메뉴 건너뛰기




Volumn 21, Issue 1, 2011, Pages 116-130

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

Author keywords

ATM; DNA damage; DNA damage response; IKK; NEMO; NF B; SUMO

Indexed keywords

ATM PROTEIN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; I KAPPA B KINASE; IKBKG PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

EID: 78650873024     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.179     Document Type: Review
Times cited : (196)

References (120)
  • 1
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-κ and IKK function
    • Perkins ND. Integrating cell-signalling pathways with NF-κ and IKK function. Nat Rev Mol Cell Biol 2007; 8:49-62.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 49-62
    • Perkins, N.D.1
  • 2
    • 67650724069 scopus 로고    scopus 로고
    • Regulation and function of NF-κB transcription factors in the immune system
    • Vallabhapurapu S, Karin M. Regulation and function of NF-κB transcription factors in the immune system. Annu Rev Immunol 2009; 27:693-733.
    • (2009) Annu Rev Immunol , vol.27 , pp. 693-733
    • Vallabhapurapu, S.1    Karin, M.2
  • 3
    • 54949147176 scopus 로고    scopus 로고
    • New regulators of NF-κ in inflammation
    • Ghosh S, Hayden MS. New regulators of NF-κ in inflammation. Nat Rev Immunol 2008; 8:837-848.
    • (2008) Nat Rev Immunol , vol.8 , pp. 837-848
    • Ghosh, S.1    Hayden, M.S.2
  • 4
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-κ signaling
    • Hayden MS, Ghosh S. Shared principles in NF-κ signaling. Cell 2008; 132:344-362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 5
    • 67650744586 scopus 로고    scopus 로고
    • The role of ubiquitin in NF-κ regulatory pathways
    • Skaug B, Jiang X, Chen ZJ. The role of ubiquitin in NF-κ regulatory pathways. Annu Rev Biochem 2009; 78:769-796.
    • (2009) Annu Rev Biochem , vol.78 , pp. 769-796
    • Skaug, B.1    Jiang, X.2    Chen, Z.J.3
  • 6
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705- 716.
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 7
    • 67649452945 scopus 로고    scopus 로고
    • J Immunol 2006; 177:7485-7496.
    • (2006) J Immunol , vol.177 , pp. 7485-7496
  • 8
    • 0022930702 scopus 로고
    • Inducibility of κ immunoglobulin enhancer- binding protein NF-κ by a posttranslational mechanism
    • Sen R, Baltimore D. Inducibility of κ immunoglobulin enhancer- binding protein NF-κ by a posttranslational mechanism. Cell 1986; 47:921-928.
    • (1986) Cell , vol.47 , pp. 921-928
    • Sen, R.1    Baltimore, D.2
  • 9
    • 0023724778 scopus 로고
    • IκB: A specific inhibitor of the NF-κB transcription factor
    • Baeuerle PA, Baltimore D. IκB: a specific inhibitor of the NF-κB transcription factor. Science 1988; 242:540-546.
    • (1988) Science , vol.242 , pp. 540-546
    • Baeuerle, P.A.1    Baltimore, D.2
  • 10
    • 35448960010 scopus 로고    scopus 로고
    • Many faces of NF-κ signaling induced by genotoxic stress
    • Wu ZH, Miyamoto S. Many faces of NF-κ signaling induced by genotoxic stress. J Mol Med 2007; 85:1187-1202.
    • (2007) J Mol Med , vol.85 , pp. 1187-1202
    • Zh, W.1    Miyamoto, S.2
  • 11
    • 33646006734 scopus 로고    scopus 로고
    • Signals from within: The DNAdamage- Induced NF-κ response
    • Janssens S, Tschopp J. Signals from within: the DNAdamage- induced NF-κ response. Cell Death Differ 2006; 13:773-784.
    • (2006) Cell Death Differ , vol.13 , pp. 773-784
    • Janssens, S.1    Tschopp, J.2
  • 12
    • 0141645610 scopus 로고    scopus 로고
    • Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation
    • Criswell T, Leskov K, Miyamoto S, Luo G, Boothman DA. Transcription factors activated in mammalian cells after clinically relevant doses of ionizing radiation. Oncogene 2003; 22:5813-5827.
    • (2003) Oncogene , vol.22 , pp. 5813-5827
    • Criswell, T.1    Leskov, K.2    Miyamoto, S.3    Luo, G.4    Boothman, D.A.5
  • 13
    • 38649124004 scopus 로고    scopus 로고
    • NEMO shuttle: A link between DNA damage and NF-κ activation in progeroid syndromes?
    • Salminen A, Suuronen T, Huuskonen J, Kaarniranta K. NEMO shuttle: a link between DNA damage and NF-κ activation in progeroid syndromes? Biochem Biophys Res Commun 2008; 367:715-718.
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 715-718
    • Salminen, A.1    Suuronen, T.2    Huuskonen, J.3    Kaarniranta, K.4
  • 14
    • 34249815846 scopus 로고    scopus 로고
    • ATM-NF-κ connection as a target for tumor radiosensitization
    • Ahmed KM, Li JJ. ATM-NF-κ connection as a target for tumor radiosensitization. Curr Cancer Drug Targets 2007; 7:335-342.
    • (2007) Curr Cancer Drug Targets , vol.7 , pp. 335-342
    • Ahmed, K.M.1    Li, J.J.2
  • 15
    • 33749249590 scopus 로고    scopus 로고
    • NF-κ activation by double-strand breaks
    • Habraken Y, Piette J. NF-κ activation by double-strand breaks. Biochem Pharmacol 2006; 72:1132-1141.
    • (2006) Biochem Pharmacol , vol.72 , pp. 1132-1141
    • Habraken, Y.1    Piette, J.2
  • 16
    • 77957374335 scopus 로고    scopus 로고
    • ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress
    • Wu ZH, Wong ET, Shi Y, et al. ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress. Mol Cell 2010; 40:75-86.
    • (2010) Mol Cell , vol.40 , pp. 75-86
    • Zh, W.1    Wong, E.T.2    Shi, Y.3
  • 17
    • 47949129452 scopus 로고    scopus 로고
    • Induction of a pro-apoptotic ATM-NF-κB pathway and its repression by ATR in response to replication stress
    • Wu ZH, Miyamoto S. Induction of a pro-apoptotic ATM-NF-κB pathway and its repression by ATR in response to replication stress. EMBO J 2008; 27:1963-1973.
