Current views of toll-like receptor signaling pathways

Gastroenterology Research and Practice

Volumn , Issue , 2010, Pages

  Takeda, Kiyoshi ^a   Yamamoto, Masahiro ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; DECTIN 1; DOUBLE STRANDED RNA; GAMMA INTERFERON; GLYCOSYLPHOSPHATIDYLINOSITOL; HEMAGGLUTININ; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 11;

CARBOXY TERMINAL SEQUENCE; IMMUNE RESPONSE; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; WEST NILE FLAVIVIRUS;

EID: 79251563125     PISSN: 16876121     EISSN: 1687630X     Source Type: Journal    
DOI: 10.1155/2010/240365     Document Type: Review

References (91)

1. Akira S., Uematsu S., Takeuchi O., Pathogen recognition and innate immunity Cell 2006 124 4 783 801
2. Beutler B., Eidenschenk C., Crozat K., Imler J.-L., Takeuchi O., Hoffmann J. A., Akira S., Genetic analysis of resistance to viral infection Nature Reviews Immunology 2007 7 10 753 766
3. Medzhitov R., Recognition of microorganisms and activation of the immune response Nature 2007 449 7164 819 826
4. Janeway C. A. Jr., Approaching the asymptote? Evolution and revolution in immunology Cold Spring Harbor Symposia on Quantitative Biology 1989 54 1 1 13
5. Lemaitre B., Nicolas E., Michaut L., Reichhart J.-M., Hoffmann J. A., The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults Cell 1996 86 6 973 983
6. Medzhitov R., Preston-Hurlburt P., Janeway C. A. Jr., A human homologue of the Drosophila toll protein signals activation of adaptive immunity Nature 1997 388 6640 394 397
7. Hoffmann J. A., The immune response of Drosophila Nature 2003 426 6962 33 38
8. Gay N. J., Keith F. J., Drosophila Toll and IL-1 receptor Nature 1991 351 6325 355 356
9. Yamamoto M., Takeda K., Akira S., TIR domain-containing adaptors define the specificity of TLR signaling Molecular Immunology 2004 40 12 861 868
10. Kawai T., Akira S., Innate immune recognition of viral infection Nature Immunology 2006 7 2 131 137 (Pubitemid 43135878)
11. Poltorak A., He X., Smirnova I., Liu M.-Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., Beutler B., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene Science 1998 282 5396 2085 2088
12. Qureshi S. T., Larivire L., Leveque G., Clermont S., Moore K. J., Gros P., Malo D., Endotoxin-tolerant mice have mutations in toll-like receptor 4 (Tlr4) Journal of Experimental Medicine 1999 189 4 615 625
13. Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., Akira S., Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product Journal of Immunology 1999 162 7 3749 3752
14. Takeuchi O., Sato S., Horiuchi T., Hoshino K., Takeda K., Dong Z., Modlin R. L., Akira S., Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins Journal of Immunology 2002 169 1 10 14
15. Alexopoulou L., Thomas V., Schnare M., Lobet Y., Anguita J., Schoen R. T., Medzhitov R., Fikrig E., Flavell R. A., Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice Nature Medicine 2002 8 8 878 884
16. Takeuchi O., Kawai T., Mhlradt P. F., Morr M., Radolf J. D., Zychlinsky A., Takeda K., Akira S., Discrimination of bacterial lipoproteins by Toll-like recepttor 6 International Immunology 2001 13 7 933 940
17. Wagner H., Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity Current Opinion in Microbiology 2002 5 1 62 69
18. Krieg A. M., CpG motifs in bacterial DNA and their immune effects Annual Review of Immunology 2002 20 709 760
19. Coban C., Ishii K. J., Kawai T., Hemmi H., Sato S., Uematsu S., Yamamoto M., Takeuchi O., Itagaki S., Kumar N., Horii T., Akira S., Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin Journal of Experimental Medicine 2005 201 1 19 25
