메뉴 건너뛰기




Volumn 74, Issue 13, 2008, Pages 1608-1624

Cancer chemopreventive potential of apples, apple juice, and apple components

Author keywords

Apples; Cancer chemoprevention; Malus sp; Oligomeric procyanidins; Polyphenols; Rosaceae

Indexed keywords

ANTHOCYANIN; ANTINEOPLASTIC AGENT; APPLE EXTRACT; APPLEPHENON; CATECHIN; CHLOROGENIC ACID; COUMARIC ACID; EPICATECHIN; PHLORIZIN; POLYPHENOL; PROCYANIDIN DERIVATIVE; QUERCETIN DERIVATIVE; UNCLASSIFIED DRUG; URSOLIC ACID;

EID: 56249137618     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0028-1088300     Document Type: Review
Times cited : (235)

References (158)
  • 1
    • 0018693333 scopus 로고
    • Chemoprevention of cancer with retinoids
    • Sporn MB, Newton DL. Chemoprevention of cancer with retinoids. Fed Proc 1979; 38: 2528-34
    • (1979) Fed Proc , vol.38 , pp. 2528-2534
    • Sporn, M.B.1    Newton, D.L.2
  • 2
    • 33745683516 scopus 로고    scopus 로고
    • Progress in chemoprevention drug development: The promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer - a plan to move forward
    • Kelloff GJ, Lippman SM, Dannenberg AJ, Sigman CC, Pearce HL, Reid BJ et al. Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer - a plan to move forward. Clin Cancer Res 2006; 12: 3661-97
    • (2006) Clin Cancer Res , vol.12 , pp. 3661-3697
    • Kelloff, G.J.1    Lippman, S.M.2    Dannenberg, A.J.3    Sigman, C.C.4    Pearce, H.L.5    Reid, B.J.6
  • 4
    • 56249148044 scopus 로고    scopus 로고
    • Wirtschaftsvereinigung Alkoholfreie Getränke e.V. Pro-Kopf-Verbrauch alkoholfreier Getränke in Deutschland 2006. Germany: Wirtschaftsvereinigung Alkoholfreie Getränke; 2008
    • Wirtschaftsvereinigung Alkoholfreie Getränke e.V. Pro-Kopf-Verbrauch alkoholfreier Getränke in Deutschland 2006. Germany: Wirtschaftsvereinigung Alkoholfreie Getränke; 2008
  • 5
    • 11144335228 scopus 로고    scopus 로고
    • Apple phytochemicals and their health benefits
    • Boyer J, Liu RH. Apple phytochemicals and their health benefits. Nutr J 2004; 3: 5
    • (2004) Nutr J , vol.3 , pp. 5
    • Boyer, J.1    Liu, R.H.2
  • 6
    • 56249141701 scopus 로고    scopus 로고
    • Souci SW, Fachmann W, Kraut H, revised by Kirchhoff E. Food composition and nutrition tables, based on the 6th edition. Stuttgart: medpharm GmbH Scientific Publishers; 2005
    • Souci SW, Fachmann W, Kraut H, revised by Kirchhoff E. Food composition and nutrition tables, based on the 6th edition. Stuttgart: medpharm GmbH Scientific Publishers; 2005
  • 7
    • 10844242299 scopus 로고    scopus 로고
    • Polyphenols in apples: Distribution of polyphenols in apple tissue and comparison of fruit and juice
    • Thielen C, Will F, Zacharlas J, Dietrich H, Jacob H. Polyphenols in apples: Distribution of polyphenols in apple tissue and comparison of fruit and juice. Dtsch Lebensmitt Rundsch 2004; 100: 389-98
    • (2004) Dtsch Lebensmitt Rundsch , vol.100 , pp. 389-398
    • Thielen, C.1    Will, F.2    Zacharlas, J.3    Dietrich, H.4    Jacob, H.5
  • 8
    • 38049025188 scopus 로고    scopus 로고
    • Apple peel as a contributor to whole fruit quantity of potentially healthful bioactive compounds. Cultivar and year implication
    • Lata B, Tomala K. Apple peel as a contributor to whole fruit quantity of potentially healthful bioactive compounds. Cultivar and year implication. J Agric Food Chem 2007; 55: 10795-802
    • (2007) J Agric Food Chem , vol.55 , pp. 10795-10802
    • Lata, B.1    Tomala, K.2
  • 9
    • 28444451592 scopus 로고    scopus 로고
    • Great differences in antioxidant properties exist between 56 apple cultivars and vegetation seasons
    • Lata B, Przeradzka M, Binkowska M. Great differences in antioxidant properties exist between 56 apple cultivars and vegetation seasons. J Agric Food Chem 2005; 53: 8970-8
    • (2005) J Agric Food Chem , vol.53 , pp. 8970-8978
    • Lata, B.1    Przeradzka, M.2    Binkowska, M.3
  • 11
    • 0141706521 scopus 로고    scopus 로고
    • Variability of the polyphenolic composition of cider apple (Malus domestica) fruits and juices
    • Guyot S, Mamet N, Sanoner P, Drilleau JF. Variability of the polyphenolic composition of cider apple (Malus domestica) fruits and juices. J Agric Food Chem 2003; 51: 6240-7
    • (2003) J Agric Food Chem , vol.51 , pp. 6240-6247
    • Guyot, S.1    Mamet, N.2    Sanoner, P.3    Drilleau, J.F.4
  • 13
    • 6344243544 scopus 로고    scopus 로고
    • Quantitation of polyphenols in different apple varieties
    • Vrhovsek U, Riga A, Tonon D, Mattivi F. Quantitation of polyphenols in different apple varieties. J Agric Food Chem 2004; 52: 6532-8
    • (2004) J Agric Food Chem , vol.52 , pp. 6532-6538
    • Vrhovsek, U.1    Riga, A.2    Tonon, D.3    Mattivi, F.4
  • 14
    • 0000038398 scopus 로고    scopus 로고
    • Bestimmung phenolischer Verbindungen in Tafel- und Mostäpfeln mittels HPLC
    • Keller P, Strekker P, Arnold G, Schieber A, Carle R. Bestimmung phenolischer Verbindungen in Tafel- und Mostäpfeln mittels HPLC. Fluessiges Obst 2001; 68: 480-3
    • (2001) Fluessiges Obst , vol.68 , pp. 480-483
    • Keller, P.1    Strekker, P.2    Arnold, G.3    Schieber, A.4    Carle, R.5
  • 16
    • 0000313215 scopus 로고    scopus 로고
    • Differentiation by phenolic profile of apple juices prepared according to two membrane techniques
    • Mangos JJ, Suarez B, Picinelli A, Moreno J, Blanco D. Differentiation by phenolic profile of apple juices prepared according to two membrane techniques. J Agric Food Chem 1997; 45: 4777-84
    • (1997) J Agric Food Chem , vol.45 , pp. 4777-4784
    • Mangos, J.J.1    Suarez, B.2    Picinelli, A.3    Moreno, J.4    Blanco, D.5
  • 17
    • 0141594732 scopus 로고    scopus 로고
    • Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC)
    • Tsao R, Yang R, Young JC, Zhu H. Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). J Agric Food Chem 2003; 51: 6347-53
    • (2003) J Agric Food Chem , vol.51 , pp. 6347-6353
    • Tsao, R.1    Yang, R.2    Young, J.C.3    Zhu, H.4
  • 19
    • 0033396531 scopus 로고    scopus 로고
    • Polyphenol profiles of French cider apple varieties (Malus domestica sp.)