    • (2008) EMBO J , vol.27 , pp. 1963-1973
    • Zh, W.1    Miyamoto, S.2
  • 18
    • 78649336706 scopus 로고    scopus 로고
    • The DNA damage response: Making it safe to play with knives
    • Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell 2010; 40:179-204.
    • (2010) Mol Cell , vol.40 , pp. 179-204
    • Ciccia, A.1    Elledge, S.J.2
  • 19
    • 63749131243 scopus 로고    scopus 로고
    • Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2
    • Reinhardt HC, Yaffe MB. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 2009; 21:245-255.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 245-255
    • Reinhardt, H.C.1    Yaffe, M.B.2
  • 20
    • 77955847245 scopus 로고    scopus 로고
    • Multiple roles of ATM in monitoring and maintaining DNA integrity
    • Derheimer FA, Kastan MB. Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett 2010; 584:3675-3681.
    • (2010) FEBS Lett , vol.584 , pp. 3675-3681
    • Derheimer, F.A.1    Kastan, M.B.2
  • 21
    • 3142534591 scopus 로고    scopus 로고
    • Initiating cellular stress responses
    • Bakkenist CJ, Kastan MB. Initiating cellular stress responses. Cell 2004; 118:9-17.
    • (2004) Cell , vol.118 , pp. 9-17
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 22
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson SP, Bartek J. The DNA-damage response in human biology and disease. Nature 2009; 461:1071-1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 23
    • 0032549815 scopus 로고    scopus 로고
    • Cotranslational biogenesis of NF-κ p50 by the 26S proteasome
    • Lin L, DeMartino GN, Greene WC. Cotranslational biogenesis of NF-κ p50 by the 26S proteasome. Cell 1998; 92:819-828.
    • (1998) Cell , vol.92 , pp. 819-828
    • Lin, L.1    Demartino, G.N.2    Greene, W.C.3
  • 24
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKα of a second, evolutionary conserved, NF-κ signaling pathway
    • Senftleben U, Cao Y, Xiao G, et al. Activation by IKKα of a second, evolutionary conserved, NF-κ signaling pathway. Science 2001; 293:1495-1499.
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3
  • 25
    • 0034745420 scopus 로고    scopus 로고
    • NF-κ-inducing kinase regulates the processing of NF-κ2 p100
    • Xiao G, Harhaj EW, Sun SC. NF-κ-inducing kinase regulates the processing of NF-κ2 p100. Mol Cell 2001; 7:401-409.
    • (2001) Mol Cell , vol.7 , pp. 401-409
    • Xiao, G.1    Harhaj, E.W.2    Sun, S.C.3
  • 26
    • 44749088134 scopus 로고    scopus 로고
    • Crosstalk via the NF-κ signaling system
    • Basak S, Hoffmann A. Crosstalk via the NF-κ signaling system. Cytokine Growth Factor Rev 2008; 19:187-197.
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 187-197
    • Basak, S.1    Hoffmann, A.2
  • 27
    • 0032217268 scopus 로고    scopus 로고
    • The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-κ inactivation
    • Huxford T, Huang DB, Malek S, Ghosh G. The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-κ inactivation. Cell 1998; 95:759-770.
    • (1998) Cell , vol.95 , pp. 759-770
    • Huxford, T.1    Huang, D.B.2    Malek, S.3    Ghosh, G.4
  • 28
    • 0032217264 scopus 로고    scopus 로고
    • Structure of an IκBα/NF-κ complex
    • Jacobs MD, Harrison SC. Structure of an IκBα/NF-κ complex. Cell 1998; 95:749-758.
    • (1998) Cell , vol.95 , pp. 749-758
    • Jacobs, M.D.1    Harrison, S.C.2
  • 29
    • 0026742527 scopus 로고
    • The precursor of NF-κ p50 has IκB-like functions
    • Rice NR, MacKichan ML, Israel A. The precursor of NF-κ p50 has IκB-like functions. Cell 1992; 71:243-253.
    • (1992) Cell , vol.71 , pp. 243-253
    • Rice, N.R.1    MacKichan, M.L.2    Israel, A.3
  • 30
    • 0027243576 scopus 로고
    • P105 and p98 precursor proteins play an active role in NF-κ-mediated signal transduction
    • Mercurio F, DiDonato JA, Rosette C, Karin M. p105 and p98 precursor proteins play an active role in NF-κ-mediated signal transduction. Genes Dev 1993; 7:705-718.
    • (1993) Genes Dev , vol.7 , pp. 705-718
    • Mercurio, F.1    Didonato, J.A.2    Rosette, C.3    Karin, M.4
  • 31
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-κ in preventing TNF-a-induced cell death
    • Beg AA, Baltimore D. An essential role for NF-κ in preventing TNF-a-induced cell death. Science 1996; 274:782-784.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 32
    • 0033119952 scopus 로고    scopus 로고
    • Embryonic lethality, liver degeneration, and impaired NF-κ activation in IKK-b-deficient mice
    • Tanaka M, Fuentes ME, Yamaguchi K, et al. Embryonic lethality, liver degeneration, and impaired NF-κ activation in IKK-b-deficient mice. Immunity 1999; 10:421-429.
    • (1999) Immunity , vol.10 , pp. 421-429
    • Tanaka, M.1    Fuentes, M.E.2    Yamaguchi, K.3
  • 33
    • 0033532386 scopus 로고    scopus 로고
    • The IKKb subunit of IκB kinase (IKK) is essential for nuclear factor κb activation and prevention of apoptosis
    • Li ZW, Chu W, Hu Y, et al. The IKKb subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis. J Exp Med 1999; 189:1839-1845.
    • (1999) J Exp Med , vol.189 , pp. 1839-1845
    • Li, Z.W.1    Chu, W.2    Hu, Y.3
  • 34
    • 0034661272 scopus 로고    scopus 로고
    • Complete lack of NF-κ activity in IKK1 and IKK2 double-deficient mice: Additional defect in neurulation
    • Li Q, Estepa G, Memet S, Israel A, Verma IM. Complete lack of NF-κ activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev 2000; 14:1729-1733.
