Human T-cell leukemia virus type I tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-κB-like sites

Cancer Research

Volumn 58, Issue 17, 1998, Pages 3993-4000

  Mori, Naoki ^a,b   Mukaida, Naofumi ^a,b   Ballard, Dean W ^d   Matsushima, Kouji ^c   Yamamoto, Naoki ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; TAX PROTEIN; TRANSCRIPTION FACTOR AP 1;

ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T LYMPHOCYTE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

BINDING SITES; CELL LINE; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; INTERLEUKIN-8; NF-KAPPA B; PROTO-ONCOGENE PROTEINS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS;

EID: 0032170525     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Matsushima, K., Baldwin, E. T., and Mukaida, N. Interleukin-8 and MCAF: novel leukocyte recruitment and activating cytokines. Chem. Immunol., 51: 236-265, 1992.
2. Mukaida, N., Harada, A., Yasumoto, K., and Matsushima, K. Properties of proinflammatory cell type-specific leukocyte chemotactic cytokines, interleukin 8 (IL-8) and monocyte chemotactic and activating factor (MCAF). Microbiol. Immunol., 36: 773-789, 1992.
3. Larsen, C. G., Anderson, A. O., Appella, E., Oppenheim, J. J., and Matsushima, K. The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes. Science (Washington DC), 243: 1464-1466, 1989.
4. Baggiolini, M., Walz, A., and Kunkel, S. L. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J. Clin. Invest., 84: 1045-1049, 1989.
5. Yoshimura, T., Matsushima, K., Tanaka, S., Robinson, E. A., Appella, E., Oppenheim, J. J., and Leonard, E. J. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defence cytokines. Proc. Natl. Acad. Sci. USA, 84: 9233-9237, 1987.
6. Baggiolini, M., and Clark-Lewis, I. Interleukin-8, a chemotactic and inflammatory cytokine. FEBS Lett., 307: 97-101, 1992.
7. Oppenheim, J. J., Zachariae, C. O., Mukaida, N., and Matsushima, K. Properties of the novel proinflammatory supergene "intercrine" cytokine family. Annu. Rev. Immunol., 9: 617-648, 1991.
8. Strieter, R. M., Kunkel, S. L., Showell, H. J., Remick, D. G., Phan, S. H., Ward, P. A., and Marks, R. M. Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-α, LPS, and IL-1β. Science (Washington DC), 243: 1467-1469, 1989.
9. Poiesz, B. J., Ruscetti, F. W., Gazdar, A. F., Bunn, P. A., Minna, J. D., and Gallo, R. C. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA, 77: 7415-7419, 1980.
10. Yoshida, M., Miyoshi, I., and Hinuma, Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc. Natl. Acad. Sci. USA, 79: 2031-2035, 1982.
11. Takatsuki, K., Yamaguchi, K., Watanabe, T., Mochizuki, M., Kiyokawa, T., Mori, S., and Miyata, N. Adult T-cell leukemia and HTLV-I related diseases. In: K. Takatsuki, Y. Hinuma, and M. Yoshida (eds.), Gann Monograph on Cancer Research No. 39. Advances in Adult T-Cell Leukemia and HTLV-I Research, pp. 1-15. Boca Raton: CRC, 1992.
12. Gassain, A., Barin, F., Vernant, J. C., Gout, O., Maurs, L., Calender, A., and de The, G. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet, 2: 407-410, 1985.
13. Osame, M., Usuku, K., Izumo, S., Ijichi, N., Amitani, H., Igata, A., Matsumoto, M., and Tara, M. HTLV-I associated myelopathy, a new clinical entity. Lancet, 1: 1031-1032, 1986.
14. Nishioka, K., Maruyama, I., Sato, K., Kitajima, L. Nakajima, Y., and Osame, M. Chronic inflammatory arthropathy associated with HTLV-I. Lancet, 1: 441, 1989.
15. Mochizuki, M., Watanabe, T., Yamaguchi, K., Takatsuki, K., Yoshimura, K., Shirao, M., Nakashima, S., Mori, S., Araki, S., and Miyata, N. HTLV-I uveitis: a distinct clinical entity caused by HTLV-I. Jpn. J. Cancer Res., 83: 236-239, 1992.
16. Mori, N., Murakami, S., Oda, S., Prager, D., and Eto, S. Production of interleukin 8 in adult T-cell leukemia cells: possible transactivation of the interleukin 8 gene by human T-cell leukemia virus type I tax. Cancer Res., 55: 3592-3597, 1995.
17. Yamada, Y., Ohmoto, Y., Hata, T., Yamamura, M., Murata, K., Tsukasaki, K., Kohno, T., Chen, Y., Kamihira, S., and Tomonaga, M. Features of the cytokines secreted by adult T cell leukemia (ATL) cells. Leuk. Lymphoma, 21: 443-447, 1996.