20. Diebold S. S., Kaisho T., Hemmi H., Akira S., Reis E Sousa C., Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA Science 2004 303 5663 1529 1531 (Pubitemid 38314425)
21. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., Bauer S., Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 Science 2004 303 5663 1526 1529
22. Miller R. L., Gerster J. F., Owens M. L., Slade H. B., Tomai M. A., Review article Imiquimod applied topically: a novel immune response modifier and new class of drug International Journal of Immunopharmacology 1999 21 1 1 14
23. Tyring S., Immune response modification: imiquimod Australasian Journal of Dermatology 1998 39 supplement 1 S11 S13
24. Hayashi F., Smith K. D., Ozinsky A., Hawn T. R., Yi E. C., Goodlett D. R., Eng J. K., Akira S., Underhill D. M., Aderem A., The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5 Nature 2001 410 6832 1099 1103
25. Plattner F., Yarovinsky F., Romero S., Didry D., Carlier M.-F., Sher A., Soldati-Favre D., Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response Cell Host and Microbe 2008 3 2 77 87
26. Yarovinsky F., Zhang D., Andersen J. F., Bannenberg G. L., Serhan C. N., Hayden M. S., Hieny S., Sutterwala F. S., Flavell R. A., Ghosh S., Sher A., Immunology: TLR11 activation of dendritic cells by a protozoan profilin-like protein Science 2005 308 5728 1626 1629
27. Zhang D., Zhang G., Hayden M. S., Greenblatt M. B., Bussey C., Flavell R. A., Ghosh S., A Toll-like receptor that prevents infection by uropathogenic bacteria Science 2004 303 5663 1522 1526
28. Jin M. S., Lee J.-O., Structures of the Toll-like receptor family and its ligand complexes Immunity 2008 29 2 182 191
29. Choe J., Kelker M. S., Wilson I. A., Structural biology: crystal structure of human toll-like receptor 3 (TLR3) ectodomain Science 2005 309 5734 581 585
30. Kim H. M., Park B. S., Kim J.-I., Kim S. E., Lee J., Oh S. C., Enkhbayar P., Matsushima N., Lee H., Yoo O. J., Lee J.-O., Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran Cell 2007 130 5 906 917
31. Jin M. S., Kim S. E., Heo J. Y., Lee M. E., Kim H. M., Paik S.-G., Lee H., Lee J.-O., Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide Cell 2007 130 6 1071 1082
32. Kang J. Y., Nan X., Jin M. S., Youn S.-J., Ryu Y. H., Mah S., Han S. H., Lee H., Paik S.-G., Lee J.-O., Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer Immunity 2009 31 6 873 848
33. Miyake K., Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors Seminars in Immunology 2007 19 1 3 10
34. Hoebe K., Georgel P., Rutschmann S., Du X., Mudd S., Crozat K., Sovath S., Shamel L., Hartung T., Zhringer U., Beutler B., CD36 is a sensor of diacylglycerides Nature 2005 433 7025 523 527
35. Gantner B. N., Simmons R. M., Canavera S. J., Akira S., Underhill D. M., Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2 Journal of Experimental Medicine 2003 197 9 1107 1117
36. Latz E., Schoenemeyer A., Visintin A., Fitzgerald K. A., Monks B. G., Knetter C. F., Lien E., Nilsen N. J., Espevik T., Golenbock D. T., TLR9 signals after translocating from the ER to CpG DNA in the lysosome Nature Immunology 2004 5 2 190 198
37. Nishiya T., Kajita E., Miwa S., DeFranco A. L., TLR3 and TLR7 are targeted to the same intracellular compartments by distinct regulatory elements Journal of Biological Chemistry 2005 280 44 37107 37117