    • (2000) Genes Dev , vol.14 , pp. 1729-1733
    • Li, Q.1    Estepa, G.2    Memet, S.3    Israel, A.4    Verma, I.M.5
  • 35
    • 0033634663 scopus 로고    scopus 로고
    • Female mice heterozygous for IKKg/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
    • Makris C, Godfrey VL, Krahn-Senftleben G, et al. Female mice heterozygous for IKKg/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell 2000; 5:969-979.
    • (2000) Mol Cell , vol.5 , pp. 969-979
    • Makris, C.1    Godfrey, V.L.2    Krahn-Senftleben, G.3
  • 36
    • 0033638970 scopus 로고    scopus 로고
    • NEMO/ IKKg-deficient mice model incontinentia pigmenti
    • Schmidt-Supprian M, Bloch W, Courtois G, et al. NEMO/ IKKg-deficient mice model incontinentia pigmenti. Mol Cell 2000; 5:981-992.
    • (2000) Mol Cell , vol.5 , pp. 981-992
    • Schmidt-Supprian, M.1    Bloch, W.2    Courtois, G.3
  • 37
    • 0034175632 scopus 로고    scopus 로고
    • Severe liver degeneration and lack of NF-κ activation in NEMO/IKKgdeficient mice
    • Rudolph D, Yeh WC, Wakeham A, et al. Severe liver degeneration and lack of NF-κ activation in NEMO/IKKgdeficient mice. Genes Dev 2000; 14:854-862.
    • (2000) Genes Dev , vol.14 , pp. 854-862
    • Rudolph, D.1    Yeh, W.C.2    Wakeham, A.3
  • 38
    • 33645312379 scopus 로고    scopus 로고
    • Circuitry of nuclear factor κb signaling
    • Hoffmann A, Baltimore D. Circuitry of nuclear factor κB signaling. Immunol Rev 2006; 210:171-186.
    • (2006) Immunol Rev , vol.210 , pp. 171-186
    • Hoffmann, A.1    Baltimore, D.2
  • 39
    • 0141567432 scopus 로고    scopus 로고
    • Regulation of secondary lymphoid organ development by the nuclear factor-κB signal transduction pathway
    • Weih F, Caamano J. Regulation of secondary lymphoid organ development by the nuclear factor-κB signal transduction pathway. Immunol Rev 2003; 195:91-105.
    • (2003) Immunol Rev , vol.195 , pp. 91-105
    • Weih, F.1    Caamano, J.2
  • 40
    • 0024404496 scopus 로고
    • UVinduced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein
    • Stein B, Rahmsdorf HJ, Steffen A, Litfin M, Herrlich P. UVinduced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol 1989; 9:5169-5181.
    • (1989) Mol Cell Biol , vol.9 , pp. 5169-5181
    • Stein, B.1    Rahmsdorf, H.J.2    Steffen, A.3    Litfin, M.4    Herrlich, P.5
  • 41
    • 0029790979 scopus 로고    scopus 로고
    • Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents
    • Knebel A, Rahmsdorf HJ, Ullrich A, Herrlich P. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J 1996; 15:5314-5325.
    • (1996) EMBO J , vol.15 , pp. 5314-5325
    • Knebel, A.1    Rahmsdorf, H.J.2    Ullrich, A.3    Herrlich, P.4
  • 42
    • 26444537414 scopus 로고    scopus 로고
    • The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-κ
    • Kokura S, Yoshida N, Sakamoto N, et al. The radical scavenger edaravone enhances the anti-tumor effects of CPT-11 in murine colon cancer by increasing apoptosis via inhibition of NF-κ. Cancer Lett 2005; 229:223-233.
    • (2005) Cancer Lett , vol.229 , pp. 223-233
    • Kokura, S.1    Yoshida, N.2    Sakamoto, N.3
  • 44
    • 0023927962 scopus 로고
    • Semi-quinone formation from the catechol and ortho-quinone metabolites of the antitumor agent VP-16-213
    • van Maanen JM, Verkerk UH, Broersen J, et al. Semi-quinone formation from the catechol and ortho-quinone metabolites of the antitumor agent VP-16-213. Free Radic Res Commun 1988; 4:371-384.
    • (1988) Free Radic Res Commun , vol.4 , pp. 371-384
    • Van Maanen, J.M.1    Verkerk, U.H.2    Broersen, J.3
  • 45
    • 0141673128 scopus 로고    scopus 로고
    • Biological chemistry of reactive transduction mechanisms
    • Mikkelsen RB, Wardman P. Biological chemistry of reactive transduction mechanisms. Oncogene 2003; 22:5734-5754.
    • (2003) Oncogene , vol.22 , pp. 5734-5754
    • Mikkelsen, R.B.1    Wardman, P.2
  • 46
    • 34147190965 scopus 로고    scopus 로고
    • Radiation-induced cell signaling: Inside-out and outside-in
    • Valerie K, Yacoub A, Hagan MP, et al. Radiation-induced cell signaling: inside-out and outside-in. Mol Cancer Ther 2007; 6:789-801.
    • (2007) Mol Cancer Ther , vol.6 , pp. 789-801
    • Valerie, K.1    Yacoub, A.2    Hagan, M.P.3
  • 47
    • 77955997469 scopus 로고    scopus 로고
    • Nuclear IKKb is an adaptor protein for IκBa ubiquitination and degradation in UV-induced NF-κ activation
    • Tsuchiya Y, Asano T, Nakayama K, et al. Nuclear IKKb is an adaptor protein for IκBa ubiquitination and degradation in UV-induced NF-κ activation. Mol Cell 2010; 39:570-582.
    • (2010) Mol Cell , vol.39 , pp. 570-582
    • Tsuchiya, Y.1    Asano, T.2    Nakayama, K.3
  • 48
    • 0027363407 scopus 로고
    • NF-κ activation by ultraviolet light not dependent on a nuclear signal
    • Devary Y, Rosette C, DiDonato JA, Karin M. NF-κ activation by ultraviolet light not dependent on a nuclear signal. Science 1993; 261:1442-1445.
    • (1993) Science , vol.261 , pp. 1442-1445
    • Devary, Y.1    Rosette, C.2    Didonato, J.A.3    Karin, M.4
  • 49
    • 0344222192 scopus 로고    scopus 로고
    • Sequential DNA damage-independent and -dependent activation of NF-κ by UV
    • Bender K, Gottlicher M, Whiteside S, Rahmsdorf HJ, Herrlich P. Sequential DNA damage-independent and -dependent activation of NF-κ by UV. EMBO J 1998; 17:5170-5181.
