Tumours derived from HTLV-I tax transgenic mice are characterized by enhanced levels of apoptosis and oncogene expression

Journal of Pathology

Volumn 186, Issue 2, 1998, Pages 209-214

  Hall, Anthony P ^a   Irvine, Jane ^a   Blyth, Karen ^a   Cameron, Ewan R ^a   Onions, David E ^a   Campbell, Moyra E M ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Apoptosis; HTLV I; Oncogene; Transformation; Transgenes

Indexed keywords

DNA FRAGMENT; ONCOPROTEIN; TAX PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; GENE EXPRESSION; HUMAN T CELL LEUKEMIA VIRUS 1; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; VIRUS CARCINOGENESIS;

ADENOMA; ANIMALS; APOPTOSIS; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION; GENE PRODUCTS, TAX; GENES, PX; HUMAN T-LYMPHOTROPIC VIRUS 1; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; MICE; MICE, TRANSGENIC; NEOPLASM PROTEINS; ONCOGENE PROTEINS; PHENOTYPE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0031720385     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9896(1998100)186:2<209::AID-PATH162>3.0.CO;2-I     Document Type: Article

References (28)

1. Hinuma Y, Nagata K, Hanaoka M. Adult T-cell leukaemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sci USA 1981; 78: 6467-6480.
2. Cann AJ, Rosenblatt JD, Wachsman W, et al. Identification of the gene responsible for human T-cell leukaemia virus transcriptional regulation. Nature 1985; 318: 571-574.
3. Tanaka A, Takahashi C, Yamaoka S, et al. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proc Natl Acad Sci USA 1990; 87: 1071-1075.
4. Grassman R, Berchtold S, Radant I, et al. Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. J Virol 1992; 66: 4570-4575.
5. Ozden S, Coscoy L, Gonzalez Dunia D. HTLV-I transgenic models: an overview. J Acquired Immune Deficiency Syndromes Hum Retrovirol 1996; 13: S154-S161.
6. Duyao MP, Kessler DJ, Spicer DB, et al. Transactivation of the c-myc promoter by human T cell leukemia virus type 1 tax is mediated by NF kappa B. J Biol Chem 1992; 267: 16288-16 291.
7. Fujii M, Sassone Corsi P, Verma IM. c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type 1. Proc Natl Acad Sci USA 1988; 85: 8526-8530.
8. Hooper WC, Rudolph DL, Lairmore MD, et al. Constitutive expression of c-jun and jun-B cell lines infected with human T-lymphotropic virus types I and II. Biochem Biophys Res Commun 1991; 181:976-980.
9. Yamada T, Yamaoka S, Goto T. et al. The human T-cell leukemia virus type I Tax protein induces apoptosis which is blocked by the Bcl-2 protein. J Virol 1994; 68: 3374-3379.
10. Chlichlia K, Moldenhauer G, Daniel PT, et al. Immediate effects of reversible HTLV-I tax function: T-cell activation and apoptosis. Oncogene 1995; 10: 269-277.
11. Preston GA, Lyon TT, Yin Y, et al. Induction of apoptosis by the c-fos protein. Mol Cell Biol 1996; 16: 211-218.
12. Evan G, Wyllie A, Gilbert C, et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992; 69: 119.
13. Rao L, Debbas M, Sabbatini P, et al. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2. Prot Natl Acad Sci USA 1992; 89: 7742-7746.
14. Gavrieli Y, Sherman Y, Ben Sasson SA. Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J Cell Biol 1992; 119: 493-501.
15. Clevers H, Lonberg N, Dunlap S, et al. An enhancer located in a CpG-island 3′ to the TCR-CD3-epsilon gene confers T lymphocyte-specificity to its promoter. EMBO J 1989; 8: 2527-2535.
16. Posnett DN, McGrath H, Tam JP. A novel method for producing antipeptide antibodies. Production of site-specific antibodies to the T cell antigen receptor beta-chain. J Biol Chem 1988; 263: 1719-1725.
17. Schuh AC, Keating SJ, Monteclaro FS, et al. Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice. Nature 1990; 346: 756-760.
18. Green JE, Baird AM, Hinrichs SH, et al. Adrenal medullary tumors and iris proliferation in a transgenic mouse model of neurofibromatosis. Am J Pathol 1992; 140: 1401-1410.
19. Marriott SJ, Lindholm PF, Reid RL, et al. Soluble HTLV-I Tax1 protein stimulates proliferation of human peripheral blood lymphocytes. New Biol 1991; 3: 678-686.
20. Kishi S, Saijyo S, Arai M, et al. Resistance to fas-mediated apoptosis of peripheral T cells in human T lymphocyte virus type I (HTLV-I) transgenic mice with autoimmune arthropathy. J Exp Med 1997; 186: 57-64.
21. Copeland KF, Haaksma AG, Goudsmit J, et al. Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax. AIDS Res Hum Retroviruses 1994; 10: 1259-1268.
22. Stone DM, Norton LK, Magnuson NS, et al. Elevated pim-1 and c-myc proto-oncogene induction in B lymphocytes from BLV-infected cows with persistent B lymphocytosis. Leukemia 1996; 10: 1629-1638.
23. Iwahashi M, Otsuka M, Shimotakahara S, et al. Expression of fos protooncogene product by monoclonal antibody FO-120 in smouldering adult T-cell leukaemia (ATL). Br J Haematol 1994; 86: 193-194.
24. Fujita M, Shiku H. Differences in sensitivity to induction of apoptosis among rat fibroblast cells transformed by HTLV-I gene or cellular nuclear oncogenes. Oncogene 1995; 11: 15-20.
25. Rogel A, Popliker M, Webb CG, et al. p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors. Mol Cell Biol 1985; 5: 2851-2855.
26. Reid RL, Lindholm PF, Mireskandari A, et al. Stabilization of wild-type p53 in human T-lymphocytes transformed by HTLV-I. Ontogene 1993; 8: 3029-3036.
27. Cereseto A, Diella F, Mulloy JC, et al. p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells. Blood 1996; 88: 1551-1560.
28. Uittenbogaard MN, Giebler HA, Reisman D, et al. Transcriptional repression of p53 by human T-cell leukaemia virus type I protein. J Biol Chem 1995; 270: 28 503-28 506.