-
1
-
-
2942650916
-
In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis
-
Aubin J, Davy A, Soriano P. 2004. In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev 18:1482-1494.
-
(2004)
Genes Dev
, vol.18
, pp. 1482-1494
-
-
Aubin, J.1
Davy, A.2
Soriano, P.3
-
2
-
-
0342995868
-
Requirement of LIM domains for LIM1 function in mouse head development
-
Cheah SS, Kwan KM, Behringer RR. 2000. Requirement of LIM domains for LIM1 function in mouse head development. Genesis 27:12-21.
-
(2000)
Genesis
, vol.27
, pp. 12-21
-
-
Cheah, S.S.1
Kwan, K.M.2
Behringer, R.R.3
-
3
-
-
0346890213
-
Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway
-
Chen W, White MA, Cobb MH. 2002. Stimulus-specific requirements for MAP3 kinases in activating the JNK pathway. J Biol Chem 277:49105-49110.
-
(2002)
J Biol Chem
, vol.277
, pp. 49105-49110
-
-
Chen, W.1
White, M.A.2
Cobb, M.H.3
-
4
-
-
1642473157
-
The transforming growth factor-beta superfamily of receptors
-
de Caestecker M. 2004. The transforming growth factor-beta superfamily of receptors. Cytokine Growth Factor Rev 15:1-11.
-
(2004)
Cytokine Growth Factor Rev
, vol.15
, pp. 1-11
-
-
de Caestecker, M.1
-
5
-
-
0029988995
-
A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site-specific recombination
-
Dymecki SM. 1996. A modular set of Flp, FRT and lacZ fusion vectors for manipulating genes by site-specific recombination. Gene 171: 197-201.
-
(1996)
Gene
, vol.171
, pp. 197-201
-
-
Dymecki, S.M.1
-
6
-
-
0034487368
-
Widespread recombinase expression using FLPeR (flipper) mice
-
Farley FW, Soriano P, Steffen LS, Dymecki SM. 2000. Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28:106-110.
-
(2000)
Genesis
, vol.28
, pp. 106-110
-
-
Farley, F.W.1
Soriano, P.2
Steffen, L.S.3
Dymecki, S.M.4
-
7
-
-
0033578721
-
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression
-
Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K, Nishida E. 1999. Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem 274:27161-27167.
-
(1999)
J Biol Chem
, vol.274
, pp. 27161-27167
-
-
Hanafusa, H.1
Ninomiya-Tsuji, J.2
Masuyama, N.3
Nishita, M.4
Fujisawa, J.5
Shibuya, H.6
Matsumoto, K.7
Nishida, E.8
-
8
-
-
38549084725
-
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation
-
Hasegawa M, Fujimoto Y, Lucas PC, Nakano H, Fukase K, Nunez G, Inohara N. 2008. A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation. EMBO J 27:373-383.
-
(2008)
EMBO J
, vol.27
, pp. 373-383
-
-
Hasegawa, M.1
Fujimoto, Y.2
Lucas, P.C.3
Nakano, H.4
Fukase, K.5
Nunez, G.6
Inohara, N.7
-
9
-
-
0036872791
-
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain
-
Hayashi S, Lewis P, Pevny L, McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Gene Expr Patterns 2:93-97.
-
(2002)
Gene Expr Patterns
, vol.2
, pp. 93-97
-
-
Hayashi, S.1
Lewis, P.2
Pevny, L.3
McMahon, A.P.4
-
10
-
-
0033538447
-
Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells
-
Hollnagel A, Oehlmann V, Heymer J, Rüther U, Nordheim A. 1999. Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells. J Biol Chem 274:19838-19845.
-
(1999)
J Biol Chem
, vol.274
, pp. 19838-19845
-
-
Hollnagel, A.1
Oehlmann, V.2
Heymer, J.3
Rüther, U.4
Nordheim, A.5
-
11
-
-
33749407705
-
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways
-
Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J. 2006. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. J Biol Chem 281:28802-28810.