18. Fujisawa, J., Seiki, M., Kiyokawa, T., and Yoshida, M. Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor. Proc. Natl. Acad. Sci. USA, 82: 2277-2281, 1985.
19. Sodroski, J. G., Rosen, C. A., and Haseltine, W. A. Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science (Washington DC), 225: 381-385, 1984.
20. Siekevitz, M., Feinberg, M. B., Holbrook, N., Wong-Staal, F., and Greene, W. C. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA, 84: 5389-5393, 1987.
21. Ballard, D. W., Bohnlein, E., Lowenthal, J. W., Wano, Y., Franza, B. R., and Greene, W. C. HTLV-I tax induces cellular proteins that activate the KB element in the IL-2 receptor α gene. Science (Washington DC), 241: 1652-1655, 1988.
22. Mori, N., and Prager, D. Transactivation of the interleukin-Iα promoter by human T-cell leukemia virus type I and type II Tax proteins. Blood, 87: 3410-3417, 1996.
23. Mori, N., Shirakawa, F., Shimizu, H., Murakami, S., Oda, S., Yamamoto, K., and Eto, S. Transcriptional regulation of the human interleukin-6 gene promoter in human T-cell leukemia virus type I-infected T-cell lines: evidence for the involvement of NF-KB. Blood, 84: 2904-2911, 1994.
24. Mori, N., Gill, P. S., Mougdil, T., Murakami, S., Eto, S., and Prager, D. Interleukin-10 gene expression in adult T-cell leukemia. Blood, 88: 1035-1045, 1996.
25. Fujii, M., Sassone-Corsi, P., and Verma, I. M. c-fos promoter trans-activation by the tax 1 protein of human T-cell leukemia virus type I. Proc. Natl. Acad. Sci. USA, 85: 8526-8530, 1988.
26. tax protein in the human T-cell line, Jurkat. J. Virol., 63: 3220-3226, 1989.
27. Mori, N., Murakami, S., Oda, S., and Eto, S. Human T-cell leukemia virus type I tax induces intracellular adhesion molecule-1 expression in T cells. Blood, 84: 350-351, 1994.
28. Armstrong, A. P., Franklin, A. A., Uittenbogaard, M. N., Giebler, H. A., and Nyborg, J. K. Pleiotropic effect of the human T-cell leukemia virus Tax protein on the DNA binding activity of eukaryotic transcription factors. Proc. Natl. Acad. Sci. USA, 90: 7303-7307, 1993.
29. Suzuki, T., Fujisawa, J., Toita, M., and Yoshida, M. The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1. Proc. Natl. Acad. Sci. USA, 90: 610-614, 1993.
30. Wagner, S., and Green, M. R. HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization. Science (Washington DC), 262: 395-399, 1993.
31. Zhao, L-J., and Giam, C-Z. Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. Proc. Natl. Acad. Sci. USA, 89: 7070-7074, 1992.
32. SRF causes the aberrant induction of cellular immediate early genes through CArG boxes. Genes Dev., 6: 2066-2076, 1992.
33. Hirai, H., Fujisawa, J., Suzuki, T., Ueda, K., Muramatsu, M., Tsuboi, A., Arai, N., and Yoshida, M. Transcriptional activator Tax of HTLV-1 binds to the NF-KB precursor p105. Oncogene, 7: 1737-1742, 1992.
34. Hirai, H., Suzuki, T., Fujisawa, J., Inoue, J., and Yoshida, M. Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor KB and induces nuclear translocation of transcription factor NF-KB proteins for transcriptional activation. Proc. Natl. Acad. Sci. USA, 91: 3584-3588, 1994.
35. Kanno, T., Franzoso, G., and Siebenlist, U. Human T-cell leukemia virus type I Tax-protein-mediated activation of NF-KB from p100 (NF-KB2)-inhibited cytoplasmic reservoirs. Proc. Natl. Acad. Sci. USA, 91: 12634-12638, 1994.
36. Kanno, T., Brown, K., Franzoso, G., and Siebenlist, U. Kinetic analysis of human T-cell leukemia virus type I Tax-mediated activation of NF-KB. Mol. Cell. Biol., 14: 6443-6451, 1994.
37. Suzuki, T., Hirai, H., Murakami, T., and Yoshida, M. Tax protein of HTLV-1 destabilizes the complexes of NF-KB and IKB-α and induces nuclear translocation of NF-KB for transcriptional activation. Oncogene, 10: 1199-1207, 1995.
38. Brockman, J. A., Scherer, D. C., McKinsey, T. A., Hall, S. M., Qi, X., Lee, W. Y., and Ballard, D. W. Coupling of a signal response domain in IKBα to multiple pathways for NF-KB activation. Mol. Cell. Biol., 15: 2809-2818, 1995.
