MicroRNA miR-29 modulates expression of immunoinhibitory molecule B7-H3: Potential implications for immune based therapy of human solid tumors

Cancer Research

Volumn 69, Issue 15, 2009, Pages 6275-6281

  Xu, Hong ^a   Cheung, Irene Y ^a   Guo, Hong Fen ^a   Cheung, Nai Kong V ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 H3 PROTEIN; GLYCOPROTEIN; IMMUNOGLOBULIN; IMMUNOMODULATING AGENT; ISOPROTEIN; LUCIFERASE; MEMBRANE PROTEIN; MESSENGER RNA; MICRORNA; MICRORNA 29; MICRORNA 29 A; MICRORNA 29 B; MICRORNA 29 C; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 8 H9; MONOCLONAL ANTIBODY MAB 1027; PRONASE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN METASTASIS; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CELL FRACTIONATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG TARGETING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOAFFINITY CHROMATOGRAPHY; IMMUNOFLUORESCENCE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOLID TUMOR; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

3' UNTRANSLATED REGIONS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; HELA CELLS; HUMANS; MICRORNAS; NEOPLASMS; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 68049117231     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-4517     Document Type: Article

References (31)

1. Flies DB, Chen L. The new B7s: playing a pivotal role in tumor immunity. J Immunother 2007;30:251-260 (Pubitemid 46586641)
2. Chapoval AI, Ni J, Lau JS, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-γ production. Nat Immunol 2001;2:269-274
3. Steinberger P, Majdic O, Derdak SV, et al. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J Immunol 2004;172:2352-2359 (Pubitemid 38182383)
4. Sun M, Richards S, Prasad DV, Mai XM, Rudensky A, Dong C. Characterization of mouse and human B7-H3 genes. J Immunol 2002;168:6294-6297 (Pubitemid 34620050)
5. Suh WK, Gajewska BU, Okada H, et al. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat Immunol 2003;4:899-906. (Pubitemid 37098661)
6. Castriconi R, Dondero A, Augugliaro R, et al. Identification of 4Ig-B7-H3 as a neuroblastomaassociated molecule that exerts a protective role from an NK cell-mediated lysis. Proc Natl Acad Sci U S A 2004;101:12640-12645 (Pubitemid 39122076)
7. Roth TJ, Sheinin Y, Lohse CM, et al. B7-H3 ligand expression by prostate cancer: a novel marker of prognosis and potential target for therapy. Cancer Res 2007;67:7893-7900 (Pubitemid 47281385)
8. Zang X, Thompson RH, Al-Ahmadie HA, et al. B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci U S A 2007;104:19458-19463
9. Crispen PL, Sheinin Y, Roth TJ, et al. Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma. Clin Cancer Res 2008;14:5150-5157
10. Boorjian SA, Sheinin Y, Crispen PL, et al. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin Cancer Res 2008;14:4800-4808
11. Sun X, Vale M, Leung E, Kanwar JR, Gupta R, Krissansen GW. Mouse B7-H3 induces antitumor immunity. Gene Ther 2003;10:1728-1734 (Pubitemid 37121044)
12. Wu CP, Jiang JT, Tan M, et al. Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis. World J Gastroenterol 2006;12:457-459 (Pubitemid 43329266)
13. Hofmeyer KA, Ray A, Zang X. The contrasting role of B7-H3. Proc Natl Acad Sci U S A 2008;105:10277-10278
14. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004;116:281-297
15. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120:15-20.
16. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006;20:515-524 (Pubitemid 43345317)
17. Gartel AL, Kandel ES. miRNAs: little known mediators of oncogenesis. Semin Cancer Biol 2008;18:103-110
18. Modak S, Kramer K, Gultekin SH, Guo HF, Cheung NK. Monoclonal antibody 8H9targets a novel cellsurface antigen expressed by a wide spectrum of human solid tumors. Cancer Res 2001;61:4048-4054 (Pubitemid 32720969)
19. Kramer K, Modak S, Kushner BH, et al. Radioimmunotherapy of metastatic cancer to the central nervous system: phase I study of intrathecal 131I-8H9. Am Assoc Cancer Res 2007;LB-4 (Presentation).
20. Kramer K, Kushner BH, Modak S, et al. Effective intrathecal radioimmunotherapy-based salvage regimen for metastatic central nervous system (CNS) neuroblastoma (NB). ISPNO 2008.
21. Lewis BP, Shih IH, Jones-Rhoades MW, Bartel DP, Burge CB. Prediction of mammalian microRNA targets. Cell 2003;115:787-798
22. Hashiguchi M, Kobori H, Ritprajak P, Kamimura Y, Kozono H, Azuma M. Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counterreceptor for B7-H3 and enhances T cell responses. Proc Natl Acad Sci U S A 2008;105:10495-10500
23. Pekarsky Y, Santanam U, Cimmino A, et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29and miR-181. Cancer Res 2006;66:11590-11593 (Pubitemid 46094168)
24. Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci U S A 2007;104:15805-15810 (Pubitemid 350035380)
25. Mott JL, Kobayashi S, Bronk SF, Gores GJ. mir-29 regulates Mcl-1 protein expression and apoptosis. Oncogene 2007;26:6133-6140 (Pubitemid 47414372)
26. Wang H, Garzon R, Sun H, et al. NF-nB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell 2008;14:369-381
27. Sun Y, Wang Y, Zhao J, et al. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer 2006;53:143-151 (Pubitemid 43994236)
28. Bartel DP, Chen CZ. Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 2004;5:396-400.
29. Laneve P, Di Marcotullio L, Gioia U, et al. The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc Natl Acad Sci U S A 2007;104:7957-7962 (Pubitemid 47185858)
30. Welch C, Chen Y, Stallings RL. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 2007;26:5017-5022 (Pubitemid 47172643)
31. Chen Y, Stallings RL. Differential patterns of micro- RNA expression in neuroblastoma are correlated with prognosis, differentiation, and apoptosis. Cancer Res 2007;67:976-983 (Pubitemid 46270752)