38. Tabeta K., Hoebe K., Janssen E. M., Du X., Georgel P., Crozat K., Mudd S., Mann N., Sovath S., Goode J., Shamel L., Herskovits A. A., Portnoy D. A., Cooke M., Tarantino L. M., Wiltshire T., Steinberg B. E., Grinstein S., Beutler B., The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9 Nature Immunology 2006 7 2 156 164
39. Ewald S. E., Lee B. L., Lau L., Wickliffe K. E., Shi G.-P., Chapman H. A., Barton G. M., The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor Nature 2008 456 7222 658 662
40. Park B., Brinkmann M. M., Spooner E., Lee C. C., Kim Y.-M., Ploegh H. L., Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 Nature Immunology 2008 9 12 1407 1414
41. Barton G. M., Kagan J. C., Medzhitov R., Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA Nature Immunology 2006 7 1 49 56
42. Karin M., Yamamoto Y., Wang Q. M., The IKK NF- B system: a treasure trove for drug development Nature Reviews Drug Discovery 2004 3 1 17 26
43. Yamamoto M., Yamazaki S., Uematsu S., Sato S., Hemmmi H., Hoshino K., Kaisho T., Kuwata H., Takeuchi O., Takeshige K., Saitoh T., Yamaoka S., Yamamoto N., Yamamoto S., Muta T., Takeda K., Akira S., Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein I B Nature 2004 430 6996 218 222
44. Goto A., Matsushita K., Gesellchen V., Chamy L. E., Kuttenkeuler D., Takeuchi O., Hoffmann J. A., Akira S., Boutros M., Reichhart J.-M., Akirins are highly conserved nuclear proteins required for NF- B-dependent gene expression in drosophila and mice Nature Immunology 2008 9 1 97 104
45. Yamamoto M., Takeda K., Role of nuclear I B proteins in the regulation of host immune responses Journal of Infection and Chemotherapy 2008 14 4 265 269
46. Delaney J. R., Mlodzik M., TGF- activated kinase-1: new insights into the diverse roles of TAK1 in development and immunity Cell Cycle 2006 5 24 2852 2855
47. Komatsu Y., Shibuya H., Takeda N., Ninomiya-Tsuji J., Yasui T., Miyado K., Sekimoto T., Ueno N., Matsumoto K., Yamada G., Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis Mechanisms of Development 2002 119 2 239 249
48. Sanjo H., Takeda K., Tsujimura T., Ninomiya-Tsuji J., Matsumoto K., Akira S., TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling Molecular and Cellular Biology 2003 23 4 1231 1238
49. Inagaki M., Komatsu Y., Scott G., Yamada G., Ray M., Ninomiya-Tsuji J., Mishina Y., Generation of a conditional mutant allele for Tab1 in mouse Genesis 2008 46 8 431 439
50. Adhikari A., Xu M., Chen Z. J., Ubiquitin-mediated activation of TAK1 and IKK Oncogene 2007 26 22 3214 3226
51. Hofmann R. M., Pickart C. M., Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair Cell 1999 96 5 645 653
52. Kawai T., Akira S., TLR signaling Seminars in Immunology 2007 19 1 24 32
53. Yamamoto M., Okamoto T., Takeda K., Sato S., Sanjo H., Uematsu S., Saitoh T., Yamamoto N., Sakurai H., Ishii K. J., Yamaoka S., Kawai T., Matsuura Y., Takeuchi O., Akira S., Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling Nature Immunology 2006 7 9 962 970
54. Sato S., Sanjo H., Takeda K., Ninomiya-Tsuji J., Yamamoto M., Kawai T., Matsumoto K., Takeuchi O., Akira S., Essential function for the kinase TAK1 in innate and adaptive immune responses Nature Immunology 2005 6 11 1087 1095
55. Shim J.-H., Xiao C., Paschal A. E., Bailey S. T., Rao P., Hayden M. S., Lee K.-Y., Bussey C., Steckel M., Tanaka N., Yamada G., Akira S., Matsumoto K., Ghosh S., TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo Genes and Development 2005 19 22 2668 2681
56. Janssens S., Beyaert R., Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members Molecular Cell 2003 11 2 293 302
57. Suzuki N., Suzuki S., Yeh W.-C., IRAK-4 as the central TIR signaling mediator in innate immunity Trends in Immunology 2002 23 10 503 506
