa, Tsutomu ^a   Prestrelski, Steven J ^a  

^a AMGEN INC   (United States)

Author keywords

Additives; Aggregation; Lyophilization; Proteins; Reconstitution; Stability

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; BETA CYCLODEXTRIN; CHONDROITIN 4 SULFATE; CHONDROITIN 6 SULFATE; DERMATAN SULFATE; DEXTRAN SULFATE; DRUG ADDITIVE; FUCOIDIN; GLUTAMIC ACID; GLYCINE; HEPARIN; MANNITOL; OCTYL GLUCOSIDE; PHOSPHATE; PHOSVITIN; PHYTIC ACID; POLOXAMER; POLYLYSINE; POLYPHOSPHATE; POLYSACCHARIDE SULFATE; POLYSORBATE 20; PYROPHOSPHATE; RECOMBINANT INTERLEUKIN 2; RIBONUCLEASE A; SUCROSE; SURFACTANT;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING; PRECIPITATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; STORAGE; TEMPERATURE;

ANIMALS; BUFFERS; CATTLE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STORAGE; FREEZE DRYING; HUMANS; HYDROGEN-ION CONCENTRATION; INTERLEUKIN-2; PROTEIN BINDING; RECOMBINANT PROTEINS; RIBONUCLEASE, PANCREATIC; TEMPERATURE;

EID: 0029986925     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016074811306     Document Type: Article

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