Somatic mutations of the lysyl oxidase gene on chromosome 5q23.1 in colorectal tumors

International Journal of Cancer

Volumn 97, Issue 5, 2002, Pages 636-642

  Csiszar, Katalin ^a   Fong, Sheri F T ^a   Ujfalusi, Aniko ^a   Krawetz, Stephen A ^b   Salvati, Eugene P ^c   Mackenzie, James W ^d   Boyd, Charles D ^a  

^a UNIVERSITY OF HAWAII   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Muhlenberg Regional Medical Center   (United States)

^d ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

Chromosome 5; Colon cancer; LOX; Mutations

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); DNA; GENE PRODUCT; MESSENGER RNA; PROTEIN LOX; PROTEIN LYSINE 6 OXIDASE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOGENESIS; CELL GROWTH; CHROMOSOMAL LOCALIZATION; CHROMOSOME 5Q; CHROMOSOME LOSS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DNA SEQUENCE; EXON; FEMALE; GENE DELETION; GENE FUNCTION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC ANALYSIS; GENOME; GROWTH REGULATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADENOCARCINOMA; AGED; BLOTTING, SOUTHERN; CHROMOSOMES, HUMAN, PAIR 5; COHORT STUDIES; COLON; COLORECTAL NEOPLASMS; DNA MUTATIONAL ANALYSIS; FEMALE; HUMANS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MUTATION; PHYSICAL CHROMOSOME MAPPING; PROTEIN-LYSINE 6-OXIDASE; RNA, MESSENGER; SEQUENCE DELETION;

EID: 0037050723     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.10035     Document Type: Article

References (40)

1. Lysyl oxidase: Properties, regulation and multiple functions in biology
2. The role of lysyl oxidase and collagen cross-linking during sea urchin development
3. Micro injection of recombinant lysyl oxidase blocks oncogenic p21-Ha-Ras and progesterone effects on Xenopus laevis oocyte maturation
4. Immunohistochemical localization of lysyl oxidase with monoclonal antibodies
5. Localization and activity of lysyl oxidase within nuclei of fibrogenic cells
6. Quantitative polymerase chain reaction of lysyl oxidase mRNA in malignantly transformed human cell lines demonstrates that their low lysyl oxidase activity is due to low quantities of its mRNA and low levels of transcription of the respective gene
7. Deficient production of lysyl oxidase in cultures of malignantly transformed human cells
8. Expression of gene rrg is associated with reversion of NIH3T3 transformed by LTR-c-H-ras
9. Lysyl oxidase and rrg messenger RNA
10. Functional analysis of the promoter and first intron of the human lysyl oxidase gene
11. Reduced lysyl oxidase messenger RNA levels in experimental and human prostate cancer
12. Lysyl oxidase-like protein localizes to sites of de novo fibrinogenesis and in the early stromal reaction of ductal breast carcinoma
13. Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma
14. Transcriptional and post-transcriptional control of lysyl oxidase expression in vascular smooth muscle cells: Effects of TGF-beta and serum deprivation
15. Identification of the lysyl oxidase gene as a target of the antioncogenic transcription factor, IRF-1 and its possible role in tumor suppression
16. Molecular cloning of human lysyl oxidase and assignment of the gene to chromosome 5q23.3-31.2
17. The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5
18. Two distinct regions of deletion on the long arm of chromosome 5 in differentiated adenocarcinomas of the stomach
19. Loss of heterozygosity at 5q21 in non-small cell lung cancer: A frequent event but without evidence of apc mutation
20. Allelic deletion mapping on chromosome 5 in human lung carcinomas
21. Structural alterations of chromosome 5 in twelve human prostate cell lines
22. Deletion mapping identifies loss of heterozygosity at 5p15.1-15.2, 5q11 and 5q34-35 in human male germ cell tumors
23. Chromosomal imbalance maps of malignant solid tumors: A cytogenetic survey of 3185 neoplasms
24. DNA banking: The effects of storage of blood and isolated DNA on the integrity of DNA
25. A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene
26. Isolation and characterization of a 1 Mb region of 5q23.3-q31.2 surrounding the human lysyl oxidase gene
27. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
28. Expression of E-cadherin, α-catenin, α-catenin and plakoglobin in esophageal carcinomas and its prognostic significance
29. Identification of deletion mutations and three new genes at the familial polyposis locus
30. Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients
31. Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction
32. High resolution genetic map of the adenomatous polyposis coli gene (APC) region
33. Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1-1.5 Mb and preparation of a PAC-based physical map
34. Homozygous deletions of human chromosome 3p in lung tumors
35. Chromosome 9p deletions in invasive and noninvasive nonfunctional pituitary adenomas: The deleted region involves markers outside of the MTS1 and MTS2 genes
36. Genetic instabilities in human cancers
37. A genetic model for colorectal tumorigenesis
38. Loss of heterozygosity of tumor suppressor gene loci in human colorectal carcinoma
39. Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cells
40. Modulation of ras transformation affecting chromatin supraorganization as assessed by image analysis