-
1
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
4938153
-
Folkman J Tumor angiogenesis: Therapeutic implications N Engl J Med 1971, 285(21):1182-1186 4938153
-
(1971)
N Engl J Med
, vol.285
, Issue.21
, pp. 1182-1186
-
-
Folkman, J.1
-
2
-
-
0015008620
-
Isolation of a tumor factor responsible for angiogenesis
-
10.1084/jem.133.2.275 4332371
-
Folkman J Merler E Abernathy C Williams G Isolation of a tumor factor responsible for angiogenesis J Exp Med 1971, 133(2):275-288 10.1084/ jem.133.2.275 4332371
-
(1971)
J Exp Med
, vol.133
, Issue.2
, pp. 275-288
-
-
Folkman, J.1
Merler, E.2
Abernathy, C.3
Williams, G.4
-
3
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
12538485
-
Mendel DB Laird AD Xin X Louie SG Christensen JG Li G Schreck RE Abrams TJ Ngai TJ Lee LB Murray LJ Carver J Chan E Moss KG Haznedar JO Sukbuntherng J Blake RA Sun L Tang C Miller T Shirazian S McMahon G Cherrington JM In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship Clin Cancer Res 2003, 9(1):327-337 12538485
-
(2003)
Clin Cancer Res
, vol.9
, Issue.1
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
Louie, S.G.4
Christensen, J.G.5
Li, G.6
Schreck, R.E.7
Abrams, T.J.8
Ngai, T.J.9
Lee, L.B.10
Murray, L.J.11
Carver, J.12
Chan, E.13
Moss, K.G.14
Haznedar, J.O.15
Sukbuntherng, J.16
Blake, R.A.17
Sun, L.18
Tang, C.19
Miller, T.20
Shirazian, S.21
McMahon, G.22
Cherrington, J.M.23
more..
-
4
-
-
0038204144
-
SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
-
10.1182/blood-2002-07-2307 12531805
-
O'Farrell AM Abrams TJ Yuen HA Ngai TJ Louie SG Yee KW Wong LM Hong W Lee LB Town A Smolich BD Manning WC Murray LJ Heinrich MC Cherrington JM SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo Blood 2003, 101(9):3597-3605 10.1182/ blood-2002-07-2307 12531805
-
(2003)
Blood
, vol.101
, Issue.9
, pp. 3597-3605
-
-
O'Farrell, A.M.1
Abrams, T.J.2
Yuen, H.A.3
Ngai, T.J.4
Louie, S.G.5
Yee, K.W.6
Wong, L.M.7
Hong, W.8
Lee, L.B.9
Town, A.10
Smolich, B.D.11
Manning, W.C.12
Murray, L.J.13
Heinrich, M.C.14
Cherrington, J.M.15
-
5
-
-
0036402628
-
BAY 43-9006: Early clinical data in patients with advanced solid malignancies
-
10.2174/1381612023393053 12369852
-
Hotte SJ Hirte HW BAY 43-9006: Early clinical data in patients with advanced solid malignancies Curr Pharm Des 2002, 8(25):2249-2253 10.2174/ 1381612023393053 12369852
-
(2002)
Curr Pharm Des
, vol.8
, Issue.25
, pp. 2249-2253
-
-
Hotte, S.J.1
Hirte, H.W.2
-
6
-
-
0036401105
-
BAY 43-9006: Preclinical data
-
10.2174/1381612023393026 12369853
-
Wilhelm S Chien DS BAY 43-9006: Preclinical data Curr Pharm Des 2002, 8(25):2255-2257 10.2174/1381612023393026 12369853
-
(2002)
Curr Pharm Des
, vol.8
, Issue.25
, pp. 2255-2257
-
-
Wilhelm, S.1
Chien, D.S.2
-
7
-
-
0037208589
-
Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/ leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
-
10.1200/JCO.2003.10.066 12506171
-
Kabbinavar F Hurwitz HI Fehrenbacher L Meropol NJ Novotny WF Lieberman G Griffing S Bergsland E Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer J Clin Oncol 2003, 21(1):60-65 10.1200/ JCO.2003.10.066 12506171
-
(2003)
J Clin Oncol
, vol.21
, Issue.1
, pp. 60-65
-
-
Kabbinavar, F.1
Hurwitz, H.I.2
Fehrenbacher, L.3
