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Volumn 15, Issue 6, 2003, Pages 740-746

Epithelial-mesenchymal transitions in development and pathologies

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; GUANOSINE TRIPHOSPHATASE; TRANSFORMING GROWTH FACTOR BETA; TYROSINE KINASE RECEPTOR; UVOMORULIN;

EID: 0344845003     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2003.10.006     Document Type: Review
Times cited : (1498)

References (42)
  • 1
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery J.P. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2:2002;442-454.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 2
    • 0344181734 scopus 로고
    • An epithelial scatter factor released by embryo fibroblasts
    • Stoker M., Perryman M. An epithelial scatter factor released by embryo fibroblasts. J Cell Science. 327:1985;239-242.
    • (1985) J Cell Science , vol.327 , pp. 239-242
    • Stoker, M.1    Perryman, M.2
  • 3
    • 0345044274 scopus 로고    scopus 로고
    • Involvement of MAPK and Rac in epithelial cell scattering
    • Edme N, Downward J, Thiery JP, Boyer B: Involvement of MAPK and Rac in epithelial cell scattering, J Cell Sci 2002, 115.
    • (2002) J Cell Sci , pp. 115
    • Edme, N.1    Downward, J.2    Thiery, J.P.3    Boyer, B.4
  • 4
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
    • A very exhaustive study that compares the in vitro and in vivo behaviour of a Ha-Ras-transformed murine mammary epithelial cell line. In vitro, the TGFβ signalling pathway cooperates with the activated Ras/MAPK pathway to promote EMT. In vivo these two pathways are required for the metastatic process. The PI3K-specific Ras mutant is able to induce scatter activity but not EMT in vitro and tumourigenicity but not metastasis in vivo.
    • Janda E., Lehmann K., Killisch I., Jechlinger M., Herzig M., Downward J., Beug H., Grunert S. Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol. 156:2002;299-313 A very exhaustive study that compares the in vitro and in vivo behaviour of a Ha-Ras-transformed murine mammary epithelial cell line. In vitro, the TGFβ signalling pathway cooperates with the activated Ras/MAPK pathway to promote EMT. In vivo these two pathways are required for the metastatic process. The PI3K-specific Ras mutant is able to induce scatter activity but not EMT in vitro and tumourigenicity but not metastasis in vivo.
    • (2002) J Cell Biol , vol.156 , pp. 299-313
    • Janda, E.1    Lehmann, K.2    Killisch, I.3    Jechlinger, M.4    Herzig, M.5    Downward, J.6    Beug, H.7    Grunert, S.8
  • 5
    • 0037102190 scopus 로고    scopus 로고
    • MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial-to-mesenchymal transition
    • Pinkas J., Leder P. MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial-to-mesenchymal transition. Cancer Res. 62:2002;4781-4790.
    • (2002) Cancer Res , vol.62 , pp. 4781-4790
    • Pinkas, J.1    Leder, P.2
  • 6
    • 0037186189 scopus 로고    scopus 로고
    • The SH2-containing inositol-5-phosphatase (SHIP)-1 is implicated in the control of cell-cell junction and induces dissociation and dispersion of MDCK cells
    • Mancini A., Koch A., Wilms R., Tamura T. The SH2-containing inositol-5-phosphatase (SHIP)-1 is implicated in the control of cell-cell junction and induces dissociation and dispersion of MDCK cells. Oncogene. 21:2002;1477-1484.
    • (2002) Oncogene , vol.21 , pp. 1477-1484
    • Mancini, A.1    Koch, A.2    Wilms, R.3    Tamura, T.4
  • 7
    • 0037728809 scopus 로고    scopus 로고
    • The protein kinase akt induces epithelial-mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    • Grille S.J., Bellacosa A., Upson J., Klein-Szanto A.J., Van Roy F., Lee-Kwon W., Donowitz M., Tsichlis P.N., Larue L. The protein kinase akt induces epithelial-mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Res. 63:2003;2172-2178.