-
(2006)
J Biol Chem
, vol.281
, pp. 28802-28810
-
-
Huangfu, W.C.1
Omori, E.2
Akira, S.3
Matsumoto, K.4
Ninomiya-Tsuji, J.5
-
12
-
-
0346243941
-
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
-
Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K. 2003. Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J 22:6277-6288.
-
(2003)
EMBO J
, vol.22
, pp. 6277-6288
-
-
Ishitani, T.1
Takaesu, G.2
Ninomiya-Tsuji, J.3
Shibuya, H.4
Gaynor, R.B.5
Matsumoto, K.6
-
13
-
-
33646713486
-
The TGF beta activated kinase TAK1 regulates vascular development in vivo
-
Jadrich JL, O'Connor MB, Coucouvanis E. 2006. The TGF beta activated kinase TAK1 regulates vascular development in vivo. Development 133:1529-1541.
-
(2006)
Development
, vol.133
, pp. 1529-1541
-
-
Jadrich, J.L.1
O'Connor, M.B.2
Coucouvanis, E.3
-
14
-
-
0037032817
-
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
-
Johnson GL, Lapadat R. 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
-
(2002)
Science
, vol.298
, pp. 1911-1912
-
-
Johnson, G.L.1
Lapadat, R.2
-
15
-
-
34248147701
-
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation
-
Kajino T, Omori E, Ishii S, Matsumoto K, Ninomiya-Tsuji J. 2007. TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation. J Biol Chem 282:9475-9481.
-
(2007)
J Biol Chem
, vol.282
, pp. 9475-9481
-
-
Kajino, T.1
Omori, E.2
Ishii, S.3
Matsumoto, K.4
Ninomiya-Tsuji, J.5
-
16
-
-
4344712350
-
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains
-
Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ. 2004. TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains. Mol Cell 15:535-548.
-
(2004)
Mol Cell
, vol.15
, pp. 535-548
-
-
Kanayama, A.1
Seth, R.B.2
Sun, L.3
Ea, C.K.4
Hong, M.5
Shaito, A.6
Chiu, Y.H.7
Deng, L.8
Chen, Z.J.9
-
17
-
-
0033832891
-
Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
-
Karlsson L, Lindahl P, Heath J, Betsholtz C. 2000. Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127:3457-3466.
-
(2000)
Development
, vol.127
, pp. 3457-3466
-
-
Karlsson, L.1
Lindahl, P.2
Heath, J.3
Betsholtz, C.4
-
18
-
-
38049153165
-
TAK1 is a central mediator of NOD2 signaling in epidermal cells
-
Kim JY, Omori E, Matsumoto K, Nunez G, Ninomiya-Tsuji J. 2008. TAK1 is a central mediator of NOD2 signaling in epidermal cells. J Biol Chem 283:137-144.
-
(2008)
J Biol Chem
, vol.283
, pp. 137-144
-
-
Kim, J.Y.1
Omori, E.2
Matsumoto, K.3
Nunez, G.4
Ninomiya-Tsuji, J.5
-
19
-
-
17844393079
-
TAX1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway
-
Kishida S, Sanjo H, Akira S, Matsumoto K, Ninomiya-Tsuji J. 2005. TAX1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway Genes Cells 10:447-454.
-
(2005)
Genes Cells
, vol.10
, pp. 447-454
-
-
Kishida, S.1
Sanjo, H.2
Akira, S.3
Matsumoto, K.4
Ninomiya-Tsuji, J.5
-
21
-
-
0034629146
-
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
-
Kishimoto K, Matsumoto K, Ninomiya-Tsuji J. 2000. TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. J Biol Chem 275:7359-7364.
-
(2000)
J Biol Chem
, vol.275
, pp. 7359-7364
-
-
Kishimoto, K.1
Matsumoto, K.2
Ninomiya-Tsuji, J.3
-
22
-
-
0036895537
-
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis
-
Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado K, Sekimoto T, Ueno N, Matsumoto K, Yamada G. 2002. Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev 119:239-249.
