메뉴 건너뛰기




Volumn 3, Issue 6, 2011, Pages 714-749

Human T-cell lymphotropic virus: A model of NF-κB-associated tumorigenesis

Author keywords

ATL; HTLV; IKK; Immune escape; NF B; PDLIM2; Tax; Transformation; Tumorigenesis; Virus host interaction; WWOX

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ONCOPROTEIN; TAX PROTEIN;

EID: 79959668389     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v3060714     Document Type: Article
Times cited : (57)

References (263)
  • 1
    • 25444488764 scopus 로고    scopus 로고
    • History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2
    • Gallo, R. History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2. Oncogene 2005, 24, 5926-5930.
    • (2005) Oncogene , vol.24 , pp. 5926-5930
    • Gallo, R.1
  • 2
    • 25444461701 scopus 로고    scopus 로고
    • Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2
    • Feuer, G.; Green, P.L. Comparative biology of human T-cell lymphotropic virus type 1 (HTLV-1) and HTLV-2. Oncogene 2005, 24, 5996-56004.
    • (2005) Oncogene , vol.24 , pp. 5996-56004
    • Feuer, G.1    Green, P.L.2
  • 3
    • 47649123935 scopus 로고    scopus 로고
    • Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: Toward rational targeted therapy
    • Oh, U.; Jacobson, S. Treatment of HTLV-I-associated myelopathy/tropical spastic paraparesis: Toward rational targeted therapy. Neurol. Clin. 2008, 26, 781-797.
    • (2008) Neurol. Clin , vol.26 , pp. 781-797
    • Oh, U.1    Jacobson, S.2
  • 6
    • 0035667194 scopus 로고    scopus 로고
    • Oncogenic retroviruses in animals and humans
    • Burmeister, T. Oncogenic retroviruses in animals and humans. Rev. Med. Virol. 2001, 11, 369-380.
    • (2001) Rev. Med. Virol , vol.11 , pp. 369-380
    • Burmeister, T.1
  • 7
    • 25444459429 scopus 로고    scopus 로고
    • Activation of NF-kappaB by HTLV-I and implications for cell transformation
    • Sun, S.C.; Yamaoka, S. Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene 2005, 24, 5952-5964.
    • (2005) Oncogene , vol.24 , pp. 5952-5964
    • Sun, S.C.1    Yamaoka, S.2
  • 8
    • 33947578030 scopus 로고    scopus 로고
    • Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
    • Matsuoka, M., Jeang, K.T. Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat. Rev. Cancer 2007, 7, 270-280.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 270-280
    • Matsuoka, M.1    Jeang, K.T.2
  • 9
    • 74549180403 scopus 로고    scopus 로고
    • Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
    • Higuchi, M.; Fujii, M. Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis. Retrovirology 2009, 6, 117.
    • (2009) Retrovirology , vol.6 , pp. 117
    • Higuchi, M.1    Fujii, M.2
  • 10
    • 0025037838 scopus 로고
    • The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells
    • Pozzatti, R.; Vogel, J.; Jay, G. The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol. Cell Biol. 1990, 10, 413-417.
    • (1990) Mol. Cell Biol , vol.10 , pp. 413-417
    • Pozzatti, R.1    Vogel, J.2    Jay, G.3
  • 11
    • 0026773365 scopus 로고
    • Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture
    • Grassmann, R.; Berchtold, S.; Radant, I.; Alt, M.; Fleckenstein, B.; Sodroski, J.G.; Haseltine, W.A.; Ramstedt, U. Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. J. Virol. 1992, 66, 4570-4575.
    • (1992) J. Virol , vol.66 , pp. 4570-4575
    • Grassmann, R.1    Berchtold, S.2    Radant, I.3    Alt, M.4    Fleckenstein, B.5    Sodroski, J.G.6    Haseltine, W.A.7    Ramstedt, U.8
  • 12
    • 0027478979 scopus 로고
    • Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway
    • Akagi, T.; Shimotohno, K. Proliferative response of Tax1-transduced primary human T cells to anti-CD3 antibody stimulation by an interleukin-2-independent pathway. J. Virol. 1993, 67, 1211-1217.
    • (1993) J. Virol , vol.67 , pp. 1211-1217
    • Akagi, T.1    Shimotohno, K.2
  • 14
    • 0029163594 scopus 로고
    • Differences in sensitivity to induction of apoptosis among rat fibroblast cells transformed by HTLV-I tax gene or cellular nuclear oncogenes
    • Fujita, M.; Shiku, H. Differences in sensitivity to induction of apoptosis among rat fibroblast cells transformed by HTLV-I tax gene or cellular nuclear oncogenes. Oncogene 1995, 11, 15-20.
    • (1995) Oncogene , vol.11 , pp. 15-20
    • Fujita, M.1    Shiku, H.2
  • 15
    • 0026640786 scopus 로고
    • Phenotypic progression of a rat lymphoid cell line immortalized by human T-lymphotropic virus type I to induce lymphoma/leukemia-like disease in rats
    • Oka, T.; Sonobe, H.; Iwata, J.; Kubonishi, I.; Satoh, H.; Takata, M.; Tanaka, Y.; Tateno, M.; Tozawa, H.; Mori, S. et al. Phenotypic progression of a rat lymphoid cell line immortalized by human T-lymphotropic virus type I to induce lymphoma/leukemia-like disease in rats. J. Virol. 1992, 66, 6686-6694.
    • (1992) J. Virol , vol.66 , pp. 6686-6694
    • Oka, T.1    Sonobe, H.2    Iwata, J.3    Kubonishi, I.4    Satoh, H.5    Takata, M.6    Tanaka, Y.7    Tateno, M.8    Tozawa, H.9    Mori, S.10
  • 16
    • 0026510820 scopus 로고
    • Tax protein of human T-cell leukemia virus type I is required for maintenance of the transformed phenotype
    • Yamaoka, S.; Tobe, T.; Hatanaka, M. Tax protein of human T-cell leukemia virus type I is required for maintenance of the transformed phenotype. Oncogene 1992, 7, 433-437.
    • (1992) Oncogene , vol.7 , pp. 433-437
    • Yamaoka, S.1    Tobe, T.2    Hatanaka, M.3
  • 17
    • 0023189928 scopus 로고
    • The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice
    • Nerenberg, M.; Hinrichs, S.H.; Reynolds, R.K.; Khoury, G.; Jay, G. The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 1987, 237, 1324-1329.
    • (1987) Science , vol.237 , pp. 1324-1329
    • Nerenberg, M.1    Hinrichs, S.H.2    Reynolds, R.K.3    Khoury, G.4    Jay, G.5
  • 22
    • 0031720385 scopus 로고    scopus 로고
    • Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression
    • Hall, A.P.; Irvine, J.; Blyth, K.; Cameron, E.R.; Onions, D.E.; Campbell, M.E. Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression. J. Pathol. 1998, 186, 209-214.
    • (1998) J. Pathol , vol.186 , pp. 209-214
    • Hall, A.P.1    Irvine, J.2    Blyth, K.3    Cameron, E.R.4    Onions, D.E.5    Campbell, M.E.6
  • 25
    • 0028858129 scopus 로고
    • Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1
    • Akagi, T.; Ono, H.; Shimotohno, K. Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1. Blood 1995, 86, 4243-4249.
    • (1995) Blood , vol.86 , pp. 4243-4249
    • Akagi, T.1    Ono, H.2    Shimotohno, K.3
  • 26
    • 33745852665 scopus 로고    scopus 로고
    • Alternative pathways of NF-kappaB activation: A double-edged sword in health and disease
    • Xiao, G.; Rabson, A.B.; Young, W.; Qing, G.; Qu, Z. Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev. 2006, 17, 281-293.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 281-293
    • Xiao, G.1    Rabson, A.B.2    Young, W.3    Qing, G.4    Qu, Z.5
  • 27
    • 79959658547 scopus 로고    scopus 로고
    • NF-kappaB and Cancer: A Paradigm of Yin-Yang
    • Xiao, G.; Fu, J. NF-kappaB and Cancer: A Paradigm of Yin-Yang. Am. J. Cancer Res. 2011, 1, 192-221.
    • (2011) Am. J. Cancer Res , vol.1 , pp. 192-221
    • Xiao, G.1    Fu, J.2
  • 28
    • 0026742527 scopus 로고
    • The precursor of NF-kappa B p50 has I kappa B-like functions
    • Rice, N.R.; MacKichan, M.L.; Israel, A. The precursor of NF-kappa B p50 has I kappa B-like functions. Cell 1992, 71, 243-253.
    • (1992) Cell , vol.71 , pp. 243-253
    • Rice, N.R.1    Mackichan, M.L.2    Israel, A.3
  • 29
    • 0027243576 scopus 로고
    • P105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction
    • Mercurio, F.; DiDonato, J.A.; Rosette, C.; Karin, M. p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. Genes Dev. 1993, 7, 705-718.
    • (1993) Genes Dev , vol.7 , pp. 705-718
    • Mercurio, F.1    Didonato, J.A.2    Rosette, C.3    Karin, M.4
  • 30
    • 0034746514 scopus 로고    scopus 로고
    • Shared pathways of Ikappa B kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappa B precursor p105 and I kappa Balpha
    • Heissmeyer, V.; Krappmann, D.; Hatada, E.N.; Scheidereit, C. Shared pathways of Ikappa B kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappa B precursor p105 and I kappa Balpha. Mol. Cell Biol. 2001, 21, 1024-1035.
    • (2001) Mol. Cell Biol , vol.21 , pp. 1024-1035
    • Heissmeyer, V.1    Krappmann, D.2    Hatada, E.N.3    Scheidereit, C.4
  • 32
    • 0034745420 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
    • Xiao, G.; Harhaj, E.W.; Sun, S.C. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol. Cell 2001, 7, 401-409.
    • (2001) Mol. Cell , vol.7 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.C.3
  • 33
    • 12844275943 scopus 로고    scopus 로고
    • Regulation of NF-kappa B2 p100 processing by its cis-acting domain
    • Qing, G.; Qu, Z.; Xiao, G. Regulation of NF-kappa B2 p100 processing by its cis-acting domain. J. Biol. Chem. 2005, 280, 18-27.
    • (2005) J. Biol. Chem , vol.280 , pp. 18-27
    • Qing, G.1    Qu, Z.2    Xiao, G.3
  • 34
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl, H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 1999, 18, 6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 35
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-kappa B pathway
    • Chen, Z.J. Ubiquitin signalling in the NF-kappa B pathway. Nat. Cell Biol. 2005, 7, 758-765.
    • (2005) Nat. Cell Biol , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 37
    • 77957252647 scopus 로고    scopus 로고
    • The IKK complex, a central regulator of NF-kappaB activation
    • Israel, A. The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb. Perspect. Biol. 2010, 2, a000158.
    • (2010) Cold Spring Harb. Perspect. Biol , vol.2
    • Israel, A.1
  • 38
    • 0036203419 scopus 로고    scopus 로고
    • The phosphorylation status of nuclear NF-kappaB determines its association with CBP/p300 or HDAC-1
    • Zhong, H.; May, M.J; Jimi, E.; Ghosh, S. The phosphorylation status of nuclear NF-kappaB determines its association with CBP/p300 or HDAC-1. Mol. Cell 2002, 9, 625-636.
    • (2002) Mol. Cell , vol.9 , pp. 625-636
    • Zhong, H.1    May, M.J.2    Jimi, E.3    Ghosh, S.4
  • 39
    • 0034802887 scopus 로고    scopus 로고
    • The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression
    • Ashburner, B.P.; Westerheide, S.D.; Baldwin, A.S., Jr. The p65 (RelA) subunit of NF-kappaB interacts with the histone deacetylase (HDAC) corepressors HDAC1 and HDAC2 to negatively regulate gene expression. Mol. Cell Biol. 2001, 21, 7065-7077.
    • (2001) Mol. Cell Biol , vol.21 , pp. 7065-7077
    • Ashburner, B.P.1    Westerheide, S.D.2    Baldwin Jr., A.S.3
  • 40
    • 0347955360 scopus 로고    scopus 로고
    • Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA
    • Ryo, A.; Suizu, F.; Yoshida, Y.; Perrem, K.; Liou, Y.C.; Wulf, G.; Rottapel, R.; Yamaoka, S.; Lu, K.P. Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol. Cell 2003, 12, 1413-1426.
    • (2003) Mol. Cell , vol.12 , pp. 1413-1426
    • Ryo, A.1    Suizu, F.2    Yoshida, Y.3    Perrem, K.4    Liou, Y.C.5    Wulf, G.6    Rottapel, R.7    Yamaoka, S.8    Lu, K.P.9
  • 41
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF-kappaB action regulated by reversible acetylation
    • Chen, L.F.; Fischle, W.; Verdin, E.; Greene, W.C. Duration of nuclear NF-kappaB action regulated by reversible acetylation. Science 2001, 293, 1653-1657.
    • (2001) Science , vol.293 , pp. 1653-1657
    • Chen, L.F.1    Fischle, W.2    Verdin, E.3    Greene, W.C.4
  • 42
    • 28844498364 scopus 로고    scopus 로고
    • Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100
    • Qing, G.; Qu, Z.; Xiao, G. Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100. J. Biol. Chem. 2005, 280, 40578-40582.
    • (2005) J. Biol. Chem , vol.280 , pp. 40578-40582
    • Qing, G.1    Qu, Z.2    Xiao, G.3
  • 43
    • 2942731516 scopus 로고    scopus 로고
    • Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
    • Liao, G.; Zhang, M.; Harhaj, E.W.; Sun, S.C. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J. Biol. Chem. 2004, 279, 26243-26250.
    • (2004) J. Biol. Chem , vol.279 , pp. 26243-26250
    • Liao, G.1    Zhang, M.2    Harhaj, E.W.3    Sun, S.C.4
  • 44
    • 52049095036 scopus 로고    scopus 로고
    • New insights into NF-kappaB regulation and function
    • Sun, S.C.; Ley, S.C. New insights into NF-kappaB regulation and function. Trends Immunol. 2008, 29, 469-478.