    • Sanoner P, Guyot S, Marner N, Molle D, Drilleau JP. Polyphenol profiles of French cider apple varieties (Malus domestica sp.). J Agric Food Chem 1999; 47: 4847-53
    • (1999) J Agric Food Chem , vol.47 , pp. 4847-4853
    • Sanoner, P.1    Guyot, S.2    Marner, N.3    Molle, D.4    Drilleau, J.P.5
  • 21
    • 0001171808 scopus 로고    scopus 로고
    • Reversed-phase HPLC following thiolysis for quantitative estimation and characterization of the four main classes of phenolic compounds in different tissue zones of a French cider apple variety (Malus domestica var. Kermerrien)
    • Guyot S, Marnet N, Laraba D, Sanoner P, Drilleau JF. Reversed-phase HPLC following thiolysis for quantitative estimation and characterization of the four main classes of phenolic compounds in different tissue zones of a French cider apple variety (Malus domestica var. Kermerrien). J Agric Food Chem 1998; 46: 1698-705
    • (1998) J Agric Food Chem , vol.46 , pp. 1698-1705
    • Guyot, S.1    Marnet, N.2    Laraba, D.3    Sanoner, P.4    Drilleau, J.F.5
  • 22
    • 0035134932 scopus 로고    scopus 로고
    • Thiolysis-HPLC characterization of apple procyanidins covering a large range of polymerization states
    • Guyot S, Marnet N, Drilleau J. Thiolysis-HPLC characterization of apple procyanidins covering a large range of polymerization states. J Agric Food Chem 2001; 49: 14-20
    • (2001) J Agric Food Chem , vol.49 , pp. 14-20
    • Guyot, S.1    Marnet, N.2    Drilleau, J.3
  • 23
    • 0035957866 scopus 로고    scopus 로고
    • Separation of apple procyanidins into different degrees of polymerization by high-speed counter-current chromatography
    • Shibusawa Y, Yanagida A, Isozaki M, Shindo H, Ito Y. Separation of apple procyanidins into different degrees of polymerization by high-speed counter-current chromatography. J Chromatogr A 2001; 915: 253-7
    • (2001) J Chromatogr A , vol.915 , pp. 253-257
    • Shibusawa, Y.1    Yanagida, A.2    Isozaki, M.3    Shindo, H.4    Ito, Y.5
  • 25
    • 0034714599 scopus 로고    scopus 로고
    • Fractionation of apple procyanidins according to their degree of polymerization by normal-phase high-performance liquid chromatography
    • Yanagida A, Kanda T, Takahashi T, Kamimura A, Hamazono T, Honda S. Fractionation of apple procyanidins according to their degree of polymerization by normal-phase high-performance liquid chromatography. J Chromatogr A 2000; 890: 251-9
    • (2000) J Chromatogr A , vol.890 , pp. 251-259
    • Yanagida, A.1    Kanda, T.2    Takahashi, T.3    Kamimura, A.4    Hamazono, T.5    Honda, S.6
  • 26
    • 29044434744 scopus 로고    scopus 로고
    • Apple (Malus pumila) procyanidins fractionated according to the degree of polymerization using normal-phase chromatography and characterized by HPLC-ESI/MS and MALDI-TOF/MS
    • Shoji T, Masumoto S, Moriichi N, Kanda T, Ohtake Y. Apple (Malus pumila) procyanidins fractionated according to the degree of polymerization using normal-phase chromatography and characterized by HPLC-ESI/MS and MALDI-TOF/MS. J Chromatogr A 2006; 1102: 206-13
    • (2006) J Chromatogr A , vol.1102 , pp. 206-213
    • Shoji, T.1    Masumoto, S.2    Moriichi, N.3    Kanda, T.4    Ohtake, Y.5
  • 27
    • 38949131470 scopus 로고    scopus 로고
    • Flavan-3-ols: Nature, occurrence and biological activity
    • Aron PM, Kennedy JA. Flavan-3-ols: nature, occurrence and biological activity. Mol Nutr Food Res 2008; 52: 79-104
    • (2008) Mol Nutr Food Res , vol.52 , pp. 79-104
    • Aron, P.M.1    Kennedy, J.A.2
  • 28
    • 41049090410 scopus 로고    scopus 로고
    • Content and mean polymerization degree of procyanidins in extracts obtained from clear and cloudy apple juices
    • Huemmer W, Dietrich H, Will F, Schreier P, Richling E. Content and mean polymerization degree of procyanidins in extracts obtained from clear and cloudy apple juices. Biotechnol J 2008; 3: 234-43
    • Biotechnol , vol.J 2008 , Issue.3 , pp. 234-243
    • Huemmer, W.1    Dietrich, H.2    Will, F.3    Schreier, P.4    Richling, E.5
  • 29
    • 34548317131 scopus 로고    scopus 로고
    • Isolation of ursolic acid from apple peels by high speed counter-current chromatography
    • Frighetto RTS, Welendorf RM, Nigro EN, Frighetto N, Siani AC. Isolation of ursolic acid from apple peels by high speed counter-current chromatography. Food Chem 2008; 106: 767-71
    • (2008) Food Chem , vol.106 , pp. 767-771
    • Frighetto, R.T.S.1    Welendorf, R.M.2    Nigro, E.N.3    Frighetto, N.4    Siani, A.C.5
  • 30
    • 34250659001 scopus 로고    scopus 로고
    • Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity
    • He X, Liu RH. Triterpenoids isolated from apple peels have potent antiproliferative activity and may be partially responsible for apple's anticancer activity. J Agric Food Chem 2007; 55: 4366-70
    • (2007) J Agric Food Chem , vol.55 , pp. 4366-4370
    • He, X.1    Liu, R.H.2
  • 31
    • 33947209997 scopus 로고    scopus 로고
    • Diet and cancer: Facts and controversies
    • Milner JA. Diet and cancer: facts and controversies. Nutr Cancer 2006; 56: 216-24
    • (2006) Nutr Cancer , vol.56 , pp. 216-224
    • Milner, J.A.1
  • 32
    • 0033863355 scopus 로고    scopus 로고
    • Dietary intake and bioavailability of polyphenols
    • Scalbert A. Williamson C. Dietary intake and bioavailability of polyphenols. J Nutr 2000; 130: 20735-855
    • (2000) J Nutr , vol.130 , pp. 20735-20855
    • Scalbert, A.1    Williamson, C.2
  • 33
    • 0034928799 scopus 로고    scopus 로고
    • Inhibition of carcinogenesis by dietary polyphenolic compounds
    • Yang CS, Landau JM, Huang MT, Newmark HL. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr 2001; 21: 381-406
    • (2001) Annu Rev Nutr , vol.21 , pp. 381-406
    • Yang, C.S.1    Landau, J.M.2    Huang, M.T.3    Newmark, H.L.4
  • 34
    • 79959471549 scopus 로고    scopus 로고
    • Bioavailability and bioefficacy of polyphenols in humans. 1. Review of 97 bioavailability studies
    • Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. 1. Review of 97 bioavailability studies. Am J Clin Nutr 2005; 81: 2305-425
    • (2005) Am J Clin Nutr , vol.81 , pp. 2305-2425
    • Manach, C.1    Williamson, G.2    Morand, C.3    Scalbert, A.4    Remesy, C.5
  • 35
    • 0034904141 scopus 로고    scopus 로고
    • Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats
    • Crespy V, Morand C, Besson C, Manach C, Demigne C, Remesy C. Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats. J Nutr 2001; 131: 2109-14
    • (2001) J Nutr , vol.131 , pp. 2109-2114
    • Crespy, V.1    Morand, C.2    Besson, C.3    Manach, C.4    Demigne, C.5    Remesy, C.6
  • 37
    • 29344454917 scopus 로고    scopus 로고
    • Colonic availability of apple polyphenols - a study in ileostomy subjects
    • Kahle K, Kraus M, Scheppach W, Richling E. Colonic availability of apple polyphenols - a study in ileostomy subjects. Mol Nutr Food Res 2005; 49: 1143-50
    • (2005) Mol Nutr Food Res , vol.49 , pp. 1143-1150
    • Kahle, K.1    Kraus, M.2    Scheppach, W.3    Richling, E.4
  • 38
    • 38049025736 scopus 로고    scopus 로고
    • Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption
    • Kahle K, Huemmer W, Kempf M, Scheppach W, Erk T, Richling E. Polyphenols are intensively metabolized in the human gastrointestinal tract after apple juice consumption. J Agric Food Chem 2007; 55: 10605-14
