메뉴 건너뛰기




Volumn 30, Issue 5-6, 2009, Pages 292-299

Targeting vascular endothelial growth factor in renal cell carcinoma

Author keywords

Clear cell renal cell carcinoma; Hypoxia inducible factors; Renal cell carcinoma; Vascular endothelial growth factor; Von Hippel Lindau gene

Indexed keywords

AFLIBERCEPT; ALPHA INTERFERON; ALPHA2A INTERFERON; BEVACIZUMAB; GROWTH FACTOR RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; INTERLEUKIN 2; PLACEBO; PLACENTAL GROWTH FACTOR; RECOMBINANT INTERFERON; SORAFENIB; SUNITINIB; TEMSIROLIMUS; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; VON HIPPEL LINDAU PROTEIN;

EID: 70450176108     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1159/000260241     Document Type: Short Survey
Times cited : (10)

References (49)
  • 1
    • 84988865449 scopus 로고    scopus 로고
    • National Cancer Institute of the US Natioanal Institute of Health
    • National Cancer Institute of the US Natioanal Institute of Health, Kidney Cancer Statistics. www.cancer.gov/cancertopics/types/ kidney.
    • Kidney Cancer Statistics
  • 4
    • 0034071278 scopus 로고    scopus 로고
    • Prognostic indicators for renal cell carcinoma: A multivariate analysis of 643 patients using the revised 1997 TNM staging criteria
    • Tsui KH, Shvarts O, Smith RB, Figlin RA, De Kernion JB, Belldegrun A: Prognostic indicators for renal cell carcinoma: a multivariate analysis of 643 patients using the revised 1997 TNM staging criteria. J Urol 2000; 163: 1090-1095.
    • (2000) J Urol , vol.163 , pp. 1090-1095
    • Tsui, K.H.1    Shvarts, O.2    Smith, R.B.3    Figlin, R.A.4    De Kernion, J.B.5    Belldegrun, A.6
  • 5
    • 34247200050 scopus 로고    scopus 로고
    • Immunotherapy for metastatic renal cell carcinoma
    • McDermott DF, Rini BI: Immunotherapy for metastatic renal cell carcinoma. BJU Int 2007; 99(5 pt B):1282-1288.
    • (2007) BJU Int , vol.99 , Issue.5 PART B , pp. 1282-1288
    • McDermott, D.F.1    Rini, B.I.2
  • 7
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • Kim WY, Kaelin WG: Role of VHL gene mutation in human cancer. J Clin Oncol 2004; 22: 4991-5004.
    • (2004) J Clin Oncol , vol.22 , pp. 4991-5004
    • Kim, W.Y.1    Kaelin, W.G.2
  • 10
    • 0038037735 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia: Role of the HIF system
    • Pugh CW, Ratcliffe PJ: Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med 2003; 9: 677-684.
    • (2003) Nat Med , vol.9 , pp. 677-684
    • Pugh, C.W.1    Ratcliffe, P.J.2
  • 11
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick RK, McKnight SL: A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001; 294: 1337-1340.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 13
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumor growth
    • Harris AL: Hypoxia - a key regulatory factor in tumor growth. Nat Rev Cancer 2002; 2: 38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 14
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285: 1182-1186.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 15
    • 0034076189 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis and arteriogenesis
    • Carmeliet P: Mechanisms of angiogenesis and arteriogenesis. Nat Med 2000; 6: 389-395.
    • (2000) Nat Med , vol.6 , pp. 389-395
    • Carmeliet, P.1
  • 16
    • 0035313488 scopus 로고    scopus 로고
    • FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition
    • Cross MJ, Claesson-Welsh L: FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol Sci 2001; 22: 201-207.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 201-207
    • Cross, M.J.1    Claesson-Welsh, L.2
  • 17
    • 0036439461 scopus 로고    scopus 로고
    • Signaling pathways in vascular development
    • Rossant J, Howard L: Signaling pathways in vascular development. Annu Rev Cell Dev Biol 2002; 18: 541-573.
    • (2002) Annu Rev Cell Dev Biol , vol.18 , pp. 541-573
    • Rossant, J.1    Howard, L.2
  • 18
    • 0242636164 scopus 로고    scopus 로고
    • Growing and shaping the vascular tree: Multiple roles for VEGF
    • Ruhrberg C: Growing and shaping the vascular tree: multiple roles for VEGF. Bioessays 2003; 25: 1052-1060.
    • (2003) Bioessays , vol.25 , pp. 1052-1060
    • Ruhrberg, C.1
  • 19
    • 0031038068 scopus 로고    scopus 로고
    • Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor-β 1 , platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis
    • Relf M, LeJeune S, Scott PA, Fox S, Smith K, Leek R, Moghaddam A, Whitehouse R, Bicknell R, Harris AL: Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor-β1 , platelet-derived endothelial cell growth factor, placenta growth factor, and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res 1997; 57: 963-969.
    • (1997) Cancer Res , vol.57 , pp. 963-969
    • Relf, M.1    Lejeune, S.2    Scott, P.A.3    Fox, S.4    Smith, K.5    Leek, R.6    Moghaddam, A.7    Whitehouse, R.8    Bicknell, R.9    Harris, A.L.10
  • 20
    • 0030678133 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer
    • Crew JP, O'Brien T, Bradburn M, Fuggle S, Bicknell R, Cranston D, Harris AL: Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer. Cancer Res 1997; 57: 5281-5285. (Pubitemid 27516364)
    • (1997) Cancer Research , vol.57 , Issue.23 , pp. 5281-5285
    • Crew, J.P.1    O'Brien, T.2    Bradburn, M.3    Fuggle, S.4    Bicknell, R.5    Cranston, D.6    Harris, A.L.7
  • 23
    • 25444506836 scopus 로고    scopus 로고
    • Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function
    • Patel NS, Li JL, Generali D, Poulsom R, Cranston DW, Harris AL: Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function. Cancer Res 2005; 65: 8690-8697.
    • (2005) Cancer Res , vol.65 , pp. 8690-8697
    • Patel, N.S.1    Li, J.L.2    Generali, D.3    Poulsom, R.4    Cranston, D.W.5    Harris, A.L.6
  • 24
    • 0038507194 scopus 로고    scopus 로고
    • Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1αexpression in renal cell carcinomas
