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Epithelial-mesenchymal transitions in tumour progression
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Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:2002;442-454.
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Thiery, J.P.1
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An epithelial scatter factor released by embryo fibroblasts
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Stoker M., Perryman M. An epithelial scatter factor released by embryo fibroblasts. J Cell Science. 327:1985;239-242.
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Involvement of MAPK and Rac in epithelial cell scattering
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Edme N, Downward J, Thiery JP, Boyer B: Involvement of MAPK and Rac in epithelial cell scattering, J Cell Sci 2002, 115.
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J Cell Sci
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Edme, N.1
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Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
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A very exhaustive study that compares the in vitro and in vivo behaviour of a Ha-Ras-transformed murine mammary epithelial cell line. In vitro, the TGFβ signalling pathway cooperates with the activated Ras/MAPK pathway to promote EMT. In vivo these two pathways are required for the metastatic process. The PI3K-specific Ras mutant is able to induce scatter activity but not EMT in vitro and tumourigenicity but not metastasis in vivo.
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Janda E., Lehmann K., Killisch I., Jechlinger M., Herzig M., Downward J., Beug H., Grunert S. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol. 156:2002;299-313 A very exhaustive study that compares the in vitro and in vivo behaviour of a Ha-Ras-transformed murine mammary epithelial cell line. In vitro, the TGFβ signalling pathway cooperates with the activated Ras/MAPK pathway to promote EMT. In vivo these two pathways are required for the metastatic process. The PI3K-specific Ras mutant is able to induce scatter activity but not EMT in vitro and tumourigenicity but not metastasis in vivo.
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J Cell Biol
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Janda, E.1
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0037102190
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MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial-to-mesenchymal transition
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Pinkas J., Leder P. MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial-to-mesenchymal transition. Cancer Res. 62:2002;4781-4790.
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Pinkas, J.1
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The SH2-containing inositol-5-phosphatase (SHIP)-1 is implicated in the control of cell-cell junction and induces dissociation and dispersion of MDCK cells
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Mancini A., Koch A., Wilms R., Tamura T. The SH2-containing inositol-5-phosphatase (SHIP)-1 is implicated in the control of cell-cell junction and induces dissociation and dispersion of MDCK cells. Oncogene. 21:2002;1477-1484.
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Mancini, A.1
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0037728809
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The protein kinase akt induces epithelial-mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
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Grille S.J., Bellacosa A., Upson J., Klein-Szanto A.J., Van Roy F., Lee-Kwon W., Donowitz M., Tsichlis P.N., Larue L. The protein kinase akt induces epithelial-mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res. 63:2003;2172-2178.
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Grille, S.J.1
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Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions
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Lamorte L., Royal I., Naujokas M., Park M. Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Mol Biol Cell. 13:2002;1449-1461.
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Lamorte, L.1
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Metastasis is driven by sequential elevation of H-ras and Smad2 levels
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An elegant demonstration of the role of EMT in skin carcinoma tumour progression. The cooperation of H-Ras and TGFβ signalling pathways is further documented in this study. In addition the work reveals that a sequential elevation of H-Ras activity is required for the progression and transformation of squamous cell carcinoma into spindle cell carcinoma. Nuclear accumulation of smad2 is observed in cells having undergone an EMT.
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Oft M., Akhurst R.J., Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol. 4:2002;487-494 An elegant demonstration of the role of EMT in skin carcinoma tumour progression. The cooperation of H-Ras and TGFβ signalling pathways is further documented in this study. In addition the work reveals that a sequential elevation of H-Ras activity is required for the progression and transformation of squamous cell carcinoma into spindle cell carcinoma. Nuclear accumulation of smad2 is observed in cells having undergone an EMT.
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Nat Cell Biol
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Oft, M.1
Akhurst, R.J.2
Balmain, A.3
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10
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0037087507
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Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: Steps towards invasiveness
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Gotzmann J., Huber H., Thallinger C., Wolschek M., Jansen B., Schulte-Hermann R., Beug H., Mikulits W. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: steps towards invasiveness. J Cell Sci. 115:2002;1189-1202.