    • (1998) EMBO J , vol.17 , pp. 5170-5181
    • Bender, K.1    Gottlicher, M.2    Whiteside, S.3    Rahmsdorf, H.J.4    Herrlich, P.5
  • 50
    • 0035937809 scopus 로고    scopus 로고
    • ATM is required for IκB kinase (IKKk) activation in response to DNA double strand breaks
    • Li N, Banin S, Ouyang H, et al. ATM is required for IκB kinase (IKKk) activation in response to DNA double strand breaks. J Biol Chem 2001; 276:8898-8903.
    • (2001) J Biol Chem , vol.276 , pp. 8898-8903
    • Li, N.1    Banin, S.2    Ouyang, H.3
  • 51
    • 0032497587 scopus 로고    scopus 로고
    • A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-κ
    • Lee SJ, Dimtchev A, Lavin MF, Dritschilo A, Jung M. A novel ionizing radiation-induced signaling pathway that activates the transcription factor NF-κ. Oncogene 1998; 17:1821-1826.
    • (1998) Oncogene , vol.17 , pp. 1821-1826
    • Lee, S.J.1    Dimtchev, A.2    Lavin, M.F.3    Dritschilo, A.4    Jung, M.5
  • 52
    • 0033118909 scopus 로고    scopus 로고
    • The ATM protein is required for sustained activation of NF-κ following DNA damage
    • Piret B, Schoonbroodt S, Piette J. The ATM protein is required for sustained activation of NF-κ following DNA damage. Oncogene 1999; 18:2261-2271.
    • (1999) Oncogene , vol.18 , pp. 2261-2271
    • Piret, B.1    Schoonbroodt, S.2    Piette, J.3
  • 53
    • 0344305376 scopus 로고    scopus 로고
    • Sequential modification of NEMO/IKKg by SUMO-1 and ubiquitin mediates NF-κ activation by genotoxic stress
    • Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S. Sequential modification of NEMO/IKKg by SUMO-1 and ubiquitin mediates NF-κ activation by genotoxic stress. Cell 2003; 115:565-576.
    • (2003) Cell , vol.115 , pp. 565-576
    • Huang, T.T.1    Wuerzberger-Davis, S.M.2    Zh, W.3    Miyamoto, S.4
  • 54
    • 1342304040 scopus 로고    scopus 로고
    • ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-κ through a common MEK/extracellular signal-regulated kinase/ p90(rsk) signaling pathway in response to distinct forms of DNA damage
    • Panta GR, Kaur S, Cavin LG, et al. ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-κ through a common MEK/extracellular signal-regulated kinase/ p90(rsk) signaling pathway in response to distinct forms of DNA damage. Mol Cell Biol 2004; 24:1823-1835.
    • (2004) Mol Cell Biol , vol.24 , pp. 1823-1835
    • Panta, G.R.1    Kaur, S.2    Cavin, L.G.3
  • 55
    • 33644538632 scopus 로고    scopus 로고
    • Molecular linkage between the kinase ATM and NF-κ signaling in response to genotoxic stimuli
    • Wu ZH, Shi Y, Tibbetts RS, Miyamoto S. Molecular linkage between the kinase ATM and NF-κ signaling in response to genotoxic stimuli. Science 2006; 311:1141-1146.
    • (2006) Science , vol.311 , pp. 1141-1146
    • Zh, W.1    Shi, Y.2    Tibbetts, R.S.3    Miyamoto, S.4
  • 56
    • 0034737193 scopus 로고    scopus 로고
    • NF-κ activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events
    • Huang TT, Wuerzberger-Davis SM, Seufzer BJ, et al. NF-κ activation by camptothecin. A linkage between nuclear DNA damage and cytoplasmic signaling events. J Biol Chem 2000; 275:9501-9509.
    • (2000) J Biol Chem , vol.275 , pp. 9501-9509
    • Huang, T.T.1    Wuerzberger-Davis, S.M.2    Seufzer, B.J.3
  • 58
    • 33846783142 scopus 로고    scopus 로고
    • NF-κ activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage
    • Wuerzberger-Davis SM, Nakamura Y, Seufzer BJ, Miyamoto S. NF-κ activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene 2007; 26:641-651.
    • (2007) Oncogene , vol.26 , pp. 641-651
    • Wuerzberger-Davis, S.M.1    Nakamura, Y.2    Seufzer, B.J.3    Miyamoto, S.4
  • 59
    • 33644843626 scopus 로고    scopus 로고
    • Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue
    • Rashi-Elkeles S, Elkon R, Weizman N, et al. Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue. Oncogene 2006; 25:1584-1592.
    • (2006) Oncogene , vol.25 , pp. 1584-1592
    • Rashi-Elkeles, S.1    Elkon, R.2    Weizman, N.3
  • 60
    • 0033229891 scopus 로고    scopus 로고
    • Lack of involvement of ataxia telangiectasia mutated (ATM) in regulation of nuclear factor-κB (NF-κ) in human diploid fibroblasts
    • Ashburner BP, Shackelford RE, Baldwin AS Jr, Paules RS. Lack of involvement of ataxia telangiectasia mutated (ATM) in regulation of nuclear factor-κB (NF-κ) in human diploid fibroblasts. Cancer Res 1999; 59:5456-5460.
    • (1999) Cancer Res , vol.59 , pp. 5456-5460
    • Ashburner, B.P.1    Shackelford, R.E.2    Baldwin Jr., A.S.3    Paules, R.S.4
  • 61
    • 33748188499 scopus 로고    scopus 로고
    • PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress
    • Mabb AM, Wuerzberger-Davis SM, Miyamoto S. PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress. Nat Cell Biol 2006; 8:986-993.
    • (2006) Nat Cell Biol , vol.8 , pp. 986-993
    • Mabb, A.M.1    Wuerzberger-Davis, S.M.2    Miyamoto, S.3
  • 62
    • 28944447430 scopus 로고    scopus 로고
    • PIDD mediates NF-κ activation in response to DNA damage
    • Janssens S, Tinel A, Lippens S, Tschopp J. PIDD mediates NF-κ activation in response to DNA damage. Cell 2005; 123:1079-1092.