58. Li S., Strelow A., Fontana E. J., Wesche H., IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase Proceedings of the National Academy of Sciences of the United States of America 2002 99 8 5567 5572
59. Adachi O., Kawai T., Takeda K., Matsumoto M., Tsutsui H., Sakagami M., Nakanishi K., Akira S., Targeted disruption of the MyD88 gene results in loss of IL-1- and IL- 18-mediated function Immunity 1998 9 1 143 150
60. Takeuchi O., Kaufmann A., Grote K., Kawai T., Hoshino K., Morr M., Mhlradt P. F., Akira S., Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway Journal of Immunology 2000 164 2 554 557
61. Yamamoto M., Sato S., Hemmi H., Sanjo H., Uematsu S., Kaisho T., Hoshino K., Takeuchi O., Kobayashi M., Fujita T., Takeda K., Akira S., Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 Nature 2002 420 6913 324 329
62. Horng T., Barton G. M., Flavell R. A., Medzhitov R., The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors Nature 2002 420 6913 329 333
63. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., Takeuchi O., Sugiyama M., Okabe M., Takeda K., Akira S., Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway Science 2003 301 5633 640 643 (Pubitemid 36927946)
64. Hoebe K., Du X., Georgel P., Janssen E., Tabeta K., Kim S. O., Goode J., Lin P., Mann N., Mudd S., Crozat K., Sovath S., Han J., Beutler B., Identification of Lps2 as a key transducer of MyD88-independent TIR signalling Nature 2003 424 6950 743 748
65. Alexopoulou L., Holt A. C., Medzhitov R., Flavell R. A., Recognition of double-stranded RNA and activation of NF- B by Toll-like receptor 3 Nature 2001 413 6857 732 738
66. Yamamoto M., Sato S., Hemmi H., Uematsu S., Hoshino K., Kaisho T., Takeuchi O., Takeda K., Akira S., TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway Nature Immunology 2003 4 11 1144 1150 (Pubitemid 37428043)
67. Fitzgerald K. A., Rowe D. C., Barnes B. J., Caffrey D. R., Visintin A., Latz E., Monks B., Pitha P. M., Golenbock D. T., LPS-TLR4 signaling to IRF-3/7 and NF- B involves the toll adapters TRAM and TRIF Journal of Experimental Medicine 2003 198 7 1043 1055
68. Oshiumi H., Sasai M., Shida K., Fujita T., Matsumoto M., Seya T., TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon- Journal of Biological Chemistry 2003 278 50 49751 49762
69. Kagan J. C., Su T., Horng T., Chow A., Akira S., Medzhitov R., TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon- Nature Immunology 2008 9 4 361 368
70. Tseng P.-H., Matsuzawa A., Zhang W., Mino T., Vignali D. A. A., Karin M., Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines Nature Immunology 2010 11 70 75
71. Carty M., Goodbody R., Schrder M., Stack J., Moynagh P. N., Bowie A. G., The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling Nature Immunology 2006 7 10 1074 1081
72. Kim Y., Zhou P., Qian L., Chuang J.-Z., Lee J., Li C., Iadecola C., Nathan C., Ding A., MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival Journal of Experimental Medicine 2007 204 9 2063 2074
73. Gilliet M., Cao W., Liu Y.-J., Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases Nature Reviews Immunology 2008 8 8 594 606
74. Honda K., Taniguchi T., IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors Nature Reviews Immunology 2006 6 9 644 658
75. Hcker H., Redecke V., Blagoev B., Kratchmarova I., Hsu L.-C., Wang G. G., Kamps M. P., Raz E., Wagner H., Hcker G., Mann M., Karin M., Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6 Nature 2006 439 7073 204 207