    • (2003) Cancer Res , vol.63 , pp. 2172-2178
    • Grille, S.J.1    Bellacosa, A.2    Upson, J.3    Klein-Szanto, A.J.4    Van Roy, F.5    Lee-Kwon, W.6    Donowitz, M.7    Tsichlis, P.N.8    Larue, L.9
  • 8
    • 0036000104 scopus 로고    scopus 로고
    • Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions
    • Lamorte L., Royal I., Naujokas M., Park M. Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Mol Biol Cell. 13:2002;1449-1461.
    • (2002) Mol Biol Cell , vol.13 , pp. 1449-1461
    • Lamorte, L.1    Royal, I.2    Naujokas, M.3    Park, M.4
  • 9
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • An elegant demonstration of the role of EMT in skin carcinoma tumour progression. The cooperation of H-Ras and TGFβ signalling pathways is further documented in this study. In addition the work reveals that a sequential elevation of H-Ras activity is required for the progression and transformation of squamous cell carcinoma into spindle cell carcinoma. Nuclear accumulation of smad2 is observed in cells having undergone an EMT.
    • Oft M., Akhurst R.J., Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol. 4:2002;487-494 An elegant demonstration of the role of EMT in skin carcinoma tumour progression. The cooperation of H-Ras and TGFβ signalling pathways is further documented in this study. In addition the work reveals that a sequential elevation of H-Ras activity is required for the progression and transformation of squamous cell carcinoma into spindle cell carcinoma. Nuclear accumulation of smad2 is observed in cells having undergone an EMT.
    • (2002) Nat Cell Biol , vol.4 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 10
    • 0037087507 scopus 로고    scopus 로고
    • Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: Steps towards invasiveness
    • Gotzmann J., Huber H., Thallinger C., Wolschek M., Jansen B., Schulte-Hermann R., Beug H., Mikulits W. Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-β1 and Ha-Ras: steps towards invasiveness. J Cell Sci. 115:2002;1189-1202.
    • (2002) J Cell Sci , vol.115 , pp. 1189-1202
    • Gotzmann, J.1    Huber, H.2    Thallinger, C.3    Wolschek, M.4    Jansen, B.5    Schulte-Hermann, R.6    Beug, H.7    Mikulits, W.8
  • 11
    • 0037474330 scopus 로고    scopus 로고
    • Epithelial-to-mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth-factor-β-induced growth arrest
    • Nicolas F.J., Lehmann K., Warne P.H., Hill C.S., Downward J. Epithelial-to-mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth-factor-β-induced growth arrest. J Biol Chem. 278:2003;3251-3256.
    • (2003) J Biol Chem , vol.278 , pp. 3251-3256
    • Nicolas, F.J.1    Lehmann, K.2    Warne, P.H.3    Hill, C.S.4    Downward, J.5
  • 12
    • 0037200041 scopus 로고    scopus 로고
    • Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor β1
    • Kim J.T., Joo C.K. Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor β1. J Biol Chem. 277:2002;31938-31948.
    • (2002) J Biol Chem , vol.277 , pp. 31938-31948
    • Kim, J.T.1    Joo, C.K.2
  • 13
    • 0036048217 scopus 로고    scopus 로고
    • Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling
    • This study provides further insights into the cross-talk mechanisms between integrin- and cadherin-mediated adhesions. Src, together with FAK, one of its substrates, must be activated to induce the internalisation of E-cadherin in epithelial colon carcinoma cells. Most importantly this mechanism is clearly dependent on integrin-matrix interaction.
    • Avizienyte E., Wyke A.W., Jones R.J., McLean G.W., Westhoff M.A., Brunton V.G., Frame M.C. Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol. 4:2002;632-638 This study provides further insights into the cross-talk mechanisms between integrin- and cadherin-mediated adhesions. Src, together with FAK, one of its substrates, must be activated to induce the internalisation of E-cadherin in epithelial colon carcinoma cells. Most importantly this mechanism is clearly dependent on integrin-matrix interaction.