    • (2005) Cell , vol.123 , pp. 1079-1092
    • Janssens, S.1    Tinel, A.2    Lippens, S.3    Tschopp, J.4
  • 63
    • 0037382303 scopus 로고    scopus 로고
    • The death domain kinase RIP has an essential role in DNA damage-induced NF-κ activation
    • Hur GM, Lewis J, Yang Q, et al. The death domain kinase RIP has an essential role in DNA damage-induced NF-κ activation. Genes Dev 2003; 17:873-882.
    • (2003) Genes Dev , vol.17 , pp. 873-882
    • Hur, G.M.1    Lewis, J.2    Yang, Q.3
  • 64
    • 65349178993 scopus 로고    scopus 로고
    • Caspase-2 activation in the absence of PIDDosome formation
    • Manzl C, Krumschnabel G, Bock F, et al. Caspase-2 activation in the absence of PIDDosome formation. J Cell Biol 2009; 185:291-303.
    • (2009) J Cell Biol , vol.185 , pp. 291-303
    • Manzl, C.1    Krumschnabel, G.2    Bock, F.3
  • 65
    • 70449102637 scopus 로고    scopus 로고
    • A nuclear poly(ADPribose)- Dependent signalosome confers DNA damage-induced IκB kinase activation
    • Stilmann M, Hinz M, Arslan SC, et al. A nuclear poly(ADPribose)- dependent signalosome confers DNA damage-induced IκB kinase activation. Mol Cell 2009; 36:365-378.
    • (2009) Mol Cell , vol.36 , pp. 365-378
    • Stilmann, M.1    Hinz, M.2    Arslan, S.C.3
  • 66
    • 77954274504 scopus 로고    scopus 로고
    • The PARP side of the nucleus: Molecular actions, physiological outcomes, and clinical targets
    • Krishnakumar R, Kraus WL. The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell 2010; 39:8-24.
    • (2010) Mol Cell , vol.39 , pp. 8-24
    • Krishnakumar, R.1    Kraus, W.L.2
  • 67
    • 0029997148 scopus 로고    scopus 로고
    • Topoisomerase poisons activate the transcription factor NF-κ in ACH-2 and CEM cells
    • Piret B, Piette J. Topoisomerase poisons activate the transcription factor NF-κ in ACH-2 and CEM cells. Nucleic Acids Res 1996; 24:4242-4248.
    • (1996) Nucleic Acids Res , vol.24 , pp. 4242-4248
    • Piret, B.1    Piette, J.2
  • 68
    • 60149100173 scopus 로고    scopus 로고
    • Ionizing radiationinduced NF-κ activation requires PARP-1 function to confer radioresistance
    • Veuger SJ, Hunter JE, Durkacz BW. Ionizing radiationinduced NF-κ activation requires PARP-1 function to confer radioresistance. Oncogene 2009; 28:832-842.
    • (2009) Oncogene , vol.28 , pp. 832-842
    • Veuger, S.J.1    Hunter, J.E.2    Durkacz, B.W.3
  • 69
    • 62449084941 scopus 로고    scopus 로고
    • CIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-κB activation
    • Jin HS, Lee DH, Kim DH, et al. cIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-κB activation. Cancer Res 2009; 69:1782-1791.
    • (2009) Cancer Res , vol.69 , pp. 1782-1791
    • Jin, H.S.1    Lee, D.H.2    Kim, D.H.3
  • 70
    • 3042523535 scopus 로고    scopus 로고
    • Activation of transcription factor NF-κ requires ELKS, an IκB kinase regulatory subunit
    • Ducut Sigala JL, Bottero V, Young DB, et al. Activation of transcription factor NF-κ requires ELKS, an IκB kinase regulatory subunit. Science 2004; 304:1963-1967.
    • (2004) Science , vol.304 , pp. 1963-1967
    • Ducut Sigala, J.L.1    Bottero, V.2    Young, D.B.3
  • 71
    • 77957333810 scopus 로고    scopus 로고
    • A cytoplasmic ATMTRAF6- cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κ activation
    • Hinz M, Stilmann M, Arslan SC, et al. A cytoplasmic ATMTRAF6- cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κ activation. Mol Cell 2010; 40:63-74.
    • (2010) Mol Cell , vol.40 , pp. 63-74
    • Hinz, M.1    Stilmann, M.2    Arslan, S.C.3
  • 72
    • 0033529866 scopus 로고    scopus 로고
    • Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
    • Kudo N, Matsumori N, Taoka H, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci USA 1999; 96:9112-9117.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 9112-9117
    • Kudo, N.1    Matsumori, N.2    Taoka, H.3
  • 73
    • 33846128759 scopus 로고    scopus 로고
    • Calciumdependent regulation of NEMO nuclear export in response to genotoxic stimuli
    • Berchtold CM, Wu ZH, Huang TT, Miyamoto S. Calciumdependent regulation of NEMO nuclear export in response to genotoxic stimuli. Mol Cell Biol 2007; 27:497-509.
    • (2007) Mol Cell Biol , vol.27 , pp. 497-509
    • Berchtold, C.M.1    Zh, W.2    Huang, T.T.3    Miyamoto, S.4
  • 74
    • 57649114834 scopus 로고    scopus 로고
    • DNA doublestrand breaks activate a multi-functional genetic program in developing lymphocytes
    • Bredemeyer AL, Helmink BA, Innes CL, et al. DNA doublestrand breaks activate a multi-functional genetic program in developing lymphocytes. Nature 2008; 456:819-823.
    • (2008) Nature , vol.456 , pp. 819-823
    • Bredemeyer, A.L.1    Helmink, B.A.2    Innes, C.L.3
  • 75
    • 77956915114 scopus 로고    scopus 로고
    • AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling
    • Sherman MH, Kuraishy AI, Deshpande C, et al. AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling. Mol Cell 2010; 39:873-885.
    • (2010) Mol Cell , vol.39 , pp. 873-885
    • Sherman, M.H.1    Kuraishy, A.I.2    Deshpande, C.3
  • 76
    • 61349144249 scopus 로고    scopus 로고
    • ATM mediates constitutive NF-κ activation in high-risk myelodysplastic syndrome and acute myeloid leukemia
    • Grosjean-Raillard J, Tailler M, Ades L, et al. ATM mediates constitutive NF-κ activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene 2009; 28:1099-1109.