-
(2002)
Mech Dev
, vol.119
, pp. 239-249
-
-
Komatsu, Y.1
Shibuya, H.2
Takeda, N.3
Ninomiya-Tsuji, J.4
Yasui, T.5
Miyado, K.6
Sekimoto, T.7
Ueno, N.8
Matsumoto, K.9
Yamada, G.10
-
23
-
-
0030773834
-
Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
-
Kretzschmar M, Doody J, Massague J. 1997. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1. Nature 389:618-622.
-
(1997)
Nature
, vol.389
, pp. 618-622
-
-
Kretzschmar, M.1
Doody, J.2
Massague, J.3
-
24
-
-
0036195189
-
Conditional alleles in mice: Practical considerations for tissue-specific knockouts
-
Kwan KM. 2002. Conditional alleles in mice: Practical considerations for tissue-specific knockouts. Genesis 32:49-62.
-
(2002)
Genesis
, vol.32
, pp. 49-62
-
-
Kwan, K.M.1
-
25
-
-
21344455768
-
BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk
-
Miyazono K, Maeda S, Imamura T. 2005. BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev 16:251-263.
-
(2005)
Cytokine Growth Factor Rev
, vol.16
, pp. 251-263
-
-
Miyazono, K.1
Maeda, S.2
Imamura, T.3
-
26
-
-
0033580466
-
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway
-
Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K. 1999. The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398:252-256.
-
(1999)
Nature
, vol.398
, pp. 252-256
-
-
Ninomiya-Tsuji, J.1
Kishimoto, K.2
Hiyama, A.3
Inoue, J.4
Cao, Z.5
Matsumoto, K.6
-
27
-
-
33745851830
-
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
-
Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart CR, Ninomiya-Tsuji J. 2006. TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. J Biol Chem 281: 19610-19617.
-
(2006)
J Biol Chem
, vol.281
, pp. 19610-19617
-
-
Omori, E.1
Matsumoto, K.2
Sanjo, H.3
Sato, S.4
Akira, S.5
Smart, C.R.6
Ninomiya-Tsuji, J.7
-
28
-
-
0035968214
-
An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK
-
Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, Ninomiya-Tsuji J, Tsuchiya M, Matsumoto K. 2001. An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK. J Biol Chem 276:24396-24400.
-
(2001)
J Biol Chem
, vol.276
, pp. 24396-24400
-
-
Ono, K.1
Ohtomo, T.2
Sato, S.3
Sugamata, Y.4
Suzuki, M.5
Hisamoto, N.6
Ninomiya-Tsuji, J.7
Tsuchiya, M.8
Matsumoto, K.9
-
29
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
-
Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH. 2001. Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions. Endocr Rev 22:153-183.
-
(2001)
Endocr Rev
, vol.22
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
Xu, B.E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
30
-
-
27544434183
-
Essential function for the kinase TAK1 in innate and adaptive immune responses
-
Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S. 2005. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 6:1087-1095.
-
(2005)
Nat Immunol
, vol.6
, pp. 1087-1095
-
-
Sato, S.1
Sanjo, H.2
Takeda, K.3
Ninomiya-Tsuji, J.4
Yamamoto, M.5
Kawai, T.6
Matsumoto, K.7
Takeuchi, O.8
Akira, S.9
-
31
-
-
0032481312
-
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
-
Shibuya H, Iwata H, Masuyama N, Gotoh Y, Yamaguchi K, Irie K, Matsumoto K, Nishida E, Ueno N. 1998. Role of TAK1 and TAB1 in BMP signaling in early Xenopus development. EMBO J 17:1019-1028.
-
(1998)
EMBO J
, vol.17
, pp. 1019-1028
-
-
Shibuya, H.1
Iwata, H.2
Masuyama, N.3
Gotoh, Y.4
Yamaguchi, K.5
Irie, K.6
Matsumoto, K.7
Nishida, E.8
Ueno, N.9
-
32
-
-
0029940355
-
TAB1: An activator of the TAK1 MAPKKK in TGF-beta signal transduction
-
Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K. 1996. TAB1: An activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science 272: 1179-1182.