Meropol, N.J.4
Novotny, W.F.5
Lieberman, G.6
Griffing, S.7
Bergsland, E.8
-
8
-
-
0027197245
-
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
-
10.1038/362841a0 7683111
-
Kim KJ Li B Winer J Armanini M Gillett N Phillips HS Ferrara N Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo Nature 1993, 362(6423):841-844 10.1038/ 362841a0 7683111
-
(1993)
Nature
, vol.362
, Issue.6423
, pp. 841-844
-
-
Kim, K.J.1
Li, B.2
Winer, J.3
Armanini, M.4
Gillett, N.5
Phillips, H.S.6
Ferrara, N.7
-
9
-
-
0141988568
-
Fundamental concepts of the angiogenic process
-
10.2174/1566524033479465 14601638
-
Folkman J Fundamental concepts of the angiogenic process Curr Mol Med 2003, 3(7):643-651 10.2174/1566524033479465 14601638
-
(2003)
Curr Mol Med
, vol.3
, Issue.7
, pp. 643-651
-
-
Folkman, J.1
-
10
-
-
0034956272
-
The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis
-
11349215
-
John A Tuszynski G The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis Pathol Oncol Res 2001, 7(1):14-23 11349215
-
(2001)
Pathol Oncol Res
, vol.7
, Issue.1
, pp. 14-23
-
-
John, A.1
Tuszynski, G.2
-
11
-
-
0033551899
-
Integrin signaling
-
10.1126/science.285.5430.1028 10446041
-
Giancotti FG Ruoslahti E Integrin signaling Science 1999, 285(5430):1028-1032 10.1126/science.285.5430.1028 10446041
-
(1999)
Science
, vol.285
, Issue.5430
, pp. 1028-1032
-
-
Giancotti, F.G.1
Ruoslahti, E.2
-
12
-
-
0038304470
-
The diverse roles of integrins and their ligands in angiogenesis
-
10.1101/sqb.2002.67.143 12858535
-
Hynes RO Lively JC McCarty JH Taverna D Francis SE Hodivala-Dilke K Xiao Q The diverse roles of integrins and their ligands in angiogenesis Cold Spring Harb Symp Quant Biol 2002, 67:143-153 10.1101/sqb.2002.67.143 12858535
-
(2002)
Cold Spring Harb Symp Quant Biol
, vol.67
, pp. 143-153
-
-
Hynes, R.O.1
Lively, J.C.2
McCarty, J.H.3
Taverna, D.4
Francis, S.E.5
Hodivala-Dilke, K.6
Xiao, Q.7
-
13
-
-
26444557730
-
alpha5beta1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion kinase, and Ca2+/calmodulin-dependent protein kinase IV
-
10.1002/jcb.20488 15962308
-
Lee BH Ruoslahti E alpha5beta1 integrin stimulates Bcl-2 expression and cell survival through Akt, focal adhesion kinase, and Ca2+/ calmodulin-dependent protein kinase IV J Cell Biochem 2005, 95(6):1214-1223 10.1002/jcb.20488 15962308
-
(2005)
J Cell Biochem
, vol.95
, Issue.6
, pp. 1214-1223
-
-
Lee, B.H.1
Ruoslahti, E.2
-
14
-
-
33644959471
-
Distinct roles of beta1 integrins during angiogenesis
-
10.1016/j.ejcb.2005.09.010 16546568
-
Mettouchi A Meneguzzi G Distinct roles of beta1 integrins during angiogenesis Eur J Cell Biol 2006, 85(3-4):243-247 10.1016/ j.ejcb.2005.09.010 16546568
-
(2006)
Eur J Cell Biol
, vol.85
, Issue.3-4
, pp. 243-247
-
-
Mettouchi, A.1
Meneguzzi, G.2
-
15
-
-
0036792466
-
Inhibition of endothelial cell survival and angiogenesis by protein kinase A
-
151143 12370271 10.1172/JCI200214268
-
Kim S Bakre M Yin H Varner JA Inhibition of endothelial cell survival and angiogenesis by protein kinase A J Clin Invest 2002, 110(7):933-941 151143 12370271 10.1172/JCI200214268
-
(2002)
J Clin Invest
, vol.110
, Issue.7
, pp. 933-941
-
-
Kim, S.1
Bakre, M.2
Yin, H.3
Varner, J.A.4
-
16
-
-
0033843942
-
Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin
-
1876892 10751360
-
Kim S Bell K Mousa SA Varner JA Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin Am J Pathol 2000, 156(4):1345-1362 1876892 10751360
-
(2000)
Am J Pathol
, vol.156
, Issue.4
, pp. 1345-1362
-
-
Kim, S.1
Bell, K.2
Mousa, S.A.3
Varner, J.A.4
-
17
-
-
33749577839
-
A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo
-
10.1158/1535-7163.MCT-06-0100 16985061
-
Khalili P Arakelian A Chen G Plunkett ML Beck I Parry GC Donate F Shaw DE Mazar AP Rabbani SA A non-RGD-based integrin binding peptide (ATN-161) blocks breast cancer growth and metastasis in vivo Mol Cancer Ther 2006, 5(9):2271-2280 10.1158/1535-7163.MCT-06-0100 16985061
-
(2006)
Mol Cancer Ther
, vol.5
, Issue.9
, pp. 2271-2280
-
-
Khalili, P.1
Arakelian, A.2
Chen, G.3
Plunkett, M.L.4
Beck, I.5
Parry, G.C.6
Donate, F.7
Shaw, D.E.8
Mazar, A.P.9
Rabbani, S.A.10
-
18
-
-
33745728177
-
The small alpha5beta1 integrin antagonist, SJ749, reduces proliferation and clonogenicity of human astrocytoma cells
-
10.1158/0008-5472.CAN-05-4105 16778170
-
Maglott A Bartik P Cosgun S Klotz P Ronde P Fuhrmann G Takeda K Martin S Dontenwill M The small alpha5beta1 integrin antagonist, SJ749, reduces proliferation and clonogenicity of human astrocytoma cells Cancer Res 2006, 66(12):6002-6007 10.1158/0008-5472.CAN-05-4105 16778170
-
(2006)
Cancer Res
, vol.66
, Issue.12
, pp. 6002-6007
-
-
Maglott, A.1
Bartik, P.2
Cosgun, S.3
Klotz, P.4
Ronde, P.5
Fuhrmann, G.6
Takeda, K.7
Martin, S.8
Dontenwill, M.9
-
19
-
-
0037446897
-
Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins
-
153630 12682293 10.1073/pnas.0730882100
-
Sudhakar A Sugimoto H Yang C Lively J Zeisberg M Kalluri R Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins Proc Natl Acad Sci U S A 2003, 100(8):4766-4771 153630 12682293 10.1073/ pnas.0730882100
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.8
, pp. 4766-4771
-
-
Sudhakar, A.1
Sugimoto, H.2
Yang, C.3
Lively, J.4
Zeisberg, M.5
Kalluri, R.6
-
20
-
-
0035895247
-
A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis
-
14637 11209058 10.1073/pnas.98.2.620
-
Yi M Ruoslahti E A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis Proc Natl Acad Sci U S A 2001, 98(2):620-624 14637 11209058 10.1073/pnas.98.2.620
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.2
, pp. 620-624
-
-
Yi, M.1
Ruoslahti, E.2
-
21
-
-
33749349945
-
Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent
-
17024968
-
Ramakrishnan V Bhaskar V Law DA Wong MH DuBridge RB Breinberg D O'Hara C Powers DB Liu G Grove J Hevezi P Cass KM Watson S Evangelista F Powers RA Finck B Wills M Caras I Fang Y McDonald D Johnson D Murray R Jeffry U Preclinical evaluation of an anti-alpha5beta1 integrin antibody as a novel anti-angiogenic agent J Exp Ther Oncol 2006, 5(4):273-286 17024968
-
(2006)
J Exp Ther Oncol
, vol.5
, Issue.4
, pp. 273-286
-
-
Ramakrishnan, V.1
Bhaskar, V.2
Law, D.A.3
Wong, M.H.4
DuBridge, R.B.5
Breinberg, D.6
O'Hara, C.7
Powers, D.B.8
Liu, G.9
Grove, J.10
Hevezi, P.11
Cass, K.M.12
Watson, S.13
Evangelista, F.14
Powers, R.A.15
Finck, B.16
Wills, M.17
Caras, I.18
Fang, Y.19
McDonald, D.20
Johnson, D.21
Murray, R.22
Jeffry, U.23
more..