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J Cell Sci
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Gotzmann, J.1
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Jansen, B.5
Schulte-Hermann, R.6
Beug, H.7
Mikulits, W.8
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11
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0037474330
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Epithelial-to-mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth-factor-β-induced growth arrest
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Nicolas F.J., Lehmann K., Warne P.H., Hill C.S., Downward J. Epithelial-to-mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth-factor-β-induced growth arrest. J Biol Chem. 278:2003;3251-3256.
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J Biol Chem
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Nicolas, F.J.1
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Downward, J.5
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12
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Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor β1
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Kim J.T., Joo C.K. Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor β1. J Biol Chem. 277:2002;31938-31948.
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Kim, J.T.1
Joo, C.K.2
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13
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0036048217
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Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
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This study provides further insights into the cross-talk mechanisms between integrin- and cadherin-mediated adhesions. Src, together with FAK, one of its substrates, must be activated to induce the internalisation of E-cadherin in epithelial colon carcinoma cells. Most importantly this mechanism is clearly dependent on integrin-matrix interaction.
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Avizienyte E., Wyke A.W., Jones R.J., McLean G.W., Westhoff M.A., Brunton V.G., Frame M.C. Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol. 4:2002;632-638 This study provides further insights into the cross-talk mechanisms between integrin- and cadherin-mediated adhesions. Src, together with FAK, one of its substrates, must be activated to induce the internalisation of E-cadherin in epithelial colon carcinoma cells. Most importantly this mechanism is clearly dependent on integrin-matrix interaction.
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Nat Cell Biol
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Avizienyte, E.1
Wyke, A.W.2
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Mclean, G.W.4
Westhoff, M.A.5
Brunton, V.G.6
Frame, M.C.7
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14
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0037434738
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Kinetics of v-src-induced epithelial-mesenchymal transition in developing glandular stomach
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Shimizu Y., Yamamichi N., Saitoh K., Watanabe A., Ito T., Yamamichi-Nishina M., Mizutani M., Yahagi N., Suzuki T., Sasakawa C., et al. Kinetics of v-src-induced epithelial-mesenchymal transition in developing glandular stomach. Oncogene. 22:2003;884-893.
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Oncogene
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Shimizu, Y.1
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Ito, T.5
Yamamichi-Nishina, M.6
Mizutani, M.7
Yahagi, N.8
Suzuki, T.9
Sasakawa, C.10
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15
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0036305635
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ROCK and Dia have opposing effects on adherens junctions downstream of Rho
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Normal levels of RhoA favour adherens junction assembly through the activation of diaphanous, one of its effectors. Diaphanous induces microtubule and actin filament assembly. By contrast, high levels of RhoA or the activation of RhoC preferentially activate Rho kinases, which destabilise adherens junctions, possibly through acto-myosin contraction.
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Sahai E., Marshall C.J. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol. 4:2002;408-415 Normal levels of RhoA favour adherens junction assembly through the activation of diaphanous, one of its effectors. Diaphanous induces microtubule and actin filament assembly. By contrast, high levels of RhoA or the activation of RhoC preferentially activate Rho kinases, which destabilise adherens junctions, possibly through acto-myosin contraction.
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Nat Cell Biol
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Sahai, E.1
Marshall, C.J.2
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16
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0037119356
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High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling
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Psichari E., Balmain A., Plows D., Zoumpourlis V., Pintzas A. High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling. J Biol Chem. 277:2002;29490-29495.
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J Biol Chem
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Psichari, E.1
Balmain, A.2
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Zoumpourlis, V.4
Pintzas, A.5
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17
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0037243197
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STAT5a activation mediates the epithelial-to-mesenchymal transition induced by incogenic RhoA
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Benitah S.A., Valeron P.F., Rui H., Lacal J.C. STAT5a activation mediates the epithelial-to-mesenchymal transition induced by incogenic RhoA. Mol Biol Cell. 14:2003;40-53.
