Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice

Nature Immunology

Volumn 9, Issue 1, 2008, Pages 97-104

  Goto, Akira ^a,d   Matsushita, Kazufumi ^b   Gesellchen, Viola ^c   Chamy, Laure El ^a   Kuttenkeuler, David ^c   Takeuchi, Osamu ^b   Hoffmann, Jules A ^a   Akira, Shizuo ^b   Boutros, Michael ^c   Reichhart, Jean Marc ^a  

^a INSTITUT DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b OSAKA UNIVERSITY   (Japan)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AKIRIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NUCLEAR PROTEIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENE ISOLATION; GRAM NEGATIVE BACTERIUM; IMMUNE DEFICIENCY; INNATE IMMUNITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, MAMMALIAN; FIBROBLASTS; HUMANS; IMMUNITY, NATURAL; INTERLEUKIN-1BETA; MICE; MICE, TRANSGENIC; NF-KAPPA B; NUCLEAR PROTEINS; PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 37349109479     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1543     Document Type: Article

References (43)

1. Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006).
2. Brennan, C.A. & Anderson, K.V. Drosophila: The genetics of innate immune recognition and response. Annu. Rev. Immunol. 22, 457-483 (2004).
3. Hoffmann, J.A. The immune response of Drasophila. Nature 426 33-38 (2003).
4. Lemaitre, B. & Hoffmann, J. The host defense of Drosophila melanogaster. Annu. Rev. Immunol. 25, 697-743 (2007).
5. Haffmann, J.A. & Reichhart, J.M. Drosophila innate immunity: An evolutionary perspective. Nat. Immunol. 3, 121-126 (2002).
6. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M. & Hoffmann, J.A. The dorsoventral regulatory gene cassette spatzlel Toll/cactus controls the patent antifungal response in Drosophila adults. Cell 86, 973-983 (1996).
7. Weber, A.N. et al. Binding of the Drosophila cytokine Spatzle to Toll is direct and establishes signaling. Nat. Immunol. 4, 794-800 (2003).
8. Ip, Y. et al. Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell 75, 753-763 (1993).
9. Rutschmann, S. et al. The Rel protein, DIF mediates the antifungal but not the antibacterial host defense in Drosophila. Immunity 12, 569-580 (2000).
10. Tauszig-Delamasure, S., Bilak, H., Capovilla, M., Hoffmann, J.A. & Imler, J.L. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat. Immunol. 3 91-97 (2002).
11. Stoven, S. et al. Caspase-mediated processing of the Drosophila NF-κB factor Relish. Proc. Natl. Acad Sci. USA 100, 5991-5996 (2003).
12. Silverman, N. et al. A Drasophila IκB kinase complex required for Relish cleavage and antibacterial immunity. Genes Dev. 14, 2461-2471 (2000).
13. Dushay, M.S., Asling, B. & Hultmark, D. Origins of immunity: Relish a compound Rel-like gene in the antibacterial defense of Drosophila. Proc. Natl. Acad Sci. USA 93, 10343-10347 (1996).
14. Mak, T.W. & Yeh, W.C. Signaling for survival and apoptosis in the immune system. Arthritis Res. 4, S243-S252 (2002).
15. Choe, K.M., Werner, T., Stoven, S., Hultmark, D. & Anderson, K.V. Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 296, 359-362 (2002).
16. Gottar, M. et al. The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 416, 640-644 (2002).
17. Leulier, F. et al. The Drosophila immune system detects bacteria through specific peptidoglycary recognition. Nat. Immunol. 4, 478-484 (2003).
18. Kaneko, T. et al. Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity 20, 637-649 (2004).
19. Mellroth, P. et al. Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro. Prac. Natl. Acad. Sci. USA 102, 6455-6460 (2005).