    • (2007) J Agric Food Chem , vol.55 , pp. 10605-10614
    • Kahle, K.1    Huemmer, W.2    Kempf, M.3    Scheppach, W.4    Erk, T.5    Richling, E.6
  • 39
    • 0035176633 scopus 로고    scopus 로고
    • Chlorogenic acid and caffeic acid are absorbed in humans
    • Olthof MR, Hollman PCH, Koran MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr 2001; 131: 66-71
    • (2001) J Nutr , vol.131 , pp. 66-71
    • Olthof, M.R.1    Hollman, P.C.H.2    Koran, M.B.3
  • 40
    • 0037977138 scopus 로고    scopus 로고
    • Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans
    • Olthof MR, Hollman PCH, Buijsman MNCP, van Amelsvoort JMM, Katan MB. Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans. J Nutr 2003; 133: 1806-14
    • (2003) J Nutr , vol.133 , pp. 1806-1814
    • Olthof, M.R.1    Hollman, P.C.H.2    Buijsman, M.N.C.P.3    van Amelsvoort, J.M.M.4    Katan, M.B.5
  • 41
    • 0038653491 scopus 로고    scopus 로고
    • Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats
    • Gonthier M-P, Verny M-A, Besson C, Remesy C, Scalbert A. Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats. J Nutr 2003; 133: 1853-9
    • (2003) J Nutr , vol.133 , pp. 1853-1859
    • Gonthier, M.-P.1    Verny, M.-A.2    Besson, C.3    Remesy, C.4    Scalbert, A.5
  • 42
    • 0033735623 scopus 로고    scopus 로고
    • Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption
    • Walle T, Otake Y, Walle UK, Wilson FA. Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption. J Nutr 2000; 130: 2658-61
    • (2000) J Nutr , vol.130 , pp. 2658-2661
    • Walle, T.1    Otake, Y.2    Walle, U.K.3    Wilson, F.A.4
  • 43
    • 0034795649 scopus 로고    scopus 로고
    • Carbon dioxide is the major metabolite of quercetin in humans
    • Walle T, Walle UK, Halushka PV. Carbon dioxide is the major metabolite of quercetin in humans. J Nutr 2001; 131: 2648-52
    • (2001) J Nutr , vol.131 , pp. 2648-2652
    • Walle, T.1    Walle, U.K.2    Halushka, P.V.3
  • 44
    • 1542286856 scopus 로고    scopus 로고
    • Concentrations of proanthocyanidins in common foods and estimations of normal consumption
    • Gu L, Kelm MA, Hammerstone JF, Bescher G, Holden J, Haytowitz D et al. Concentrations of proanthocyanidins in common foods and estimations of normal consumption. J Nutr 2004; 134: 613-7
    • (2004) J Nutr , vol.134 , pp. 613-617
    • Gu, L.1    Kelm, M.A.2    Hammerstone, J.F.3    Bescher, G.4    Holden, J.5    Haytowitz, D.6
  • 45
    • 24344443633 scopus 로고    scopus 로고
    • Occurrence and biological significance of proanthocyanidins in the American diet
    • Prior RL, Gu L. Occurrence and biological significance of proanthocyanidins in the American diet. Phytochemistry 2005; 66: 2264-80
    • (2005) Phytochemistry , vol.66 , pp. 2264-2280
    • Prior, R.L.1    Gu, L.2
  • 46
    • 0035662997 scopus 로고    scopus 로고
    • Bioavailability of flavan-3-ols and procyanidins: Gastrointestinal tract influences and their relevance to bioactive forms in vivo
    • Spencer JP, Schroeter H, Rechner AR, Rice-Evans C. Bioavailability of flavan-3-ols and procyanidins: gastrointestinal tract influences and their relevance to bioactive forms in vivo. Antioxid Redox Signal 2001; 3: 1023-39
    • (2001) Antioxid Redox Signal , vol.3 , pp. 1023-1039
    • Spencer, J.P.1    Schroeter, H.2    Rechner, A.R.3    Rice-Evans, C.4
  • 48
    • 56249144374 scopus 로고    scopus 로고
    • Cancer chemopreventive potential of apple juice - Results of a short-term human intervention study with ileostomy patients
    • Gerhauser C, Klimo K, Kahle K, Garreta A, Steinle R, Scheppach W et al. Cancer chemopreventive potential of apple juice - Results of a short-term human intervention study with ileostomy patients. EJC Suppl 2008; 6: 50
    • (2008) EJC Suppl , vol.6 , pp. 50
    • Gerhauser, C.1    Klimo, K.2    Kahle, K.3    Garreta, A.4    Steinle, R.5    Scheppach, W.6
  • 49
    • 0033745131 scopus 로고    scopus 로고
    • Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids
    • Deprez S, Brezillon C, Rabot S, Philippe C, Mila I, Lapierre C et al. Polymeric proanthocyanidins are catabolized by human colonic microflora into low-molecular-weight phenolic acids. J Nutr 2000; 130: 2733-8
    • (2000) J Nutr , vol.130 , pp. 2733-2738
    • Deprez, S.1    Brezillon, C.2    Rabot, S.3    Philippe, C.4    Mila, I.5    Lapierre, C.6
  • 50
    • 27844439469 scopus 로고    scopus 로고
    • Overview of mechanisms of cancer chemopreventive agents
    • De Flora S, Ferguson LR. Overview of mechanisms of cancer chemopreventive agents. Mutat Res 2005; 591: 8-15
    • (2005) Mutat Res , vol.591 , pp. 8-15
    • De Flora, S.1    Ferguson, L.R.2
  • 51
    • 0028242181 scopus 로고
    • Antimutagens as cancer chemopreventive agents in the diet
    • Ferguson LR. Antimutagens as cancer chemopreventive agents in the diet. Mutat Res 1994; 307: 395-410
    • (1994) Mutat Res , vol.307 , pp. 395-410
    • Ferguson, L.R.1
  • 52
    • 0032998995 scopus 로고    scopus 로고
    • Pectins and xyloglucans exhibit antimutagenic activities against nitroaromatic compounds
    • Hensel A, Meier K. Pectins and xyloglucans exhibit antimutagenic activities against nitroaromatic compounds. Planta Med 1999; 65: 395-9
    • (1999) Planta Med , vol.65 , pp. 395-399
    • Hensel, A.1    Meier, K.2
  • 53
    • 0038402725 scopus 로고    scopus 로고
    • Kestell P. Contrasting effects of non-starch polysaccharide and resistant starch-based diets on the disposition and excretion of the food carcinogen, 2-amino-3-methylimidazo(4,5-f]quinoline (IQ), in a rat model
    • Ferguson LR, Zhu S, Kestell P. Contrasting effects of non-starch polysaccharide and resistant starch-based diets on the disposition and excretion of the food carcinogen, 2-amino-3-methylimidazo(4,5-f]quinoline (IQ), in a rat model. Food Chem Toxicol 2003; 41: 785-92
    • (2003) Food Chem Toxicol , vol.41 , pp. 785-792
    • Ferguson, L.R.1    Zhu, S.2
  • 54
    • 1242283914 scopus 로고    scopus 로고
    • Mechanisms by which resistant starches and non-starch polysaccharide sources affect the metabolism and disposition of the food carcinogen, 2-amino-3-methylimidazo[4,5-f] quinoline
    • Kestell P, Zhu S, Ferguson LR. Mechanisms by which resistant starches and non-starch polysaccharide sources affect the metabolism and disposition of the food carcinogen, 2-amino-3-methylimidazo[4,5-f] quinoline. J Chromatogr B Analyt Technol Biomed Life Sci 2004; 802:201-10
    • (2004) J Chromatogr B Analyt Technol Biomed Life Sci , vol.802 , pp. 201-210
    • Kestell, P.1    Zhu, S.2    Ferguson, L.R.3
  • 55
    • 34247603065 scopus 로고    scopus 로고
    • Coordinate regulation of Phase 1 and II xenobiotic metabolisms by the Ah receptor and Nrf2
    • Kohle C, Bock KW. Coordinate regulation of Phase 1 and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem Pharmacol 2007; 73: 1853-62
    • (2007) Biochem Pharmacol , vol.73 , pp. 1853-1862
    • Kohle, C.1    Bock, K.W.2
  • 56
    • 33846513021 scopus 로고    scopus 로고
    • Cytochrome P450 1A1 expression and activity in Caco-2 cells: Modulation by apple juice extract and certain apple polyphenols
