Molecular determinants of PDLIM2 in suppressing HTLV-I Tax-mediated tumorigenesis

Oncogene

Volumn 29, Issue 49, 2010, Pages 6499-6507

  Fu, J ^a,b   Yan, P ^a,b   Li, S ^a,b   Qu, Z ^a,b   Xiao, G ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

HTLV I; PDLIM2; protein degradation; protein shuttling; Tax; tumorigenesis

Indexed keywords

AMINO ACID; LAMIN B; ONCOPROTEIN; PROTEASOME; PROTEIN PDLIM2; TAX PROTEIN; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CANCER INHIBITION; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CELL NUCLEUS MATRIX; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOSKELETON; EPIGENETICS; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; VIRUS REPLICATION;

AMINO ACID MOTIFS; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; GENE PRODUCTS, TAX; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MICROFILAMENT PROTEINS; PROTEIN INTERACTION DOMAINS AND MOTIFS; T-LYMPHOCYTES;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 78650033289     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.374     Document Type: Article

References (35)

1. Akagi T, Ono H, Shimotohno K. (1995). Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1. Blood 86: 4243-4249.
2. Bex F, McDowall A, Burny A, Gaynor R. (1997). The human T-cell leukemia virus type 1 transactivator protein Tax colocalizes in unique nuclear structures with NF-kB proteins. J Virol 71: 3484-3497.
3. Boxus M, Twizere JC, Legros S, Dewulf JF, Kettmann R, Willems L. (2008). The HTLV-1 Tax interactome. Retrovirology 5: 76-110.
4. Fryrear KA, Durkin SS, Gupta SK, Tiedebohl JB, Semmes OJ. (2009). Dimerization and a novel Tax speckled structure localization signal are required for Tax nuclear localization. J Virol 83: 5339-5352.
5. Gallo RC. (2005). The discovery of the first human retrovirus: HTLV-1 and HTLV-2. Retrovirology 2: 17.
6. Grassmann R, Aboud M, Jeang KT. (2005). Molecular mechanisms of cellular transformation by HTLV-1 Tax. Oncogene 24: 5976-5985.
7. Grassmann R, Berchtold S, Radant I, Alt M, Fleckenstein B, Sodroski JG et al. (1992). Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. J Virol 66: 4570-4575.
8. Grossman WJ, Kimata JT, Wong FH, Zutter M, Ley TJ, Ratner L. (1995). Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Proc Natl Acad Sci USA 92: 1057-1061.
9. Hasegawa H, Sawa H, Lewis MJ, Orba Y, Sheehy N, Yamamoto Y et al. (2006). Thymus-derived leukemia-lymphoma in mice trans-genic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12: 466-472.
10. Kwon H, Ogle L, Benitez B, Bohuslav J, Montano M, Felsher DW et al. (2005). Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J Biol Chem 280: 35713-35722.
11. Loughran G, Healy NC, Kiely PA, Huigsloot M, Kedersha NL, O'Connor R. (2005). Mystique is a new insulin-like growth factor-I-regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage-independent growth. Mol Biol Cell 16: 1811-1822.
12. Nerenberg M, Hinrichs SH, Reynolds RK, Khoury G, Jay G. (1987). The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice. Science 237: 1324-1329.
13. Oka T, Sonobe H, Iwata J, Kubonishi I, Satoh H, Takata M et al. (1992). Phenotypic progression of a rat lymphoid cell line immortalized by human T-cell leukemia virus type 1 to induce lymphoma/leukemia-like disease in rats. J Virol 66: 6686-6694.
14. Peebles RS, Maliszewski CR, Sato TA, Hanley-Hyde J, Maroulakou IG, Hunziker R et al. (1995). Abnormal B-cell function in HTLV-I-tax transgenic mice. Oncogene 10: 1045-1051.