20. Takehana, A. et al. Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/ relish-mediated antibacterial defense and the prophenoloxidase cascade in Dirosophila larvae. Proc. Natl. Acad. Sci. USA 99, 13705-13710 (2002).
21. Choe, K.M., Lee, H. & Anderson, K.V. Drosophila peptidoglycan recognition protein LC (PGRP-LC) acts as a signal-transducing innate immune receptor. Proc. Natl. Acad. Sci. USA 102, 1122-1126 (2005).
22. Georgel, P. et al. Drosaphila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis, Dev. Cell 1, 503-514 (2001)
23. Kelliher, M.A. et al. The death domain kinase RIP mediates the TNF-induced NF-κB signal. Immunity 8, 297-7303 (1998).
24. Leulier, F., Rodriguez, A., Khush, R.S., Abrams, J.M. & Lemaitre, B. The Drosophila caspase Dredd is required to resist gram-negative bacterial infection. EMBO Rep. 1, 353-358 (2000).
25. Naitza, S. et al. The Drosophila immune defense against gram-negative infection requires the death protein dFADD. Immunity 17, 575-581 (2002).
26. Zhuang, Z.H. et al. Drosophila TAB2 is required for the immune activation of JNK and NF-κB. Cell. Signal. 18, 964-970 (2006).
27. Gesellchen, V., Kuttenkeuler, D., Steckel, M,., Pelte, N. & Boutros, M. An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosqphila. EMBO Rep. 6, 979-984 (2005).
28. Vidal, S. et al. Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/ NF-κB-dependent innate immune responses. Genes Dev. 15, 1900-1912 (2001).
29. Rutschmann, S. et al. Role of Drosophila IKKγ in a-toll-independent antibacterial immune response. Nat. Immunol. 1, 342-347 (2000).
30. Lu, Y., Wu, L.P. & Anderson, K.V. The antibacterial arm of the Drosophila innate immune response requires an IκB kinase. Genes Dev. 15, 104-110 (2001).
31. Deng, L. et al. Activation-of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiqulin chain. Cell 103, 351-361 (2000).
32. Wang, C. et al. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351 (2001).
33. Boutros, M. et al. Genome-wide RNAi analysis of graiih ana viability in Drosophila cells. Science 303, 832-835 (2004).
34. Crosby, M.A., Goodman, J.L., Strelets, V.B., Zhang, P. & Gelbart, W.M. FlyBase: Genomes by-the dozen. Nucleic Acids Res. 35, D486-D491 (2007).
35. Reichhart, J.M. et al. Splice-activated UAS hairpin vector gives complete RNAi knockout of single or double target transcripts in Drosophila melanagaster. Genesis 34, 160-164 (2002).
36. Pena-Rangel, M.T., Rodriguez, I. & Riesgo-Escovar, J.R. A misexpression study examining dorsal thorax formation in Drosaphila melanogaster. Genetics 160, 1035-1050 (2002).
37. DasGupta, R., Kaykas, A., Moon, R.T. & Perrimon, N. Functional genomic analysis of the Wnt-wingless signaling pathway. Science 308, 826-833 (2005).
38. Blumenthal, A. et al. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate, inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108, 965-973 (2006).
39. Gross, I., Georgel, P., Kappler, C., Reichhart, J.M. & Hoffmann, J.A. Drosophila immunity: A comparative analysis of the Rel proteins dorsal and Dif in the induction of the genes encoding diptericin and cecropin. Nucleic Acids Res. 24, 1238-12413 (1996).
40. Combet, C., Blanchet, C., Geourjon, C. & Deleage, G. NPSO: Network protein sequence analysis. Trends Biochem. Sci. 25, 147-150 (2000).
41. Kumar, S., Tamura, K. & Nei, M. MEGA3: Integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief. Bioinform. 5, 150-163 (2004).
42. Leclerc, V. et al. Prophenoloxidase activation is not required for survival to microbial infections in Drosophila. EMBO Rep. 7, 231-235 (2006).
43. Ligoxygakis, P., Pelte, N., Hoffmann, J.A. & Reichhart, J.M. Activation of Drosophila Toll during fungal infection by a blood serine protease. Science 297, 114-116 (2002).