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Mol Biol Cell
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Benitah, S.A.1
Valeron, P.F.2
Rui, H.3
Lacal, J.C.4
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18
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0037405501
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Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition
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Masszi A., Di Ciano C., Sirokmany G., Arthur W.T., Rotstein O.D., Wang J., McCulloch C.A., Rosivall L., Mucsi I., Kapus A. Central role for Rho in TGF-β1-induced α-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol. 284:2003;F911-F924.
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Am J Physiol Renal Physiol
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Masszi, A.1
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Wang, J.6
Mcculloch, C.A.7
Rosivall, L.8
Mucsi, I.9
Kapus, A.10
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19
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0036513626
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The snail superfamily of zinc-finger transcription factors
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Nieto M.A. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol. 3:2002;155-166.
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Nat Rev Mol Cell Biol
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Nieto, M.A.1
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20
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0037326569
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The transcription factor Slug represses E-cadherin expression and induces epithelial-to-mesenchymal transitions: A comparison with Snail and E47 repressors
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Bolos V., Peinado H., Perez-Moreno M.A., Fraga M.F., Esteller M., Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial-to-mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci. 116:2003;499-511.
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J Cell Sci
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Bolos, V.1
Peinado, H.2
Perez-Moreno, M.A.3
Fraga, M.F.4
Esteller, M.5
Cano, A.6
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21
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0037086277
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The SLUG zinc-finger protein represses E-cadherin in breast cancer
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Hajra K.M., Chen D.Y., Fearon E.R. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62:2002;1613-1618.
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Hajra, K.M.1
Chen, D.Y.2
Fearon, E.R.3
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22
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0038756636
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Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
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Peinado H., Quintanilla M., Cano A. Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem. 278:2003;21113-21123.
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J Biol Chem
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Peinado, H.1
Quintanilla, M.2
Cano, A.3
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23
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0037131409
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Snail induction of epithelial-to-mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression
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Guaita S., Puig I., Franci C., Garrido M., Dominguez D., Batlle E., Sancho E., Dedhar S., De Herreros A.G., Baulida J. Snail induction of epithelial-to-mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J Biol Chem. 277:2002;39209-39216.
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J Biol Chem
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Guaita, S.1
Puig, I.2
Franci, C.3
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Dominguez, D.5
Batlle, E.6
Sancho, E.7
Dedhar, S.8
De Herreros, A.G.9
Baulida, J.10
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24
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0037453706
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MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer
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This study describes a novel pathway for the transcriptional regulation of snail, linking estrogen receptor activity in the control of proliferation and differentiation to the control of E-cadherin expression. This work has far-reaching implications for breast carcinoma tumour progression in relation to estrogen receptor status.
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Fujita N., Jaye D.L., Kajita M., Geigerman C., Moreno C.S., Wade P.A. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell. 113:2003;207-219 This study describes a novel pathway for the transcriptional regulation of snail, linking estrogen receptor activity in the control of proliferation and differentiation to the control of E-cadherin expression. This work has far-reaching implications for breast carcinoma tumour progression in relation to estrogen receptor status.
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Cell
, vol.113
, pp. 207-219
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Fujita, N.1
Jaye, D.L.2
Kajita, M.3
Geigerman, C.4
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Wade, P.A.6
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25
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0037108828
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Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation
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Louro I.D., Bailey E.C., Li X., South L.S., McKie-Bell P.R., Yoder B.K., Huang C.C., Johnson M.R., Hill A.E., Johnson R.L., et al. Comparative gene expression profile analysis of GLI and c-MYC in an epithelial model of malignant transformation. Cancer Res. 62:2002;5867-5873.
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Cancer Res
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Louro, I.D.1
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Li, X.3
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Mckie-Bell, P.R.5
Yoder, B.K.6
Huang, C.C.7
Johnson, M.R.8
Hill, A.E.9
Johnson, R.L.10
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26
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0037821924
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Alx1, a member of the Cart1/Alx3/Alx4 subfamily of paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo
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Ettensohn C.A., Illies M.R., Oliveri P., De Jong D.L. Alx1, a member of the Cart1/Alx3/Alx4 subfamily of paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo. Development. 130:2003;2917-2928.
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Development
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Ettensohn, C.A.1
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27
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0037326619
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Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest
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Aybar M.J., Nieto M.A., Mayor R. Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Development. 130:2003;483-494.