    • (2009) Oncogene , vol.28 , pp. 1099-1109
    • Grosjean-Raillard, J.1    Tailler, M.2    Ades, L.3
  • 77
    • 34547660308 scopus 로고    scopus 로고
    • Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    • Keats JJ, Fonseca R, Chesi M, et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 2007; 12:131-144.
    • (2007) Cancer Cell , vol.12 , pp. 131-144
    • Keats, J.J.1    Fonseca, R.2    Chesi, M.3
  • 78
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-κ pathways by diverse genetic abnormalities in multiple myeloma
    • Annunziata CM, Davis RE, Demchenko Y, et al. Frequent engagement of the classical and alternative NF-κ pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 2007; 12:115-130.
    • (2007) Cancer Cell , vol.12 , pp. 115-130
    • Annunziata, C.M.1    Davis, R.E.2    Demchenko, Y.3
  • 79
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    • Barbie DA, Tamayo P, Boehm JS, et al. Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 2009; 462:108-112.
    • (2009) Nature , vol.462 , pp. 108-112
    • Barbie, D.A.1    Tamayo, P.2    Boehm, J.S.3
  • 80
    • 70449109147 scopus 로고    scopus 로고
    • Requirement for NF-κ signalling in a mouse model of lung adenocarcinoma
    • Meylan E, Dooley AL, Feldser DM, et al. Requirement for NF-κ signalling in a mouse model of lung adenocarcinoma. Nature 2009; 462:104-107.
    • (2009) Nature , vol.462 , pp. 104-107
    • Meylan, E.1    Dooley, A.L.2    Feldser, D.M.3
  • 81
    • 34249993765 scopus 로고    scopus 로고
    • Integrative genomic approaches identify IKBKE as a breast cancer oncogene
    • Boehm JS, Zhao JJ, Yao J, et al. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell 2007; 129:1065-1079.
    • (2007) Cell , vol.129 , pp. 1065-1079
    • Boehm, J.S.1    Zhao, J.J.2    Yao, J.3
  • 82
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova J, Horejsi Z, Koed K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 2005; 434:864-870.
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1    Horejsi, Z.2    Koed, K.3
  • 83
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J, Rezaei N, Liontos M, et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006; 444:633-637.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3
  • 84
    • 77951241720 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors activate NF-κ in human leukemia cells through an ATM/NEMO-related pathway
    • Rosato RR, Kolla SS, Hock SK, et al. Histone deacetylase inhibitors activate NF-κ in human leukemia cells through an ATM/NEMO-related pathway. J Biol Chem 2010; 285:10064-10077.
    • (2010) J Biol Chem , vol.285 , pp. 10064-10077
    • Rosato, R.R.1    Kolla, S.S.2    Hock, S.K.3
  • 86
    • 61649103747 scopus 로고    scopus 로고
    • Structural basis for recognition of diubiquitins by NEMO
    • Lo YC, Lin SC, Rospigliosi CC, et al. Structural basis for recognition of diubiquitins by NEMO. Mol Cell 2009; 33:602-615.
    • (2009) Mol Cell , vol.33 , pp. 602-615
    • Lo, Y.C.1    Lin, S.C.2    Rospigliosi, C.C.3
  • 87
    • 62549155321 scopus 로고    scopus 로고
    • Specific recognition of linear ubiquitin chains by NEMO is important for NF-κ activation
    • Rahighi S, Ikeda F, Kawasaki M, et al. Specific recognition of linear ubiquitin chains by NEMO is important for NF-κ activation. Cell 2009; 136:1098-1109.
    • (2009) Cell , vol.136 , pp. 1098-1109
    • Rahighi, S.1    Ikeda, F.2    Kawasaki, M.3
  • 88
    • 44449125603 scopus 로고    scopus 로고
    • Crystal structure of a vFlip-IKKg complex: Insights into viral activation of the IKK signalosome
    • Bagneris C, Ageichik AV, Cronin N, et al. Crystal structure of a vFlip-IKKg complex: insights into viral activation of the IKK signalosome. Mol Cell 2008; 30:620-631.
    • (2008) Mol Cell , vol.30 , pp. 620-631
    • Bagneris, C.1    Ageichik, A.V.2    Cronin, N.3
  • 89
    • 42949159409 scopus 로고    scopus 로고
    • Structure of a NEMO/ IKK-associating domain reveals architecture of the interaction site
    • Rushe M, Silvian L, Bixler S, et al. Structure of a NEMO/ IKK-associating domain reveals architecture of the interaction site. Structure 2008; 16:798-808.
    • (2008) Structure , vol.16 , pp. 798-808
    • Rushe, M.1    Silvian, L.2    Bixler, S.3
  • 90
    • 70349995780 scopus 로고    scopus 로고
    • Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin
    • Yoshikawa A, Sato Y, Yamashita M, et al. Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin. FEBS Lett 2009; 583:3317-3322.
    • (2009) FEBS Lett , vol.583 , pp. 3317-3322
    • Yoshikawa, A.1    Sato, Y.2    Yamashita, M.3
  • 91
    • 70450225039 scopus 로고    scopus 로고
    • DARPinassisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding
    • Grubisha O, Kaminska M, Duquerroy S, et al. DARPinassisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding. J Mol Biol 2010; 395:89-104.
    • (2010) J Mol Biol , vol.395 , pp. 89-104
    • Grubisha, O.1    Kaminska, M.2    Duquerroy, S.3
  • 92
    • 0037124036 scopus 로고    scopus 로고
    • NEMO trimerizes through its coiled-coil C-terminal domain
    • Agou F, Ye F, Goffinont S, et al. NEMO trimerizes through its coiled-coil C-terminal domain. J Biol Chem 2002; 277:17464-17475.
    • (2002) J Biol Chem , vol.277 , pp. 17464-17475
    • Agou, F.1    Ye, F.2    Goffinont, S.3
  • 93
    • 34247560784 scopus 로고    scopus 로고
    • NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex
    • Fontan E, Traincard F, Levy SG, et al. NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex. FEBS J 2007; 274:2540-2551.
    • (2007) FEBS J , vol.274 , pp. 2540-2551
    • Fontan, E.1    Traincard, F.2    Levy, S.G.3
  • 94
    • 67650895663 scopus 로고    scopus 로고
    • NEMO oligomerization and its ubiquitin-binding properties
    • Ivins FJ, Montgomery MG, Smith SJ, et al. NEMO oligomerization and its ubiquitin-binding properties. Biochem J 2009; 421:243-251.
