Cranberry juice suppressed the diclofenac metabolism by human liver microsomes, but not in healthy human subjects

British Journal of Clinical Pharmacology

Volumn 68, Issue 2, 2009, Pages 194-200

  Ushijima, Kentarou ^a   Tsuruoka, Shu Ichi ^a   Tsuda, Hidetoshi ^a   Hasegawa, Gohki ^a   Obi, Yuri ^a   Kaneda, Tae ^a   Takahashi, Masaki ^a   Maekawa, Tomohiro ^a   Sasaki, Tomohiro ^b   Koshimizu, Taka Aki ^a   Fujimura, Akio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Cranberry juice; Diclofenac; Interaction

Indexed keywords

CYTOCHROME P450 2C9; DICLOFENAC; IBUPROFEN; SULFAPHENAZOLE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CRANBERRY JUICE; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG PROTEIN BINDING; FEMALE; FOOD DRUG INTERACTION; FOOD INTAKE; GASTROINTESTINAL SYMPTOM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IN VITRO STUDY; LIVER MICROSOME METABOLISM; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ADULT; ARYL HYDROCARBON HYDROXYLASES; BEVERAGES; CYCLOOXYGENASE INHIBITORS; DICLOFENAC; DRUG MONITORING; EPIDEMIOLOGIC METHODS; FEMALE; FOOD-DRUG INTERACTIONS; HUMANS; MALE; MICROSOMES, LIVER; PLANT EXTRACTS; VACCINIUM MACROCARPON; YOUNG ADULT;

EID: 68449095641     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2009.03436.x     Document Type: Article

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