15. Pozzatti R, Vogel J, Jay G. (1990). The human T-lymphotropic virus type I tax gene can cooperate with the ras oncogene to induce neoplastic transformation of cells. Mol Cell Biol 10: 413-417.
16. Qing G, Qu Z, Xiao G. (2005). Regulation of NF-kB2 p100 processing by its cis-activating domain. J Biol Chem 280: 18-27.
17. Qing G, Qu Z, Xiao G. (2007). Proteasome-mediated endoproteolytic processing of the NF-kB2 precursor at the kB promoter. Proc Natl Acad Sci USA 104: 5324-5329.
18. Qu Z, Fu J, Yan P, Hu J, Cheng S, Xiao G. (2010a). Epigenetic repression of PDLIM2: implications for the biology and treatment of breast cancer. J Biol Chem 285: 11786-11792.
19. Qu Z, Qing G, Rabson R, Xiao G. (2004). Tax deregulation of NF-kB2 p100 processing involves both b-TrCP-dependent and independent mechanisms. J Biol Chem 279: 44563-44572.
20. Qu Z, Yan P, Fu J, Jiang J, Grusby MJ, Smithgall TE et al. (2010b). DNA methylation-dependent repression of PDZ-LIM-containing protein 2 in colon cancer and its role as a potential therapeutic target. Cancer Res 70: 1766-1772.
21. Radivojac P, Iakoucheva LM, Oldfield CJ, Obradovic Z, Uversky VN, Dunker AK. (2007). Intrinsic disorder and functional proteomics. Biophys J 92: 1439-1456.
22. Rousset R, Fabre S, Desbois C, Bantignies F, Jalinot P. (1998). The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins. Oncogene 16: 643-654.
23. Semmes OJ, Jeang KT. (1996). Localization of human T-cell leukemia virus type 1 tax to subnuclear compartments that overlap with interchromatin speckles. J Virol 70: 6347-6357.
24. Sun SC, Yamaoka S. (2005). Activation of NF-kB by HTLV-I and implications for cell transformation. Oncogene 24: 5952-5964.
25. Takatsuki K. (2005). Discovery of adult T-cell leukemia. Retrovirology 2: 16.
26. Tanaka A, Takahashi C, Yamaoka S, Nosaka T, Maki M, Hatanaka M. (1990). Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proc Natl Acad Sci USA 87: 1071-1075.
27. Tanaka T, Grusby MJ, Kaisho T. (2007). PDLIM2-mediated termination of transcription factor NF-kB activation by intranuclear sequestration and degradation of the p65 subunit. Nat Immunol 8: 584-591.
28. Tanaka T, Soriano MA, Grusby MJ. (2005). SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity 22: 729-736.
29. Torrado M, Senatorov VV, Trivedi R, Fariss RN, Tomarev SI. (2004). Pdlim2, a novel PDZ-LIM domain protein, interacts with alpha-actinins and filamin A. Invest Ophthalmol Vis Sci 45: 3955-3963.
30. Xiao G, Harhaj EW, Sun SC. (2000). Domain-specific interaction with IKKg is an essential step in Tax-mediated activation of IKK. J Biol Chem 275: 34060-34067.
31. Xiao G, Rabson A, Young W, Qing G, Qu Z. (2006). Alternative pathways of NF-kB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev 17: 281-293.
32. Yamaoka S, Tobe T, Hatanaka M. (1992). Tax protein of human T-cell leukemia virus type 1 is required for maintenance of the transformed phenotype. Oncogene 7: 43-47.
33. Yan P, Fu J, Qu Z, Li S, Tanaka T, Grusby MJ et al. (2009a). PDLIM2 suppresses HTLV-I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood 113: 4370-4380.
34. Yan P, Qu Z, Ishikawa C, Mori N, Xiao G. (2009b). HTLV-I-mediated repression of PDLIM2 involves DNA methylation but independent of the viral oncoprotein Tax. Neoplasia 11: 1036-1041.
35. Yoshida M. (2005). Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis. Oncogene 24: 5931-5937.