-
(1996)
Science
, vol.272
, pp. 1179-1182
-
-
Shibuya, H.1
Yamaguchi, K.2
Shirakabe, K.3
Tonegawa, A.4
Gotoh, Y.5
Ueno, N.6
Irie, K.7
Nishida, E.8
Matsumoto, K.9
-
33
-
-
27744577296
-
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
-
Shim JH, Xiao C, Paschal AE, Bailey ST, Rao P, Hayden MS, Lee KY, Bussey C, Steckel M, Tanaka N, Yamada G, Akira S, Matsumoto K, Ghosh S. 2005. TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19:2668-2681.
-
(2005)
Genes Dev
, vol.19
, pp. 2668-2681
-
-
Shim, J.H.1
Xiao, C.2
Paschal, A.E.3
Bailey, S.T.4
Rao, P.5
Hayden, M.S.6
Lee, K.Y.7
Bussey, C.8
Steckel, M.9
Tanaka, N.10
Yamada, G.11
Akira, S.12
Matsumoto, K.13
Ghosh, S.14
-
34
-
-
14844295421
-
Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2
-
Singhirunnusom P, Suzuki S, Kawasaki N, Saiki I, Sakurai H. 2005. Critical roles of threonine 187 phosphorylation in cellular stress-induced rapid and transient activation of transforming growth factor-beta-activated kinase 1 (TAK1) in a signaling complex containing TAK1-binding protein TAB1 and TAB2. J Biol Chem 280:7359-7368.
-
(2005)
J Biol Chem
, vol.280
, pp. 7359-7368
-
-
Singhirunnusom, P.1
Suzuki, S.2
Kawasaki, N.3
Saiki, I.4
Sakurai, H.5
-
35
-
-
0033634977
-
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
-
Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K. 2000. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell 5:649-658.
-
(2000)
Mol Cell
, vol.5
, pp. 649-658
-
-
Takaesu, G.1
Kishida, S.2
Hiyama, A.3
Yamaguchi, K.4
Shibuya, H.5
Irie, K.6
Ninomiya-Tsuji, J.7
Matsumoto, K.8
-
36
-
-
0037422858
-
TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway
-
Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB. 2003. TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. J Mol Biol 326:105-115.
-
(2003)
J Mol Biol
, vol.326
, pp. 105-115
-
-
Takaesu, G.1
Surabhi, R.M.2
Park, K.J.3
Ninomiya-Tsuji, J.4
Matsumoto, K.5
Gaynor, R.B.6
-
37
-
-
0032529159
-
Smads and early developmental signaling by the TGFbeta superfamily
-
Whitman M. 1998. Smads and early developmental signaling by the TGFbeta superfamily. Genes Dev 12:2445-2462.
-
(1998)
Genes Dev
, vol.12
, pp. 2445-2462
-
-
Whitman, M.1
-
38
-
-
0027495527
-
A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene
-
Yagi T, Nada S, Watanabe N, Tamemoto H, Kohmura N, Ikawa Y, Aizawa S. 1993. A novel negative selection for homologous recombinants using diphtheria toxin A fragment gene. Anal Biochem 214:77-86.
-
(1993)
Anal Biochem
, vol.214
, pp. 77-86
-
-
Yagi, T.1
Nada, S.2
Watanabe, N.3
Tamemoto, H.4
Kohmura, N.5
Ikawa, Y.6
Aizawa, S.7
-
39
-
-
0033521529
-
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
-
Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K. 1999. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J 18:179-187.
-
(1999)
EMBO J
, vol.18
, pp. 179-187
-
-
Yamaguchi, K.1
Nagai, S.2
Ninomiya-Tsuji, J.3
Nishita, M.4
Tamai, K.5
Irie, K.6
Ueno, N.7
Nishida, E.8
Shibuya, H.9
Matsumoto, K.10
-
40
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction
-
Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K. 1995. Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 270:2008-2011.
-
(1995)
Science
, vol.270
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabe, K.2
Shibuya, H.3
Irie, K.4
Oishi, I.5
Ueno, N.6
Taniguchi, T.7
Nishida, E.8
Matsumoto, K.9
|