Negative feedback in noncanonical NF-κB signaling modulates NIK stability through IKKα-mediated phosphorylation

Science Signaling

Volumn 3, Issue 123, 2010, Pages

  Razani, Bahram ^a,b   Zarnegar, Brian ^a   Ytterberg, A Jimmy ^a,e   Shiba, Travis ^a   Dempsey, Paul W ^a   Ware, Carl F ^c,d   Loo, Joseph A ^a,b   Cheng, Genhong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

B CELL ACTIVATING FACTOR RECEPTOR; I KAPPA B; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; LYMPHOTOXIN BETA RECEPTOR; NUCLEAR FACTOR KAPPA B INDUCING KINASE; PHOSPHOTRANSFERASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UNCLASSIFIED DRUG;

ARTICLE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NEGATIVE FEEDBACK; PRIORITY JOURNAL;

ANIMALS; B-CELL ACTIVATION FACTOR RECEPTOR; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; FEEDBACK, PHYSIOLOGICAL; FIBROBLASTS; HUMANS; I-KAPPA B KINASE; IMMUNOPRECIPITATION; INHIBITOR OF APOPTOSIS PROTEINS; LYMPHOTOXIN BETA RECEPTOR; MICE; MUTATION; NF-KAPPA B; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; SERINE; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 2; TNF RECEPTOR-ASSOCIATED FACTOR 3; TRANSFECTION;

EID: 77953824286     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000778     Document Type: Article

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44. -/- MEFs. Funding: Part of this work was supported by NIH research grants T32 GM008042 (to the UCLA Medical Scientist Training Program supporting B. R.), F30 HL095309 (to B. R.), AI33068 and CA69381 (to C. F. W.), and R01 AI069120 and R01 GM078607 (to G. C.). Author contributions: B. R., B. Z., A. J. Y., T. S., and P. W. D. performed all experiments; B. R., A. J. Y., C. F. W., J. A. L., and G. C. designed experiments and analyzed data; B. R. and G. C. wrote the paper. Competing interests: None to report.