    • Pohl C, Will F, Dietrich H, Schrenk D. Cytochrome P450 1A1 expression and activity in Caco-2 cells: modulation by apple juice extract and certain apple polyphenols. J Agric Food Chem 2006; 54: 10262-8
    • (2006) J Agric Food Chem , vol.54 , pp. 10262-10268
    • Pohl, C.1    Will, F.2    Dietrich, H.3    Schrenk, D.4
  • 58
    • 53449092391 scopus 로고    scopus 로고
    • Fractionation of polyphenol-enriched apple juice extracts to identify constituents with cancer chemopreventive potential
    • Zessner H, Pan L, Will F, Klimo K, Knauft J, Niewohner R et al. Fractionation of polyphenol-enriched apple juice extracts to identify constituents with cancer chemopreventive potential. Mol Nutr Food Res 2008; 52 1:528-44
    • (2008) Mol Nutr Food Res , vol.52 , Issue.1 , pp. 528-544
    • Zessner, H.1    Pan, L.2    Will, F.3    Klimo, K.4    Knauft, J.5    Niewohner, R.6
  • 59
    • 15244341034 scopus 로고    scopus 로고
    • Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes
    • Wilms LC, Hollman PC, Boots AW, Kleinjans JC. Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mutat Res 2005; 582: 155-62
    • (2005) Mutat Res , vol.582 , pp. 155-162
    • Wilms, L.C.1    Hollman, P.C.2    Boots, A.W.3    Kleinjans, J.C.4
  • 60
    • 34548180899 scopus 로고    scopus 로고
    • Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers
    • Wilms LC, Boots AW, de Boer VC, Maas LM, Pachen DM, Gottschalk RW et al. Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis 2007; 28: 1800-6
    • (2007) Carcinogenesis , vol.28 , pp. 1800-1806
    • Wilms, L.C.1    Boots, A.W.2    de Boer, V.C.3    Maas, L.M.4    Pachen, D.M.5    Gottschalk, R.W.6
  • 61
    • 33644827448 scopus 로고    scopus 로고
    • Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression of genes involved in the biotransformation of xenobiotics
    • Veeriah S, Kautenburger T, Habermann N, Sauer J, Dietrich H, Will F et al. Apple flavonoids inhibit growth of HT29 human colon cancer cells and modulate expression of genes involved in the biotransformation of xenobiotics. Mol Carcinogen 2006; 45: 164-74
    • (2006) Mol Carcinogen , vol.45 , pp. 164-174
    • Veeriah, S.1    Kautenburger, T.2    Habermann, N.3    Sauer, J.4    Dietrich, H.5    Will, F.6
  • 62
    • 43049118613 scopus 로고    scopus 로고
    • Apple polyphenols modulate expression of selected genes related to toxicological defence and stress response in human colon adenoma cells
    • Veeriah S, Miene C, Habermann N, Hofmann T, Klenow S, Sauer J et al. Apple polyphenols modulate expression of selected genes related to toxicological defence and stress response in human colon adenoma cells, Int J Cancer 2008; 122: 2647-55
    • (2008) Int J Cancer , vol.122 , pp. 2647-2655
    • Veeriah, S.1    Miene, C.2    Habermann, N.3    Hofmann, T.4    Klenow, S.5    Sauer, J.6
  • 64
    • 0343458043 scopus 로고    scopus 로고
    • Antioxidant activity of fresh apples
    • Eberhardt MV, Lee CY, Liu RH. Antioxidant activity of fresh apples. Nature 2000; 405: 903-4
    • (2000) Nature , vol.405 , pp. 903-904
    • Eberhardt, M.V.1    Lee, C.Y.2    Liu, R.H.3
  • 65
    • 0034846868 scopus 로고    scopus 로고
    • Antioxidant and antiradical activities of flavonoids
    • Burda S, Oleszek W. Antioxidant and antiradical activities of flavonoids. J Agric Food Chem 2001; 49: 2774-9
    • (2001) J Agric Food Chem , vol.49 , pp. 2774-2779
    • Burda, S.1    Oleszek, W.2
  • 66
    • 0344951109 scopus 로고    scopus 로고
    • Apple peels as a value-added food ingredient
    • Wolfe KL, Liu RH. Apple peels as a value-added food ingredient. J Agric Food Chem 2003; 51: 1676-83
    • (2003) J Agric Food Chem , vol.51 , pp. 1676-1683
    • Wolfe, K.L.1    Liu, R.H.2
  • 67
    • 0346363392 scopus 로고    scopus 로고
    • Major phenolics in apple and their contribution to the total antioxidant capacity
    • Lee KW, Kim YJ, Kim DO, Lee HJ, Lee CY. Major phenolics in apple and their contribution to the total antioxidant capacity. J Agric Food Chem 2003; 51: 6516-20
    • (2003) J Agric Food Chem , vol.51 , pp. 6516-6520
    • Lee, K.W.1    Kim, Y.J.2    Kim, D.O.3    Lee, H.J.4    Lee, C.Y.5
  • 68
    • 3242769761 scopus 로고    scopus 로고
    • Radical scavenging activities of peels and pulps from cv. Golden Delicious apples as related to their phenolic composition
    • Chinnici F, Bendini A, Gaiani A, Riponi C. Radical scavenging activities of peels and pulps from cv. Golden Delicious apples as related to their phenolic composition. J Agric Food Chem 2004; 52: 4684-9
    • (2004) J Agric Food Chem , vol.52 , pp. 4684-4689
    • Chinnici, F.1    Bendini, A.2    Gaiani, A.3    Riponi, C.4
  • 69
    • 17144372919 scopus 로고    scopus 로고
    • Cultivar and growing region determine the antioxidant polyphenolic concentration and composition of apples grown in New Zealand
    • McGhie TK, Hunt M, Barnett LE. Cultivar and growing region determine the antioxidant polyphenolic concentration and composition of apples grown in New Zealand. J Agric Food Chem 2005; 53: 3065-70
    • (2005) J Agric Food Chem , vol.53 , pp. 3065-3070
    • McGhie, T.K.1    Hunt, M.2    Barnett, L.E.3
  • 70
    • 0033799932 scopus 로고    scopus 로고
    • An improved, rapid in vitro method to measure antioxidant activity. Application on selected flavonoids and apple juice
    • van der Sluis AA, Dekker M, Verkerk R, Jongen WM. An improved, rapid in vitro method to measure antioxidant activity. Application on selected flavonoids and apple juice. J Agric Food Chem 2000; 48: 4116-22
    • (2000) J Agric Food Chem , vol.48 , pp. 4116-4122
    • van der Sluis, A.A.1    Dekker, M.2    Verkerk, R.3    Jongen, W.M.4
  • 71
    • 19944407137 scopus 로고    scopus 로고
    • Major phytochemicals in apple cultivars: Contribution to peroxyl radical trapping efficiency
    • Vanzani P, Rossetto M, Rigo A, Vrhovsek U, Mattivi F, D'Amato E et al. Major phytochemicals in apple cultivars: contribution to peroxyl radical trapping efficiency. J Agric Food Chem 2005; 53: 3377-82
    • (2005) J Agric Food Chem , vol.53 , pp. 3377-3382
    • Vanzani, P.1    Rossetto, M.2    Rigo, A.3    Vrhovsek, U.4    Mattivi, F.5    D'Amato, E.6
  • 72
    • 31544453931 scopus 로고    scopus 로고
    • Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines
    • Schaefer S, Baum M, Eisenbrand G, Dietrich H, Will F, Janzowski C. Polyphenolic apple juice extracts and their major constituents reduce oxidative damage in human colon cell lines. Mol Nutr Food Res 2006; 50: 24-33
    • (2006) Mol Nutr Food Res , vol.50 , pp. 24-33
    • Schaefer, S.1    Baum, M.2    Eisenbrand, G.3    Dietrich, H.4    Will, F.5    Janzowski, C.6
  • 73
    • 34247129979 scopus 로고    scopus 로고
    • Anticancer properties of phenolics from apple waste on colon carcinogenesis in vitro
    • McCann MJ, Gill CI, G OB, Rao JR, McRoberts WC, Hughes P et al. Anticancer properties of phenolics from apple waste on colon carcinogenesis in vitro. Food Chem Toxicol 2007; 45: 1224-30
    • (2007) Food Chem Toxicol , vol.45 , pp. 1224-1230
    • McCann, M.J.1    Gill2    CI, G.O.3    Rao, J.R.4    McRoberts, W.C.5    Hughes, P.6
  • 74
    • 37349048495 scopus 로고    scopus 로고
    • Effect of reddening-ripening on the antioxidant activity of polyphenol extracts from cv. 'Annurca' apple fruits