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Development
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Aybar, M.J.1
Nieto, M.A.2
Mayor, R.3
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28
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0036745757
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Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition
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EMT in development may be tightly coupled to cell-cycle regulation, as shown in this important study on the behaviour of avian neural crest cells. EMT occurs only in dorsal neuroepithelial cells during the S phase. This study also addresses mechanisms of EMT in relation to neural crest inducers and to asymmetric cell division.
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Burstyn-Cohen T., Kalcheim C. Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition. Dev Cell. 3:2002;383-395 EMT in development may be tightly coupled to cell-cycle regulation, as shown in this important study on the behaviour of avian neural crest cells. EMT occurs only in dorsal neuroepithelial cells during the S phase. This study also addresses mechanisms of EMT in relation to neural crest inducers and to asymmetric cell division.
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Dev Cell
, vol.3
, pp. 383-395
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Burstyn-Cohen, T.1
Kalcheim, C.2
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29
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0038724267
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Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition
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Chagraoui J., Lepage-Noll A., Anjo A., Uzan G., Charbord P. Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition. Blood. 101:2003;2973-2982.
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Blood
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Chagraoui, J.1
Lepage-Noll, A.2
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31
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0036138824
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Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
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Yang J., Liu Y. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol. 13:2002;96-107.
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J Am Soc Nephrol
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Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells
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Lan H.Y. Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells. Curr Opin Nephrol Hypertens. 12:2003;25-29.
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Lan, H.Y.1
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0037472881
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Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells
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Severe alteration of the mesothelium lining of the peritoneal cavity is observed in patients undergoing dialysis. The present study demonstrates that EMT is directly implicated in the denudation process.
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Yanez-Mo M., Lara-Pezzi E., Selgas R., Ramirez-Huesca M., Dominguez-Jimenez C., Jimenez-Heffernan J.A., Aguilera A., Sanchez-Tomero J.A., Bajo M.A., Alvarez V., et al. Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med. 348:2003;403-413 Severe alteration of the mesothelium lining of the peritoneal cavity is observed in patients undergoing dialysis. The present study demonstrates that EMT is directly implicated in the denudation process.
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N Engl J Med
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, pp. 403-413
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Yanez-Mo, M.1
Lara-Pezzi, E.2
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Dominguez-Jimenez, C.5
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Aguilera, A.7
Sanchez-Tomero, J.A.8
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0037406810
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Response of lens epithelial cells to injury: Role of lumican in epithelial-mesenchymal transition
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Saika S., Miyamoto T., Tanaka S., Tanaka T., Ishida I., Ohnishi Y., Ooshima A., Ishiwata T., Asano G., Chikama T., et al. Response of lens epithelial cells to injury: role of lumican in epithelial-mesenchymal transition. Invest Ophthalmol Vis Sci. 44:2003;2094-2102.
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Invest Ophthalmol Vis Sci
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Saika, S.1
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Ooshima, A.7
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0037115521
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GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice
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Ahmed F., Wyckoff J., Lin E.Y., Wang W., Wang Y., Hennighausen L., Miyazaki J., Jones J., Pollard J.W., Condeelis J.S., et al. GFP expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. Cancer Res. 62:2002;7166-7169.
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Cancer Res
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Ahmed, F.1
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The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
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Xue C., Plieth D., Venkov C., Xu C., Neilson E.G. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res. 63:2003;3386-3394.
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Cancer Res
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Xue, C.1
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Correlation of snail expression with histological grade and lymph node status in breast carcinomas
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Blanco M.J., Moreno-Bueno G., Sarrio D., Locascio A., Cano A., Palacios J., Nieto M.A. Correlation of snail expression with histological grade and lymph node status in breast carcinomas. Oncogene. 21:2002;3241-3246.
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Oncogene
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Blanco, M.J.1
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Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer
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Rosivatz E., Becker I., Specht K., Fricke E., Luber B., Busch R., Hofler H., Becker K.F. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol. 161:2002;1881-1891.
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Am J Pathol
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Rosivatz, E.1
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