76. Oganesyan G., Saha S. K., Guo B., He J. Q., Shahangian A., Zarnegar B., Perry A., Cheng G., Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response Nature 2006 439 7073 208 211
77. Fitzgerald K. A., McWhirter S. M., Faia K. L., Rowe D. C., Latz E., Golenbock D. T., Coyle A. J., Liao S.-M., Maniatis T., IKKE and TBKI are essential components of the IRF3 signalling pathway Nature Immunology 2003 4 5 491 496
78. Sharma S., Ten Oever B. R., Grandvaux N., Zhou G.-P., Lin R., Hiscott J., Triggering the interferon antiviral response through an IKK-related pathway Science 2003 300 5622 1148 1151
79. Yoneyama M., Suhara W., Fukuhara Y., Fukuda M., Nishida E., Fujita T., Direct triggering of the type I interferon system by virus infection: activation of a transcription factor complex containing IRF-3 and CBP/p300 EMBO Journal 1998 17 4 1087 1095
80. Fujita F., Taniguchi Y., Kato T., Narita Y., Furuya A., Ogawa T., Sakurai H., Joh T., Itoh M., Delhase M., Karin M., Nakanishi M., Identification of NAP1, a Regulatory Subunit of I B Kinase-Related Kinases That Potentiates NF- B Signaling Molecular and Cellular Biology 2003 23 21 7780 7793
81. Ryzhakov G., Randow F., SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK EMBO Journal 2007 26 13 3180 3190
82. Sasai M., Shingai M., Funami K., Yoneyama M., Fujita T., Matsumoto M., Seya T., NAK-associated protein 1 participates in both the TLR3 and the cytoplasmic pathways in type I IFN induction Journal of Immunology 2006 177 12 8676 8683
83. Kawai T., Sato S., Ishii K. J., Coban C., Hemmi H., Yamamoto M., Terai K., Matsuda M., Inoue J.-I., Uematsu S., Takeuchi O., Akira S., Interferon- induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 Nature Immunology 2004 5 10 1061 1068
84. Honda K., Yanai H., Negishi H., Asagiri M., Sato M., Mizutani T., Shimada N., Ohba Y., Takaoka A., Yoshida N., Taniguchi T., IRF-7 is the master regulator of type-I interferon-dependent immune responses Nature 2005 434 7034 772 777
85. Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F., Matsuda M., Coban C., Ishii K. J., Kawai T., Takeuchi O., Akira S., Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon- induction Journal of Experimental Medicine 2005 201 6 915 923
86. Hoshino K., Sugiyama T., Matsumoto M., Tanaka T., Saito M., Hemmi H., Ohara O., Akira S., Kaisho T., I B kinase- is critical for interferon- production induced by Toll-like receptors 7 and 9 Nature 2006 440 7086 949 953
87. Kawai T., Akira S., The roles of TLRs, RLRs and NLRs in pathogen recognition International Immunology 2009 21 4 317 337
88. Negishi H., Fujita Y., Yanai H., Sakaguchi S., Ouyang X., Shinohara M., Takayanagi H., Ohba Y., Taniguchi T., Honda K., Evidence for licensing of IFN- -induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program Proceedings of the National Academy of Sciences of the United States of America 2006 103 41 15136 15141
89. Schmitz F., Heit A., Guggemoos S., Krug A., Mages J., Schiemann M., Adler H., Drexler I., Haas T., Lang R., Wagner H., Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN- production in myeloid dendritic cells European Journal of Immunology 2007 37 2 315 327
90. Tailor P., Tamura T., Kong H. J., Kubota T., Kubota M., Borghi P., Gabriele L., Ozato K., The feedback phase of type I interferon induction in dendritic cells requires interferon regulatory factor 8 Immunity 2007 27 2 228 239
91. Takaoka A., Yanai H., Kondo S., Duncan G., Negishi H., Mizutani T., Kano S.-I., Honda K., Ohba Y., Mak T. W., Taniguchi T., Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors Nature 2005 434 7030 243 249