Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes

Journal of Virology

Volumn 72, Issue 5, 1998, Pages 4458-4462

  Robek, Michael D ^a   Wong, Fen Hwa ^a,c   Ratner, Lee ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; PROTEIN P12; PROTEIN P13; PROTEIN P30; TAX PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CELL IMMORTALIZATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; MOLECULAR CLONING; OPEN READING FRAME; PRIORITY JOURNAL; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS TRANSFORMATION; VIRUS TYPING;

EID: 0031969651     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.5.4458-4462.1998     Document Type: Article

References (39)

1. Balotta, C., P. Lusso, R. Crowley, R. C. Gallo, and G. Franchini. 1993. Antisense phosphorothioate oligodeoxynucleotides targeted to the vpr gene inhibit human immunodeficiency virus type 1 replication in primary human macrophages. J. Virol. 67:4409-4414.
2. Berneman, Z. N., R. B. Gartenhaus, M. S. Reitz, Jr., W. A. Blattner, A. Manns, B. Hanchard, O. Ikehara, R. C. Gallo, and M. E. Klotman. 1992. Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers. Proc. Natl. Acad. Sci. USA 89:3005-3009.
3. Cann, A. J., J. D. Rosenblatt, W. Wachsman, N. P. Shah, and I. S. Y. Chen. 1985. Identification of the gene responsible for human T-cell leukemia virus transcriptional regulation. Nature (London) 318:571-574.
4. Chen, Y.-M. A., S.-H. Chen, C.-Y. Fu, J. Y. Chen, and M. Osame. 1997. Antibody reactivities to tumor-suppressor protein p53 and HTLV-1 Tof, Rex, and Tax in HTLV-1 infected people with different clinical status. Int. J. Cancer 71:1-7.
5. Chou, K. S., A. Okayama, N. Tachibana, T. H. Lee, and M. Essex. 1995. Nucleotide sequence analysis of a full-length human T-cell leukemia virus type I from adult T-cell leukemia cells: a prematurely terminated pX open reading frame II. Int. J. Cancer 60:701-706.
6. Ciminale, V., G. N. Pavlakis, D. Derse, C. P. Cunningham, and B. K. Felber. 1992. Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I. J. Virol. 66:1737-1745.
7. Ciminale, V., D. M. D'Agostino, L. Zotti, G. Franchini, B. K. Felber, and L. Chieco-Bianchi. 1995. Expression and characterization of proteins produced by mRNAs spliced into the X region of the human T-cell leukemia/lymphoma virus type II. Virology 209:445-456.
8. Cockerell, G., J. Rovnak, P. L. Green, and I. S. Y. Chen. 1996. A deletion in the proximinal untranslated pX region of human T-cell leukemia virus type II decreases viral replication but not infectivity in vivo. Blood 87:1030-1035.
9. Collins, N. D., and M. D. Lairmore. 1997. Unpublished data.
10. + lymphocyte transformation and infection in a rabbit model with a molecular clone of human T-cell lymphotropic virus type 1. J. Virol. 70: 7241-7246.
11. Connor, R. I., B. K. Chen, S. Choe, and N. R. Landau. 1995. Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 206:935-944.
12. Derse, D., J. Mikorits, and F. Ruscetti. 1997. X-I and X-II open reading frames of HTLV-I are not required for virus replication or for immortalization of primary T-cells in vitro. Virology 237:123-128.
13. Felber, B. K., H. Paskalis, C. Kleinman-Ewing, F. Wong-Staal, and G. N. Pavlakis. 1985. The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science 229:675-679.
14. + ATPase. J. Virol. 67:7701-7704.
15. Frank, D. A., M. J. Robertson, A. Bonni, J. Ritz, and M. E. Greenberg. 1995. Interleukin 2 signalling involves the phosphorylation of STAT proteins. Proc. Natl. Acad. Sci. USA 92:7779-7783.
16. Fuerst, T. R., E. G. Niles, F. W. Studier, and B. Moss. 1986. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 83: 8122-8126.
17. Gessain, A., F. Barin, J.-C. Vernant, O. Gout, L. Maurs, A. Calendar, and G. de The. 1985. Antibodies to human T-lymphotropic virus type I in patients with tropical spastic paraparesis. Lancet ii:407-410.
18. Green, P. L., T. M. Ross, I. S. Y. Chen, and S. Pettiford. 1995. Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation. J. Virol. 69:387-394.
19. Hansen, M. B., S. E. Nielsen, and K. Berg. 1989. Re-examination and further development of a precise and rapid dye method for measuring cell growth/ cell kill. J. Immunol. Methods 119:203-210.