    • (2008) Trends Immunol , vol.29 , pp. 469-478
    • Sun, S.C.1    Ley, S.C.2
  • 45
    • 79959658546 scopus 로고    scopus 로고
    • Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain
    • Xiao, G.; Sun S.C. Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain. J. Biol. Chem. 2000, 19, 1448-1456.
    • (2000) J. Biol. Chem , vol.19 , pp. 1448-1456
    • Xiao, G.1    Sun, S.C.2
  • 46
    • 40249115896 scopus 로고    scopus 로고
    • TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
    • Gardam, S.; Sierro, F.; Basten, A.; Mackay, F.; Brink, R. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 2008, 28, 391-401.
    • (2008) Immunity , vol.28 , pp. 391-401
    • Gardam, S.1    Sierro, F.2    Basten, A.3    Mackay, F.4    Brink, R.5
  • 47
    • 8444220390 scopus 로고    scopus 로고
    • TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells
    • Grech, A.P.; Amesbury, M.; Chan, T.; Gardam, S.; Basten, A.; Brink, R. TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity 2004, 21, 629-642.
    • (2004) Immunity , vol.21 , pp. 629-642
    • Grech, A.P.1    Amesbury, M.2    Chan, T.3    Gardam, S.4    Basten, A.5    Brink, R.6
  • 49
    • 24744432290 scopus 로고    scopus 로고
    • Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes
    • Moore, C.R.; Bishop, G.A. Differential regulation of CD40-mediated TNF receptor-associated factor degradation in B lymphocytes. J. Immunol. 2005, 175, 3780-3789.
    • (2005) J. Immunol , vol.175 , pp. 3780-3789
    • Moore, C.R.1    Bishop, G.A.2
  • 52
    • 0037151118 scopus 로고    scopus 로고
    • Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100
    • Fong, A.; Sun, S.C., Genetic evidence for the essential role of beta-transducin repeat-containing protein in the inducible processing of NF-kappa B2/p100. J. Biol. Chem. 2002, 277, 22111-22114.
    • (2002) J. Biol. Chem , vol.277 , pp. 22111-22114
    • Fong, A.1    Sun, S.C.2
  • 54
    • 3142663912 scopus 로고    scopus 로고
    • Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation
    • Xiao, G.; Fong, A.; Sun, S.C. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J. Biol. Chem. 2004, 279, 30099-30105.
    • (2004) J. Biol. Chem , vol.279 , pp. 30099-30105
    • Xiao, G.1    Fong, A.2    Sun, S.C.3
  • 55
    • 42149110830 scopus 로고    scopus 로고
    • Control of canonical NF-kappaB activation through the NIK-IKK complex pathway
    • Zarnegar, B.; Yamazaki, S.; He, J.Q.; Cheng, G. Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc. Natl. Acad. Sci. U. S. A. 2008, 105, 3503-3508.
    • (2008) Proc. Natl. Acad. Sci. U. S. A , vol.105 , pp. 3503-3508
    • Zarnegar, B.1    Yamazaki, S.2    He, J.Q.3    Cheng, G.4
  • 56
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    • Delhase, M.; Hayakawa, M.; Chen, Y.; Karin, M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 1999, 284, 309-313.
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 57
    • 77953824286 scopus 로고    scopus 로고
    • Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation
    • Razani, B.; Zarnegar, B.; Ytterberg, A.J.; Shiba, T.; Dempsey, P.W.; Ware, C.F.; Loo, J.A.; Cheng, G. Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. Sci. Signal 2010, 3, pe41.
    • (2010) Sci. Signal , vol.3 , pp. 41
    • Razani, B.1    Zarnegar, B.2    Ytterberg, A.J.3    Shiba, T.4    Dempsey, P.W.5    Ware, C.F.6    Loo, J.A.7    Cheng, G.8
  • 59
    • 0026699666 scopus 로고
    • Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements
    • Krikos, A.; Laherty, C.D.; Dixit, V.M. Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J. Biol. Chem. 1992, 267, 17971-17976.
    • (1992) J. Biol. Chem , vol.267 , pp. 17971-17976
    • Krikos, A.1    Laherty, C.D.2    Dixit, V.M.3
  • 60
    • 77649225756 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
    • Shembade, N.; Ma, A.; Harhaj, E.W. Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Science 2010, 327, 1135-1139.
    • (2010) Science , vol.327 , pp. 1135-1139
    • Shembade, N.1    Ma, A.2    Harhaj, E.W.3
  • 62
    • 0033712615 scopus 로고    scopus 로고
    • Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation
    • Zhang, S.Q.; Kovalenko, A.; Cantarella, G.; Wallach, D. Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity 2000, 12, 301-311.
    • (2000) Immunity , vol.12 , pp. 301-311
    • Zhang, S.Q.1    Kovalenko, A.2    Cantarella, G.3    Wallach, D.4
  • 64
    • 35648958721 scopus 로고    scopus 로고
    • IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway
    • Hutti, J.E.; Turk, B.E.; Asara, J.M.; Ma, A.; Cantley, L.C.; Abbott, D.W. IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol. Cell Biol. 2007, 27, 7451-7461.
    • (2007) Mol. Cell Biol , vol.27 , pp. 7451-7461
    • Hutti, J.E.1    Turk, B.E.2    Asara, J.M.3    Ma, A.4    Cantley, L.C.5    Abbott, D.W.6
  • 65
    • 77449150629 scopus 로고    scopus 로고
    • CYLD: A tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes
    • Sun, S.C. CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes. Cell Death Differ. 2010, 17, 25-34.
    • (2010) Cell Death Differ , vol.17 , pp. 25-34
    • Sun, S.C.1
  • 66
    • 0042467554 scopus 로고    scopus 로고
    • Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
    • Brummelkamp, T.R.; Nijman, S.M.; Dirac, A.M.; Bernards, R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 2003, 424, 797-801.
    • (2003) Nature , vol.424 , pp. 797-801
    • Brummelkamp, T.R.1    Nijman, S.M.2    Dirac, A.M.3    Bernards, R.4
  • 67
    • 0041967054 scopus 로고    scopus 로고
    • The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination
    • Kovalenko, A.; Chable-Bessia, C.; Cantarella, G.; Israel, A.; Wallach, D.; Courtois, G. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 2003, 424, 801-805.
    • (2003) Nature , vol.424 , pp. 801-805
    • Kovalenko, A.1    Chable-Bessia, C.2    Cantarella, G.3    Israel, A.4    Wallach, D.5    Courtois, G.6
  • 68
    • 0042467558 scopus 로고    scopus 로고
    • CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members
    • Trompouki, E.; Hatzivassiliou, E.; Tsichritzis, T.; Farmer, H.; Ashworth, A.; Mosialos, G. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature 2003, 424, 793-796.
    • (2003) Nature , vol.424 , pp. 793-796
    • Trompouki, E.1    Hatzivassiliou, E.2    Tsichritzis, T.3    Farmer, H.4    Ashworth, A.5    Mosialos, G.6
  • 70
    • 37349111560 scopus 로고    scopus 로고
    • RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling
    • Li, S.; Wang, L.; Berman, M.A.; Zhang, Y.; Dorf, M.E. RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling. Mol. Cell 2006, 24, 497-509.
    • (2006) Mol. Cell , vol.24 , pp. 497-509
    • Li, S.1    Wang, L.2    Berman, M.A.3    Zhang, Y.4    Dorf, M.E.5
  • 71
    • 0035930630 scopus 로고    scopus 로고
    • Protein phosphatase 2A interacts with and directly dephosphorylates RelA
    • Yang, J.; Fang, G.H; Wadzinski, B.E.; Sakurai, H.; Richmond, A. Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J. Biol. Chem. 2001, 276, 47828-47833.
    • (2001) J. Biol. Chem , vol.276 , pp. 47828-47833
    • Yang, J.1    Fang, G.H.2    Wadzinski, B.E.3    Sakurai, H.4    Richmond, A.5
  • 72
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung, F.; Hoberg, J.E.; Ramsey, C.S.; Keller, M.D.; Jones, D.R.; Frye, R.A.; Mayo, M.W. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004, 23, 2369-2380.
    • (2004) EMBO J , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 73
    • 0037697247 scopus 로고    scopus 로고
    • SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription
    • Wu, M.; Xu, L.G.; Zhai, Z.; Shu, H.B. SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. J. Biol. Chem. 2003, 278, 27072-27079.
    • (2003) J. Biol. Chem , vol.278 , pp. 27072-27079
    • Wu, M.1    Xu, L.G.2    Zhai, Z.3    Shu, H.B.4
  • 74
    • 0037462477 scopus 로고    scopus 로고
    • Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity
    • Šošić, D.; Richardson, J.A.; Yu, K.; Ornitz, D.M.; Olson, E.N. Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell 2003, 112, 169-180.
    • (2003) Cell , vol.112 , pp. 169-180
    • Šošić, D.1    Richardson, J.A.2    Yu, K.3    Ornitz, D.M.4    Olson, E.N.5
  • 75
    • 0033048966 scopus 로고    scopus 로고
    • Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor
    • Yang, J.P.; Hori, M.; Sanda, T.; Okamoto, T. Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor. J. Biol. Chem. 1999, 274, 15662-15670.
    • (1999) J. Biol. Chem , vol.274 , pp. 15662-15670
    • Yang, J.P.1    Hori, M.2    Sanda, T.3    Okamoto, T.4
  • 76
    • 0027168447 scopus 로고
    • NF-kappa B controls expression of inhibitor I kappa B alpha: Evidence for an inducible autoregulatory pathway
    • Sun, S.C.; Ganchi, P.A.; Ballard, D.W.; Greene, W.C. NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 1993, 259, 1912-1915.
    • (1993) Science , vol.259 , pp. 1912-1915
    • Sun, S.C.1    Ganchi, P.A.2    Ballard, D.W.3    Greene, W.C.4
  • 77
    • 3142771914 scopus 로고    scopus 로고
    • Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response
    • Saccani, S.; Marazzi, I.; Beg, A.A.; Natoli, G. Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. J. Exp. Med. 2004, 200, 107-113.
    • (2004) J. Exp. Med , vol.200 , pp. 107-113
    • Saccani, S.1    Marazzi, I.2    Beg, A.A.3    Natoli, G.4
  • 78
    • 34249066486 scopus 로고    scopus 로고
    • PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit
    • Tanaka, T.; Grusby, M.J.; Kaisho, T. PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat. Immunol. 2007, 8, 584-591.
    • (2007) Nat. Immunol , vol.8 , pp. 584-591
    • Tanaka, T.1    Grusby, M.J.2    Kaisho, T.3
  • 79
    • 78650033289 scopus 로고    scopus 로고
    • Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis
    • Fu, J.; Yan, P.; Li, S.; Qu, Z.; Xiao, G. Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis. Oncogene 2010, 29, 6499-6507.
    • (2010) Oncogene , vol.29 , pp. 6499-6507
    • Fu, J.1    Yan, P.2    Li, S.3    Qu, Z.4    Xiao, G.5
  • 80
    • 27144476790 scopus 로고    scopus 로고
    • Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia
    • Watanabe, M.; Ohsuqi, T.; Shoda, M.; Ishida, T.; Aizawa, S.; Maruyama-Nagai, M.; Utsunomiya, A.; Koga, S.; Yamada, Y.; Kamihira, S. et al. Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia. Blood 2005, 106, 2462-2471.
    • (2005) Blood , vol.106 , pp. 2462-2471
    • Watanabe, M.1    Ohsuqi, T.2    Shoda, M.3    Ishida, T.4    Aizawa, S.5    Maruyama-Nagai, M.6    Utsunomiya, A.7    Koga, S.8    Yamada, Y.9    Kamihira, S.10
  • 81
    • 0023712373 scopus 로고
    • HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene
    • Ballard, D.W.; Böhnlein, E.; Lowenthal, J.W.; Wano, Y.; Franza, B.R.; Greene, W.C. HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene. Science 1988, 241, 1652-1655.
    • (1988) Science , vol.241 , pp. 1652-1655
    • Ballard, D.W.1    Böhnlein, E.2    Lowenthal, J.W.3    Wano, Y.4    Franza, B.R.5    Greene, W.C.6
  • 82
    • 0024596569 scopus 로고
    • Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins
    • Böhnlein, E.; Siekevitz, M.; Ballard, D.W.; Lowenthal, J.W.; Rimsky, L.; Bogérd, H.; Hoffman, J.; Wano, Y.; Franza, B.R.; Greene, W.C. Stimulation of the human immunodeficiency virus type 1 enhancer by the human T-cell leukemia virus type I tax gene product involves the action of inducible cellular proteins. J. Virol. 1989, 63, 1578-1586.
    • (1989) J. Virol , vol.63 , pp. 1578-1586
    • Böhnlein, E.1    Siekevitz, M.2    Ballard, D.W.3    Lowenthal, J.W.4    Rimsky, L.5    Bogérd, H.6    Hoffman, J.7    Wano, Y.8    Franza, B.R.9    Greene, W.C.10
  • 83
    • 0023900857 scopus 로고
    • HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor
    • Leung, K.; Nabel, G.L. HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor. Nature 1988, 333, 776-778.
    • (1988) Nature , vol.333 , pp. 776-778
    • Leung, K.1    Nabel, G.L.2
  • 84
    • 0023930054 scopus 로고
    • Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product
    • Ruben, S.; Poteat, H.; Tan, T.H.; Kawakami, K.; Roeder, R.; Haseltine, W.; Rosen, C.A. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. Science 1988, 241, 89-92.
    • (1988) Science , vol.241 , pp. 89-92
    • Ruben, S.1    Poteat, H.2    Tan, T.H.3    Kawakami, K.4    Roeder, R.5    Haseltine, W.6    Rosen, C.A.7
  • 85
    • 0032589261 scopus 로고    scopus 로고
    • IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1
    • Chu, Z.L.; Shin, Y.A.; Yang, J.M.; DiDonato, J.A.; Ballard, D.W. IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1. J. Biol. Chem. 1999, 274, 15297-15300.
