HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein

Biochemical and Biophysical Research Communications

Volumn 365, Issue 1, 2008, Pages 189-194

  Yu, Qingsheng ^a   Minoda, Yasumasa ^a   Yoshida, Ryoko ^a   Yoshida, Hideyuki ^a   Iha, Hidekatsu ^b   Kobayashi, Takashi ^a   Yoshimura, Akihiko ^a   Takaesu, Giichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b OITA UNIVERSITY   (Japan)

Author keywords

Adapter protein; HTLV 1; MAP3K; NF B; TAK1; Tax; TRAF; Ubiquitination

Indexed keywords

ADAPTOR PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN TAB2; TAK1 BINDING PROTEIN 2; TAX PROTEIN; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 5; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN T CELL LEUKEMIA VIRUS 1; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BINDING SITES; CELL LINE; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; MAP KINASE KINASE KINASES; NF-KAPPA B; UBIQUITIN-PROTEIN LIGASES;

HUMAN T-LYMPHOTROPIC VIRUS 1;

EID: 36148980800     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.172     Document Type: Article

References (29)

1. Yoshida M. Discovery of HTLV-1, the first human retrovirus, its unique regulatory mechanisms, and insights into pathogenesis. Oncogene 24 (2005) 5931-5937
2. Grassmann R., Aboud M., and Jeang K.T. Molecular mechanisms of cellular transformation by HTLV-1 Tax. Oncogene 24 (2005) 5976-5985
3. Yoshida M. Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu. Rev. Immunol. 19 (2001) 475-496
4. Jeong S.J., Radonovich M., Brady J.N., and Pise-Masison C.A. HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity. Blood 104 (2004) 1490-1497
5. Robek M.D., and Ratner L. Immortalization of CD4(+) and CD8(+) T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone. J. Virol. 73 (1999) 4856-4865
6. Yamaoka S., Courtois G., Bessia C., Whiteside S.T., Weil R., Agou F., Kirk H.E., Kay R.J., and Israel A. Complementation cloning of NEMO, a component of the IκB kinase complex essential for NF-κB activation. Cell 93 (1998) 1231-1240
7. Algarte M., Lecine P., Costello R., Plet A., Olive D., and Imbert J. In vivo regulation of interleukin-2 receptor a gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells. EMBO J. 14 (1995) 5060-5072
8. Hayden M.S., and Ghosh S. Signaling to NF-κB. Genes Dev. 18 (2004) 2195-2224
9. Karin M., and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18 (2000) 621-663
10. Chen Z.J., Bhoj V., Seth R.B., and Ubiquitin. TAK1 and IKK: is there a connection?. Cell Death Differ. 13 (2006) 687-692
11. Sato S., Sanjo H., Takeda K., Ninomiya-Tsuji J., Yamamoto M., Kawai T., Matsumoto K., Takeuchi O., and Akira S. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6 (2005) 1087-1095
12. Liu H.H., Xie M., Schneider M.D., and Chen Z.J. Essential role of TAK1 in thymocyte development and activation. Proc. Natl. Acad. Sci. USA 103 (2006) 11677-11682
13. Shim J.H., Xiao C., Paschal A.E., Bailey S.T., Rao P., Hayden M.S., Lee K.Y., Bussey C., Steckel M., Tanaka N., Yamada G., Akira S., Matsumoto K., and Ghosh S. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19 (2005) 2668-2681
14. Takaesu G., Surabhi R.M., Park K.J., Ninomiya-Tsuji J., Matsumoto K., and Gaynor R.B. TAK1 is critical for IκB kinase-mediated activation of the NF-κB pathway. J. Mol. Biol. 326 (2003) 105-115
15. Ninomiya-Tsuji J., Kishimoto K., Hiyama A., Inoue J., Cao Z., and Matsumoto K. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398 (1999) 252-256
16. Kanayama A., Seth R.B., Sun L., Ea C.K., Hong M., Shaito A., Chiu Y.H., Deng L., and Chen Z.J. TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains. Mol. Cell 15 (2004) 535-548
17. Ishitani T., Takaesu G., Ninomiya-Tsuji J., Shibuya H., Gaynor R.B., and Matsumoto K. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J. 22 (2003) 6277-6288
18. Takaesu G., Kishida S., Hiyama A., Yamaguchi K., Shibuya H., Irie K., Ninomiya-Tsuji J., and Matsumoto K. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 5 (2000) 649-658
19. Wu X., and Sun S.C. Retroviral oncoprotein Tax deregulates NF-κB by activating Tak1 and mediating the physical association of Tak1-IKK. EMBO Rep. 8 (2007) 510-515
20. Suzuki S., Singhirunnusorn P., Mori A., Yamaoka S., Kitajima I., Saiki I., and Sakurai H. Constitutive activation of TAK1 by HTLV-1 tax-dependent overexpression of TAB2 induces activation of JNK-ATF2 but not IKK-NF-κB. J. Biol. Chem. 282 (2007) 25177-25181
21. Chiari E., Lamsoul I., Lodewick J., Chopin C., Bex F., and Pique C. Stable ubiquitination of human T-cell leukemia virus type 1 tax is required for proteasome binding. J. Virol. 78 (2004) 11823-11832
22. Wong B.R., Besser D., Kim N., Arron J.R., Vologodskaia M., Hanafusa H., and Choi Y. TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol. Cell 4 (1999) 1041-1049
23. Boussif O., Lezoualc′h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., and Behr J.P. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA 92 (1995) 7297-7301
24. Kishida S., Sanjo H., Akira S., Matsumoto K., and Ninomiya-Tsuji J. TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway. Genes Cells 10 (2005) 447-454
25. Geleziunas R., Ferrell S., Lin X., Mu Y., Cunningham Jr. E.T., Grant M., Connelly M.A., Hambor J.E., Marcu K.B., and Greene W.C. Human T-cell leukemia virus type 1 Tax induction of NF-κB involves activation of the IκB kinase a (IKKa) and IKKb cellular kinases. Mol. Cell. Biol. 18 (1998) 5157-5165
26. Kishimoto K., Matsumoto K., and Ninomiya-Tsuji J. TAK1 mitogen-activated protein kinase is activated by autophosphorylation within its activation loop. J. Biol. Chem. 275 (2000) 7359-7364
27. Peloponese Jr. J.M., Iha H., Yedavalli V.R., Miyazato A., Li Y., Haller K., Benkirane M., and Jeang K.T. Ubiquitination of human T-cell leukemia virus type 1 tax modulates its activity. J. Virol. 78 (2004) 11686-11695
28. Lamsoul I., Lodewick J., Lebrun S., Brasseur R., Burny A., Gaynor R.B., and Bex F. Exclusive ubiquitination and sumoylation on overlapping lysine residues mediate NF-κB activation by the human T-cell leukemia virus tax oncoprotein. Mol. Cell. Biol. 25 (2005) 10391-10406
29. Nasr R., Chiari E., El-Sabban M., Mahieux R., Kfoury Y., Abdulhay M., Yazbeck V., Hermine O., de The H., Pique C., and Bazarbachi A. Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-κB activation. Blood 107 (2006) 4021-4029