    • (2002) Nat Cell Biol , vol.4 , pp. 632-638
    • Avizienyte, E.1    Wyke, A.W.2    Jones, R.J.3    Mclean, G.W.4    Westhoff, M.A.5    Brunton, V.G.6    Frame, M.C.7
  • 15
    • 0036305635 scopus 로고    scopus 로고
    • ROCK and Dia have opposing effects on adherens junctions downstream of Rho
    • Normal levels of RhoA favour adherens junction assembly through the activation of diaphanous, one of its effectors. Diaphanous induces microtubule and actin filament assembly. By contrast, high levels of RhoA or the activation of RhoC preferentially activate Rho kinases, which destabilise adherens junctions, possibly through acto-myosin contraction.
    • Sahai E., Marshall C.J. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol. 4:2002;408-415 Normal levels of RhoA favour adherens junction assembly through the activation of diaphanous, one of its effectors. Diaphanous induces microtubule and actin filament assembly. By contrast, high levels of RhoA or the activation of RhoC preferentially activate Rho kinases, which destabilise adherens junctions, possibly through acto-myosin contraction.
    • (2002) Nat Cell Biol , vol.4 , pp. 408-415
    • Sahai, E.1    Marshall, C.J.2
  • 16
    • 0037119356 scopus 로고    scopus 로고
    • High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling
    • Psichari E., Balmain A., Plows D., Zoumpourlis V., Pintzas A. High activity of serum response factor in the mesenchymal transition of epithelial tumor cells is regulated by RhoA signaling. J Biol Chem. 277:2002;29490-29495.
    • (2002) J Biol Chem , vol.277 , pp. 29490-29495
    • Psichari, E.1    Balmain, A.2    Plows, D.3    Zoumpourlis, V.4    Pintzas, A.5
  • 17
    • 0037243197 scopus 로고    scopus 로고
    • STAT5a activation mediates the epithelial-to-mesenchymal transition induced by incogenic RhoA
    • Benitah S.A., Valeron P.F., Rui H., Lacal J.C. STAT5a activation mediates the epithelial-to-mesenchymal transition induced by incogenic RhoA. Mol Biol Cell. 14:2003;40-53.
    • (2003) Mol Biol Cell , vol.14 , pp. 40-53
    • Benitah, S.A.1    Valeron, P.F.2    Rui, H.3    Lacal, J.C.4
  • 19
    • 0036513626 scopus 로고    scopus 로고
    • The snail superfamily of zinc-finger transcription factors
    • Nieto M.A. The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol. 3:2002;155-166.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 20
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial-to-mesenchymal transitions: A comparison with Snail and E47 repressors
    • Bolos V., Peinado H., Perez-Moreno M.A., Fraga M.F., Esteller M., Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial-to-mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci. 116:2003;499-511.
    • (2003) J Cell Sci , vol.116 , pp. 499-511
    • Bolos, V.1    Peinado, H.2    Perez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 21
    • 0037086277 scopus 로고    scopus 로고
    • The SLUG zinc-finger protein represses E-cadherin in breast cancer
    • Hajra K.M., Chen D.Y., Fearon E.R. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62:2002;1613-1618.
    • (2002) Cancer Res , vol.62 , pp. 1613-1618
    • Hajra, K.M.1    Chen, D.Y.2    Fearon, E.R.3
  • 22
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • Peinado H., Quintanilla M., Cano A. Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem. 278:2003;21113-21123.
    • (2003) J Biol Chem , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 24
    • 0037453706 scopus 로고    scopus 로고
    • MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer
    • This study describes a novel pathway for the transcriptional regulation of snail, linking estrogen receptor activity in the control of proliferation and differentiation to the control of E-cadherin expression. This work has far-reaching implications for breast carcinoma tumour progression in relation to estrogen receptor status.