    • (1999) J. Biol. Chem , vol.274 , pp. 15297-15300
    • Chu, Z.L.1    Shin, Y.A.2    Yang, J.M.3    Didonato, J.A.4    Ballard, D.W.5
  • 86
    • 0033551607 scopus 로고    scopus 로고
    • IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein
    • Harhaj, E.W.; Sun, S.C. IKKgamma serves as a docking subunit of the IkappaB kinase (IKK) and mediates interaction of IKK with the human T-cell leukemia virus Tax protein. J. Biol. Chem. 1999, 274, 22911-22914.
    • (1999) J. Biol. Chem , vol.274 , pp. 22911-22914
    • Harhaj, E.W.1    Sun, S.C.2
  • 87
    • 0033580931 scopus 로고    scopus 로고
    • Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma
    • Jin, D.Y.; Giordano, V.; Kibler, K.V.; Nakano, H.; Jeang, K.T. Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma. J. Biol. Chem. 1999, 274, 17402-17405.
    • (1999) J. Biol. Chem , vol.274 , pp. 17402-17405
    • Jin, D.Y.1    Giordano, V.2    Kibler, K.V.3    Nakano, H.4    Jeang, K.T.5
  • 88
    • 0034602407 scopus 로고    scopus 로고
    • Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK
    • Xiao, G.; Harhaj, E.W.; Sun, S.C. Domain-specific interaction with the I kappa B kinase (IKK)regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK. J. Biol. Chem. 2000, 275, 34060-34067.
    • (2000) J. Biol. Chem , vol.275 , pp. 34060-34067
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.C.3
  • 89
    • 2442577087 scopus 로고    scopus 로고
    • Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65
    • O'Mahony, A.M.; Montanp, M.; Van Beneden, K.; Chen, L.F.; Greene, W.C. Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65. J. Biol. Chem. 2004, 279, 18137-18145.
    • (2004) J. Biol. Chem , vol.279 , pp. 18137-18145
    • O'Mahony, A.M.1    Montanp, M.2    van Beneden, K.3    Chen, L.F.4    Greene, W.C.5
  • 90
    • 0029840633 scopus 로고    scopus 로고
    • Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles
    • Semmes, O.J.; Jeang, K.T. Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles. J. Virol. 1996, 70, 6347-6357.
    • (1996) J. Virol , vol.70 , pp. 6347-6357
    • Semmes, O.J.1    Jeang, K.T.2
  • 91
    • 0030896497 scopus 로고    scopus 로고
    • The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins
    • Bex, F.; McDowall, A.; Burny, A.; Gaynor, R. The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kappaB proteins. J. Virol. 1997, 71, 3484-3497.
    • (1997) J. Virol , vol.71 , pp. 3484-3497
    • Bex, F.1    McDowall, A.2    Burny, A.3    Gaynor, R.4
  • 92
    • 0030831166 scopus 로고    scopus 로고
    • HTLV-I Tax self-association in optimal trans-activation function
    • Jin, D.Y.; Jeang, K.T. HTLV-I Tax self-association in optimal trans-activation function. Nucleic Acids Res. 1997, 25, 379-387.
    • (1997) Nucleic Acids Res , vol.25 , pp. 379-387
    • Jin, D.Y.1    Jeang, K.T.2
  • 93
    • 0029861653 scopus 로고    scopus 로고
    • Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat
    • Tie, F.; Adya, N.; Greene, W.C.; Giam, C.Z. Interaction of the human T-lymphotropic virus type 1 Tax dimer with CREB and the viral 21-base-pair repeat. J. Virol. 1996, 70, 8368-8374.
    • (1996) J. Virol , vol.70 , pp. 8368-8374
    • Tie, F.1    Adya, N.2    Greene, W.C.3    Giam, C.Z.4
  • 94
    • 0034718693 scopus 로고    scopus 로고
    • Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein
    • Xiao, G.; Sun, S.C. Activation of IKKalpha and IKKbeta through their fusion with HTLV-I tax protein. Oncogene 2000, 19, 5198-5203.
    • (2000) Oncogene , vol.19 , pp. 5198-5203
    • Xiao, G.1    Sun, S.C.2
  • 96
    • 0032516520 scopus 로고    scopus 로고
    • NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation
    • Uhlik, M., Good, L.; Xiao, G.; Harhaj, E.W.; Zandi, E.; Karin, M.; Sun, S.C. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J. Biol. Chem. 1998, 273, 21132-21136.
    • (1998) J. Biol. Chem , vol.273 , pp. 21132-21136
    • Uhlik, M.1    Good, L.2    Xiao, G.3    Harhaj, E.W.4    Zandi, E.5    Karin, M.6    Sun, S.C.7
  • 98
    • 33744910363 scopus 로고    scopus 로고
    • Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells
    • Babu, G.; Waterfield, M.; Chang, M.; Wu, X.; Sun, S.C. Deregulated activation of oncoprotein kinase Tpl2/Cot in HTLV-I-transformed T cells. J. Biol. Chem. 2006, 281, 14041-14047.
    • (2006) J. Biol. Chem , vol.281 , pp. 14041-14047
    • Babu, G.1    Waterfield, M.2    Chang, M.3    Wu, X.4    Sun, S.C.5
  • 99
    • 34548493445 scopus 로고    scopus 로고
    • Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB
    • Suzuki, S.; Singhirunnusorn, P.; Mori, A.; Yamaoka, S.; Kitajima, I.; Saiki, I.; Sakurai, H. Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-kappaB. J. Biol. Chem. 2007, 282, 25177-25181.
    • (2007) J. Biol. Chem , vol.282 , pp. 25177-25181
    • Suzuki, S.1    Singhirunnusorn, P.2    Mori, A.3    Yamaoka, S.4    Kitajima, I.5    Saiki, I.6    Sakurai, H.7
  • 101
    • 77951194340 scopus 로고    scopus 로고
    • Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways
    • Suzuki, S.; Zhou, Y.; Refaat, A.; Takasaki, I.; Koizumi, K.; Yamaoka, S.; Tabuchi, Y.; Saiki, I.; Sakurai, H. Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways. J. Biol. Chem. 2010, 285, 4441-4446.
    • (2010) J. Biol. Chem , vol.285 , pp. 4441-4446
    • Suzuki, S.1    Zhou, Y.2    Refaat, A.3    Takasaki, I.4    Koizumi, K.5    Yamaoka, S.6    Tabuchi, Y.7    Saiki, I.8    Sakurai, H.9
  • 103
    • 33947491230 scopus 로고    scopus 로고
    • Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase
    • Harhaj, N.S.; Sun, S.C.; Harhaj, E.W. Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase. J. Biol. Chem. 2007, 282, 4185-4192.
    • (2007) J. Biol. Chem , vol.282 , pp. 4185-4192
    • Harhaj, N.S.1    Sun, S.C.2    Harhaj, E.W.3
  • 105
    • 78049311732 scopus 로고    scopus 로고
    • Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-κB activation
    • Avesani, F.; Romanelli, M.G.; Turci, M.; Di Gennaro, G.; Sampaio, C.; Bidoia, C.; Bertazzoni, U.; Bex, F. Association of HTLV Tax proteins with TAK1-binding protein 2 and RelA in calreticulin-containing cytoplasmic structures participates in Tax-mediated NF-κB activation. Virology 2010, 408, 39-48.
    • (2010) Virology , vol.408 , pp. 39-48
    • Avesani, F.1    Romanelli, M.G.2    Turci, M.3    di Gennaro, G.4    Sampaio, C.5    Bidoia, C.6    Bertazzoni, U.7    Bex, F.8
  • 106
    • 65249136553 scopus 로고    scopus 로고
    • HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB
    • Huang, J.; Ren, T.; Guan, H.; Jiang, Y.; Cheng, H. HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB. J. Biol. Chem. 2009, 284, 6208-6217.
    • (2009) J. Biol. Chem , vol.284 , pp. 6208-6217
    • Huang, J.1    Ren, T.2    Guan, H.3    Jiang, Y.4    Cheng, H.5
  • 107
    • 27944431565 scopus 로고    scopus 로고
    • Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein
    • Lamsoul, I.; Lodewick, J.; Lebrun, S.; Brasseur, R.; Burny, A.; Gaynor, R.B.; Bex, F. Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-kappaB activation by the human T-cell leukemia virus tax oncoprotein. Mol. Cell Biol. 2005, 25, 10391-10406.
    • (2005) Mol. Cell Biol , vol.25 , pp. 10391-10406
    • Lamsoul, I.1    Lodewick, J.2    Lebrun, S.3    Brasseur, R.4    Burny, A.5    Gaynor, R.B.6    Bex, F.7
  • 109
    • 37049024986 scopus 로고    scopus 로고
    • The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation
    • Shembade, N.; Harhaj, N.S.; Yamamoto, M.; Akira, S.; Harhaj, E.W. The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. J. Virol. 2003, 81, 13735-13742.
    • (2003) J. Virol , vol.81 , pp. 13735-13742
    • Shembade, N.1    Harhaj, N.S.2    Yamamoto, M.3    Akira, S.4    Harhaj, E.W.5
  • 111
    • 78650873024 scopus 로고    scopus 로고
    • Nuclear initiated NF-kappa B signaling: NEMO and ATM take center stage
    • Miyamoto, S. Nuclear initiated NF-kappa B signaling: NEMO and ATM take center stage. Cell Res. 2011, 21, 116-130.
    • (2011) Cell Res , vol.21 , pp. 116-130
    • Miyamoto, S.1
  • 112
    • 0344305376 scopus 로고    scopus 로고
    • Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
    • Huang, T.T.; Wuerzberger-Davis, S.M.; Wu, Z.H.; Miyamoto, S. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 2003, 115, 565-576.
    • (2003) Cell , vol.115 , pp. 565-576
    • Huang, T.T.1    Wuerzberger-Davis, S.M.2    Wu, Z.H.3    Miyamoto, S.4
  • 113
    • 0942298113 scopus 로고    scopus 로고
    • Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression
    • Verma, U.N.; Yamamoto, Y.; Prajapati, S.; Gaynor, R.B. Nuclear role of I kappa B Kinase-gamma/NF-kappa B essential modulator (IKK gamma/NEMO) in NF-kappa B-dependent gene expression. J. Biol. Chem. 2004, 279, 3509-3515.
    • (2004) J. Biol. Chem , vol.279 , pp. 3509-3515
    • Verma, U.N.1    Yamamoto, Y.2    Prajapati, S.3    Gaynor, R.B.4
  • 114
    • 0032888951 scopus 로고    scopus 로고
    • Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation
    • Bex, F.; Murphy, K.; Wattiez, R.; Burny, A.; Gaynor, R.B. Phosphorylation of the human T-cell leukemia virus type 1 transactivator tax on adjacent serine residues is critical for tax activation. J. Virol. 1999, 73, 738-745.
    • (1999) J. Virol , vol.73 , pp. 738-745
    • Bex, F.1    Murphy, K.2    Wattiez, R.3    Burny, A.4    Gaynor, R.B.5
  • 115
    • 61649087854 scopus 로고    scopus 로고
    • Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway
    • Lodewick, J.; Lamsoul, I.; Polania, A.; Lebrun, S.; Burny, A.; Ratner, L.; Bex, F. Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway. Virology 2009, 386, 68-78.
    • (2009) Virology , vol.386 , pp. 68-78
    • Lodewick, J.1    Lamsoul, I.2    Polania, A.3    Lebrun, S.4    Burny, A.5    Ratner, L.6    Bex, F.7
  • 116
    • 33846024067 scopus 로고    scopus 로고
    • Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein
    • Durkin, S.S.; Ward, M.D.; Fryrear, K.A.; Semmes, O.J. Site-specific phosphorylation differentiates active from inactive forms of the human T-cell leukemia virus type 1 Tax oncoprotein. J. Biol. Chem. 2006, 281, 31705-31712.
    • (2006) J. Biol. Chem , vol.281 , pp. 31705-31712
    • Durkin, S.S.1    Ward, M.D.2    Fryrear, K.A.3    Semmes, O.J.4
  • 117
    • 63149174264 scopus 로고    scopus 로고
    • Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB
    • Peloponese, J.M., Jr.; Yasunaga, J.; Kinjo, T.; Watashi, K.; Jeang, K.T. Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB. J. Virol. 2009, 83, 3238-3248.
    • (2009) J. Virol , vol.83 , pp. 3238-3248
    • Peloponese Jr., J.M.1    Yasunaga, J.2    Kinjo, T.3    Watashi, K.4    Jeang, K.T.5
  • 118
    • 61849086777 scopus 로고    scopus 로고
    • The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation
    • Jeong, S.J.; Rya, A.; Yamamoto, N. The prolyl isomerase Pin1 stabilizes the human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein and promotes malignant transformation. Biochem. Biophys. Res. Commun. 2009, 381, 294-299.
    • (2009) Biochem. Biophys. Res. Commun , vol.381 , pp. 294-299
    • Jeong, S.J.1    Rya, A.2    Yamamoto, N.3
  • 119
    • 66349093637 scopus 로고    scopus 로고
    • Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family
    • Fan, G.; Fan, Y.; Gupta, N.; Matsuura, I.; Liu, F.; Zhou, X.Z.; Lu, K.P.; Gélinas, C. Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family. Cancer Res. 2009, 69, 4589-4597.
    • (2009) Cancer Res , vol.69 , pp. 4589-4597
    • Fan, G.1    Fan, Y.2    Gupta, N.3    Matsuura, I.4    Liu, F.5    Zhou, X.Z.6    Lu, K.P.7    Gélinas, C.8
  • 120
    • 0035803392 scopus 로고    scopus 로고
    • Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: Evidence for the involvement of IKKalpha
    • Xiao, G.; Cvijic, M.E.; Fong, A.; Harhaj, E.W.; Uhlik, M.T.; Waterfield, M.; Sun, S.C. Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: Evidence for the involvement of IKKalpha. EMBO J. 2001, 20, 6805-6815.