    • (2009) Biochem J , vol.421 , pp. 243-251
    • Ivins, F.J.1    Montgomery, M.G.2    Smith, S.J.3
  • 95
    • 0034725592 scopus 로고    scopus 로고
    • Utilization of oriented peptide libraries to identify substrate motifs selected by ATM
    • O'Neill T, Dwyer AJ, Ziv Y, et al. Utilization of oriented peptide libraries to identify substrate motifs selected by ATM. J Biol Chem 2000; 275:22719-22727.
    • (2000) J Biol Chem , vol.275 , pp. 22719-22727
    • O'Neill, T.1    Dwyer, A.J.2    Ziv, Y.3
  • 96
    • 38049028109 scopus 로고    scopus 로고
    • Phosphorylation of serine 68 in the IκB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-a-induced NF-κ activity
    • Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB. Phosphorylation of serine 68 in the IκB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-a-induced NF-κ activity. J Biol Chem 2008; 283:76-86.
    • (2008) J Biol Chem , vol.283 , pp. 76-86
    • Palkowitsch, L.1    Leidner, J.2    Ghosh, S.3    Marienfeld, R.B.4
  • 97
    • 59149093017 scopus 로고    scopus 로고
    • The zinc finger of NEMO is a functional ubiquitin-binding domain
    • Cordier F, Grubisha O, Traincard F, et al. The zinc finger of NEMO is a functional ubiquitin-binding domain. J Biol Chem 2009; 284:2902-2907.
    • (2009) J Biol Chem , vol.284 , pp. 2902-2907
    • Cordier, F.1    Grubisha, O.2    Traincard, F.3
  • 98
    • 70350020147 scopus 로고    scopus 로고
    • NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
    • Laplantine E, Fontan E, Chiaravalli J, et al. NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. EMBO J 2009; 28:2885-2895.
    • (2009) EMBO J , vol.28 , pp. 2885-2895
    • Laplantine, E.1    Fontan, E.2    Chiaravalli, J.3
  • 99
    • 72449175818 scopus 로고    scopus 로고
    • Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
    • Galanty Y, Belotserkovskaya R, Coates J, et al. Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. Nature 2009; 462:935-939.
    • (2009) Nature , vol.462 , pp. 935-939
    • Galanty, Y.1    Belotserkovskaya, R.2    Coates, J.3
  • 100
    • 72449163470 scopus 로고    scopus 로고
    • The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
    • Morris JR, Boutell C, Keppler M, et al. The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. Nature 2009; 462:886-890.
    • (2009) Nature , vol.462 , pp. 886-890
    • Morris, J.R.1    Boutell, C.2    Keppler, M.3
  • 101
    • 27644466358 scopus 로고    scopus 로고
    • Nuclear localisation of nuclear factor-κB transcription factors in prostate cancer: An immunohistochemical study
    • Lessard L, Begin LR, Gleave ME, Mes-Masson AM, Saad F. Nuclear localisation of nuclear factor-κB transcription factors in prostate cancer: an immunohistochemical study. Br J Cancer 2005; 93:1019-1023.
    • (2005) Br J Cancer , vol.93 , pp. 1019-1023
    • Lessard, L.1    Begin, L.R.2    Gleave, M.E.3    Mes-Masson, A.M.4    Saad, F.5
  • 102
    • 53349118240 scopus 로고    scopus 로고
    • SN52, a novel nuclear factor-κB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation
    • Xu Y, Fang F, St Clair DK, et al. SN52, a novel nuclear factor-κB inhibitor, blocks nuclear import of RelB:p52 dimer and sensitizes prostate cancer cells to ionizing radiation. Mol Cancer Ther 2008; 7:2367-2376.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2367-2376
    • Xu, Y.1    Fang, F.2    St Clair, D.K.3
  • 103
    • 77950839955 scopus 로고    scopus 로고
    • RelBdependent differential radiosensitization effect of STI571 on prostate cancer cells
    • Xu Y, Fang F, Sun Y, St Clair DK, St Clair WH. RelBdependent differential radiosensitization effect of STI571 on prostate cancer cells. Mol Cancer Ther 2010; 9:803-812.
    • (2010) Mol Cancer Ther , vol.9 , pp. 803-812
    • Xu, Y.1    Fang, F.2    Sun, Y.3    St Clair, D.K.4    St Clair, W.H.5
  • 104
    • 77952559255 scopus 로고    scopus 로고
    • The Skp2 promoter integrates signaling through the NF-κ, p53, and Akt/GSK3b pathways to regulate autophagy and apoptosis
    • Barre B, Perkins ND. The Skp2 promoter integrates signaling through the NF-κ, p53, and Akt/GSK3b pathways to regulate autophagy and apoptosis. Mol Cell 2010; 38:524-538.
    • (2010) Mol Cell , vol.38 , pp. 524-538
    • Barre, B.1    Perkins, N.D.2
  • 105
    • 0037497184 scopus 로고    scopus 로고
    • A nucleosomal function for IκB kinase-alpha in NF-κ-dependent gene expression
    • Anest V, Hanson JL, Cogswell PC, et al. A nucleosomal function for IκB kinase-alpha in NF-κ-dependent gene expression. Nature 2003; 423:659-663.
    • (2003) Nature , vol.423 , pp. 659-663
    • Anest, V.1    Hanson, J.L.2    Cogswell, P.C.3
  • 106
    • 0038511129 scopus 로고    scopus 로고
    • Histone H3 phosphorylation by IKK-a is critical for cytokineinduced gene expression
    • Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB. Histone H3 phosphorylation by IKK-a is critical for cytokineinduced gene expression. Nature 2003; 423:655-659.
    • (2003) Nature , vol.423 , pp. 655-659
    • Yamamoto, Y.1    Verma, U.N.2    Prajapati, S.3    Kwak, Y.T.4    Gaynor, R.B.5
  • 107
    • 0042736200 scopus 로고    scopus 로고
    • Regulation of NF-κ2/p100 processing by its nuclear shuttling
    • Liao G, Sun SC. Regulation of NF-κ2/p100 processing by its nuclear shuttling. Oncogene 2003; 22:4868-4874.