    • D'Angelo S, Cimmino A, Raimo M, Salvatore A, Zappia V, Galletti P. Effect of reddening-ripening on the antioxidant activity of polyphenol extracts from cv. 'Annurca' apple fruits. J Agric Food Chem 2007; 55: 9977-85
    • (2007) J Agric Food Chem , vol.55 , pp. 9977-9985
    • D'Angelo, S.1    Cimmino, A.2    Raimo, M.3    Salvatore, A.4    Zappia, V.5    Galletti, P.6
  • 75
    • 0036032966 scopus 로고    scopus 로고
    • Antioxidant properties of apple juice and its protection against Cr(VI)-induced cellular injury
    • Shi D, Jiang BH. Antioxidant properties of apple juice and its protection against Cr(VI)-induced cellular injury. J Environ Pathol Toxicol Oncol 2002; 21: 233-42
    • (2002) J Environ Pathol Toxicol Oncol , vol.21 , pp. 233-242
    • Shi, D.1    Jiang, B.H.2
  • 76
    • 33746041880 scopus 로고    scopus 로고
    • Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: Role of inflammation on the promotion of initiated stem cells
    • Trosko JE, Tai MH. Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells. Contrib Microbiol 2006; 13: 45-65
    • (2006) Contrib Microbiol , vol.13 , pp. 45-65
    • Trosko, J.E.1    Tai, M.H.2
  • 77
    • 16444383793 scopus 로고    scopus 로고
    • Effects of phenolics in Empire apples on hydrogen peroxide-induced inhibition of gap-junctional intercellular communication
    • Lee KW, Lee SJ, Kang NJ, Lee CY, Lee HJ. Effects of phenolics in Empire apples on hydrogen peroxide-induced inhibition of gap-junctional intercellular communication. Biofactors 2004; 21: 361-5
    • (2004) Biofactors , vol.21 , pp. 361-365
    • Lee, K.W.1    Lee, S.J.2    Kang, N.J.3    Lee, C.Y.4    Lee, H.J.5
  • 78
    • 33644837942 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs for cancer prevention: Promise, perils and pharmacogenetics
    • Ulrich CM, Bigler J, Potter JD. Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat Rev Cancer 2006; 6: 130-40
    • (2006) Nat Rev Cancer , vol.6 , pp. 130-140
    • Ulrich, C.M.1    Bigler, J.2    Potter, J.D.3
  • 79
    • 36749091741 scopus 로고    scopus 로고
    • Nuclear factor-kappa B: From clone to clinic
    • Ahn KS, Sethi G, Aggarwal BB. Nuclear factor-kappa B: from clone to clinic. Curr Mol Med 2007; 7: 619-37
    • (2007) Curr Mol Med , vol.7 , pp. 619-637
    • Ahn, K.S.1    Sethi, G.2    Aggarwal, B.B.3
  • 80
    • 33744979273 scopus 로고    scopus 로고
    • Effect of apple extracts on NF-kappaB activation in human umbilical vein endothelial cells
    • Davis PA, Polagruto JA, Valacchi G, Phung A, Soucek K, Keen CL et al. Effect of apple extracts on NF-kappaB activation in human umbilical vein endothelial cells. Exp Biol Med 2006; 231: 594-8
    • (2006) Exp Biol Med , vol.231 , pp. 594-598
    • Davis, P.A.1    Polagruto, J.A.2    Valacchi, G.3    Phung, A.4    Soucek, K.5    Keen, C.L.6
  • 81
    • 34247571021 scopus 로고    scopus 로고
    • Effect of selected phytochemicals and apple extracts on NF-kappaB activation in human breast cancer MCF-7 cells
    • Yoon H, Liu RH. Effect of selected phytochemicals and apple extracts on NF-kappaB activation in human breast cancer MCF-7 cells. J Agric Food Chem 2007; 55: 3167-73
    • (2007) J Agric Food Chem , vol.55 , pp. 3167-3173
    • Yoon, H.1    Liu, R.H.2
  • 82
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh YJ. Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 2003; 3: 768-80
    • (2003) Nat Rev Cancer , vol.3 , pp. 768-780
    • Surh, Y.J.1
  • 83
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal BB, Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006; 71: 1397-421
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 84
    • 48649095089 scopus 로고    scopus 로고
    • Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways
    • Ramos S. Cancer chemoprevention and chemotherapy: dietary polyphenols and signalling pathways. Mol Nutr Food Res 2008; 52: 507-26
    • (2008) Mol Nutr Food Res , vol.52 , pp. 507-526
    • Ramos, S.1
  • 86
    • 34447530807 scopus 로고    scopus 로고
    • Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells
    • Fridrich D, Kern M, Pahlke G, Volz N, Will F, Dietrich H et al. Apple polyphenols diminish the phosphorylation of the epidermal growth factor receptor in HT29 colon carcinoma cells. Mol Nutr Food Res 2007; 51: 594-601
    • (2007) Mol Nutr Food Res , vol.51 , pp. 594-601
    • Fridrich, D.1    Kern, M.2    Pahlke, G.3    Volz, N.4    Will, F.5    Dietrich, H.6
  • 87
    • 22844436771 scopus 로고    scopus 로고
    • Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis
    • Gosse F, Guyot S, Roussi S, Lobstein A, Fischer B, Seiler N et al. Chemopreventive properties of apple procyanidins on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis 2005; 26: 1291-5
    • (2005) Carcinogenesis , vol.26 , pp. 1291-1295
    • Gosse, F.1    Guyot, S.2    Roussi, S.3    Lobstein, A.4    Fischer, B.5    Seiler, N.6
  • 88
    • 34447320488 scopus 로고    scopus 로고
    • Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells
    • Kern M, Pahlke G, Balavenkatraman KK, Bohmer FD, Marko D. Apple polyphenols affect protein kinase C activity and the onset of apoptosis in human colon carcinoma cells. J Agric Food Chem 2007; 55: 4999-5006
    • (2007) J Agric Food Chem , vol.55 , pp. 4999-5006
    • Kern, M.1    Pahlke, G.2    Balavenkatraman, K.K.3    Bohmer, F.D.4    Marko, D.5
  • 89
    • 33749664540 scopus 로고    scopus 로고
    • Modulation of key elements of the Wnt pathway by apple polyphenols
    • Kern M, Pahlke G, Ngiewih Y, Marko D. Modulation of key elements of the Wnt pathway by apple polyphenols. J Agric Food Chem 2006; 54: 7041-6
    • (2006) J Agric Food Chem , vol.54 , pp. 7041-7046
    • Kern, M.1    Pahlke, G.2    Ngiewih, Y.3    Marko, D.4
  • 90
    • 0031815389 scopus 로고    scopus 로고
    • Yang CS. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols
    • Yang GY, Liao J, Kim K, Yurkow EJ, Yang CS. Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. Carcinogenesis 1998; 19: 611-6
    • (1998) Carcinogenesis , vol.19 , pp. 611-616
    • Yang, G.Y.1    Liao, J.2    Kim, K.3    Yurkow, E.J.4
  • 91
    • 0034709554 scopus 로고    scopus 로고
    • Artifacts in cell culture: Rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media
    • Long LH, Clement MV, Halliwell B. Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem Biophys Res Commun 2000; 273: 50-3
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 50-53
    • Long, L.H.1    Clement, M.V.2    Halliwell, B.3
  • 92
    • 0037157039 scopus 로고    scopus 로고
    • 2 during interaction of phenolic compounds with cell culture media
    • 2 during interaction of phenolic compounds with cell culture media. J Agric Food Chem 2002; 50: 3156-60
    • (2002) J Agric Food Chem , vol.50 , pp. 3156-3160
    • Lapidot, T.1    Walker, M.D.2    Kanner, J.3
  • 93
    • 0037433478 scopus 로고    scopus 로고
    • Antiproliferative activity of apples is not due to phenolic-induced hydrogen peroxide formation
    • Liu RH, Sun J. Antiproliferative activity of apples is not due to phenolic-induced hydrogen peroxide formation. J Agric Food Chem 2003; 51: 1718-23
    • (2003) J Agric Food Chem , vol.51 , pp. 1718-1723
    • Liu, R.H.1    Sun, J.2
  • 94
    • 34247557395 scopus 로고    scopus 로고
    • Apple polyphenols and products formed in the gut differently inhibit survival of human cell lines derived from colon adenoma (LT97) and carcinoma (HT29)