    • (2001) EMBO J , vol.20 , pp. 6805-6815
    • Xiao, G.1    Cvijic, M.E.2    Fong, A.3    Harhaj, E.W.4    Uhlik, M.T.5    Waterfield, M.6    Sun, S.C.7
  • 121
    • 0034624810 scopus 로고    scopus 로고
    • Somatic mutagenesis studies of NF-kappa B signaling in human T cells: Evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein
    • Harhaj, E.W.; Good, L.; Xiao, G.; Uhlik, M.; Cvijic, M.E.; Rivera-Walsh, I.; Sun, S.C. Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein. Oncogene 2000, 19, 1448-1456.
    • (2000) Oncogene , vol.19 , pp. 1448-1456
    • Harhaj, E.W.1    Good, L.2    Xiao, G.3    Uhlik, M.4    Cvijic, M.E.5    Rivera-Walsh, I.6    Sun, S.C.7
  • 122
    • 0032568792 scopus 로고    scopus 로고
    • Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation
    • Yamaoka, S.; Courtois, G.; Bessia, C.; Whiteside, S.T.; Weil, R.; Agou, F.; Kirk, H.E.; Kay, R.J.; Israël, A. Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 1998, 93, 1231-1240.
    • (1998) Cell , vol.93 , pp. 1231-1240
    • Yamaoka, S.1    Courtois, G.2    Bessia, C.3    Whiteside, S.T.4    Weil, R.5    Agou, F.6    Kirk, H.E.7    Kay, R.J.8    Israël, A.9
  • 123
    • 7244240800 scopus 로고    scopus 로고
    • Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms
    • Qu, Z.; Qing, G.; Rabson, A.B.; Xiao, G. Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms. J. Biol. Chem. 2004, 279, 44563-44572.
    • (2004) J. Biol. Chem , vol.279 , pp. 44563-44572
    • Qu, Z.1    Qing, G.2    Rabson, A.B.3    Xiao, G.4
  • 124
    • 0035865798 scopus 로고    scopus 로고
    • Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia
    • Furukawa, Y.; Kubota, R.; Tara, M.; Izumo, S.; Osame, M. Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Blood 2001, 97, 987-993.
    • (2001) Blood , vol.97 , pp. 987-993
    • Furukawa, Y.1    Kubota, R.2    Tara, M.3    Izumo, S.4    Osame, M.5
  • 125
    • 0028907030 scopus 로고
    • Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells
    • Furukawa, Y.; Osame, M.; Kubota, R.; Tara, M.; Yoshida, M. Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells. Blood 1995, 85, 1865-1870.
    • (1995) Blood , vol.85 , pp. 1865-1870
    • Furukawa, Y.1    Osame, M.2    Kubota, R.3    Tara, M.4    Yoshida, M.5
  • 126
    • 0036707582 scopus 로고    scopus 로고
    • 5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo
    • Koiwa, T.; Hamano-Usami, A.; Ishida, T.; Okayama, A.; Yamaguchi, K.; Kamihira, S.; Watanabe, T. 5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. J. Virol. 2001, 76, 9389-9397.
    • (2001) J. Virol , vol.76 , pp. 9389-9397
    • Koiwa, T.1    Hamano-Usami, A.2    Ishida, T.3    Okayama, A.4    Yamaguchi, K.5    Kamihira, S.6    Watanabe, T.7
  • 129
    • 0029973962 scopus 로고    scopus 로고
    • Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia
    • Tamiya, S.; Matsuoka, M.; Etoh, K.; Watanabe, T.; Kamihira, S.; Yamaguchi, K.; Takatsuki, K. Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood 1996, 88, 3065-3073.
    • (1996) Blood , vol.88 , pp. 3065-3073
    • Tamiya, S.1    Matsuoka, M.2    Etoh, K.3    Watanabe, T.4    Kamihira, S.5    Yamaguchi, K.6    Takatsuki, K.7
  • 130
    • 2442670204 scopus 로고    scopus 로고
    • Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells
    • Hironaka, N.; Mochida, K.; Mori, N.; Maeda, M.; Yamamoto, N.; Yamaoka, S. Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. Neoplasia 2004, 6, 266-278.
    • (2004) Neoplasia , vol.6 , pp. 266-278
    • Hironaka, N.1    Mochida, K.2    Mori, N.3    Maeda, M.4    Yamamoto, N.5    Yamaoka, S.6
  • 131
    • 0033120826 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells
    • Mori, N.; Fujii, M.; Ikeda, S.; Yamada, Y.; Tomonaga, M.; Ballard, D.W.; Yamamoto, N. Constitutive activation of NF-kappaB in primary adult T-cell leukemia cells. Blood 1999, 93, 2360-2368.
    • (1999) Blood , vol.93 , pp. 2360-2368
    • Mori, N.1    Fujii, M.2    Ikeda, S.3    Yamada, Y.4    Tomonaga, M.5    Ballard, D.W.6    Yamamoto, N.7
  • 132
    • 35848967373 scopus 로고    scopus 로고
    • Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: Implications for therapeutic interventions
    • Yan, P.; Qing, G.; Qu, Z.; Wu, C.C.; Rabson, A.B; Xiao, G. Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: Implications for therapeutic interventions. Autophagy 2007, 3, 600-603.
    • (2007) Autophagy , vol.3 , pp. 600-603
    • Yan, P.1    Qing, G.2    Qu, Z.3    Wu, C.C.4    Rabson, A.B.5    Xiao, G.6
  • 133
    • 0038054541 scopus 로고    scopus 로고
    • Negative regulation of TCR signaling and T-cell activation by selective protein degradation
    • Jang, I.K.; Gu, H. Negative regulation of TCR signaling and T-cell activation by selective protein degradation. Curr. Opin. Immunol. 2003, 15, 315-320.
    • (2003) Curr. Opin. Immunol , vol.15 , pp. 315-320
    • Jang, I.K.1    Gu, H.2
  • 134
    • 38849106942 scopus 로고    scopus 로고
    • Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins
    • Gupta, N.; Delrow, J.; Drawid, A.; Sengupta, A.M.; Fan, G.; Gélinas, C. Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins. Cancer Res. 2008, 68, 808-814.
    • (2008) Cancer Res , vol.68 , pp. 808-814
    • Gupta, N.1    Delrow, J.2    Drawid, A.3    Sengupta, A.M.4    Fan, G.5    Gélinas, C.6
  • 135
    • 0033545404 scopus 로고    scopus 로고
    • Gene expression profiles in HTLV-I-immortalized T cells: Deregulated expression of genes involved in apoptosis regulation
    • Harhaj, E.W.; Good, L.; Xiao, G.; Sun, S.C. Gene expression profiles in HTLV-I-immortalized T cells: deregulated expression of genes involved in apoptosis regulation. Oncogene 1999, 18, 1341-1349.
    • (1999) Oncogene , vol.18 , pp. 1341-1349
    • Harhaj, E.W.1    Good, L.2    Xiao, G.3    Sun, S.C.4
  • 136
    • 0024475243 scopus 로고
    • Absence of transcription of lck (lymphocyte specific protein tyrosine kinase) message in IL-2-independent, HTLV-I-transformed T cell lines
    • Koga, Y.; Oh-Hori, N.; Sato, H.; Yamamoto, N.; Kimura, G.; Nomoto, K. Absence of transcription of lck (lymphocyte specific protein tyrosine kinase) message in IL-2-independent, HTLV-I-transformed T cell lines. J. Immunol. 1989, 142, 4493-4499.
    • (1989) J. Immunol , vol.142 , pp. 4493-4499
    • Koga, Y.1    Oh-Hori, N.2    Sato, H.3    Yamamoto, N.4    Kimura, G.5    Nomoto, K.6
  • 137
    • 0024544026 scopus 로고
    • Human T cell leukemia/lymphoma virus type I infection of a CD4+ proliferative/cytotoxic T cell clone progresses in at least two distinct phases based on changes in function and phenotype of the infected cells
    • Yssel, H.; de Waal Malefyt, R.; Duc Dodon, M.D.; Blanchard, D.; Gazzolo, L.; de Vries, J.E.; Spits, H. Human T cell leukemia/lymphoma virus type I infection of a CD4+ proliferative/cytotoxic T cell clone progresses in at least two distinct phases based on changes in function and phenotype of the infected cells. J. Immunol. 1989, 142, 2279-2289.
    • (1989) J. Immunol , vol.142 , pp. 2279-2289
    • Yssel, H.1    de Waal, M.R.2    Duc, D.M.D.3    Blanchard, D.4    Gazzolo, L.5    de Vries, J.E.6    Spits, H.7
  • 138
    • 0025135244 scopus 로고
    • Human T cell leukemia virus type I prevents cell surface expression of the T cell receptor through down-regulation of the CD3-gamma, -delta, -epsilon, and -zeta genes
    • de Waal Malefyt, R.; Yssel, H.; Spits, H.; de Vries, J.E.; Sancho, J.; Terhorst, C.; Alarcon, B. Human T cell leukemia virus type I prevents cell surface expression of the T cell receptor through down-regulation of the CD3-gamma, -delta, -epsilon, and -zeta genes. J. Immunol. 1990, 145, 2297-2303.
    • (1990) J. Immunol , vol.145 , pp. 2297-2303
    • de Waal, M.R.1    Yssel, H.2    Spits, H.3    de Vries, J.E.4    Sancho, J.5    Terhorst, C.6    Alarcon, B.7
  • 139
    • 0032946939 scopus 로고    scopus 로고
    • Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines
    • Weil, R.; Levraud, J.; Dodon, M.D.; Bessia, C.; Hazan, U.; Kourilsky, P.; Israël, A. Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines. J. Virol. 1999, 73, 3709-3717.
    • (1999) J. Virol , vol.73 , pp. 3709-3717
    • Weil, R.1    Levraud, J.2    Dodon, M.D.3    Bessia, C.4    Hazan, U.5    Kourilsky, P.6    Israël, A.7
  • 140
    • 13544261552 scopus 로고    scopus 로고
    • Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappaB pathway
    • Harhaj, E.W,; Harhaj, N.S.; Grant, C.; Mostoller, K.; Alefantis, T.; Sun, S.C.; Wigdahl, B. Human T cell leukemia virus type I Tax activates CD40 gene expression via the NF-kappaB pathway. Virology 2005, 333, 145-158.
    • (2005) Virology , vol.333 , pp. 145-158
    • Harhaj, E.W.1
  • 141
    • 27444433531 scopus 로고    scopus 로고
    • Elevated expression of CD30 in adult T-cell leukemia cell lines: Possible role in constitutive NF-kappaB activation
    • Higuchi, M.; Matsuda, T.; Mori, N.; Yamada, Y.; Horie, R.; Watanabe, T.; Takahashi, M.; Oie, M.; Fujii, M. Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation. Retrovirology 2005, 2, 29.
    • (2005) Retrovirology , vol.2 , pp. 29
    • Higuchi, M.1    Matsuda, T.2    Mori, N.3    Yamada, Y.4    Horie, R.5    Watanabe, T.6    Takahashi, M.7    Oie, M.8    Fujii, M.9
  • 142
    • 0030860479 scopus 로고    scopus 로고
    • Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax
    • Cowan, E.P.; Alexander, R.K.; Daniel, S.; Kashanchi, F.; Brady, J.N. Induction of tumor necrosis factor alpha in human neuronal cells by extracellular human T-cell lymphotropic virus type 1 Tax. J. Virol. 1997, 71, 6982-6989.
    • (1997) J. Virol , vol.71 , pp. 6982-6989
    • Cowan, E.P.1    Alexander, R.K.2    Daniel, S.3    Kashanchi, F.4    Brady, J.N.5
  • 143
    • 56449108537 scopus 로고    scopus 로고
    • The proto-oncogene Bcl3, induced by Tax, represses Tax-mediated transcription via p300 displacement from the human T-cell leukemia virus type 1 promoter
    • Kim, Y.M.; Sharma, N.; Nyborg, J.K. The proto-oncogene Bcl3, induced by Tax, represses Tax-mediated transcription via p300 displacement from the human T-cell leukemia virus type 1 promoter. J. Virol. 2008, 82, 11939-11947.
    • (2008) J. Virol , vol.82 , pp. 11939-11947
    • Kim, Y.M.1    Sharma, N.2    Nyborg, J.K.3
  • 145
    • 34249848120 scopus 로고    scopus 로고
    • CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells
    • Wright, C.W.; Rumble, J.M.; Duckett, C.S. CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. J. Biol. Chem. 2007, 282, s10252-s10262.
    • (2007) J. Biol. Chem , vol.282
    • Wright, C.W.1    Rumble, J.M.2    Duckett, C.S.3
  • 146
    • 0038651209 scopus 로고    scopus 로고
    • Hodgkin's lymphoma and CD30 signal transduction
    • Horie, R.; Higashihara, M.; Watanabe, T. Hodgkin's lymphoma and CD30 signal transduction. Int. J. Hematol. 2003, 77, 37-47.
    • (2003) Int. J. Hematol , vol.77 , pp. 37-47
    • Horie, R.1    Higashihara, M.2    Watanabe, T.3
  • 147
    • 25444533092 scopus 로고    scopus 로고
    • Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response
    • Marriott, S.J.; Semmes, O.J. Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response. Oncogene 2005, 24, 5986-5995.
    • (2005) Oncogene , vol.24 , pp. 5986-5995
    • Marriott, S.J.1    Semmes, O.J.2
  • 148
    • 77956649822 scopus 로고    scopus 로고
    • HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death
    • Chlichlia, K.; Khazaie, K. HTLV-1 Tax: Linking transformation, DNA damage and apoptotic T-cell death. Chem. Biol. Interact. 2010, 188, 359-365.
