Human T cell leukemia virus type I tax enhances IL-4 gene expression in T cells

European Journal of Immunology

Volumn 31, Issue 9, 2001, Pages 2623-2632

  Li Weber, Min ^a   Giaisi, Marco ^a   Chlichlia, Katerina ^a   Khazaie, Khashayarsha ^a   Krammer, Peter H ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

CCAAT enhancer binding protein; HTLV 1; IL 4; Tax

Indexed keywords

CYTOKINE; ESTROGEN RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; RECOMBINANT PROTEIN; TRANSACTIVATOR PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HORMONE BINDING; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; T CELL LEUKEMIA; T LYMPHOCYTE;

CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELLS, CULTURED; GENE PRODUCTS, TAX; HUMANS; INTERLEUKIN-4; JURKAT CELLS; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; RNA, MESSENGER; T-LYMPHOCYTES; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 0034806874     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200109)31:9<2623::AID-IMMU2623>3.0.CO;2-4     Document Type: Article

References (62)

1. Molecular biology of the type I human T cell leukemia virus (HTLV-I) and adult T cell leukemia
2. Antibodies to human T-lymphotropic virus type 1 in patients with tropical spastic paraparesis
3. HTLV-I associated myelopathy, a new clinical entity
4. Functional activation of the long terminal repeat of human T cell leukemia virus type 1 by a trans-acting factor
5. A transcriptional activator protein encoded by the x-lor region of the human T cell leukemia virus
6. Multiple control levels of cell proliferation by human T cell leukemia virus type 1 Tax protein
7. Regulation of gene expression by HTLV-1 Tax protein
8. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering
9. HTLV-I Tax induces cellular proteins that activate the κB element in the IL-2 receptor α gene
10. HTLV-I transactivatior induces interleukin-2 receptor expression through an NF-κB like factor
11. Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I Tax gene product
12. Transactivation of the interleukin-1 alpha promoter by human T cell leukemia virus type I and type II Tax proteins
13. Interleukin-10 expression and adult T cell leukemia
14. Transactivation of the human interleukin-6 gene by human T-lymphotropic virus type 1 Tax protein
15. Human T cell leukemia virus type I tax transactivates the interleukin-6 gene in human rheumatoid synovial cells
16. Human T cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-kappaB-like sites
17. Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site
18. Triple synergism of human T-lymphotropic virus type 1-encoded tax, GATA-binding protein, and AP-1 is required for constitutive expression of the interleukin-5 gene in adult T cell leukemia cells
19. Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-1 Tax1
20. Interleuki-4: A prototypic immunoregulatory lymphokine
21. Functions of IL-4 and control of its expression
22. Leukemic cells from a chronic T-lymphocytic leukemia patient proliferated in response to both interleukin-2 and interleukin-4 without prior stimulation and produced interleukin-2 mRNA with stimulation
23. Time course and cytokine dependence of human T cell lymphotropic virus type 1 T-lymphocyte transformation as revealed by a microtiter infectivity assay
24. Leukemic cell from some adult T cell leukemia patients proliferate in response to interleukin-4
25. Characterization and regulation of interleukin-4 receptor in adult T cell leukemia cells
26. A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor
27. Reduced levels of hsp90 compromise steroid receptor action in vivo
28. CCAAT-enhancer binding protein: A componenet of a differentiation switch
29. Hormone-dependent transcriptional regulation and cellular transformation by Fos-steroid receptor fusion proteins
30. Immediate effects of reversible HTLV-1 tax function: T cell activation and apoptosis
31. Soluble HTLV-I Tax1 protein stimulates proliferation of human peripheral blood lymphocytes
32. HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization
33. Recognition of bZIP proteins by the human T cell leukemia virus transactivator Tax
34. Mechanism of DNA-binding enhancement by the human T cell leukemia virus transactivator Tax
35. Complex formation between CREB and Tax enhances the binding affinity of CREB for the human T cell leukemia virus type 1 21-base-pair repeats
36. Transactivation by the human T cell leukemia virus Tax protein is mediated through enhanced binding of activating transcription factor-2 (ATF-2) ATF-2 response and cAMP element-binding
37. Nuclear factor-IL6 activates the human IL-4 promoter in T cells
38. Cloning of the cDNA encoding human C/EBPγ, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter
39. Differential precipitation and zinc chelate chromatography purification of biologically active HTLV-I Tax1 expressed in E. coli
40. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
41. Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28
42. Induction of nuclear NF-kappa B DNA binding activity after exposure of lymphoid cells to soluble tax1 protein
43. Extracellular Tax1 protein stimulates tumor necrosis factor-β and immunoglobulin kappa light chain expression in lymphoid cells
44. Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets
45. Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter
46. Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter
47. An 11-base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T cell activation signals
48. A novel enhancer element in the human IL-4 promoter is suppressed by a position-independent silencer
49. Vav synergizes with protein kinase CΘ to mediate IL-4 gene expression in response to CD28 costimulation in T cells
50. Phosphorylation at threonine-235 by ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
51. Novel mechanism of C/EBPβ(NF-M) transcriptional control: Activation through derepression
52. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ
53. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain
54. Functional and physical associations between NF-kB and C/EBP family members: A Rel domain-bZIP interaction
55. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
56. Synergistiv transcriptional activation of the IL8 gene by NF-κB p65 (ReIA) and NF-IL6
57. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP
58. NF-IL6 and NF-κB in cytokine gene regulation
59. Regulation of the expression of human Cε germline transcript: Identification of a novel IL-4 responsive element
60. Activation of the Ig germ-line γ1 promoter: Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL4 site
61. Characterization of an interleukin-4 (IL-4) responsive region in the immunoglobulin heavy chain germline ε promoter: Regulation by NF-IL4, a C/EBP family member and NF-κB/p50
62. Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ε-deficient mice