    • Fujita N., Jaye D.L., Kajita M., Geigerman C., Moreno C.S., Wade P.A. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell. 113:2003;207-219 This study describes a novel pathway for the transcriptional regulation of snail, linking estrogen receptor activity in the control of proliferation and differentiation to the control of E-cadherin expression. This work has far-reaching implications for breast carcinoma tumour progression in relation to estrogen receptor status.
    • (2003) Cell , vol.113 , pp. 207-219
    • Fujita, N.1    Jaye, D.L.2    Kajita, M.3    Geigerman, C.4    Moreno, C.S.5    Wade, P.A.6
  • 26
    • 0037821924 scopus 로고    scopus 로고
    • Alx1, a member of the Cart1/Alx3/Alx4 subfamily of paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo
    • Ettensohn C.A., Illies M.R., Oliveri P., De Jong D.L. Alx1, a member of the Cart1/Alx3/Alx4 subfamily of paired-class homeodomain proteins, is an essential component of the gene network controlling skeletogenic fate specification in the sea urchin embryo. Development. 130:2003;2917-2928.
    • (2003) Development , vol.130 , pp. 2917-2928
    • Ettensohn, C.A.1    Illies, M.R.2    Oliveri, P.3    De Jong, D.L.4
  • 27
    • 0037326619 scopus 로고    scopus 로고
    • Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest
    • Aybar M.J., Nieto M.A., Mayor R. Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Development. 130:2003;483-494.
    • (2003) Development , vol.130 , pp. 483-494
    • Aybar, M.J.1    Nieto, M.A.2    Mayor, R.3
  • 28
    • 0036745757 scopus 로고    scopus 로고
    • Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition
    • EMT in development may be tightly coupled to cell-cycle regulation, as shown in this important study on the behaviour of avian neural crest cells. EMT occurs only in dorsal neuroepithelial cells during the S phase. This study also addresses mechanisms of EMT in relation to neural crest inducers and to asymmetric cell division.
    • Burstyn-Cohen T., Kalcheim C. Association between the cell cycle and neural crest delamination through specific regulation of G1/S transition. Dev Cell. 3:2002;383-395 EMT in development may be tightly coupled to cell-cycle regulation, as shown in this important study on the behaviour of avian neural crest cells. EMT occurs only in dorsal neuroepithelial cells during the S phase. This study also addresses mechanisms of EMT in relation to neural crest inducers and to asymmetric cell division.
    • (2002) Dev Cell , vol.3 , pp. 383-395
    • Burstyn-Cohen, T.1    Kalcheim, C.2
  • 29
    • 0038724267 scopus 로고    scopus 로고
    • Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition
    • Chagraoui J., Lepage-Noll A., Anjo A., Uzan G., Charbord P. Fetal liver stroma consists of cells in epithelial-to-mesenchymal transition. Blood. 101:2003;2973-2982.
    • (2003) Blood , vol.101 , pp. 2973-2982
    • Chagraoui, J.1    Lepage-Noll, A.2    Anjo, A.3    Uzan, G.4    Charbord, P.5
  • 31
    • 0036138824 scopus 로고    scopus 로고
    • Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis
    • Yang J., Liu Y. Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis. J Am Soc Nephrol. 13:2002;96-107.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 96-107
    • Yang, J.1    Liu, Y.2
  • 32
    • 0037229290 scopus 로고    scopus 로고
    • Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells
    • Lan H.Y. Tubular epithelial-myofibroblast transdifferentiation mechanisms in proximal tubule cells. Curr Opin Nephrol Hypertens. 12:2003;25-29.
    • (2003) Curr Opin Nephrol Hypertens , vol.12 , pp. 25-29
    • Lan, H.Y.1
  • 33
    • 0037472881 scopus 로고    scopus 로고
    • Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells
    • Severe alteration of the mesothelium lining of the peritoneal cavity is observed in patients undergoing dialysis. The present study demonstrates that EMT is directly implicated in the denudation process.
