The grapefruit-drug interaction debate: Role of statins [1]

American Family Physician

Volumn 76, Issue 2, 2007, Pages 190-

  Reamy, Brian V ^a   Stephens, Mark B ^a  

^a Uniformed Services University of the Health Sciences and the Walter Reed National Military Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; SIMVASTATIN;

ATHEROSCLEROTIC CARDIOVASCULAR DISEASE; FOOD DRUG INTERACTION; GRAPEFRUIT; GRAPEFRUIT JUICE; HUMAN; HYPERLIPIDEMIA; LETTER; MORTALITY; PHYSICIAN; UNITED STATES;

ATHEROSCLEROSIS; BEVERAGES; CITRUS PARADISI; FOOD-DRUG INTERACTIONS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS;

EID: 34547153752     PISSN: 0002838X     EISSN: 0002838X     Source Type: Journal    
DOI: None     Document Type: Letter

References (6)

1. Stump AL, Mayo T, Blum A. Management of grapefruit-drug interactions. Am Fam Physician 2006;74:605-8.
2. McGlynn EA, Asch SM, Adams J, Kessey J, Hicks J, DeCristofaro A, et al. The quality of health care delivered to adults in the United States. N Engl J Med 2003; 348:2635-45.
3. Kantola T, Kivisto KT, Neuvonen PJ. Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid. Clin Pharmacol Ther 1998;63:397-402.
4. Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors. Clin Pharmacol Ther 1998;64:477-83.
5. Rogers JD, Zhao J, Liu L, Amin RD, Gagliano KD, Porras AG, et al. Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Clin Pharmacol Ther 1999;66:358-66.
6. Lilja JJ, Kivisto KT, Neuvonen PJ. Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin. Clin Pharmacol Ther 2000;68:384-90.