The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells

Nature Cell Biology

Volumn 2, Issue 2, 2000, Pages 84-89

  Batlle, Eduard ^a   Sancho, Elena ^a   Francí, Clara ^a   Domínguez, David ^a   Monfar, Mercè ^a   Baulida, Josep ^a   De Herreros, Antonio García ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ARTICLE; BLADDER CARCINOMA; BREAST CANCER; COLON CANCER; CONTROLLED STUDY; EPITHELIUM TUMOR; FIBROBLAST; GENE REPRESSION; HUMAN; HUMAN CELL; METASTASIS POTENTIAL; NONHUMAN; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; TUMOR GROWTH;

BINDING SITES; CADHERINS; DNA, ANTISENSE; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMAN; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASMS, GLANDULAR AND EPITHELIAL; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; REPRESSOR PROTEINS; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS;

EID: 0033789680     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35000034     Document Type: Article

References (22)

1. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
2. A causal role for E-cadherin in the transition from adenoma to carcinoma
3. E-cadherin mediated adhesion system in cancer cells
4. Mechanisrns identified in the transcriptional control of epithelial gene expression
5. Transcriptional defects underlie loss of E-cadherin expression in breast cancer
6. Role of E boxes in the repression of E-cadherin expression
7. Definition of the DNA-binding site repertoire for the Drosophila transcription factor SNAIL
8. The transition to endoreduplication in trophoblast giant cells is regulated by the mSNA zinc finger transcription factor
9. Cell shape changes during gastrulation in Drosophila
10. Isolation of Sna, a mouse gene homologous to the Drosophila genes snail and escargot: Its expression pattern suggests multiple roles in postimplantation development
11. Dynamic behaviour of the cadherin-based cell-cell adhesion system during Drosophila gastrulation
12. Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo
13. Control of cell behaviour during vertebrate development by Slug, a zinc finger gene
14. The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin- 2 withdrawal
15. Epithelial-mesenchymal transitions in cancer progression
16. An overview of epithelio-mesenchymal transformation
17. Developmentally regulated expression of the cell-cell adhesion glycoprotein Cell-CAM 120/80 in peri-implantation mouse embryos and extraembryonic membranes
18. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak
19. Recognition of the laminin E8 cell-binding site by an integrin possessing the α 6 integrin subunit is essential for epithelial polarization in developing kidney
20. Tight control of gene expression in mammalian cells by tetracycline responsive promoters
21. Rapid detection of octamer binding proteins with 'mini-extracts' from a small number of cells
22. Basal expression of the histone H5 gene is controlled by positive and negative cis-acting sequences