    • (2010) Chem. Biol. Interact , vol.188 , pp. 359-365
    • Chlichlia, K.1    Khazaie, K.2
  • 150
    • 46749111541 scopus 로고    scopus 로고
    • Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells
    • Saitoh, Y.; Yamamoto, N.; Dewan, M.Z.; Sugimoto, H.; Martinez Bruyn, V.J.; Iwasaki, Y.; Matsubara, K.; Qi, X.; Saitoh, T.; Imoto, I. et al. Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Blood 2008, 111, 5118-5129.
    • (2008) Blood , vol.111 , pp. 5118-5129
    • Saitoh, Y.1    Yamamoto, N.2    Dewan, M.Z.3    Sugimoto, H.4    Martinez, B.V.J.5    Iwasaki, Y.6    Matsubara, K.7    Qi, X.8    Saitoh, T.9    Imoto, I.10
  • 151
    • 78049419078 scopus 로고    scopus 로고
    • Epigenetic alteration of the NF-kappaB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer
    • Yamamoto, M.; Ito, T.; Shimizu, T.; Ishida, T.; Semba, K.; Watanabe, S.; Yamaguchi, N.; Inoue, J., Epigenetic alteration of the NF-kappaB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer. Cancer Sci. 2010, 101, 2391-2397.
    • (2010) Cancer Sci , vol.101 , pp. 2391-2397
    • Yamamoto, M.1    Ito, T.2    Shimizu, T.3    Ishida, T.4    Semba, K.5    Watanabe, S.6    Yamaguchi, N.7    Inoue, J.8
  • 152
    • 34248371224 scopus 로고    scopus 로고
    • Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters
    • Qing, G.; Qu, Z.; Xiao, G. Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters. Proc. Natl. Acad Sci. U. S. A. 2007, 104, 5324-5329.
    • (2007) Proc. Natl. Acad Sci. U. S. A , vol.104 , pp. 5324-5329
    • Qing, G.1    Qu, Z.2    Xiao, G.3
  • 153
    • 15444372287 scopus 로고    scopus 로고
    • Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100
    • Qing, G.; Xiao, G. Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100. J. Biol. Chem. 2005, 280, 9765-9768.
    • (2005) J. Biol. Chem , vol.280 , pp. 9765-9768
    • Qing, G.1    Xiao, G.2
  • 154
    • 0027524248 scopus 로고
    • HTLV-I encoded Tax in association with NF-kappa B precursor p105 enhances nuclear localization of NF-kappa B p50 and p65 in transfected cells
    • Watanabe, M.; Muramatsu, M.; Hirai, H.; Suzuki, T.; Fujisawa, J.; Yoshida, M.; Arai, K.; Arai, N. HTLV-I encoded Tax in association with NF-kappa B precursor p105 enhances nuclear localization of NF-kappa B p50 and p65 in transfected cells. Oncogene 1992, 8, 2949-2958.
    • (1992) Oncogene , vol.8 , pp. 2949-2958
    • Watanabe, M.1    Muramatsu, M.2    Hirai, H.3    Suzuki, T.4    Fujisawa, J.5    Yoshida, M.6    Arai, K.7    Arai, N.8
  • 155
    • 0029664659 scopus 로고    scopus 로고
    • Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: A potential mechanism for constitutive induction of NF-kappaB
    • McKinsey, T.A.; Brockman, J.A.; Scherer, D.C.; Al-Murrani, S.W.; Green, P.L.; Ballard, D.W. Inactivation of IkappaBbeta by the tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-kappaB. Mol. Cell Biol. 1996, 16, 2083-2090.
    • (1996) Mol. Cell Biol , vol.16 , pp. 2083-2090
    • McKinsey, T.A.1    Brockman, J.A.2    Scherer, D.C.3    Al-Murrani, S.W.4    Green, P.L.5    Ballard, D.W.6
  • 156
    • 0029978840 scopus 로고    scopus 로고
    • Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta
    • Good, L.; Sun, S.C. Persistent activation of NF-kappa B/Rel by human T-cell leukemia virus type 1 tax involves degradation of I kappa B beta. J. Virol. 1996, 70, 2730-2735.
    • (1996) J. Virol , vol.70 , pp. 2730-2735
    • Good, L.1    Sun, S.C.2
  • 157
    • 0028979596 scopus 로고
    • Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor
    • Maggirwar, S.B.; Harhaj, E.W.; Sun, S.C. Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor. Oncogene 1995, 11, 993-998.
    • (1995) Oncogene , vol.11 , pp. 993-998
    • Maggirwar, S.B.1    Harhaj, E.W.2    Sun, S.C.3
  • 158
    • 0038724819 scopus 로고    scopus 로고
    • Deregulation of NF-kappaB and its upstream kinases in cancer
    • Sun, S.C.; Xiao, G. Deregulation of NF-kappaB and its upstream kinases in cancer. Cancer Metastasis Rev. 2003, 22, 405-422.
    • (2003) Cancer Metastasis Rev , vol.22 , pp. 405-422
    • Sun, S.C.1    Xiao, G.2
  • 160
    • 0027240625 scopus 로고
    • A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-kappa B p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappa B site and CArG box
    • Suzuki, T.; Hirai, H.; Fujisawa, J.; Fujita, T.; Yoshida, M., A trans-activator Tax of human T-cell leukemia virus type 1 binds to NF-kappa B p50 and serum response factor (SRF) and associates with enhancer DNAs of the NF-kappa B site and CArG box. Oncogene 1993, 8, 2391-2397.
    • (1993) Oncogene , vol.8 , pp. 2391-2397
    • Suzuki, T.1    Hirai, H.2    Fujisawa, J.3    Fujita, T.4    Yoshida, M.5
  • 161
    • 0028151387 scopus 로고
    • Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription
    • Suzuki, T.; Hirai, H.; Yoshida, M. Tax protein of HTLV-1 interacts with the Rel homology domain of NF-kappa B p65 and c-Rel proteins bound to the NF-kappa B binding site and activates transcription. Oncogene 1994, 9, 3099-3105.
    • (1994) Oncogene , vol.9 , pp. 3099-3105
    • Suzuki, T.1    Hirai, H.2    Yoshida, M.3
  • 162
    • 0028985016 scopus 로고
    • HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100
    • Murakami, T.; Hirai, H.; Suzuki, T.; Fujisawa, J.; Yoshida, M. HTLV-1 Tax enhances NF-kappa B2 expression and binds to the products p52 and p100, but does not suppress the inhibitory function of p100. Virology 1995, 206, 1066-1074.
    • (1995) Virology , vol.206 , pp. 1066-1074
    • Murakami, T.1    Hirai, H.2    Suzuki, T.3    Fujisawa, J.4    Yoshida, M.5
  • 163
    • 0028960315 scopus 로고
    • Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation
    • Suzuki, T.; Hirai, H.; Murakami, T.; Yoshida, M. Tax protein of HTLV-1 destabilizes the complexes of NF-kappa B and I kappa B-alpha and induces nuclear translocation of NF-kappa B for transcriptional activation. Oncogene 1995, 10, 1199-1207.
    • (1995) Oncogene , vol.10 , pp. 1199-1207
    • Suzuki, T.1    Hirai, H.2    Murakami, T.3    Yoshida, M.4
  • 164
    • 0030297115 scopus 로고    scopus 로고
    • Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein
    • Petropoulos, L.; Lin, R.; Hiscott, J. Human T cell leukemia virus type 1 tax protein increases NF-kappa B dimer formation and antagonizes the inhibitory activity of the I kappa B alpha regulatory protein. Virology 1996, 225, 52-64.
    • (1996) Virology , vol.225 , pp. 52-64
    • Petropoulos, L.1    Lin, R.2    Hiscott, J.3
  • 165
    • 0028055290 scopus 로고
    • Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: Implications for viral latency
    • Beraud, C.; Sun, S.C.; Ganchi, P.; Ballard, D.W.; Greene, W.C. Human T-cell leukemia virus type I Tax associates with and is negatively regulated by the NF-kappa B2 p100 gene product: implications for viral latency. Mol. Cell Biol. 1994, 14, 1374-1382.
    • (1994) Mol. Cell Biol , vol.14 , pp. 1374-1382
    • Beraud, C.1    Sun, S.C.2    Ganchi, P.3    Ballard, D.W.4    Greene, W.C.5
  • 166
    • 0028329892 scopus 로고
    • Interactions between HTLV-I Tax and NF-kappa B/Rel proteins in T cells
    • Lacoste, J.; Lanoix, J.; Pepin, N.; Hiscott, J. Interactions between HTLV-I Tax and NF-kappa B/Rel proteins in T cells. Leukemia 1994, 8, S71-S76.
    • (1994) Leukemia , vol.8
    • Lacoste, J.1    Lanoix, J.2    Pepin, N.3    Hiscott, J.4
  • 167
    • 0028089344 scopus 로고
    • Overproduction of NFKB2 (lyt-10) and c-Rel: A mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway
    • Lanoix, J.; Lacoste, J.; Pepin, N.; Rice, N.; Hiscott, J. Overproduction of NFKB2 (lyt-10) and c-Rel: a mechanism for HTLV-I Tax-mediated trans-activation via the NF-kappa B signalling pathway. Oncogene 1994, 9, 841-852.
    • (1994) Oncogene , vol.9 , pp. 841-852
    • Lanoix, J.1    Lacoste, J.2    Pepin, N.3    Rice, N.4    Hiscott, J.5
  • 168
    • 66149089133 scopus 로고    scopus 로고
    • PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
    • Yan, P.; Fu, J.; Qu, Z.; Li, S.; Tanaka, T.; Grusby, M.J.; Xiao, G., PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood 2009, 113, 4370-4380.
    • (2009) Blood , vol.113 , pp. 4370-4380
    • Yan, P.1    Fu, J.2    Qu, Z.3    Li, S.4    Tanaka, T.5    Grusby, M.J.6    Xiao, G.7
  • 169
    • 0025723525 scopus 로고
    • Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: Evidence for a pretranslational component of regulation
    • Arima, N.; Molitor, J.A.; Smith, M.R.; Kim, J.H.; Daitoku, Y.; Greene, W.C. Human T-cell leukemia virus type I Tax induces expression of the Rel-related family of kappa B enhancer-binding proteins: evidence for a pretranslational component of regulation. J. Virol. 1991, 65, 6892-6899.
    • (1991) J. Virol , vol.65 , pp. 6892-6899
    • Arima, N.1    Molitor, J.A.2    Smith, M.R.3    Kim, J.H.4    Daitoku, Y.5    Greene, W.C.6
  • 170
    • 0031888483 scopus 로고    scopus 로고
    • Characterization of mRNA expression of IkappaB alpha and NF-kappaB subfamilies in primary adult T-cell leukemia cells
    • Inoue, M.; Matsuoka, M.; Yamaguchi, K.; Takatsuki, K.; Yoshida, M. Characterization of mRNA expression of IkappaB alpha and NF-kappaB subfamilies in primary adult T-cell leukemia cells. Jpn. J. Cancer Res. 1998, 89, 53-59.
    • (1998) Jpn. J. Cancer Res , vol.89 , pp. 53-59
    • Inoue, M.1    Matsuoka, M.2    Yamaguchi, K.3    Takatsuki, K.4    Yoshida, M.5
  • 171
    • 0027324889 scopus 로고
    • Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: Transcriptional activation of c-rel by Tax protein
    • Li, C.C.; Ruscetti, F.W.; Rice, N.R.; Chen, E.; Yang, N.S.; Mikovits, J.; Longo, D.L. Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein. J. Virol. 1993, 67, 4205-4213.
    • (1993) J. Virol , vol.67 , pp. 4205-4213
    • Li, C.C.1    Ruscetti, F.W.2    Rice, N.R.3    Chen, E.4    Yang, N.S.5    Mikovits, J.6    Longo, D.L.7
  • 172
    • 79551625912 scopus 로고    scopus 로고
    • The tumor suppressor gene wwox links the canonical and non-canonical NF-kappaB pathways in HTLV-I Tax-mediated tumorigenesis
    • Fu, J.; Qu, Z.; Yan, P.; Ishikawa, C.; Aqeilan, R.; Rabson, A.B.; Xiao, G. The tumor suppressor gene wwox links the canonical and non-canonical NF-kappaB pathways in HTLV-I Tax-mediated tumorigenesis. Blood 2011, 117, 1652-1661.
    • (2011) Blood , vol.117 , pp. 1652-1661
    • Fu, J.1    Qu, Z.2    Yan, P.3    Ishikawa, C.4    Aqeilan, R.5    Rabson, A.B.6    Xiao, G.7
  • 173
    • 27144477415 scopus 로고    scopus 로고
    • Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells
    • Jeong, S.J.; Pise-Masison, C.A.; Radonovich, M.F.; Park, H.U.; Brady, J.N. Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Oncogene 2005, 24, 6719-6728.
    • (2005) Oncogene , vol.24 , pp. 6719-6728
    • Jeong, S.J.1    Pise-Masison, C.A.2    Radonovich, M.F.3    Park, H.U.4    Brady, J.N.5
  • 174
    • 59149088384 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type I tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway
    • Fukuda, R.I.; Tsuchiya, K.; Suzuki, K.; Itoh, K; Fujita, J.; Utsunomiya, A.; Tsuji, T. Human T-cell leukemia virus type I tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway. J. Biol. Chem. 2009, 284, 2680-2689.
    • (2009) J. Biol. Chem , vol.284 , pp. 2680-2689
    • Fukuda, R.I.1    Tsuchiya, K.2    Suzuki, K.3    Itoh, K.4    Fujita, J.5    Utsunomiya, A.6    Tsuji, T.7
  • 175
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Köntgen, F.; Grumont, R.J.; Strasser, A.; Metcalf, D.; Li, R.; Tarlinton, D.; Gerondakis, S. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 1995, 9, 1965-1977.
    • (1995) Genes Dev , vol.9 , pp. 1965-1977
    • Köntgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6    Gerondakis, S.7
  • 176
    • 0033023431 scopus 로고    scopus 로고
    • C-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function
    • Liou, H.C.; Jin, Z.; Tumang, J.; Andjelic, S.; Smith, K.A.; Liou, M.L. c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int. Immunol. 1999, 11, 361-371.
