Interaction potential between cranberry juice and warfarin

American Journal of Health-System Pharmacy

Volumn 64, Issue 5, 2007, Pages 490-494

  Pham, David Q ^a,b   Pham, Antony Q ^c  

^a LONG ISLAND UNIVERSITY   (United States)

^b KINGS COUNTY HOSPITAL CENTER   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anticoagulants; Drug interactions; International Normalized Ratio; Juices; Metabolism; Toxicity; Vaccinium macrocarpon; Warfarin

Indexed keywords

CEFALEXIN; CYCLOSPORIN; CYTOCHROME P450 2C9; CYTOCHROME P450 3A; DIGOXIN; FLUCONAZOLE; FLURBIPROFEN; PHENYTOIN; VITAMIN K GROUP; WARFARIN;

AGED; ANTICOAGULANT THERAPY; AREA UNDER THE CURVE; BLEEDING; CASE REPORT; CLINICAL TRIAL; CRANBERRY JUICE; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; ENZYME INDUCTION; ENZYME INHIBITION; FOOD DRUG INTERACTION; HUMAN; HUMAN EXPERIMENT; INTERNATIONAL NORMALIZED RATIO; MALE; NORMAL HUMAN; PATIENT MONITORING; PRIORITY JOURNAL; REVIEW; SINGLE DRUG DOSE; UNITED KINGDOM;

EID: 33847394490     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/ajhp060370     Document Type: Review

References (29)

1. Bailey DG, Spense JF, Munoz C et al. Interaction of citrus juices with felodipine and nifedipine. Lancet. 1991; 337:268-9.
2. Malhotra S, Bailey DG, Paine MF et al. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther. 2001; 69:14-23.
3. Di Marco MP, Edwards DJ, Wainer IW et al. The effect of grapefruit juice and Seville orange juice on the pharmacokinetics of dextromethorphan: the role of gut CYP3A and P-glycoprotein. Life Sci. 2002; 71:1149-60.
4. Takanaga H, Ohnishi A, Matsuo H et al. Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on a irreversible enzyme inhibition model. Br J Clin Pharmacol. 2000; 49:49-58.
5. Hirsh I, Dalen JE, Anderson DR et al. Oral anticoagulants: mechanisms of action, clinical effectiveness and optimal therapeutic range. Chest. 1998; 114:445S-9S.
6. Fihn SD, McDonell M, Martin D et al. Risk factors for complications of chronic anticoagulation. Ann Intern Med. 1993; 118:511-20.
7. The Stroke Prevention in Atrial Fibrillation Investigators. Bleeding during antithrombotic therapy in patients with atrial fibrillation. Arch Intern Med. 1996; 156:409-16.
8. Lee CR, Goldstein JA, Pieper JA. Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data. Pharmacogenetics. 2002; 12:251-63.
9. Herman D, Locatelli I, Grabnar I et al. Influence of CYP2C9 polymorphisms, demographic factors and concomitant drug therapy on warfarin metabolism and maintenance dose. Pharmacogenomics J. 2005; 5:193-202.
10. Committee on Safety of Medicines, Medicines and Healthcare Products Regulatory Agency. Possible interaction between warfarin and cranberry juice. Curr Probl Pharmacovigil. 2003; 29:8.
11. Committee on Safety of Medicines, Medicines and Healthcare Products Regulatory Agency. Interaction between warfarin and cranberry juice: new advice. Curr Probl Pharmacovigil. 2004; 30:10.
12. Holbrook AM, Pereira J, Labiris R et al. Systematic overview of warfarin and its drug and food interactions. Arch Intern Med. 2005; 165:1095-106.
13. Ferguson LR. Role of plant polyphenols in genomic stability. Mutat Res. 2001; 475:89-111.
14. Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact. 2002; 139:1-21.
15. Sanderson J, McLauchlan WR, Williamson G. Quecetin inhibits hydrogen peroxide-induced oxidation of the rat lens. Free Radic Biol Med. 1999; 26:639-45.
16. Griffiths P. The role of cranberry juice in the treatment of urinary tract infections. Br J Community Nurs. 2003; 8:557-61.
17. Grenier J, Fradette C, Morelli G et al. Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans. Clin Pharmacol Ther. 2006; 79:255-62.
18. Greenblatt DJ, von Molkte LL, Perloff ES et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther. 2006; 79:125-33.
19. Grant P. Warfarin and cranberry juice: an interaction? J Heart Valve Dis. 2004; 13:25-6.
20. Kamali F, Khan TL, King BP et al. Contribution of age, body size and CYP2C9 genotype to anticoagulant response to warfarin. Clin Pharmacol Ther. 2004; 75:204-12.
21. D'Andrea G, D'Ambrosio RL, Di Perna P et al. A polymorphism in VKORC1 gene is associated with an inter-individual variability in the dose-anticoagulant effect of warfarin. Blood. 2005; 105:645-9.
22. Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ. 2003; 327:1454.
23. Abdel-Razzak Z, Loyer P, Fautrel A et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol. 1993; 44:707-15.
24. Guillen MI, Donato MT, Jover R et al. Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes. J Pharmacol Exp Ther. 1998; 285:127-34.
25. Sunman JA, Hawke RL, LeCluyse EL et al. Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab Dispos. 2004; 32:359-63.
26. Franco V, Polanczyk CA, Clausell N et al. Role of dietary vitamin K intake in chronic oral anticoagulation: prospective evidence from observational and randomized protocols. Am J Med. 2004; 116:711-3.
27. Rindone JP, Murphy TW. Warfarin-cranberry juice interaction resulting in profound hypoprothrombinemia and bleeding. Am J Ther. 2006; 13:283-4.
28. Tracy TS, Marra C, Wrighton SA et al. Studies of flurbiprofen 4′-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9. Biochem Pharmacol. 1996; 52:1305-9.
29. Li Z, Seeram NP, Carpenter CL et al. Cranberry does not affect prothombin time in male subjects on warfarin. J Am Diet Assoc. 2006; 106:2057-61.