Activation of cyclin D1 and D2 promoters by human T-cell leukemia virus type I Tax protein is associated with IL-2-independent growth of T cells

International Journal of Cancer

Volumn 99, Issue 3, 2002, Pages 378-385

  Mori, Naoki ^a,g   Fujii, Masahiro ^b   Hinz, Michael ^c   Nakayama, Katsushi ^a   Yamada, Yasuaki ^a   Ikeda, Shuichi ^d   Yamasaki, Yoshihiro ^e   Kashanchi, Fatah ^f   Tanaka, Yuetsu ^g   Tomonaga, Masao ^h   Yamamoto, Naoki ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^c HUMBOLDT UNIVERSITY   (Germany)

^d Sasebo Shiritsu Sogo Hospital   (Japan)

^e KOKURA MEMORIAL HOSPITAL   (Japan)

^f RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF THE RYUKYUS   (Japan)

^h NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Cyclin D1; Cyclin D2; Human T cell leukemia virus type 1; NF B; Tax

Indexed keywords

CYCLIN D1; CYCLIN D2; INTERLEUKIN 2; MESSENGER RNA; TAX PROTEIN;

ARTICLE; CELL GROWTH; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LYMPHOCYTE; LYMPHOCYTE TRANSFORMATION; PRIORITY JOURNAL; PROMOTER REGION; T CELL LEUKEMIA;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CYCLIN D1; CYCLINS; GENE PRODUCTS, TAX; HUMANS; INTERLEUKIN-2; KINETICS; LEUKEMIA, T-CELL; MICE; NF-KAPPA B; PLASMIDS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0037140911     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10388     Document Type: Article

References (52)

1. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
2. Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera
3. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease
4. Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture
5. Characterization of T cells immortalized by Tax1 of human T-cell leukemia virus type 1
6. Oncogenic transformation by the tax gene of human T-cell leukemia virus type 1 in vitro
7. Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways
8. The tat gene of human T-lymphotropic virus type induces mesenchymal tumors in transgenic mice
9. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type 1
10. A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus
11. Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus type 1
12. HTLV-1 Tax induces expression of various immediate early serum responsive genes
13. HTLV-1 transactivator protein, Tax, is a trans-repressor of the human β-polymerase gene
14. Repression of bax gene expression by the HTLV-1 Tax protein: Implications for suppression of apoptosis in virally infected cells
15. Human T-cell lymphotropic/leukemia virus type 1 Tax abrogates p53-induced cell cycle arrest and apoptosis through its CREB/ATF functional domain
16. Human T-cell leukemia virus type 1 oncoprotein Tax represses Smad-dependent transforming growth factor β signaling through interaction with CREB-binding protein/p300
17. 1 phase progression: Cycling on cue
18. Principles of CDK regulation
19. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
20. Human T-cell leukemia virus type 1 Tax and cell cycle progression: Role of cyclin D-cdk and p110Rb
21. Cell type-specific E2F activation and cell cycle progression induced by the oncogene product Tax of human T-cell leukemia virus type 1
22. INK4a
23. Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells
24. Transformation of human leukocytes by cocultivation with an adult T cell leukemia virus producer cell line
25. Isolation and transmission of human retrovirus (human T-cell leukemia virus)
26. Characterization of a novel HTLV-infected cell line
27. Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells
28. tax protein in the human T-cell line, Jurkat
29. Electroporation: Application to human lymphoid cell lines for stable introduction of a transactivator gene of human T-cell leukemia virus type 1
30. Human T-cell leukemia virus type 1 Tax protein abrogates interleukin-2 dependence in a mouse T-cell line
31. Identification of HTLV-1 tax trans-activator mutants exhibiting novel transcriptional phenotypes
32. Coupling of a signal response domain in IκBα to multiple pathways for NF-κB activation
33. Inactivation of IκBβ by the Tax protein of human T-cell leukemia virus type 1: A potential mechanism for constitutive induction of NF-κB
34. 1-to-S-phase transition
35. Functional analysis of the human cyclin D2 and cyclin D3 promoters
36. 1 monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type 1 and related retroviruses
37. waf1/cip1/sdi1
38. Molecular cloning and chromosomal mapping of DNA rearranged with the parathyroid hormone gene in a parathyroid adenoma
39. A variant chromosome translocation at 11q13 identifying PRADI/cyclin D1 as the BCL-1 gene
40. Overexpression of cyclin D2 in chronic B-cell malignancies
41. Function of a human cyclin gene as an oncogene
42. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice
43. Hepatocellular carcinoma results from chronic cyclin D1 overexpression in transgenic mice
44. Cyclin D2 overexpression in transgenic mice induces thymic and epidermal hyperplasia whereas cyclin D3 expression results only in epidermal hyperplasia
45. Constitutive activation of NF-κB in primary adult T-cell leukemia cells
46. Ablation of transplanted HTLV-1 Tax-transformed tumors in mice by antisense inhibition of NF-κB
47. Constitutive activation of NF-κB is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type 1 Tax protein
48. Molecular mechanism of tumorigenesis in mice transgenic for the human T cell leukemia virus Tax gene
49. Characterization of peripheral blood T-lymphocytes transduced with HTLV-1 Tax mutants with different trans-activating phenotypes
50. + T lymphocytes by human T-cell leukemia virus type 1 Tax mutants expressed in a functional molecular clone
51. Human T-cell leukemia virus type-1 (HTLV-1) Tax is expressed at the same level in infected cells of HTLV-1-associated myelopathy or tropical spastic paraparesis patients as in asymptomatic carriers but at a lower level in adult T-cell leukemia cells
52. Methylation analysis of cell cycle control genes in adult T-cell leukemia/lymphoma