20. Hinuma, Y., K. Nagata, M. Hanaoka, M. Nakai, T. Matsumoto, K. Kinoshita, S. Shirakawa, and I. Miyoshi. 1981. Adult T-cell leukemia antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc. Natl. Acad. Sci. USA 78:6476-6480.
21. Inoue, J., M. Seiki, and M. Yoshida. 1986. The second pX product p27X-III of HTLV-1 is required for gag gene expression. FEES Lett. 209:187-190.
22. Inoue, J., M. Yoshida, and M. Seiki. 1987. Transcriptional (p40X) and post transcriptional (p27X-III) regulators are required for the expression and replication of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA 84:3653-3657.
23. Kimata, J. T., F. H. Wong, J. J. Wang, and L. Ratner. 1994. Construction and characterization of infectious human T-cell leukemia virus type 1 molecular clones. Virology 204:656-664.
24. Koralnik, I. J., A. Gessain, M. E. Klotman, A. L. Monico, Z. N. Berneman, and G. Franchini. 1992. Protein isoforms encoded by the pX region of human T-cell leukemia/lymphoma virus type I. Proc. Natl. Acad. Sci. USA 89:8813-8817.
25. Koralnik, I. J., J. F. Lemp, Jr., R. C. Gallo, and G. Franchini. 1992. In vitro infection of human macrophages by human T-cell leukemia/lymphoma virus type I (HTLV-I). AIDS Res. Hum. Retroviruses 8:1845-1849.
26. II proteins encoded by human T-cell leukemia/lymphotropic virus type I open reading frames I and II are localized in three different cellular compartments. J. Virol. 67:2360-2366.
27. +-ATPase 16 kDa subunit protein. J. Gen. Virol. 76:1909-1916.
28. Migone, T.-S., J.-X. Lin, A. Cereseto, J. C. Mulloy, J. J. O'Shea, G. Franchini, and W. J. Leonard. 1995. Constitutively activated Jak-STAT pathway in T-cells transformed with HTLV-1. Science 269:79-81.
29. c chains and affects their expression on the cell surface. J. Virol. 70:3599-3605.
30. Osame, M., K. Usuku, S. Izumo, N. Ijichi, H. Amitini, and A. Igata. 1986. HTLV-I associated myelopathy: a new clinical entity. Lancet i:1031-1032. (Letter.)
31. Persaud, D., J. L. Muñoz, S. L. Tarsis, E. S. Parks, and W. P. Parks. 1995. Time course and cytokine dependence of human T-cell lymphotropic virus type 1 T-lymphocyte transformation as revealed by a microtiter infectivity assay. J. Virol. 69:6297-6303.
32. Poiesz, B. J., F. W. Ruscetti, A. F. Gazdar, P. A. Bunn, J. D. Minna, and R. C. Gallo. 1980. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 77:7415-7419.
33. Ratner, L., S. F. Josephs, B. Starcich, B. Hahn, G. M. Shaw, R. C. Gallo, and F. Wong-Staal, 1985. Nucleotide sequence analysis of a variant human T-cell leukemia virus (HTLV-Ib) provirus with a deletion in pX-I. J. Virol. 54: 781-790.
34. Seiki, M., J. Inoue, T. Takeda, and M. Yoshida. 1986. Direct evidence that the p40x of human T-cell leukemia virus rype-1 is a trans-activating transcriptional activator. EMBO J. 5:561-565.
35. Takemoto, S., J. C. Mulloy, A. Cereseto, T. S. Migone, B. K. R. Patel, M. Matsuoka, K. Yamaguchi, K. Takatsuki, S. Kamihara, J. D. White, W. J. Leonard, T. Waldmann, and G. Franchini. 1997. Proliferation of adult T cell leukemia/lymphoma cells is associated with constitutive activation of Jak/ STAT proteins. Proc. Natl. Acad. Sci. USA 94:13897-13902.
36. Threadgill, D. S., W. K. Steagall, M. T. Flaherty, F. J. Fuller, S. T. Perry, K. E. Rushlow, S. F. Le Grice, and S. L. Payne. 1993. Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant J. Virol. 67:2592-2600.
37. Willems, L., P. Kerkhofs, F. Dequiedt, D. Portetelle, M. Mammerickx, A. Burney, and R. Kettmann. 1994. Attenuation of bovine leukemia virus by deletion of R3 and G4 open reading frames. Proc. Natl. Acad. Sci. USA 91: 11532-11536.
38. Willems, L., R. Kettmann, F. Dequiedt, D. Portetelle, V. Voneche, I. Cornil, P. Kerkhofs, A. Burney, and M. Mammerickx. 1993. In vivo infection of sheep by bovine leukemia virus mutants. J. Virol. 67:4078-4085.
39. Xu, X., S.-H. Kang, O. Heidenreich, M. Okerholm. J. J. O'Shea, and M. I. Nerenberg. 1995. Constitutive activation of different Jak tyrosine kinases in human T-cell leukemia virus type 1 tax protein or virus-transformed cells. J. Clin. Invest. 96:1548-1555.