Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IκB kinase (IKK)

Cell Research

Volumn 16, Issue 11, 2006, Pages 895-901

  Qing, Guoliang ^a   Yan, Pengrong ^a   Xiao, Gutian ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Autophagy; Geldanamycin; Hsp90; I B kinase; NF B; Proteasome; Selective degradation; Therapy

Indexed keywords

BENZOQUINONE DERIVATIVE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; I KAPPA B; I KAPPA B KINASE; MACROCYCLIC LACTAM; PROTEASOME; UBIQUITIN;

ANIMAL; ARTICLE; AUTOPHAGY; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; HELA CELL; HUMAN; IMMUNOBLOTTING; METABOLISM; MOUSE; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; BENZOQUINONES; CELL LINE; CELLS, CULTURED; GENE EXPRESSION; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; IMMUNOBLOTTING; LACTAMS, MACROCYCLIC; MICE; MODELS, BIOLOGICAL; POLYMERASE CHAIN REACTION; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; UBIQUITIN;

EID: 33751111683     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/sj.cr.7310109     Document Type: Article

References (30)

1. Levine B, Klionsky DJ. Development by self-digestion molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6:463-477.
2. Lodish H, Berk A, Matsudaira P, et al. Molecular Cell Biology. 5th Edition, New York: WH Freeman and Company. 2004: 59.
3. Dai C, Whitesell L. HSP90: a rising star on the horizon of anticancer targets. Future Oncol 2005; 1:529-540.
4. Zhang H, Burrows F. Targeting multiple signal transduction pathways through inhibition of Hsp90. J Mol Med 2004; 82:488-499.
5. Whitesell L, Mimnaugh EG, De Costa B, Myers CE, Neckers LM. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sc USA 1994; 91:8324-8328.
6. Majeski AE, Dice JF. Mechanisms of chaperone-mediated autophagy. Int J Biochem Cell 2004; 36:2435-2444.
7. Chen G, Cao P, Goeddel DV. TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. Mol Cell 2002; 9:401-410.
8. Xiao G, Rabson A, Young W, Qing G, Qu Z. Alternative pathways of NF-kappaB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev 2006; 17:281-293.
9. Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006; 441:431-436.
10. Xiao G, Harhaj EW, Sun SC. Domain-specific interaction with the I kappa B kinase (IKK) regulatory subunit IKK gamma is an essential step in tax-mediated activation of IKK. J Biol Chem 2000; 275:34060-34067.
11. Qing G, Qu Z, Xiao G. Regulation of NF-kappaB2 p100 processing by its cis-acting domain. J Biol Chem 2004; 280:18-27.
12. Harhaj EW, Good L, Xiao G, et al. Somatic mutagenesis studies of NF-kappaB signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappaB activation by T-cell costimulatory signals and HTLV-I Tax protein. Oncogene 2000; 19:1448-1456.
13. Qing G, Qu Z, Xiao G. Stabilization of basally translated NF-kappaB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-kappaB2 p100. J Biol Chem 2005; 280:40578-40582.
14. Qu Z, Qing G, Rabson A, Xiao G. Tax deregulation of NF-kappaB2 p100 processing involves both beta-TrCP-dependent and -independent mechanisms. J Biol Chem 2004; 279:44563-44572.
15. Xiao G, Harhaj EW, Sun SC. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 2001; 8:401-409.
16. Xiao G, Civijic ME, Fong A, et al. Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J 2001; 20:6805-6815.
17. Qing G, Xiao G. Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100. J Biol Chem 2005; 280:9765-9768.
18. Basso AD, Solit DB, Chiosis G, et al. Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function. J Biol Chem 2002; 277:39858-39866.
19. Broemer M, Krappmann D, Scheidereit C. Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation. Oncogene 2004; 23:5378-5386.
20. Chowdary DR, Dermody JJ, Jha KK, Ozer HL. Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway. Mol Cell Biol 1994; 14:1997-2003.
21. Orlowski M, Wilk S. Ubiquitin-independent proteolytic functions of the proteasome. Arch Biochem Biophys 2003; 415:1-5.
22. Edinger AL, Thompson CB. Defective autophagy leads to cancer. Cancer Cell 2003; 4:442-424.
23. Mizushima N. The pleiotropic role of autophagy: from protein metabolism to bactericide. Cell Death Differ 2005; 12 Suppl 2:1535-1541.
24. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306:990-995.
25. Samari HR, Seglen PO. Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. J Biol Chem 1998; 273:23758-23763.
26. Kuma A, Hatano M, Matsui M, et al. The role of autophagy during the early neonatal starvation period. Nature 2004; 432:1032-1036.
27. Yu L, Wan F, Dutta S, et al. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci USA 2006; 103:4952-4957.
28. Agarraberes FA, Dice JF. A molecular chaperone complex at the lysosomal membrane is required for protein translocation. J Cell Sci 2001; 114:2491-2499.
29. Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-734.
30. Levine B, Yuan J. Autophagy in cell death: an innocent convict? J Clin Invest 2005; 115:2679-2688.