    • (1999) Int. Immunol , vol.11 , pp. 361-371
    • Liou, H.C.1    Jin, Z.2    Tumang, J.3    Andjelic, S.4    Smith, K.A.5    Liou, M.L.6
  • 177
    • 79952116189 scopus 로고    scopus 로고
    • Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis
    • Ishikawa, C.; Nakachi, S.; Senba, M.; Sugai, M.; Mori, N. Activation of AID by human T-cell leukemia virus Tax oncoprotein and the possible role of its constitutive expression in ATL genesis. Carcinogenesis 2011, 32, 110-119.
    • (2011) Carcinogenesis , vol.32 , pp. 110-119
    • Ishikawa, C.1    Nakachi, S.2    Senba, M.3    Sugai, M.4    Mori, N.5
  • 178
    • 0025245774 scopus 로고
    • Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes
    • Smith, M.R.; Greene, W.C. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev. 1990, 4, 1875-1885.
    • (1990) Genes Dev , vol.4 , pp. 1875-1885
    • Smith, M.R.1    Greene, W.C.2
  • 179
    • 0026458338 scopus 로고
    • Mutational analysis of human T-cell leukemia virus type I Tax: Regions necessary for function determined with 47 mutant proteins
    • Semmes, O.J.; Jeang, K.T. Mutational analysis of human T-cell leukemia virus type I Tax: regions necessary for function determined with 47 mutant proteins. J. Virol. 1992, 66, 7183-7192.
    • (1992) J. Virol , vol.66 , pp. 7183-7192
    • Semmes, O.J.1    Jeang, K.T.2
  • 180
    • 0029670843 scopus 로고    scopus 로고
    • Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein
    • Yamaoka, S.; Inoue, H.; Sakurai, M.; Sugiyama, T.; Hazama, M.; Yamada, T.; Hatanaka, M. Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein. EMBO J. 1996, 15, 873-887.
    • (1996) EMBO J , vol.15 , pp. 873-887
    • Yamaoka, S.1    Inoue, H.2    Sakurai, M.3    Sugiyama, T.4    Hazama, M.5    Yamada, T.6    Hatanaka, M.7
  • 181
    • 0026045813 scopus 로고
    • Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway
    • Smith, M.R.; Greene, W.C. Type I human T cell leukemia virus tax protein transforms rat fibroblasts through the cyclic adenosine monophosphate response element binding protein/activating transcription factor pathway. J. Clin. Invest. 1991, 88, 1038-1042.
    • (1991) J. Clin. Invest , vol.88 , pp. 1038-1042
    • Smith, M.R.1    Greene, W.C.2
  • 182
    • 0031008512 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways
    • Matsumoto, K.; Shibata, H.; Fujisawa, J.I.; Inoue, H.; Hakura, A.; Tsukahara, T.; Fujii, M. Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways. J. Virol. 1997, 71, 4445-4451.
    • (1997) J. Virol , vol.71 , pp. 4445-4451
    • Matsumoto, K.1    Shibata, H.2    Fujisawa, J.I.3    Inoue, H.4    Hakura, A.5    Tsukahara, T.6    Fujii, M.7
  • 183
    • 0032549585 scopus 로고    scopus 로고
    • A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes
    • Rosin, O.; Koch, C.; Schmitt, I.; Semmes, O.J.; Jeang, K.T.; Grassmann, R. A human T-cell leukemia virus Tax variant incapable of activating NF-kappaB retains its immortalizing potential for primary T-lymphocytes. J. Biol. Chem. 1998, 271, 6698-6703.
    • (1998) J. Biol. Chem , vol.271 , pp. 6698-6703
    • Rosin, O.1    Koch, C.2    Schmitt, I.3    Semmes, O.J.4    Jeang, K.T.5    Grassmann, R.6
  • 185
    • 0030976361 scopus 로고    scopus 로고
    • Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes
    • Akagi, T.; Ono, H.; Nyunoya, H.; Shimotohno, K. Characterization of peripheral blood T-lymphocytes transduced with HTLV-I Tax mutants with different trans-activating phenotypes. Oncogene 1997, 14, 2071-2078.
    • (1997) Oncogene , vol.14 , pp. 2071-2078
    • Akagi, T.1    Ono, H.2    Nyunoya, H.3    Shimotohno, K.4
  • 186
    • 0032993635 scopus 로고    scopus 로고
    • Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone
    • Robek, M.D.; Ratner, L. Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone. J. Virol. 1999, 73, 4856-4865.
    • (1999) J. Virol , vol.73 , pp. 4856-4865
    • Robek, M.D.1    Ratner, L.2
  • 187
    • 0034007182 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells
    • Ross, T.M.; Narayan, M.; Fang, Z.Y.; Minella, A.C.; Green, P.L. Human T-cell leukemia virus type 2 tax mutants that selectively abrogate NFkappaB or CREB/ATF activation fail to transform primary human T cells. J. Virol. 2000, 74, 2655-2662.
    • (2000) J. Virol , vol.74 , pp. 2655-2662
    • Ross, T.M.1    Narayan, M.2    Fang, Z.Y.3    Minella, A.C.4    Green, P.L.5
  • 188
    • 0027058137 scopus 로고
    • Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B
    • Kitajima, I.; Shinohara, T.; Bilakovics, J.; Brown, D.A.; Xu, X.; Nerenberg, M. Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B. Science 1992, 258, 1792-1795.
    • (1992) Science , vol.258 , pp. 1792-1795
    • Kitajima, I.1    Shinohara, T.2    Bilakovics, J.3    Brown, D.A.4    Xu, X.5    Nerenberg, M.6
  • 189
    • 0036721164 scopus 로고    scopus 로고
    • Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells
    • Mori, N.; Yamada, Y.; Ikeda, S.; Yamasaki, Y.; Tsukasaki, K.; Tanaka, Y.; Tomonaga, M.; Yamamoto, N.; Fujii, M. Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood 2002, 100, 1828-1834.
    • (2002) Blood , vol.100 , pp. 1828-1834
    • Mori, N.1    Yamada, Y.2    Ikeda, S.3    Yamasaki, Y.4    Tsukasaki, K.5    Tanaka, Y.6    Tomonaga, M.7    Yamamoto, N.8    Fujii, M.9
  • 191
    • 4344643781 scopus 로고    scopus 로고
    • Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro
    • Satou, Y.; Nosaka, K.; Koya, Y.; Yasunaga, J.I.; Toyokuni, S.; Matsuoka, M. Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia 2004, 18, 1357-1363.
    • (2004) Leukemia , vol.18 , pp. 1357-1363
    • Satou, Y.1    Nosaka, K.2    Koya, Y.3    Yasunaga, J.I.4    Toyokuni, S.5    Matsuoka, M.6
  • 192
    • 33646490131 scopus 로고    scopus 로고
    • Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor
    • Sanda, T.; Asamitsu, K.; Ogura, H.; Iida, S.; Utsunomiya, A.; Ueda, R.; Okamoto, T. Induction of cell death in adult T-cell leukemia cells by a novel IkappaB kinase inhibitor. Leukemia 2006, 20, 590-598.
    • (2006) Leukemia , vol.20 , pp. 590-598
    • Sanda, T.1    Asamitsu, K.2    Ogura, H.3    Iida, S.4    Utsunomiya, A.5    Ueda, R.6    Okamoto, T.7
  • 193
    • 3242752795 scopus 로고    scopus 로고
    • Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants
    • Mitra-Kaushik, S.; Harding J.C.; Hess, J.L.; Ratner, L. Effects of the proteasome inhibitor PS-341 on tumor growth in HTLV-1 Tax transgenic mice and Tax tumor transplants. Blood 2004, 104, 802-809.
    • (2004) Blood , vol.104 , pp. 802-809
    • Mitra-Kaushik, S.1    Harding, J.C.2    Hess, J.L.3    Ratner, L.4
  • 194
    • 27444435678 scopus 로고    scopus 로고
    • Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax
    • Kwon, H.; Ogle, L.; Benitez, B.; Bohuslav, J.; Montano, M.; Felsher, D.W.; Greene, W.C. Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J. Biol. Chem. 2005, 280, 35713-35722.
    • (2005) J. Biol. Chem , vol.280 , pp. 35713-35722
    • Kwon, H.1    Ogle, L.2    Benitez, B.3    Bohuslav, J.4    Montano, M.5    Felsher, D.W.6    Greene, W.C.7
  • 195
    • 52149112086 scopus 로고    scopus 로고
    • Activation of the cyclin D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax
    • Iwanaga, R.; Ozono, E.; Fujisawa, J.; Ikeda, M.A.; Okamura, N.; Huang, Y.; Ohtani, K. Activation of the cyclin D2 and cdk6 genes through NF-kappaB is critical for cell-cycle progression induced by HTLV-I Tax. Oncogene 2008, 27, 5635-5642.
    • (2008) Oncogene , vol.27 , pp. 5635-5642
    • Iwanaga, R.1    Ozono, E.2    Fujisawa, J.3    Ikeda, M.A.4    Okamura, N.5    Huang, Y.6    Ohtani, K.7
  • 196
    • 35448938507 scopus 로고    scopus 로고
    • Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line
    • Higuchi, M.; Tsubata, C.; Kondo, R.; Yoshida, S.; Takahashi, M.; Oie, M.; Tanaka, Y.; Mahieux, R.; Matsuoka, M.; Fujii, M. Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line. J. Virol. 2007, 81, 11900-11907.
    • (2007) J. Virol , vol.81 , pp. 11900-11907
    • Higuchi, M.1    Tsubata, C.2    Kondo, R.3    Yoshida, S.4    Takahashi, M.5    Oie, M.6    Tanaka, Y.7    Mahieux, R.8    Matsuoka, M.9    Fujii, M.10
  • 197
    • 46749096836 scopus 로고    scopus 로고
    • Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism
    • Chen, J.; Petrus, M.; Bryant, B.R.; Phuc Nguyen, V.; Stamer, M.; Goldman, C.K.; Bamford, R.; Morris, J.C.; Janik, J.E.; Waldmann, T.A. Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism. Blood 2008, 111, 5163-5172.
    • (2008) Blood , vol.111 , pp. 5163-5172
    • Chen, J.1    Petrus, M.2    Bryant, B.R.3    Phuc, N.V.4    Stamer, M.5    Goldman, C.K.6    Bamford, R.7    Morris, J.C.8    Janik, J.E.9    Waldmann, T.A.10
  • 199
    • 20244390313 scopus 로고    scopus 로고
    • Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: Heterogeneous expression of EBI3 subunit by tumoral cells
    • Larousserie, F.; Bardel E.; Pflanz, S.; Arnulf, B.; Lome-Maldonado, C.; Hermine, O.; Brégeaud, L.; Perennec, M.; Brousse, N.; Kastelein, R.; Devergne, O. Analysis of interleukin-27 (EBI3/p28) expression in Epstein-Barr virus- and human T-cell leukemia virus type 1-associated lymphomas: heterogeneous expression of EBI3 subunit by tumoral cells. Am. J. Pathol. 2005, 166, 1217-1228.
    • (2005) Am. J. Pathol , vol.166 , pp. 1217-1228
    • Larousserie, F.1    Bardel, E.2    Pflanz, S.3    Arnulf, B.4    Lome-Maldonado, C.5    Hermine, O.6    Brégeaud, L.7    Perennec, M.8    Brousse, N.9    Kastelein, R.10    Devergne, O.11
  • 200
    • 0034806874 scopus 로고    scopus 로고
    • Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells
    • Li-Weber, M.; Giaisi, M.; Chlichlia, K.; Khazaie, K.; Krammer, P.H. Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells. Eur. J. Immunol. 2001, 31, 2623-2632.
    • (2001) Eur. J. Immunol , vol.31 , pp. 2623-2632
    • Li-Weber, M.1    Giaisi, M.2    Chlichlia, K.3    Khazaie, K.4    Krammer, P.H.5
  • 201
    • 70350033965 scopus 로고    scopus 로고
    • Transcriptional activation of the interleukin-21 gene and its receptor gene by human T-cell leukemia virus type 1 Tax in human T-cells
    • Mizuguchi, M.; Asao, H.; Hara, T.; Higuchi, M.; Fujii, M.; Nakamura, M. Transcriptional activation of the interleukin-21 gene and its receptor gene by human T-cell leukemia virus type 1 Tax in human T-cells. J. Biol. Chem. 2009, 284, 25501-25511.
    • (2009) J. Biol. Chem , vol.284 , pp. 25501-25511
    • Mizuguchi, M.1    Asao, H.2    Hara, T.3    Higuchi, M.4    Fujii, M.5    Nakamura, M.6
  • 202
    • 0034956699 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways
    • Mori, N.; Fujii, M.; Cheng, G.; Ikeda, S.; Yamasaki, Y.; Yamada, Y.; Tomonaga, M.; Yamamoto, N. Human T-cell leukemia virus type I tax protein induces the expression of anti-apoptotic gene Bcl-xL in human T-cells through nuclear factor-kappaB and c-AMP responsive element binding protein pathways. Virus Genes 2001, 22, 279-287.
    • (2001) Virus Genes , vol.22 , pp. 279-287
    • Mori, N.1    Fujii, M.2    Cheng, G.3    Ikeda, S.4    Yamasaki, Y.5    Yamada, Y.6    Tomonaga, M.7    Yamamoto, N.8
  • 203
    • 58049170793 scopus 로고    scopus 로고
    • MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes
    • Pichler, K.; Schneider, G.; Grassmann, R. MicroRNA miR-146a and further oncogenesis-related cellular microRNAs are dysregulated in HTLV-1-transformed T lymphocytes. Retrovirology 2008, 5, 100.
    • (2008) Retrovirology , vol.5 , pp. 100
    • Pichler, K.1    Schneider, G.2    Grassmann, R.3
  • 204
    • 84863412187 scopus 로고    scopus 로고
    • MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells
    • doi:10.1002/ijc.25115
    • Tomita, M.; Tanaka, Y.; Mori, N. MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells. Int. J. Cancer 2009, doi:10.1002/ijc.25115.
