The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution

Journal of Pharmaceutical Sciences

Volumn 90, Issue 10, 2001, Pages 1466-1477

  Jones, Latoya S ^a,b   Randolph, Theodore W ^c   Kohnert, Ulrich ^a,b   Papadimitriou, Apollon ^c   Winter, G ^a   Hagmann, Marie Luise ^a   Manning, Mark C ^a   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UCB 450   (United States)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antibody formulation; Infrared spectroscopy; Lyophilization; Protein aggregation; Reconstitution

Indexed keywords

ANTIBODY; DIMER; L SELECTIN ANTIBODY; OLIGOMER; POLYSORBATE 20; PROTEIN; SUCROSE; UNCLASSIFIED DRUG;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; FREEZE DRYING; INFRARED SPECTROSCOPY; OLIGOMERIZATION; POWDER; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; THERMODYNAMICS;

EID: 0034762065     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.1098     Document Type: Article

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