Inhibition of the alpha-ν integrins with a cyclic RGD peptide impairs angiogenesis, growth and metastasis of solid tumours in vivo

British Journal of Cancer

Volumn 86, Issue 5, 2002, Pages 788-795

  Buerkle, M A ^a   Pahernik, S A ^a   Sutter, A ^b   Jonczyk, A ^b   Messmer, K ^a   Dellian, M ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b MERCK KGAA   (Germany)

Author keywords

Angiogenesis; RGD peptides; Tumour antiangiogenesis; v integrins

Indexed keywords

ALPHA5 INTEGRIN; ARGINYLGLYCYLASPARTIC ACID; CILENGITIDE; CYCLOPEPTIDE; EMD 135981; UNCLASSIFIED DRUG;

AMELANOTIC MELANOMA; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; HAMSTER; MALE; METASTASIS; METASTASIS INHIBITION; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; SKINFOLD; SOLID TUMOR; TUMOR GROWTH;

ANIMALS; ANTIGENS, CD; ANTINEOPLASTIC AGENTS; CRICETINAE; ENDOTHELIUM; INFUSIONS, PARENTERAL; INTEGRIN ALPHA1; LEUKOCYTES; MALE; MELANOMA; MICROCIRCULATION; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; OLIGOPEPTIDES; SKIN NEOPLASMS;

EID: 0037017835     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600141     Document Type: Article

References (56)

1. Quantitative analysis of microvascular structure and function in the amelanotic melanoma A-Mel-3
2. Quantitative investigations of the adhesiveness of circulating polymorphonuclear leucocytes to blood vessel walls
3. Angiogenesis inhibition: A review
4. RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the alpha(v)beta(3) and alpha(5)beta(1) integrins
5. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
6. Leukocyte adhesion in angiogenic blood vessels. Role of E-selectin, P-selectin, and beta2 integrin in lymphotoxin-mediated leukocyte recruitment in tumor microvessels
7. Role of integrins in angiogenesis
8. Requirement of vascular integrin alpha v beta 3 for angiogenesis
9. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
10. Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
11. Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3
12. Structural and biologic properties of integrin-mediated cell adhesion
13. Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reepithelialization
14. N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists
15. Effects of photodynamic therapy on leucocyte-endothelium interaction: Differences between normal and tumour tissue
16. High-energy shock waves enhance hyperthermic response of tumors: Effects on blood flow, energy metabolism, and tumor growth
17. Quantitation and physiological characterization of angiogenic vessels in mice: Effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment
18. The role of alphav integrins during angiogenesis: Insights into potential mechanisms of action and clinical development
19. Microcirculatory blood flow, capillary morphology and local oxygen pressure of the hamster amelanotic melanoma A-Mel-3
20. Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide
21. Natural killer cells, adhesion and tumor angiogenesis
22. The implications of angiogenesis for the biology, and therapy of cancer metastasis
23. What is the evidence that tumors are angiogenesis dependent?
24. Angiogenesis in cancer, vascular, rheumatoid and other disease
25. Angiogenesis
26. Transplantable tumors of the Syrian (golden) hamster. Part I: Tumors of the alimentary tract, endocrine glands and melanomas
27. Complete local tumor remission after therapy with extra-corporeally applied high-energy shock waves (HESW)
28. Microvascular permeability of normal and neoplastic tissues
29. Extent of vascularization as a prognostic indicator in thin (<0.76 mm) malignant melanomas
30. Conformation/activity studies of rationally designed potent anti- adhesive RGD peptides
31. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
32. Integrins: Versatility, modulation, and signaling in cell adhesion
33. Quantitative angiogenesis assays: Progress and problems
34. Nonparametric estimation from incomplete observations
35. Cap image - A new kind of computer-assisted video image analysis system for dynamic capillary microscopy
36. A Monte-Carlo study of the power of some two-sample tests
37. Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
38. Integrins as dynamic regulators of vascular function
39. The role of alpha v-integrins in tumour progression and metastasis
40. Enhancement of fluid filtration across tumor vessels: Implication for delivery of macromolecules
41. Inhibition of angiogenesis in vitro by Arg-GlyAsp-containing synthetic peptide
42. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
43. Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
44. Microcirculatory studies in rat mammary carcinoma. I. Transparent chamber method, development of microvasculature, and pressures in tumor vessels
45. Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis
46. Primary tumor sizedependent inhibition of angiogenesis at a secondary site: An intravital microscopic study in mice
47. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin alphaVbeta3 during angiogenesis
48. Guidelines for the welfare of animals in experimental neoplasia
49. Intravital fluorescence videomicroscopy to study tumor angiogenesis and microcirculation
50. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma
51. Tumor angiogenesis and metastasis correlation in invasive breast carcinoma
52. Influence of the shock wave application mode on the growth of A-Mel 3 and SSK2 tumors in vivo
53. Interstitial fluid presure in DMBA-induced rat mammary tumours
54. Vascular permeability in a human tumor xenograft: Molecular size dependence and cutoff size
55. Computer assisted leukocyte adhesion measurement in intravital microscopy