    • (2009) Int. J. Cancer
    • Tomita, M.1    Tanaka, Y.2    Mori, N.3
  • 205
    • 0032827012 scopus 로고    scopus 로고
    • Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax
    • Tsukahara, T.; Kannagi, M., Ohashi, T.; Kato, H.; Arai, M.; Nunez, G.; Iwanaga, Y.; Yamamoto, N.; Ohtani, K.; Nakamura, M.; Fujii, M. Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax. J. Virol. 1999, 73, 7981-7987.
    • (1999) J. Virol , vol.73 , pp. 7981-7987
    • Tsukahara, T.1    Kannagi, M.2    Ohashi, T.3    Kato, H.4    Arai, M.5    Nunez, G.6    Iwanaga, Y.7    Yamamoto, N.8    Ohtani, K.9    Nakamura, M.10    Fujii, M.11
  • 206
    • 12344306010 scopus 로고    scopus 로고
    • p21WAF1 modulates NF-kappaB signaling and induces anti-apoptotic protein Bcl-2 in Tax-expressing rat fibroblast
    • Akita, K.; Kawata, S.; Shimotohno, K. p21WAF1 modulates NF-kappaB signaling and induces anti-apoptotic protein Bcl-2 in Tax-expressing rat fibroblast. Virology 2005, 332, 249-257.
    • (2005) Virology , vol.332 , pp. 249-257
    • Akita, K.1    Kawata, S.2    Shimotohno, K.3
  • 207
    • 56349152727 scopus 로고    scopus 로고
    • Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-kappaB and NFAT
    • Silbermann, K.; Schneider, G.; Grassmann, R. Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-kappaB and NFAT. J. Gen. Virol. 2008, 89, 2788-2798.
    • (2008) J. Gen. Virol , vol.89 , pp. 2788-2798
    • Silbermann, K.1    Schneider, G.2    Grassmann, R.3
  • 208
    • 0035865195 scopus 로고    scopus 로고
    • Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site
    • Mariner, J.M.; Lantz, V.; Waldmann, T.A.; Azimi, N. Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site. J. Immunol. 2001, 166, 2602-2609.
    • (2001) J. Immunol , vol.166 , pp. 2602-2609
    • Mariner, J.M.1    Lantz, V.2    Waldmann, T.A.3    Azimi, N.4
  • 209
    • 0032170525 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites
    • Mori, N.; Mukaida, N.; Ballard, D.W.; Matsushima, K.; Yamamoto, N. Human T-cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites. Cancer Res. 1998, 58, 3993-4000.
    • (1998) Cancer Res , vol.58 , pp. 3993-4000
    • Mori, N.1    Mukaida, N.2    Ballard, D.W.3    Matsushima, K.4    Yamamoto, N.5
  • 210
    • 0034282554 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type I tax activates transcription of the human monocyte chemoattractant protein-1 gene through two nuclear factor-kappaB sites
    • Mori, N.; Ueda, A.; Ikeda, S.; Yamasaki, Y.; Yamada, Y.; Tomonaga, M.; Morikawa, S.; Geleziunas, R.; Yoshimura, T. Yamamoto N., Human T-cell leukemia virus type I tax activates transcription of the human monocyte chemoattractant protein-1 gene through two nuclear factor-kappaB sites. Cancer Res. 2000, 60, 4939-4945.
    • (2000) Cancer Res , vol.60 , pp. 4939-4945
    • Mori, N.1    Ueda, A.2    Ikeda, S.3    Yamasaki, Y.4    Yamada, Y.5    Tomonaga, M.6    Morikawa, S.7    Geleziunas, R.8    Yoshimura, T.9    Yamamoto, N.10
  • 211
    • 44149128211 scopus 로고    scopus 로고
    • Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein
    • Pichler, K.; Kattan, T.; Gentzsch, J.; Kress, A.K.; Taylor, G.P.; Bangham, C.R.; Grassmann, R. Strong induction of 4-1BB, a growth and survival promoting costimulatory receptor, in HTLV-1-infected cultured and patients' T cells by the viral Tax oncoprotein. Blood 2008, 111, 4741-4751.
    • (2008) Blood , vol.111 , pp. 4741-4751
    • Pichler, K.1    Kattan, T.2    Gentzsch, J.3    Kress, A.K.4    Taylor, G.P.5    Bangham, C.R.6    Grassmann, R.7
  • 213
    • 0032486382 scopus 로고    scopus 로고
    • Molecular mechanisms of promoter regulation of the gp34 gene that is trans-activated by an oncoprotein Tax of human T cell leukemia virus type I
    • Ohtani, K.; Tsujimoto, A.; Tsukahara, T.; Numata, N.; Miura, S.; Sugamura, K.; Nakamura, M. Molecular mechanisms of promoter regulation of the gp34 gene that is trans-activated by an oncoprotein Tax of human T cell leukemia virus type I. J. Biol. Chem. 1998, 273, 14119-14129.
    • (1998) J. Biol. Chem , vol.273 , pp. 14119-14129
    • Ohtani, K.1    Tsujimoto, A.2    Tsukahara, T.3    Numata, N.4    Miura, S.5    Sugamura, K.6    Nakamura, M.7
  • 215
    • 33744474809 scopus 로고    scopus 로고
    • Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes
    • Wäldele, K.; Silbermann, K.; Schneider, G.; Ruckes, T.; Cullen, B.R.; Grassmann, R. Requirement of the human T-cell leukemia virus (HTLV-1) tax-stimulated HIAP-1 gene for the survival of transformed lymphocytes. Blood 2006, 107, 4491-4499.
    • (2006) Blood , vol.107 , pp. 4491-4499
    • Wäldele, K.1    Silbermann, K.2    Schneider, G.3    Ruckes, T.4    Cullen, B.R.5    Grassmann, R.6
  • 216
    • 0028046498 scopus 로고
    • Transcriptional regulation of the human interleukin-6 gene promoter in human T-cell leukemia virus type I-infected T-cell lines: Evidence for the involvement of NF-kappa B
    • Mori, N.; Shirakawa, F.; Shimizu, H.; Murakami, S.; Oda, S.; Yamamoto, K.; Eto, S. Transcriptional regulation of the human interleukin-6 gene promoter in human T-cell leukemia virus type I-infected T-cell lines: evidence for the involvement of NF-kappa B. Blood 1994, 84, 2904-2911.
    • (1994) Blood , vol.84 , pp. 2904-2911
    • Mori, N.1    Shirakawa, F.2    Shimizu, H.3    Murakami, S.4    Oda, S.5    Yamamoto, K.6    Eto, S.7
  • 217
    • 41349103438 scopus 로고    scopus 로고
    • Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia
    • Liu, S.; Liu, Z.; Xie, Z.; Pang, J.; Yu, J.; Lehmann, E.; Huynh, L.; Vukosavljevic, T.; Takeki, M.; Klisovic, R.B. et al. Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia. Blood 2008, 111, 2364-2373.
    • (2008) Blood , vol.111 , pp. 2364-2373
    • Liu, S.1    Liu, Z.2    Xie, Z.3    Pang, J.4    Yu, J.5    Lehmann, E.6    Huynh, L.7    Vukosavljevic, T.8    Takeki, M.9    Klisovic, R.B.10
  • 218
    • 0034790652 scopus 로고    scopus 로고
    • Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage
    • Nicot, C.; Mahieux, R., Pise-Masison, C.; Brady, J.; Gessain, A.; Yamaoka, S.; Franchini, G. Human T-cell lymphotropic virus type 1 Tax represses c-Myb-dependent transcription through activation of the NF-kappaB pathway and modulation of coactivator usage. Mol. Cell Biol. 2001, 21, 7391-7402.
    • (2001) Mol. Cell Biol , vol.21 , pp. 7391-7402
    • Nicot, C.1    Mahieux, R.2    Pise-Masison, C.3    Brady, J.4    Gessain, A.5    Yamaoka, S.6    Franchini, G.7
  • 219
    • 0028021754 scopus 로고
    • Human T-cell leukemia virus type I Tax protein represses gene expression through the basic helix-loop-helix family of transcription factors
    • Uittenbogaard, M.N.; Armstron, A.P.; Chiaramello, A.; Nyborg, J.K. Human T-cell leukemia virus type I Tax protein represses gene expression through the basic helix-loop-helix family of transcription factors. J. Biol. Chem. 1994, 269, 22466-22469.
    • (1994) J. Biol. Chem , vol.269 , pp. 22466-22469
    • Uittenbogaard, M.N.1    Armstron, A.P.2    Chiaramello, A.3    Nyborg, J.K.4
  • 220
    • 0028828412 scopus 로고
    • Transcriptional repression of p53 by human T-cell leukemia virus type I Tax protein
    • Uittenbogaard, M.N.; Giebler, H.A.; Reisman, D.; Nyborg, J.K. Transcriptional repression of p53 by human T-cell leukemia virus type I Tax protein. J. Biol. Chem. 1995, 270, 28503-28506.
    • (1995) J. Biol. Chem , vol.270 , pp. 28503-28506
    • Uittenbogaard, M.N.1    Giebler, H.A.2    Reisman, D.3    Nyborg, J.K.4
  • 222
  • 223
    • 0032954928 scopus 로고    scopus 로고
    • Transcriptional cross talk between NF-kappaB and p53
    • Webster, G.A.; Perkins, N.D. Transcriptional cross talk between NF-kappaB and p53. Mol. Cell Biol. 1999, 19, 3485-3495.
    • (1999) Mol. Cell Biol , vol.19 , pp. 3485-3495
    • Webster, G.A.1    Perkins, N.D.2
  • 224
    • 4444226454 scopus 로고    scopus 로고
    • HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity
    • Jeong, S.J.; Radonovich, M.F.; Brady, J.N.; Pise-Masison, C.A. HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity. Blood 2004, 104, 1490-1497.
    • (2004) Blood , vol.104 , pp. 1490-1497
    • Jeong, S.J.1    Radonovich, M.F.2    Brady, J.N.3    Pise-Masison, C.A.4
  • 225
    • 0034053965 scopus 로고    scopus 로고
    • Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation
    • Pise-Masison, C.A.; Mahieux, R.; Jiang, H.; Ashcroft, M.; Radonovich, M.F.; Duvall, J.; Guillerm, C.; Brady, J.N. Inactivation of p53 by human T-cell lymphotropic virus type 1 Tax requires activation of the NF-kappaB pathway and is dependent on p53 phosphorylation. Mol Cell Biol. 2000, 20, 3377-3386.
    • (2000) Mol Cell Biol , vol.20 , pp. 3377-3386
    • Pise-Masison, C.A.1    Mahieux, R.2    Jiang, H.3    Ashcroft, M.4    Radonovich, M.F.5    Duvall, J.6    Guillerm, C.7    Brady, J.N.8
  • 226
    • 15444366928 scopus 로고    scopus 로고
    • A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity
    • Jeong, S.J.; Pise-Masison, C.A.; Radonovich, M.F.; Park, H.U.; Brady, J.N. A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity. J. Biol. Chem. 2005, 280, 10326-10332.
    • (2005) J. Biol. Chem , vol.280 , pp. 10326-10332
    • Jeong, S.J.1    Pise-Masison, C.A.2    Radonovich, M.F.3    Park, H.U.4    Brady, J.N.5
  • 228
    • 0036599406 scopus 로고    scopus 로고
    • P53 stabilization is decreased upon NFkappaB activation: A role for NFkappaB in acquisition of resistance to chemotherapy
    • Tergaonkar, V.; Pando, M.; Vafa, O.; Wahl, G.; Verma, I. p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy. Cancer Cell 2002, 1, 493-503.
    • (2002) Cancer Cell , vol.1 , pp. 493-503
    • Tergaonkar, V.1    Pando, M.2    Vafa, O.3    Wahl, G.4    Verma, I.5
  • 230
    • 53449083111 scopus 로고    scopus 로고
    • Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells
    • Bellon, M.; Nicot, C. Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells. Blood 2008, 112, 2946-2955.
    • (2008) Blood , vol.112 , pp. 2946-2955
    • Bellon, M.1    Nicot, C.2
  • 232
    • 0037082471 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type I Tax transactivates the matrix metalloproteinase-9 gene: Potential role in mediating adult T-cell leukemia invasiveness
    • Mori, N.; Sato, H.; Hayashibara, T.; Senba, M.; Hayashi, T.; Yamada, Y.; Kamihira, S.; Ikeda, S.; Yamasaki, Y.; Morikawa, S. et al. Human T-cell leukemia virus type I Tax transactivates the matrix metalloproteinase-9 gene: potential role in mediating adult T-cell leukemia invasiveness. Blood 2002, 99, 1341-1349.
    • (2002) Blood , vol.99 , pp. 1341-1349
    • Mori, N.1    Sato, H.2    Hayashibara, T.3    Senba, M.4    Hayashi, T.5    Yamada, Y.6    Kamihira, S.7    Ikeda, S.8    Yamasaki, Y.9    Morikawa, S.10
  • 233
    • 0026019768 scopus 로고
    • High incidence of antibodies to HTLV-I tax in blood relatives of adult T cell leukemia patients
    • Okayama, A.; Chen, Y.M.; Tachibana, N.; Shioiri, S.; Lee, T.H.; Tsuda, K.; Essex, M. High incidence of antibodies to HTLV-I tax in blood relatives of adult T cell leukemia patients. J. Infect. Dis. 1991, 163, 47-52.
    • (1991) J. Infect. Dis , vol.163 , pp. 47-52
    • Okayama, A.1    Chen, Y.M.2    Tachibana, N.3    Shioiri, S.4    Lee, T.H.5    Tsuda, K.6    Essex, M.7
  • 234
    • 0021868991 scopus 로고
    • Effect of human serum anti-HTLV antibodies on viral antigen induction in vitro cultured peripheral lymphocytes from adult T-cell leukemia patients and healthy virus carriers
    • Tochikura, T.; Iwahashi, M.; Matsumoto, T.; Koyanagi, Y.; Hinuma, Y; Yamamoto, N. Effect of human serum anti-HTLV antibodies on viral antigen induction in vitro cultured peripheral lymphocytes from adult T-cell leukemia patients and healthy virus carriers. Int. J. Cancer 1985, 36, 1-7.