    • Yanez-Mo M., Lara-Pezzi E., Selgas R., Ramirez-Huesca M., Dominguez-Jimenez C., Jimenez-Heffernan J.A., Aguilera A., Sanchez-Tomero J.A., Bajo M.A., Alvarez V., et al. Peritoneal dialysis and epithelial-to-mesenchymal transition of mesothelial cells. N Engl J Med. 348:2003;403-413 Severe alteration of the mesothelium lining of the peritoneal cavity is observed in patients undergoing dialysis. The present study demonstrates that EMT is directly implicated in the denudation process.
    • (2003) N Engl J Med , vol.348 , pp. 403-413
    • Yanez-Mo, M.1    Lara-Pezzi, E.2    Selgas, R.3    Ramirez-Huesca, M.4    Dominguez-Jimenez, C.5    Jimenez-Heffernan, J.A.6    Aguilera, A.7    Sanchez-Tomero, J.A.8    Bajo, M.A.9    Alvarez, V.10
  • 36
    • 0038745381 scopus 로고    scopus 로고
    • The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
    • Xue C., Plieth D., Venkov C., Xu C., Neilson E.G. The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis. Cancer Res. 63:2003;3386-3394.
    • (2003) Cancer Res , vol.63 , pp. 3386-3394
    • Xue, C.1    Plieth, D.2    Venkov, C.3    Xu, C.4    Neilson, E.G.5
  • 37
    • 85047698213 scopus 로고    scopus 로고
    • Correlation of snail expression with histological grade and lymph node status in breast carcinomas
    • Blanco M.J., Moreno-Bueno G., Sarrio D., Locascio A., Cano A., Palacios J., Nieto M.A. Correlation of snail expression with histological grade and lymph node status in breast carcinomas. Oncogene. 21:2002;3241-3246.
    • (2002) Oncogene , vol.21 , pp. 3241-3246
    • Blanco, M.J.1    Moreno-Bueno, G.2    Sarrio, D.3    Locascio, A.4    Cano, A.5    Palacios, J.6    Nieto, M.A.7
  • 38
    • 0036840363 scopus 로고    scopus 로고
    • Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer
    • Rosivatz E., Becker I., Specht K., Fricke E., Luber B., Busch R., Hofler H., Becker K.F. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am J Pathol. 161:2002;1881-1891.
    • (2002) Am J Pathol , vol.161 , pp. 1881-1891
    • Rosivatz, E.1    Becker, I.2    Specht, K.3    Fricke, E.4    Luber, B.5    Busch, R.6    Hofler, H.7    Becker, K.F.8
  • 39
    • 0038700554 scopus 로고    scopus 로고
    • Host microenvironment in breast cancer development: Epithelial- mesenchymal transition in breast cancer development
    • Vincent-Salomon A., Thiery J.P. Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res. 5:2003;101-106.
    • (2003) Breast Cancer Res , vol.5 , pp. 101-106
    • Vincent-Salomon, A.1    Thiery, J.P.2
  • 41
    • 0042477565 scopus 로고    scopus 로고
    • Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer
    • Pierga J.Y., Bonneton C., Magdelenat H., Vincent-Salomon A., Nos C., Pouillart P., Thiery J.P. Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer. Br J Cancer. 89:2003;539-545.
    • (2003) Br J Cancer , vol.89 , pp. 539-545
    • Pierga, J.Y.1    Bonneton, C.2    Magdelenat, H.3    Vincent-Salomon, A.4    Nos, C.5    Pouillart, P.6    Thiery, J.P.7
  • 42
    • 0036546980 scopus 로고    scopus 로고
    • Neural induction, the default model and embryonic stem cells
    • Munoz-Sanjuan I., Brivanlou A.H. Neural induction, the default model and embryonic stem cells. Nat Rev Neurosci. 4:2002;271-280.
    • (2002) Nat Rev Neurosci , vol.4 , pp. 271-280
    • Munoz-Sanjuan, I.1    Brivanlou, A.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.