Autocrine production of IL-10 mediates defective IL-12 production and NF-κB activation in tumor-associated macrophages

Journal of Immunology

Volumn 164, Issue 2, 2000, Pages 762-767

  Sica, Antonio ^a   Saccani, Alessandra ^a   Bottazzi, Barbara ^a   Polentarutti, Nadia ^a   Vecchi, Annunciata ^a   Van Damme, Jo ^c   Mantovani, Alberto ^a,b  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER IMMUNOLOGY; CONTROLLED STUDY; IMMUNOREACTIVITY; MACROPHAGE ACTIVATION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN INDUCTION; TUMOR ASSOCIATED LEUKOCYTE;

EID: 0034650833     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.2.762     Document Type: Article

References (29)

1. Mantovani, A., B. Bottazzi, F. Colotta, S. Sozzani, and L. Ruco. 1992. The origin and function of macrophages. Immunol. Today 13:265.
2. Mantovani, A. 1994. Tumor-associated macrophages in neoplastic progression: a paradigm for the in vivo function of chemokines. Lab. Invest. 71:5.
3. Bottazzi, B., N. Polentarutti, R. Acero, A. Balsari, D. Boraschi, P. Ghezzi, M. Salmona, and A. Mantovani. 1983. Regulation of macrophage content of neoplasms by chemoattractants. Science 220:210.
4. Rollins, B.J., and M.E. Sunday. 1991. Suppression of tumor formalion in vivo by expression of JE gene in malignant cells. Mol. Cell. Biol. 11:3125.
5. Graves, D. T., V. L. Jiang, M. J. Williamson, and A. J. Valente. 1989. Identification of monocyte chemotactic activity produced by malignant cells. Science 245:1490.
6. Negus, R. P., G. W. Stamp, M. G. Relf, F. Burke, S. T. Malik, S. Bernasconi, P. Allavena, S. Sozzani, A. Mantovani, and F. R. Balkwill. 1995. The detection and localization of monocyte chemoattractant protein-1 (MCP-1) in human ovarian cancer. J. Clin. Invest. 95:2391.
7. Evans, R. 1972. Macrophages in syngeneic animal tumors. Transplantation 14: 468.
8. Dong, Z., R. Kumar, X. Yang, and I. J. Fidler. 1997. Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Cell 88:801.
9. DiNapoli, M. R., C. L. Calderon, and D. Lopez. 1996. The altered tumoricidal capacity of macrophages isolated from tumor-bearing mice is related to reduced expression of the inducible nitric oxide synthase gene. J. Exp. Med. 183:1323.
10. Pace, J.L., and S. W. Russell. 1981. Activation of mouse macrophages for tumor killing. I. Quantitative analysis of mouse macrophages for tumor killing. J. Immunol. 126:1863.
11. Nathan, C. 1991. Role of nitric oxide synthase in macrophage antimicrobial activity. Cun. Opin. Immunol. 3:65.
12. Varesio, L., R. B. Herberman, J. M. Gerson, and H. T. Holden. 1979. Suppression of lymphokine production by macrophages infiltrating murine virus-induced tumors. Int. J. Cancer 24:97.
13. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulalory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
14. Bottazzi, B., N. Nobili, and A. Mantovani. 1990. Expression of c-fos protooncogene in tumor-associated macrophages. J. Immunol. 144:4878.
15. Mosmann, T. R., J. H. Shumacher, D. F. Fiorentino, J. Leverah, K. W. Moore, and M. W. Bond. 1990. Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. J. Immunol. 145:2938.
16. MacNeil, I. A., T. Suda, K. W. Moore, T. R. Mosmann, and A. Zlotnik. 1990. IL-10, a novel growth cofactor for mature and immature T cells. J. Immunol. 145:4167.
17. Sica, A., A. Saccani, A. Borsatti, C. A. Power, T. N. C. Wells, W. Luini, N. Polentarutti, S. Sozzani, and A. Mantovani. 1997. Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes. J. Exp. Med. 185:969.
18. Rice, N. R., M. L. MacKichan, and A. Israel. 1992. The precursor of NF-κB p50 has IκB-like functiors. Cell 71:243.
19. Murphy, T. L., M. G. Cleveland, P. Kulesza, J. Magram, and K. M. Murphy. 1995. Regulation of interleukin-12 p40 expression through an NF-κB half-site. Mol. Cell. Biol. 15:5258.
20. Kawakami, K., C. Scheidereit, and R. G. Roeder. 1990. Identification and purification of a human immunoglobulin-binding protein (NF-κB) that activates transcription from a human immunodeficiency virus type 1 promoter in vivo. Proc. Natl. Acad. Sci. USA 85:4700.
21. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141.
22. Mosmann, T.R. 1994. Properties and functions of interleukin-10. Adv. Immunol. 56:1.
23. Wang, P., P. Wu, M. I. Siegel, R. W. Egan, and M. M. Billah. 1995. Interleukin (IL)-10 inhibits nuclear factor κB (NF-κB) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J. Biol. Chem. 270:9558.
24. Taraboletti, G., L. Perin, B. Bottazzi, A. Mantovani, R. Giavazzi, and M. Salmona. 1989. Membrane fluidity affects tumor-cell motility, invasion and lung-colonizing potential. J. Immunol. 44:707.
25. Bottazzi, B., S. Walter, D. Govoni, F. Colotta, and A. Mantovani. 1992. Monocyte chemotactic cytokine gene transfer modulates macrophage infiltration, growth, and susceptibility to IL-2 therapy of a murine melanoma. J. Immunol. 148:1280.
26. Becker, J. C., C. Czerny, and E. B. Brocker. 1994. Maintenance of clonal anergy by endogenously produced IL-10. Int. Immunol. 6:1605.
27. Luster, U., L. Folgueira, A. Juretic, M. Zuber, N. J. Luscher, M. Heberer, and G. C. Spagnoli. 1994. The pattern of cytokine gene expression in freshly excised human metastatic melanoma suggests a state of reversible anergy of tumor-infiltrating lymphocytes. Int. J. Cancer 57:612.
28. Chouaib, S., C. Asselin-Paturel, F. Mami-Chouaib, A. Caignard, and J. Y. Blay. 1997. The host-tumor immune conflict: from immunosuppression to resistance and destruction. Immunol. Today 18:493.
29. Halak, B. K., H. C. Maguire, Jr., and E. C. Lattime. 1999. Tumor-induced interleukin-10 inhibits type 1 immune responses directed at a tumor antigen as well as a non-tumor antigen present at the tumor site. Cancer Res. 59:911.