39. McKinsey, T. A., Brockman, J. A., Scherer, D. C., Al-Murrani, S. W., Green, P. L., and Ballard, D. W. Inactivation of IKBβ by the Tax protein of human T-cell leukemia virus type 1: a potential mechanism for constitutive induction of NF-KB. Mol . Cell. Biol., 16: 2083-2090, 1996.
40. Tanaka, Y., Yoshida, A., Takayama, Y., Tsujimoto, H., Tsujimoto, A., Hayami, M., and Tozawa, H. Heterogeneity of antigen molecules recognized by anti-tax 1 monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses. Jpn. J. Cancer Res., 81: 225-231, 1990.
41. Tanaka, A., Takahashi, C., Yamaoka, S., Nosaka, T., Maki, M., and Hatanaka, M. Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro. Proc. Natl. Acad. Sci. USA, 87: 1071-1075, 1990.
42. Matsumoto, K., Shibata, H., Fujisawa, J., Inoue, H., Hakura, A., Tsukahara, T., and Fujii, M. Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways. J. Virol., 71: 4445-4451, 1997.
43. Mukaida, N., Mahe, Y., and Matsushima, K. Cooperative interaction of nuclear factor-KB and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J. Biol. Chem., 265: 21128-21133, 1990.
44. Mahe, Y., Mukaida, N., Kuno, K., Akiyama, M., Ikeda, N., Matsushima, K., and Murakami, S. Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor KB and CCAAT/enhancer-binding protein-like cis-elements. J. Biol. Chem., 266: 13759-13763, 1991.
45. Yasumoto, K., Okamoto, S., Mukaida, N., Murakami, S., Mai, M., and Matsushima, K. Tumor necrosis factor α and Interferon γ synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-xB-like binding sites of the interleukin 8 gene. J. Biol. Chem., 267: 22506-22511, 1992.
46. Ishikawa, Y., Mukaida, N., Kuno, K., Rice, N., Okamoto, S., and Matsushima, K. Establishment of lipopolysaccharide-dependent nuclear factor KB activation in a cell-free system. J. Biol. Chem., 270: 4158-4164, 1995.
47. Antalis, T. M., and Godbolt, D. Isolation nuclei from hematopoietic cell types. Nucl. Acids Res., 19: 4301, 1991.
48. Saggioro, D., Panozzo, M., and Chieco-Bianchi, L. Human T-lymphotropic virus type I transcriptional regulation by methylation. Cancer Res., 50: 4968-4973, 1990.
49. Smith, M. R., and Greene, W. C. Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes. Genes Dev., 4: 1875-1885, 1990.
50. Kim, S-J., Kehrl, J. H., Burton, J., Tendler, C. L., Jeang, H-T., Danielpour, D., Thevenin, C., Kim, K. Y., Sporn, M. B., and Roberts, A. B. Transactivation of the transforming growth factor β1 (TGF-β1) gene by human T lymphotropic virus type 1 Tax: a potential mechanism for the increased production of TGF-β1 in adult T cell leukemia. J. Exp. Med., 172: 121-129, 1990.
51. Uchijima, M., Sato, H., Fujii, M., and Seiki, M. Tax proteins of human T-cell leukemia virus type 1 and 2 induce expression of the gene encoding erythroid-potentiating activity (tissue inhibitor of metalloproteinases-1, TIMP-1). J. Biol. Chem., 269: 14946-14950, 1994.
52. Tsuchiya, H., Fujii, M., Niki, T., Tokuhara, M., Matsui, M., and Seiki, M. Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. J. Virol., 67: 7001-7007, 1993.
53. Fujii, M., Niki, T., Mori, T., Matsuda, T., Matsui, M., Nomura, N., and Seiki, M. HTLV-1 Tax induces expression of various immediate early serum responsive genes. Oncogene, 6: 1023-1029, 1991.
54. Mastronarde, J. G., He, B., Monick, M. M., Mukaida, N., Matsushima, K., and Hunninghake, G. W. Induction of interleukin (IL)-8 gene expression by respiratory syncytial virus involves activation of nuclear factor (NF)-KB and NF-IL-6. J. Infect. Dis., 174: 262-267, 1996.
55. Murayama, T., Ohara, Y., Obuchi, M., Khabar, K. S. A., Higashi, H., Mukaida, N., and Matsushima, K. Human cytomegalovirus induces interleukin-8 production by a human monocytic cell line, THP-1, through acting concurrently on AP-1- and NF-KB-binding sites of the interleukin-8 gene. J. Virol., 71: 5692-5695, 1997.
56. Lee, L-F., Haskill, J. S., Mukaida, N., Matsushima, K., and Ting, J. P-Y. Identification of tumor-specific paclitaxel (Taxol)-responsive regulatory elements in the interleukin-8 promoter. Mol. Cell. Biol., 17: 5097-5105, 1997.
57. Kitajima, I., Shinohara, T., Bilakovics, J., Brown, D. A., Xu, X., and Nerenberg, M. Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-KB. Science (Washington DC), 258: 1792-1795, 1992.