    • Veeriah S, Hofmann T, Glei M, Dietrich H, Will F, Schreier P et al. Apple polyphenols and products formed in the gut differently inhibit survival of human cell lines derived from colon adenoma (LT97) and carcinoma (HT29). J Agric Food Chem 2007; 55: 2892-900
    • (2007) J Agric Food Chem , vol.55 , pp. 2892-2900
    • Veeriah, S.1    Hofmann, T.2    Glei, M.3    Dietrich, H.4    Will, F.5    Schreier, P.6
  • 95
    • 39949083560 scopus 로고    scopus 로고
    • Histone-deacetylase inhibition and butyrate formation: Fecal slurry incubations with apple pectin and apple juice extracts
    • Waldecker M, Kautenburger T, Daumann H, Veeriah S, Will F, Dietrich H et al. Histone-deacetylase inhibition and butyrate formation: Fecal slurry incubations with apple pectin and apple juice extracts. Nutrition 2008; 24: 366-74
    • (2008) Nutrition , vol.24 , pp. 366-374
    • Waldecker, M.1    Kautenburger, T.2    Daumann, H.3    Veeriah, S.4    Will, F.5    Dietrich, H.6
  • 97
    • 0038676409 scopus 로고    scopus 로고
    • Inhibition of histone deacetylase activity by butyrate
    • Davie JR. Inhibition of histone deacetylase activity by butyrate. J Nutr 2003; 133: 24855-935
    • (2003) J Nutr , vol.133 , pp. 24855-24935
    • Davie, J.R.1
  • 98
    • 0034641980 scopus 로고    scopus 로고
    • Apoptosis in development
    • Meier P, Finch A Evan G. Apoptosis in development. Nature 2000; 407: 796-801
    • (2000) Nature , vol.407 , pp. 796-801
    • Meier, P.1    Finch, A.2    Evan, G.3
  • 100
    • 0034864799 scopus 로고    scopus 로고
    • Proteasome inhibitors: From research tools to drug candidates
    • Kisselev AF, Goldberg AL. Proteasome inhibitors: from research tools to drug candidates. Chem Biol 2001; 8: 739-58
    • (2001) Chem Biol , vol.8 , pp. 739-758
    • Kisselev, A.F.1    Goldberg, A.L.2
  • 101
    • 84864322479 scopus 로고    scopus 로고
    • Tea polyphenols, their biological effects and potential molecular targets
    • Chen D, Milacic V, Chen MS, Wan SB, Lam WH, Huo C et al. Tea polyphenols, their biological effects and potential molecular targets. Histol Histopathol 2008; 23: 487-96
    • (2008) Histol Histopathol , vol.23 , pp. 487-496
    • Chen, D.1    Milacic, V.2    Chen, M.S.3    Wan, S.B.4    Lam, W.H.5    Huo, C.6
  • 102
    • 1342326225 scopus 로고    scopus 로고
    • Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death
    • Chen MS, Chen D, Dou QP. Inhibition of proteasome activity by various fruits and vegetables is associated with cancer cell death. In Vivo 2004; 18: 73-80
    • (2004) In Vivo , vol.18 , pp. 73-80
    • Chen, M.S.1    Chen, D.2    Dou, Q.P.3
  • 104
    • 38949214030 scopus 로고    scopus 로고
    • Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells
    • Gosse F, Roussi S, Guyot S, Schoenfelder A, Mann A, Bergerat JP et al. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Int J Oncol 2006; 29: 423-8
    • (2006) Int J Oncol , vol.29 , pp. 423-428
    • Gosse, F.1    Roussi, S.2    Guyot, S.3    Schoenfelder, A.4    Mann, A.5    Bergerat, J.P.6
  • 106
    • 40949084715 scopus 로고    scopus 로고
    • Apple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3
    • Miura T, China M, Kasai K, Nozaka H, Nakamura T, Shoji T et al. Apple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3. Carcinogenesis 2008; 29: 585-93
    • (2008) Carcinogenesis , vol.29 , pp. 585-593
    • Miura, T.1    China, M.2    Kasai, K.3    Nozaka, H.4    Nakamura, T.5    Shoji, T.6
  • 107
    • 7944234261 scopus 로고    scopus 로고
    • Induction of apoptosis by three types of procyanidin isolated from apple (Rosaceae Malus pumila) in human stomach cancer KATO 111 cells
    • Hibasami H, Shohji T, Shibuya I, Higo K, Kanda T. Induction of apoptosis by three types of procyanidin isolated from apple (Rosaceae Malus pumila) in human stomach cancer KATO 111 cells. Int J Mol Med 2004; 13: 795-9
    • (2004) Int J Mol Med , vol.13 , pp. 795-799
    • Hibasami, H.1    Shohji, T.2    Shibuya, I.3    Higo, K.4    Kanda, T.5
  • 109
    • 33749817962 scopus 로고    scopus 로고
    • DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients
    • Balavenkatraman KK, Jandt E, Friedrich K, Kautenburger T, Pool-Zobel BL, Ostman A et al. DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients. Oncogene 2006; 25: 6319-24
    • (2006) Oncogene , vol.25 , pp. 6319-6324
    • Balavenkatraman, K.K.1    Jandt, E.2    Friedrich, K.3    Kautenburger, T.4    Pool-Zobel, B.L.5    Ostman, A.6
  • 110
    • 0037372003 scopus 로고    scopus 로고
    • Epigenetic regulation of gene expression: How the genome integrates intrinsic and environmental signals
    • Jaenisch R, Bird A. Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 2003; 33 Suppl: 245-54
    • (2003) Nat Genet , vol.33 , Issue.SUPPL. , pp. 245-254
    • Jaenisch, R.1    Bird, A.2
  • 111
    • 48449090298 scopus 로고    scopus 로고
    • Epigenetic biomarkers for human cancer: The time is now
    • doi:10.1016/j.critrevonc. 2008.03.001
    • Mulero-Navarro S, Esteller M. Epigenetic biomarkers for human cancer: The time is now. Crit Rev Oncol Hematol 2008; doi:10.1016/j.critrevonc. 2008.03.001
    • (2008) Crit Rev Oncol Hematol
    • Mulero-Navarro, S.1    Esteller, M.2
  • 112
    • 33845969839 scopus 로고    scopus 로고
    • Dietary polyphenols may affect DNA methylation
    • Fang M, Chen D, Yang CS. Dietary polyphenols may affect DNA methylation. J Nutr 2007; 137: 223S-8S
    • (2007) J Nutr , vol.137
    • Fang, M.1    Chen, D.2    Yang, C.S.3
  • 113
    • 37149017725 scopus 로고    scopus 로고
    • Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells
    • Fini L, Selgrad M, Fogliano V, Craziani G, Romano M, Hotchkiss E et al. Annurca apple polyphenols have potent demethylating activity and can reactivate silenced tumor suppressor genes in colorectal cancer cells. J Nutr 2007; 137: 2622-8
    • (2007) J Nutr , vol.137 , pp. 2622-2628
    • Fini, L.1    Selgrad, M.2    Fogliano, V.3    Craziani, G.4    Romano, M.5    Hotchkiss, E.6
  • 114
    • 38149127981 scopus 로고    scopus 로고
    • Bioactive food components that enhance γδT cell function may play a role in cancer prevention
    • Percival SS, Bukowski JF, Milner J. Bioactive food components that enhance γδT cell function may play a role in cancer prevention. J Nutr 2008; 138: 1-4
    • (2008) J Nutr , vol.138 , pp. 1-4
    • Percival, S.S.1    Bukowski, J.F.2    Milner, J.3
  • 115
    • 38449104165 scopus 로고    scopus 로고
    • Holderness J, Jackiw L, Kimmel E, Kerns H, Radke M, Hedges JF et al. Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells. J Immunol2007; 179: 6468-78
    • Holderness J, Jackiw L, Kimmel E, Kerns H, Radke M, Hedges JF et al. Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells. J Immunol2007; 179: 6468-78
  • 116
    • 23644440265 scopus 로고    scopus 로고
    • Dietary unripe apple polyphenol inhibits the development of food allergies in murine models
    • Akiyama H, Sato Y, Watanabe T, Nagaoka MH, Yoshioko Y, Shoji T et al. Dietary unripe apple polyphenol inhibits the development of food allergies in murine models. FEBS Lett 2005; 579: 4485-91
    • (2005) FEBS Lett , vol.579 , pp. 4485-4491
    • Akiyama, H.1    Sato, Y.2    Watanabe, T.3    Nagaoka, M.H.4    Yoshioko, Y.5    Shoji, T.6