-
22
-
-
38949218370
-
Volociximab, a chimeric integrin alpha5beta1 antibody, inhibits the growth of VX2 tumors in rabbits
-
17786386
-
Bhaskar V Fox M Breinberg D Wong MH Wales PE Rhodes S Dubridge RB Ramakrishnan V Volociximab, a chimeric integrin alpha5beta1 antibody, inhibits the growth of VX2 tumors in rabbits Invest New Drugs 2007 17786386
-
(2007)
Invest New Drugs
-
-
Bhaskar, V.1
Fox, M.2
Breinberg, D.3
Wong, M.H.4
Wales, P.E.5
Rhodes, S.6
Dubridge, R.B.7
Ramakrishnan, V.8
-
23
-
-
0142151097
-
Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
-
1892429 14578181
-
Baluk P Morikawa S Haskell A Mancuso M McDonald DM Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors Am J Pathol 2003, 163(5):1801-1815 1892429 14578181
-
(2003)
Am J Pathol
, vol.163
, Issue.5
, pp. 1801-1815
-
-
Baluk, P.1
Morikawa, S.2
Haskell, A.3
Mancuso, M.4
McDonald, D.M.5
-
24
-
-
16844373504
-
Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels
-
10.1158/0008-5472.CAN-04-2691
-
Magnussen A Kasman IM Norberg S Baluk P Murray R McDonald DM Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels Cancer Res 2005 65 7 2712 2721 10.1158/0008-5472.CAN-04-2691 15805270
-
(2005)
Cancer Res
, vol.65
, pp. 2712-2721
-
-
Magnussen, A.1
Kasman, I.M.2
Norberg, S.3
Baluk, P.4
Murray, R.5
McDonald, D.M.6
-
25
-
-
0027158079
-
Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density
-
413409 8491181
-
Tran Van Nhieu G Isberg RR Bacterial internalization mediated by beta 1 chain integrins is determined by ligand affinity and receptor density Embo J 1993, 12(5):1887-1895 413409 8491181
-
(1993)
Embo J
, vol.12
, Issue.5
, pp. 1887-1895
-
-
Tran Van Nhieu, G.1
Isberg, R.R.2
-
26
-
-
4444297534
-
Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer
-
15299075
-
Afar DE Bhaskar V Ibsen E Breinberg D Henshall SM Kench JG Drobnjak M Powers R Wong M Evangelista F O'Hara C Powers D DuBridge RB Caras I Winter R Anderson T Solvason N Stricker PD Cordon-Cardo C Scher HI Grygiel JJ Sutherland RL Murray R Ramakrishnan V Law DA Preclinical validation of anti-TMEFF2-auristatin E-conjugated antibodies in the treatment of prostate cancer Mol Cancer Ther 2004, 3(8):921-932 15299075
-
(2004)
Mol Cancer Ther
, vol.3
, Issue.8
, pp. 921-932
-
-
Afar, D.E.1
Bhaskar, V.2
Ibsen, E.3
Breinberg, D.4
Henshall, S.M.5
Kench, J.G.6
Drobnjak, M.7
Powers, R.8
Wong, M.9
Evangelista, F.10
O'Hara, C.11
Powers, D.12
DuBridge, R.B.13
Caras, I.14
Winter, R.15
Anderson, T.16
Solvason, N.17
Stricker, P.D.18
Cordon-Cardo, C.19
Scher, H.I.20
Grygiel, J.J.21
Sutherland, R.L.22
Murray, R.23
Ramakrishnan, V.24
Law, D.A.25
more..
-
27
-
-
0141919559
-
E-selectin up-regulation allows for targeted drug delivery in prostate cancer
-
14559828
-
Bhaskar V Law DA Ibsen E Breinberg D Cass KM DuBridge RB Evangelista F Henshall SM Hevezi P Miller JC Pong M Powers R Senter P Stockett D Sutherland RL von Freeden-Jeffry U Willhite D Murray R Afar DE Ramakrishnan V E-selectin up-regulation allows for targeted drug delivery in prostate cancer Cancer Res 2003, 63(19):6387-6394 14559828
-
(2003)
Cancer Res
, vol.63
, Issue.19
, pp. 6387-6394
-
-
Bhaskar, V.1
Law, D.A.2
Ibsen, E.3
Breinberg, D.4
Cass, K.M.5
DuBridge, R.B.6
Evangelista, F.7
Henshall, S.M.8
Hevezi, P.9
Miller, J.C.10
Pong, M.11
Powers, R.12
Senter, P.13
Stockett, D.14
Sutherland, R.L.15
von Freeden-Jeffry, U.16
Willhite, D.17
Murray, R.18
Afar, D.E.19
Ramakrishnan, V.20
more..
-
28
-
-
0030700763
-
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
-
9334279
-
Goh KL Yang JT Hynes RO Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos Development 1997, 124(21):4309-4319 9334279
-
(1997)
Development
, vol.124
, Issue.21
, pp. 4309-4319
-
-
Goh, K.L.1
Yang, J.T.2
Hynes, R.O.3
-
29
-
-
0037391673
-
VEGF blocking therapy in the treatment of cancer
-
10.1517/14712598.3.2.263 12662141
-
Glade-Bender J Kandel JJ Yamashiro DJ VEGF blocking therapy in the treatment of cancer Expert Opin Biol Ther 2003, 3(2):263-276 10.1517/ 14712598.3.2.263 12662141
-
(2003)
Expert Opin Biol Ther
, vol.3
, Issue.2
, pp. 263-276
-
-
Glade-Bender, J.1
Kandel, J.J.2
Yamashiro, D.J.3
-
30
-
-
33745738260
-
Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: From the biology to the clinic
-
10.2174/092986706777585059 16842197
-
Ranieri G Patruno R Ruggieri E Montemurro S Valerio P Ribatti D Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic Curr Med Chem 2006, 13(16):1845-1857 10.2174/092986706777585059 16842197
-
(2006)
Curr Med Chem
, vol.13
, Issue.16
, pp. 1845-1857
-
-
Ranieri, G.1
Patruno, R.2
Ruggieri, E.3
Montemurro, S.4
Valerio, P.5
Ribatti, D.6
|