    • (2003) Oncogene , vol.22 , pp. 4868-4874
    • Liao, G.1    Sun, S.C.2
  • 108
    • 51049096558 scopus 로고    scopus 로고
    • SUMO1 modification of NF-κ2/p100 is essential for stimuli-induced p100 phosphorylation and processing
    • Vatsyayan J, Qing G, Xiao G, Hu J. SUMO1 modification of NF-κ2/p100 is essential for stimuli-induced p100 phosphorylation and processing. EMBO Rep 2008; 9:885-890.
    • (2008) EMBO Rep , vol.9 , pp. 885-890
    • Vatsyayan, J.1    Qing, G.2    Xiao, G.3    Hu, J.4
  • 109
    • 76849100745 scopus 로고    scopus 로고
    • SUMOylation-dependent localization of IKKe in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death
    • Renner F, Moreno R, Schmitz ML. SUMOylation-dependent localization of IKKe in PML nuclear bodies is essential for protection against DNA-damage-triggered cell death. Mol Cell 2010; 37:503-515.
    • (2010) Mol Cell , vol.37 , pp. 503-515
    • Renner, F.1    Moreno, R.2    Schmitz, M.L.3
  • 110
    • 0032977359 scopus 로고    scopus 로고
    • A high dose of ionizing radiation induces tissue-specific activation of nuclear factor-κB in vivo
    • Zhou D, Brown SA, Yu T, et al. A high dose of ionizing radiation induces tissue-specific activation of nuclear factor-κB in vivo. Radiat Res 1999; 151:703-709.
    • (1999) Radiat Res , vol.151 , pp. 703-709
    • Zhou, D.1    Brown, S.A.2    Yu, T.3
  • 111
    • 4344669657 scopus 로고    scopus 로고
    • Activation of nuclear factor κb in vivo selectively protects the murine small intestine against ionizing radiation-induced damage
    • Wang Y, Meng A, Lang H, et al. Activation of nuclear factor κB in vivo selectively protects the murine small intestine against ionizing radiation-induced damage. Cancer Res 2004; 64:6240-6246.
    • (2004) Cancer Res , vol.64 , pp. 6240-6246
    • Wang, Y.1    Meng, A.2    Lang, H.3
  • 112
    • 0032409387 scopus 로고    scopus 로고
    • How regulated protein translocation can produce switch-like responses
    • Ferrell JE Jr. How regulated protein translocation can produce switch-like responses. Trends Biochem Sci 1998; 23:461-465.
    • (1998) Trends Biochem Sci , vol.23 , pp. 461-465
    • Ferrell Jr., J.E.1
  • 113
    • 0025893757 scopus 로고
    • Stereological estimates of nuclear volume in the prognostic evaluation of primary flat carcinoma in situ of the urinary bladder
    • Sorensen FB, Jacobsen F. Stereological estimates of nuclear volume in the prognostic evaluation of primary flat carcinoma in situ of the urinary bladder. Histopathology 1991; 18:531-539.
    • (1991) Histopathology , vol.18 , pp. 531-539
    • Sorensen, F.B.1    Jacobsen, F.2
  • 115
    • 0033049686 scopus 로고    scopus 로고
    • Mean nuclear volume: A supplementary prognostic factor in endometrial cancer
    • Mogensen O, Sorensen FB, Bichel P, Jakobsen A. Mean nuclear volume: a supplementary prognostic factor in endometrial cancer. Int J Gynecol Cancer 1999; 9:72-79.
    • (1999) Int J Gynecol Cancer , vol.9 , pp. 72-79
    • Mogensen, O.1    Sorensen, F.B.2    Bichel, P.3    Jakobsen, A.4
  • 116
    • 0033052637 scopus 로고    scopus 로고
    • Prognostic value of sarcomatoid histology and volume-weighted mean nuclear volume in renal cell carcinoma
    • DOI 10.1046/j.1464-410X.1999.00912.x
    • Kanamaru H, Sasaki M, Miwa Y, Akino H, Okada K. Prognostic value of sarcomatoid histology and volume-weighted mean nuclear volume in renal cell carcinoma. BJU Int 1999; 83:222-226. (Pubitemid 29151517)
    • (1999) BJU International , vol.83 , Issue.3 , pp. 222-226
    • Kanamaru, H.1    Sasaki, M.2    Miwa, Y.3    Akino, H.4    Okada, K.5
  • 117
    • 0035253637 scopus 로고    scopus 로고
    • Volume-weighted mean nuclear volume predicts tumor biology of clinically organconfined prostate cancer
    • Arai Y, Okubo K, Terada N, et al. Volume-weighted mean nuclear volume predicts tumor biology of clinically organconfined prostate cancer. Prostate 2001; 46:134-141.
    • (2001) Prostate , vol.46 , pp. 134-141
    • Arai, Y.1    Okubo, K.2    Terada, N.3
  • 118
    • 0036235793 scopus 로고    scopus 로고
    • Mean nuclear volume in cervical intraepithelial neoplasia and carcinoma
    • Dey P, Powari M. Mean nuclear volume in cervical intraepithelial neoplasia and carcinoma. Anal Quant Cytol Histol 2002; 24:70-72.
    • (2002) Anal Quant Cytol Histol , vol.24 , pp. 70-72
    • Dey, P.1    Powari, M.2
  • 119
    • 58149088150 scopus 로고    scopus 로고
    • Stereological quantification of tumor volume, mean nuclear volume and total number of melanoma cells correlated with morbidity and mortality
    • Bonnelykke-Behrndtz ML, Sorensen FB, Damsgaard TE. Stereological quantification of tumor volume, mean nuclear volume and total number of melanoma cells correlated with morbidity and mortality. APMIS 2008; 116:903-911.
    • (2008) APMIS , vol.116 , pp. 903-911
    • Bonnelykke-Behrndtz, M.L.1    Sorensen, F.B.2    Damsgaard, T.E.3
  • 120
    • 0032498283 scopus 로고    scopus 로고
    • P53 mutations in bilateral breast carcinoma. Corrleation with Ki-67 expression and the mean nuclear volume
    • Ozer E, Canda T, Kuyucuodlu F. p53 mutations in bilateral breast carcinoma. Corrleation with Ki-67 expression and the mean nuclear volume. Cancer Lett 1998; 122:101-106.
    • (1998) Cancer Lett , vol.122 , pp. 101-106
    • Ozer, E.1    Canda, T.2    Kuyucuodlu, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.