  • 117
    • 34548416749 scopus 로고    scopus 로고
    • Differential regulation of CD11b on γδT cells and monocytes in response to unripe apple polyphenols
    • Graff JC, Jutila MA. Differential regulation of CD11b on γδT cells and monocytes in response to unripe apple polyphenols. J Leukoc Biol 2007; 82: 603-7
    • (2007) J Leukoc Biol , vol.82 , pp. 603-607
    • Graff, J.C.1    Jutila, M.A.2
  • 118
    • 0031041492 scopus 로고    scopus 로고
    • Identification of catechin oligomers from apple (Malus pumila cv. Fuji) in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and fast-atom bombardment mass spectrometry
    • Ohnishi-Kameyama M, Yanagida A, Kanda T, Nagata T. Identification of catechin oligomers from apple (Malus pumila cv. Fuji) in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and fast-atom bombardment mass spectrometry. Rapid Commun Mass Spectrom 1997; 11: 31-6
    • (1997) Rapid Commun Mass Spectrom , vol.11 , pp. 31-36
    • Ohnishi-Kameyama, M.1    Yanagida, A.2    Kanda, T.3    Nagata, T.4
  • 119
    • 21544446990 scopus 로고    scopus 로고
    • Characteristics and physiological functions of polyphenols from apples
    • Akazome Y. Characteristics and physiological functions of polyphenols from apples. Biofactors 2004; 22: 311-4
    • (2004) Biofactors , vol.22 , pp. 311-314
    • Akazome, Y.1
  • 120
    • 1942502249 scopus 로고    scopus 로고
    • The toxicology and safety of apple polyphenol extract
    • Shoji T, Akazome Y, Kanda T, Ikeda M. The toxicology and safety of apple polyphenol extract. Food Chem Toxicol 2004; 42: 959-67
    • (2004) Food Chem Toxicol , vol.42 , pp. 959-967
    • Shoji, T.1    Akazome, Y.2    Kanda, T.3    Ikeda, M.4
  • 121
    • 1642353497 scopus 로고    scopus 로고
    • Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract
    • Ding M, Lu Y, Bowman L, Huang C, Leonard S. Wang L et al. Inhibition of AP-1 and neoplastic transformation by fresh apple peel extract. J Biol Chem 2004; 279: 10670-6
    • (2004) J Biol Chem , vol.279 , pp. 10670-10676
    • Ding, M.1    Lu, Y.2    Bowman, L.3    Huang, C.4    Leonard, S.5    Wang, L.6
  • 122
    • 15444371406 scopus 로고    scopus 로고
    • Apples prevent mammary tumors in rats
    • Liu RH, Liu J, Chen B. Apples prevent mammary tumors in rats. J Agric Food Chem 2005; 53: 2341-3
    • (2005) J Agric Food Chem , vol.53 , pp. 2341-2343
    • Liu, R.H.1    Liu, J.2    Chen, B.3
  • 123
    • 36448962005 scopus 로고    scopus 로고
    • Effect of apple polyphenol extract on hepatoma proliferation and invasion in culture and on tumor growth, metastasis, and abnormal lipoprotein profiles in hepatomabearing rats
    • Miura D, Miura Y, Yagasaki K. Effect of apple polyphenol extract on hepatoma proliferation and invasion in culture and on tumor growth, metastasis, and abnormal lipoprotein profiles in hepatomabearing rats. Biosci Biotechnol Biochem 2007; 71: 2743-50
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 2743-2750
    • Miura, D.1    Miura, Y.2    Yagasaki, K.3
  • 124
    • 24944571147 scopus 로고    scopus 로고
    • Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats
    • Barth SW, Fahndrich C, Bub A, Dietrich H, Watzl B, Will F et al. Cloudy apple juice decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal colon of DMH-initiated rats. Carcinogenesis 2005; 26: 1414-21
    • (2005) Carcinogenesis , vol.26 , pp. 1414-1421
    • Barth, S.W.1    Fahndrich, C.2    Bub, A.3    Dietrich, H.4    Watzl, B.5    Will, F.6
  • 125
    • 33847753091 scopus 로고    scopus 로고
    • Comparative study of polyphenolic content and antiradical activity of cloudy and clear apple juices
    • Oszmianski J, Wolniak M, Wojdylo A, Wawer I. Comparative study of polyphenolic content and antiradical activity of cloudy and clear apple juices. J Sci Food Agric 2007; 87: 573-9
    • (2007) J Sci Food Agric , vol.87 , pp. 573-579
    • Oszmianski, J.1    Wolniak, M.2    Wojdylo, A.3    Wawer, I.4
  • 126
    • 34249853737 scopus 로고    scopus 로고
    • Cloudy apple juice is more effective than apple polyphenols and an apple juice derived cloud fraction in a rat model of colon carcinogenesis
    • Barth SW, Faehndrich C, Bub A, Watzl B, Will F, Dietrich H et al. Cloudy apple juice is more effective than apple polyphenols and an apple juice derived cloud fraction in a rat model of colon carcinogenesis. J Agric Food Chem 2007; 55: 1181-7
    • (2007) J Agric Food Chem , vol.55 , pp. 1181-1187
    • Barth, S.W.1    Faehndrich, C.2    Bub, A.3    Watzl, B.4    Will, F.5    Dietrich, H.6
  • 127
    • 0029066820 scopus 로고
    • Effects of apple pectin on fecal bacterial enzymes in azoxymethane-induced rat colon carcinogenesis
    • Ohkami H, Tazawa K, Yamashita I, Shimizu T, Murai K. Kobashi K et al. Effects of apple pectin on fecal bacterial enzymes in azoxymethane-induced rat colon carcinogenesis. Jpn J Cancer Res 1995; 86: 523-9
    • (1995) Jpn J Cancer Res , vol.86 , pp. 523-529
    • Ohkami, H.1    Tazawa, K.2    Yamashita, I.3    Shimizu, T.4    Murai, K.5    Kobashi, K.6
  • 128
    • 56249137443 scopus 로고    scopus 로고
    • Pan L, Zessner H, Will F, Klimo K, Frank N. Dietrich H et al. et al. Natural cloudy apple juice and a poly phenol-enriched apple juice extract prevent intestinal adenoma formation in the App (Min/+) model for colon cancer prevention. Cancer Epidemiol Biomarkers Prev 2005; 14: 2715s
    • Pan L, Zessner H, Will F, Klimo K, Frank N. Dietrich H et al. et al. Natural cloudy apple juice and a poly phenol-enriched apple juice extract prevent intestinal adenoma formation in the App (Min/+) model for colon cancer prevention. Cancer Epidemiol Biomarkers Prev 2005; 14: 2715s
  • 130
    • 34247639887 scopus 로고    scopus 로고
    • Fiber can make your gut grow
    • Goodlad RA. Fiber can make your gut grow. Nutrition 2007; 23: 434-5
    • (2007) Nutrition , vol.23 , pp. 434-435
    • Goodlad, R.A.1
  • 131
    • 51749091105 scopus 로고    scopus 로고
    • Resistant carbohydrates stimulate cell proliferation and crypt fission in wild-type mice and in the Apc mouse model of intestinal cancer, association with enhanced polyp development
    • Mandir N, Englyst H, Goodlad RA. Resistant carbohydrates stimulate cell proliferation and crypt fission in wild-type mice and in the Apc mouse model of intestinal cancer, association with enhanced polyp development. Br J Nutr; 2008: 1-11
    • (2008) Br J Nutr , pp. 1-11
    • Mandir, N.1    Englyst, H.2    Goodlad, R.A.3
  • 132
  • 133
    • 0030475091 scopus 로고    scopus 로고
    • Effects of different types of dietary fiber preparations isolated from bamboo shoots, edible burdock, apple and corn on fecal steroid profiles of rats
    • Shimizu J, Yamada N, Nakamura K, Takita T, Innami S. Effects of different types of dietary fiber preparations isolated from bamboo shoots, edible burdock, apple and corn on fecal steroid profiles of rats. J Nutr Sci Vitaminol (Tokyo) 1996; 42: 527-39
    • (1996) J Nutr Sci Vitaminol (Tokyo) , vol.42 , pp. 527-539
    • Shimizu, J.1    Yamada, N.2    Nakamura, K.3    Takita, T.4    Innami, S.5
  • 134
    • 0000530533 scopus 로고    scopus 로고
    • Apple pomace liquefaction with pectinases and cellulases: Analytical data of the corresponding juices