    • Na X, Wu G, Ryan CK, Schoen SR, di'Santagnese PA, Messing EM: Overproduction of vascular endothelial growth factor related to von Hippel-Lindau tumor suppressor gene mutations and hypoxia-inducible factor-1α expression in renal cell carcinomas. J Urol 2003; 170: 588-592.
    • (2003) J Urol , vol.170 , pp. 588-592
    • Na, X.1    Wu, G.2    Ryan, C.K.3    Schoen, S.R.4    Di'Santagnese, P.A.5    Messing, E.M.6
  • 25
    • 1342288875 scopus 로고    scopus 로고
    • Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma
    • Joo HJ, Oh DK, Kim YS, Lee KB, Kim SJ: Increased expression of caveolin-1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma. BJU Int 2004; 93: 291-296.
    • (2004) BJU Int , vol.93 , pp. 291-296
    • Joo, H.J.1    Oh, D.K.2    Kim, Y.S.3    Lee, K.B.4    Kim, S.J.5
  • 26
    • 0031970194 scopus 로고    scopus 로고
    • Evaluation of the prognostic significance of microvessel count and tumor size in renal cell carcinoma
    • Yoshino S, Kato M, Okada K: Evaluation of the prognostic significance of microvessel count and tumor size in renal cell carcinoma. Int J Urol 1998; 5: 119-123.
    • (1998) Int J Urol , vol.5 , pp. 119-123
    • Yoshino, S.1    Kato, M.2    Okada, K.3
  • 27
    • 1342288873 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor protein in human renal cell carcinoma
    • Jacobsen J, Grankvist K, Rasmuson T, Bergh A, Landberg G, Ljungberg B: Expression of vascular endothelial growth factor protein in human renal cell carcinoma. BJU Int 2004; 93: 297-302.
    • (2004) BJU Int , vol.93 , pp. 297-302
    • Jacobsen, J.1    Grankvist, K.2    Rasmuson, T.3    Bergh, A.4    Landberg, G.5    Ljungberg, B.6
  • 28
    • 39449110749 scopus 로고    scopus 로고
    • Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma
    • Yildiz E, Ayan S, Goze F, Gokce G, Gultekin EY: Relation of microvessel density with microvascular invasion, metastasis and prognosis in renal cell carcinoma. BJU Int 2008; 101: 758-764.
    • (2008) BJU Int , vol.101 , pp. 758-764
    • Yildiz, E.1    Ayan, S.2    Goze, F.3    Gokce, G.4    Gultekin, E.Y.5
  • 29
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta LG, Chen H, O'Connor SJ, et al: Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997; 57: 4593-4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3
  • 30
    • 0033979730 scopus 로고    scopus 로고
    • Anti- VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor
    • Rowe DH, Huang J, Kayton ML, et al: Anti- VEGF antibody suppresses primary tumor growth and metastasis in an experimental model of Wilms' tumor. J Pediatr Surg 2000; 35: 30-32.
    • (2000) J Pediatr Surg , vol.35 , pp. 30-32
    • Rowe, D.H.1    Huang, J.2    Kayton, M.L.3
  • 31
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang JC, Haworth L, Sherry RM, et al: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003; 349: 427-434.
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3
  • 32
    • 37349080670 scopus 로고    scopus 로고
    • AVOREN Trial investigators: Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al; AVOREN Trial investigators: Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial. Lancet 2007; 370: 2103-2111.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 34
    • 0037143764 scopus 로고    scopus 로고
    • VEGFTrap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al: VEGFTrap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2002; 99: 11393-11398.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 35
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64: 7099-7109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 37
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • TARGET Study Group
    • Escudier B, Eisen T, Stadler WM, et al; TARGET Study Group: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007; 356: 125-134.
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 38
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, et al: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003; 9: 327-337.
    • (2003) Clin Cancer Res , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 39
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer RJ, Michaelson MD, Redman BG, et al: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006; 24: 16-24.
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 40
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM, et al: Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006; 295: 2516-2524.
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 41
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon-alpha in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al: Sunitinib versus interferon-alpha in metastatic renal-cell carcinoma. N Engl J Med 2007; 356: 115-124.
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 42
    • 40949118437 scopus 로고    scopus 로고
    • Temsirolimus, an inhibitor of mammalian target of rapamycin
    • Rini B: Temsirolimus, an inhibitor of mammalian target of rapamycin. Clin Cancer Res 2008; 14: 1286-1290.
    • (2008) Clin Cancer Res , vol.14 , pp. 1286-1290
    • Rini, B.1
  • 43
    • 30044432434 scopus 로고    scopus 로고
    • Hypoxia inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
    • Thomas GV, Tran C, Mellinghoff IK, et al: Hypoxia inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006; 12: 122-127.
    • (2006) Nat Med , vol.12 , pp. 122-127
    • Thomas, G.V.1    Tran, C.2    Mellinghoff, I.K.3
  • 44
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • Atkins MB, Hidalgo M, Stadler WM, et al: Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004; 22: 909-918.
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, M.B.1    Hidalgo, M.2    Stadler, W.M.3
  • 45
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • Motzer RJ, Mazumdar M, Bacik J, et al: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999; 17: 2530-2540.
    • (1999) J Clin Oncol , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.