    • (1985) Int. J. Cancer , vol.36 , pp. 1-7
    • Tochikura, T.1    Iwahashi, M.2    Matsumoto, T.3    Koyanagi, Y.4    Hinuma, Y.5    Yamamoto, N.6
  • 235
    • 0034651545 scopus 로고    scopus 로고
    • Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes
    • Hanon, E.; Hall, S.; Taylor, G.P.; Saito, M.; Davis, R.; Tanaka, Y.; Usuku, K.; Osame, M.; Weber, J.N.; Bangham, C.R. Abundant tax protein expression in CD4+ T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes. Blood 2000, 95, 1386-1392.
    • (2000) Blood , vol.95 , pp. 1386-1392
    • Hanon, E.1    Hall, S.2    Taylor, G.P.3    Saito, M.4    Davis, R.5    Tanaka, Y.6    Usuku, K.7    Osame, M.8    Weber, J.N.9    Bangham, C.R.10
  • 236
    • 0023051070 scopus 로고
    • The second pX product p27 chi-III of HTLV-1 is required for gag gene expression
    • Inoue, J.; Seiki, M.; Yoshida, M. The second pX product p27 chi-III of HTLV-1 is required for gag gene expression. FEBS Lett. 1986, 209, 187-190.
    • (1986) FEBS Lett , vol.209 , pp. 187-190
    • Inoue, J.1    Seiki, M.2    Yoshida, M.3
  • 237
    • 0038576034 scopus 로고
    • Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins
    • Hidaka, M.; Inoue, J.; Yoshida, M.; Seiki, M. Post-transcriptional regulator (rex) of HTLV-1 initiates expression of viral structural proteins but suppresses expression of regulatory proteins. EMBO J. 1988, 7, 519-523.
    • (1988) EMBO J , vol.7 , pp. 519-523
    • Hidaka, M.1    Inoue, J.2    Yoshida, M.3    Seiki, M.4
  • 238
    • 2342668567 scopus 로고    scopus 로고
    • The HTLV-1 Rex protein induces nuclear accumulation of unspliced viral RNA by avoiding intron excision and degradation
    • Gröne, M.; Koch, C.; Grassmann, R. The HTLV-1 Rex protein induces nuclear accumulation of unspliced viral RNA by avoiding intron excision and degradation. Virology 1996, 218, 316-325.
    • (1996) Virology , vol.218 , pp. 316-325
    • Gröne, M.1    Koch, C.2    Grassmann, R.3
  • 240
    • 0034813064 scopus 로고    scopus 로고
    • Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300
    • Zhang, W.; Nisbet, J.W.; Albrecht, B.; Ding, W.; Kashanchi, F.; Bartoe, J.T.; Lairmore, M.D. Human T-lymphotropic virus type 1 p30(II) regulates gene transcription by binding CREB binding protein/p300. J. Virol. 2001, 75, 9885-9985.
    • (2001) J. Virol , vol.75 , pp. 9885-9985
    • Zhang, W.1    Nisbet, J.W.2    Albrecht, B.3    Ding, W.4    Kashanchi, F.5    Bartoe, J.T.6    Lairmore, M.D.7
  • 241
    • 31444442856 scopus 로고    scopus 로고
    • HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells
    • Satou, Y.; Yasunaga J.; Yoshida, M.; Matsuoka, M. HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc. Natl. Acad. Sci. U. S. A. 2006, 103, 720-725.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 720-725
    • Satou, Y.1    Yasunaga, J.2    Yoshida, M.3    Matsuoka, M.4
  • 242
    • 0036891865 scopus 로고    scopus 로고
    • The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription
    • Gaudray, G.; Gachon, F.; Basbous, J.; Biard-Piechaczyk, M.; Devaux, C.; Mesnard, J.M. The Complementary Strand of the Human T-Cell Leukemia Virus Type 1 RNA Genome Encodes a bZIP Transcription Factor That Down-Regulates Viral Transcription. J. Virol. 2002, 76, 12813-12822.
    • (2002) J. Virol , vol.76 , pp. 12813-12822
    • Gaudray, G.1    Gachon, F.2    Basbous, J.3    Biard-Piechaczyk, M.4    Devaux, C.5    Mesnard, J.M.6
  • 243
    • 55749089551 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation
    • Arnold, J.; Zimmerman, B., Li, M.; Lairmore, M.D.; Green, P.L. Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation. Blood 2008, 112, 3788-3797.
    • (2008) Blood , vol.112 , pp. 3788-3797
    • Arnold, J.1    Zimmerman, B.2    Li, M.3    Lairmore, M.D.4    Green, P.L.5
  • 244
    • 78751701908 scopus 로고    scopus 로고
    • The HTLV-1 hbz antisense gene indirectly promotes tax expression via down-regulation of p30(II) mRNA
    • Choudhary, G.; Ratner, L. The HTLV-1 hbz antisense gene indirectly promotes tax expression via down-regulation of p30(II) mRNA. Virology 2011, 410, 307-315.
    • (2011) Virology , vol.410 , pp. 307-315
    • Choudhary, G.1    Ratner, L.2
  • 247
    • 62649103872 scopus 로고    scopus 로고
    • In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
    • Saito, M.; Matsuzaki, T.; Satou, Y.; Yasunaga, J.; Saito, K.; Arimura, K.; Matsuoka, M.; Ohara, Y., In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology 2009, 6, 19.
    • (2009) Retrovirology , vol.6 , pp. 19
    • Saito, M.1    Matsuzaki, T.2    Satou, Y.3    Yasunaga, J.4    Saito, K.5    Arimura, K.6    Matsuoka, M.7    Ohara, Y.8
  • 248
    • 79751492338 scopus 로고    scopus 로고
    • In vivo expression of human T-lymphotropic virus type 1 basic leucine-zipper protein generates specific CD8+ and CD4+ T-lymphocyte responses that correlate with clinical outcome
    • Hilburn, S.; Rowan, A.; Demontis, M.A.; MacNamara, A.; Asquith, B.; Bangham, C.R.; Taylor, G.P. In vivo expression of human T-lymphotropic virus type 1 basic leucine-zipper protein generates specific CD8+ and CD4+ T-lymphocyte responses that correlate with clinical outcome. J. Infect. Dis. 2011, 203, 529-536.
    • (2011) J. Infect. Dis , vol.203 , pp. 529-536
    • Hilburn, S.1    Rowan, A.2    Demontis, M.A.3    Macnamara, A.4    Asquith, B.5    Bangham, C.R.6    Taylor, G.P.7
  • 249
    • 33646595661 scopus 로고    scopus 로고
    • Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1
    • Arnold, J.; Yamamoto, B.; Li, M.; Phipps, A.J.; Younis, I.; Lairmore, M.D.; Green, P.L. Enhancement of infectivity and persistence in vivo by HBZ, a natural antisense coded protein of HTLV-1. Blood 1996, 107, 3976-3982.
    • (1996) Blood , vol.107 , pp. 3976-3982
    • Arnold, J.1    Yamamoto, B.2    Li, M.3    Phipps, A.J.4    Younis, I.5    Lairmore, M.D.6    Green, P.L.7
  • 250
    • 0037126388 scopus 로고    scopus 로고
    • The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression
    • Ego, T.; Ariumi, Y.; Shimotohno, K. The interaction of HTLV-1 Tax with HDAC1 negatively regulates the viral gene expression. Oncogene 2002, 21, 7241-7246.
    • (2002) Oncogene , vol.21 , pp. 7241-7246
    • Ego, T.1    Ariumi, Y.2    Shimotohno, K.3
  • 251
    • 2942652424 scopus 로고    scopus 로고
    • Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat
    • Lu, H.; Pise-Masison, C.A.; Linton, R.; Park, H.U.; Schiltz, R.L.; Sartorelli, V.; Brady, J.N. Tax relieves transcriptional repression by promoting histone deacetylase 1 release from the human T-cell leukemia virus type 1 long terminal repeat. J. Virol. 2004, 78, 6735-6743.
    • (2004) J. Virol , vol.78 , pp. 6735-6743
    • Lu, H.1    Pise-Masison, C.A.2    Linton, R.3    Park, H.U.4    Schiltz, R.L.5    Sartorelli, V.6    Brady, J.N.7
  • 252
    • 70149097776 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax
    • Yan, P.; Qu, Z.; Ishikawa, C.; Mori, N.; Xiao, G. Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. Neoplasia 2009, 11, 1036-1041.
    • (2009) Neoplasia , vol.11 , pp. 1036-1041
    • Yan, P.1    Qu, Z.2    Ishikawa, C.3    Mori, N.4    Xiao, G.5
  • 253
    • 77951236061 scopus 로고    scopus 로고
    • Epigenetic repression of PDZ-LIM domain-containing protein 2: Implications for the biology and treatment of breast cancer
    • Qu, Z.; Fu, J.; Yan, P.; Hu, J.; Cheng, S.Y.; Xiao, G. Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. J. Biol. Chem. 2010, 285, 11786-11792.
    • (2010) J. Biol. Chem , vol.285 , pp. 11786-11792
    • Qu, Z.1    Fu, J.2    Yan, P.3    Hu, J.4    Cheng, S.Y.5    Xiao, G.6
  • 254
    • 77950193822 scopus 로고    scopus 로고
    • DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target
    • Qu, Z.; Yan, P.; Fu, J.; Jiang, J.; Grusby, M.J.; Smithgall, T.E.; Xiao, G. DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res. 2010, 70, 1766-1772.
    • (2010) Cancer Res , vol.70 , pp. 1766-1772
    • Qu, Z.1    Yan, P.2    Fu, J.3    Jiang, J.4    Grusby, M.J.5    Smithgall, T.E.6    Xiao, G.7
  • 255
    • 34250886966 scopus 로고    scopus 로고
    • Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation
    • Qing, G.; Yan, P.; Qu, Z.; Liu, H.; Xiao, G. Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation. Cell Res. 2007, 17, 520-530.
    • (2007) Cell Res , vol.17 , pp. 520-530
    • Qing, G.1    Yan, P.2    Qu, Z.3    Liu, H.4    Xiao, G.5
  • 256
    • 33751111683 scopus 로고    scopus 로고
    • Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK)
    • Qing, G.; Yan, P.; Xiao, G. Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK). Cell Res. 2006, 16, 895-901.
    • (2006) Cell Res , vol.16 , pp. 895-901
    • Qing, G.1    Yan, P.2    Xiao, G.3
  • 257
    • 34249978518 scopus 로고    scopus 로고
    • Autophagy and NF-kappaB: Fight for fate
    • Xiao, G. Autophagy and NF-kappaB: fight for fate. Cytokine Growth Factor Rev. 2007, 18, 233-243.
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 233-243
    • Xiao, G.1
  • 258
    • 0035798624 scopus 로고    scopus 로고
    • NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death
    • Rivera-Walsh, I.; Waterfiled, M.; Xiao, G.; Fong, A.; Sun, S.C. NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death. J. Biol. Chem. 2001, 276, 40385-40388.
    • (2001) J. Biol. Chem , vol.276 , pp. 40385-40388
    • Rivera-Walsh, I.1    Waterfiled, M.2    Xiao, G.3    Fong, A.4    Sun, S.C.5
  • 259
    • 77958149099 scopus 로고    scopus 로고
    • Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells
    • Swaims, A.Y.; Khani, F.; Zhang, Y.; Roberts, A.I.; Devadas, S.; Shi, Y.; Rabson, A.B. Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T cells. Blood 2010, 116, 2994-3003.
    • (2010) Blood , vol.116 , pp. 2994-3003
    • Swaims, A.Y.1    Khani, F.2    Zhang, Y.3    Roberts, A.I.4    Devadas, S.5    Shi, Y.6    Rabson, A.B.7
  • 260
    • 0027488003 scopus 로고
    • The human T-cell leukemia/lymphotropic virus type I p12I protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase
    • Franchini, G.; Mulloy, J.C.; Koralnik, I.J.; Lo Monico, A.; Sparkowski, J.J.; Andresson, T.; Goldstein, D.J.; Schlegel, R. The human T-cell leukemia/lymphotropic virus type I p12I protein cooperates with the E5 oncoprotein of bovine papillomavirus in cell transformation and binds the 16-kilodalton subunit of the vacuolar H+ ATPase. J. Virol. 1993, 67, 7701-7704.
    • (1993) J. Virol , vol.67 , pp. 7701-7704
    • Franchini, G.1    Mulloy, J.C.2    Koralnik, I.J.3    Lo, M.A.4    Sparkowski, J.J.5    Andresson, T.6    Goldstein, D.J.7    Schlegel, R.8
  • 261
    • 0030693113 scopus 로고    scopus 로고
    • X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro
    • Derse, D.; Mikovits, J.; Ruscetti, F. X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro. Virology 1997, 237, 123-128.
    • (1997) Virology , vol.237 , pp. 123-128
    • Derse, D.1    Mikovits, J.2    Ruscetti, F.3
  • 262
    • 0031969651 scopus 로고    scopus 로고
    • Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes
    • Robek, M.D.; Wong, F.H.; Ratner, L. Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes. J. Virol. 1998, 72, 4458-4462.
    • (1998) J. Virol , vol.72 , pp. 4458-4462
    • Robek, M.D.1    Wong, F.H.2    Ratner, L.3
  • 263
    • 0345688851 scopus 로고    scopus 로고
    • HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro
    • Ye, J.; Silverman, L.; Lairmore, M.D.; Green, P.L. HTLV-1 Rex is required for viral spread and persistence in vivo but is dispensable for cellular immortalization in vitro. Blood 2003, 102, 3963-3969.
    • (2003) Blood , vol.102 , pp. 3963-3969
    • Ye, J.1    Silverman, L.2    Lairmore, M.D.3    Green, P.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.