    • Will F, Bauckhage K, Dietrich H. Apple pomace liquefaction with pectinases and cellulases: analytical data of the corresponding juices. Eur Food Res Technol 2000; 211: 291-7
    • (2000) Eur Food Res Technol , vol.211 , pp. 291-297
    • Will, F.1    Bauckhage, K.2    Dietrich, H.3
  • 135
    • 0037180991 scopus 로고    scopus 로고
    • Structural characterization of oligosaccharides and polysaccharides from apple juices produced by enzymatic pomace liquefaction
    • Mehrlander K, Dietrich H, Sembries S, Dongowski G, Will F. Structural characterization of oligosaccharides and polysaccharides from apple juices produced by enzymatic pomace liquefaction. J Agric Food Chem 2002; 50: 1230-6
    • (2002) J Agric Food Chem , vol.50 , pp. 1230-1236
    • Mehrlander, K.1    Dietrich, H.2    Sembries, S.3    Dongowski, G.4    Will, F.5
  • 136
    • 0141606981 scopus 로고    scopus 로고
    • Effects of dietary fibre-rich juice colloids from apple pomace extraction juices on intestinal fermentation products and microbiota in rats
    • Sembries S, Dongowski G, Jacobasch G, Mehrlander K, Will F, Dietrich H. Effects of dietary fibre-rich juice colloids from apple pomace extraction juices on intestinal fermentation products and microbiota in rats. Br J Nutr 2003; 90: 607-15
    • (2003) Br J Nutr , vol.90 , pp. 607-615
    • Sembries, S.1    Dongowski, G.2    Jacobasch, G.3    Mehrlander, K.4    Will, F.5    Dietrich, H.6
  • 137
    • 2342545913 scopus 로고    scopus 로고
    • Dietary fiber-rich colloids from apple pomace extraction juices do not affect food intake and blood serum lipid levels, but enhance fecal excretion of steroids in rats
    • Sembries S, Dongowski G, Mehrlander K, Will F, Dietrich H. Dietary fiber-rich colloids from apple pomace extraction juices do not affect food intake and blood serum lipid levels, but enhance fecal excretion of steroids in rats. J Nutr Biochem 2004; 15: 296-302
    • (2004) J Nutr Biochem , vol.15 , pp. 296-302
    • Sembries, S.1    Dongowski, G.2    Mehrlander, K.3    Will, F.4    Dietrich, H.5
  • 138
    • 33846533238 scopus 로고    scopus 로고
    • Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats
    • Sembries, Dongowski G, Mehrlander K, Will F, Dietrich H. Physiological effects of extraction juices from apple, grape, and red beet pomaces in rats. J Agric Food Chem 2006; 54: 10269-80
    • (2006) J Agric Food Chem , vol.54 , pp. 10269-10280
    • Sembries1    Dongowski, G.2    Mehrlander, K.3    Will, F.4    Dietrich, H.5
  • 139
    • 0038314499 scopus 로고    scopus 로고
    • Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats
    • Aprikian O, Duclos V, Guyot S, Besson C, Manach C, Bemalier A et al. Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats. J Nutr 2003; 133: 1860-5
    • (2003) J Nutr , vol.133 , pp. 1860-1865
    • Aprikian, O.1    Duclos, V.2    Guyot, S.3    Besson, C.4    Manach, C.5    Bemalier, A.6
  • 140
    • 18144423848 scopus 로고    scopus 로고
    • Comparison of the antioxidant activities of nine different fruits in human plasma
    • Ko SH, Choi SW, Ye SK, Cho BL, Kim HS, Chung MH. Comparison of the antioxidant activities of nine different fruits in human plasma. J Med Food 2005; 8: 41-6
    • (2005) J Med Food , vol.8 , pp. 41-46
    • Ko, S.H.1    Choi, S.W.2    Ye, S.K.3    Cho, B.L.4    Kim, H.S.5    Chung, M.H.6
  • 141
    • 39849089794 scopus 로고    scopus 로고
    • Simple method for determining human serum 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity - possible application in clinical studies on dietary antioxidants
    • Chrzczanowicz J, Cawron A, Zwolinska A, de Graft-Johnson J, Krajewski W, Krol M et al. Simple method for determining human serum 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging activity - possible application in clinical studies on dietary antioxidants. Clin Chem Lab Med 2008; 46: 342-9
    • (2008) Clin Chem Lab Med , vol.46 , pp. 342-349
    • Chrzczanowicz, J.1    Cawron, A.2    Zwolinska, A.3    de Graft-Johnson, J.4    Krajewski, W.5    Krol, M.6
  • 142
    • 34147102977 scopus 로고    scopus 로고
    • Relevance of apple consumption for protection against oxidative damage induced by hydrogen peroxide in human lymphocytes
    • Moffei F, Tarozzi A, Carbone F, Marchesi A, Hrelia S, Angeloni C et al. Relevance of apple consumption for protection against oxidative damage induced by hydrogen peroxide in human lymphocytes. Br J Nutr 2007; 97: 921-7
    • (2007) Br J Nutr , vol.97 , pp. 921-927
    • Moffei, F.1    Tarozzi, A.2    Carbone, F.3    Marchesi, A.4    Hrelia, S.5    Angeloni, C.6
  • 143
    • 34948860488 scopus 로고    scopus 로고
    • Effect of consumption of organically and conventionally produced apples on antioxidant activity and DNA damage in humans
    • Briviba K, Stracke BA, Rufer CE, Watzl B, Weibel FP, Bub A. Effect of consumption of organically and conventionally produced apples on antioxidant activity and DNA damage in humans. J Agric Food Chem 2007; 55: 7716-21
    • (2007) J Agric Food Chem , vol.55 , pp. 7716-7721
    • Briviba, K.1    Stracke, B.A.2    Rufer, C.E.3    Watzl, B.4    Weibel, F.P.5    Bub, A.6
  • 144
  • 145
    • 1642464724 scopus 로고    scopus 로고
    • Relevance of apple polyphenols as antioxidants in human plasma: Contrasting in vifro and in vivo effects
    • Lotito SB, Frei B. Relevance of apple polyphenols as antioxidants in human plasma: contrasting in vifro and in vivo effects. Free Radic Biol Med 2004; 36: 201-11
    • (2004) Free Radic Biol Med , vol.36 , pp. 201-211
    • Lotito, S.B.1    Frei, B.2
  • 146
    • 2942530588 scopus 로고    scopus 로고
    • The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids
    • Lotito SB, Frei B. The increase in human plasma antioxidant capacity after apple consumption is due to the metabolic effect of fructose on urate, not apple-derived antioxidant flavonoids. Free Radic Biol Med 2004; 37: 251-8
    • (2004) Free Radic Biol Med , vol.37 , pp. 251-258
    • Lotito, S.B.1    Frei, B.2
  • 147
    • 33750455858 scopus 로고    scopus 로고
    • Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: Cause, consequence, or epiphenomenon?
    • Lotito SB, Frei B. Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 2006; 41: 1727-46
    • (2006) Free Radic Biol Med , vol.41 , pp. 1727-1746
    • Lotito, S.B.1    Frei, B.2
  • 154
    • 0030004263 scopus 로고    scopus 로고
    • Vegetables, fruits, and risk of colorectal cancer: A case-control study from Uruguay
    • Deneo-Pellegrini H, De Stefani E, Ronco A. Vegetables, fruits, and risk of colorectal cancer: a case-control study from Uruguay. Nutr Cancer 1996;25:297-304
    • (1996) Nutr Cancer , vol.25 , pp. 297-304
    • Deneo-Pellegrini, H.1    De Stefani, E.2    Ronco, A.3
  • 155
    • 16244371333 scopus 로고    scopus 로고
    • (The relationship between intake of vegetables and fruits and colorectal adenoma-carcinoma sequence]
    • Lee SY, Choi KY, Kim MK, Kim KM, Lee JH, Meng KH et al. (The relationship between intake of vegetables and fruits and colorectal adenoma-carcinoma sequence]. Korean J Castroenterol 2005; 45: 23-33
    • (2005) Korean J Castroenterol , vol.45 , pp. 23-33
    • Lee, S.Y.1    Choi, K.Y.2    Kim, M.K.3    Kim, K.M.4    Lee, J.H.5    Meng, K.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.