메뉴 건너뛰기




Volumn 10, Issue 12, 2010, Pages 1703-1716

Modulation of toll-like receptor function has therapeutic potential in autoimmune disease

Author keywords

autoimmune disease; inflammation; multiple sclerosis; murine models; rheumatoid arthritis; systemic lupus erythematosus; therapeutic targeting; TLR

Indexed keywords

1 [5 HYDROXY 2 (2 THIENYL) 4 QUINAZOLINYLAMINO] 3 METHYL 2,5 PYRROLEDIONE; 4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; 6 CHLORO 7 METHOXY 8 (2 METHYLNICOTINAMIDO) BETA CARBOLINE; BETA1A INTERFERON; CHAPERONIN; CPG 52364; CRX 526; DEXTRO ARGINYL DEXTRO NORLEUCYL DEXTRO NORLEUCYL DEXTRO NORLEUCYL DEXTRO ARGINYL DEXTRO NORLEUCYL DEXTRO NORLEUCYL DEXTRO NORLEUCYLGLYCYL DEXTRO TYROSINAMIDE; DISEASE MODIFYING ANTIRHEUMATIC DRUG; DV 1179; E 4464; EPIGALLOCATECHIN GALLATE; ERITORAN; GLATIRAMER; GLUCOCORTICOID; HYALURONIC ACID; I KAPPA B KINASE INHIBITOR; IMO 3100; NI 0101; OLIGODEOXYRIBONUCLEOTIDE; OPN 305; OPN 526; RITUXIMAB; SC 514; ST 2825; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; VTX 763;

EID: 78249235626     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2010.534080     Document Type: Review
Times cited : (24)

References (164)
  • 1
    • 0023013784 scopus 로고
    • Genetic analysis of families with multiple cases of rheumatoid arthritis
    • Yamashita TS, Khan MA, Kushner I. Genetic analysis of families with multiple cases of rheumatoid arthritis. Dis Markers 1986;4(1-2): 113-19
    • (1986) Dis. Markers , vol.4 , Issue.1-2 , pp. 113-119
    • Yamashita, T.S.1    Khan, M.A.2    Kushner, I.3
  • 2
    • 71649083353 scopus 로고    scopus 로고
    • Clustering and commonalities among autoimmune diseases
    • Mackay IR. Clustering and commonalities among autoimmune diseases. J Autoimmun 2009;33(3-4): 170-7
    • (2009) J. Autoimmun , vol.33 , Issue.3-4 , pp. 170-177
    • Mackay, I.R.1
  • 3
    • 0031240055 scopus 로고    scopus 로고
    • Epidemiology and estimated population burden of selected autoimmune diseases in the United States
    • Jacobson DL, Gange SJ, Rose NR, Graham NM. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997;84(3):223-43
    • (1997) Clin. Immunol. Immunopathol. , vol.84 , Issue.3 , pp. 223-243
    • Jacobson, D.L.1    Gange, S.J.2    Rose, N.R.3    Graham, N.M.4
  • 4
    • 0037708024 scopus 로고    scopus 로고
    • How immune mechanisms are affected by pregnancy
    • Luppi P. How immune mechanisms are affected by pregnancy. Vaccine 2003;21(24):3352-7
    • (2003) Vaccine , vol.21 , Issue.24 , pp. 3352-3357
    • Luppi, P.1
  • 5
    • 77649339064 scopus 로고    scopus 로고
    • Effects of tobacco smoke on immunity, inflammation and autoimmunity
    • Arnson Y, Shoenfeld Y, Amital H. Effects of tobacco smoke on immunity, inflammation and autoimmunity. J Autoimmun 2010;34(3):J258-65
    • (2010) J. Autoimmun , vol.34 , Issue.3
    • Arnson, Y.1    Shoenfeld, Y.2    Amital, H.3
  • 6
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • Dantzer R, O'Connor JC, Freund GG, et al. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 2008;9(1):46-56
    • (2008) Nat. Rev. Neurosci. , vol.9 , Issue.1 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3
  • 7
    • 63649108380 scopus 로고    scopus 로고
    • The roles of TLRs, RLRs and NLRs in pathogen recognition
    • Kawai T, Akira S. The roles of TLRs, RLRs and NLRs in pathogen recognition. Int Immunol 2009;21(4):317-37
    • (2009) Int. Immunol. , vol.21 , Issue.4 , pp. 317-337
    • Kawai, T.1    Akira, S.2
  • 8
    • 33746731651 scopus 로고    scopus 로고
    • HMGB1 signals through toll-like receptor (TLR) 4 and TLR2
    • Yu M, Wang H, Ding A, et al. HMGB1 signals through toll-like receptor (TLR) 4 and TLR2. Shock 2006;26(2):174-9
    • (2006) Shock , vol.26 , Issue.2 , pp. 174-179
    • Yu, M.1    Wang, H.2    Ding, A.3
  • 9
    • 0037033364 scopus 로고    scopus 로고
    • Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4
    • Termeer C, Benedix F, Sleeman J, et al. Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med 2002;195(1):99-111
    • (2002) J. Exp. Med. , vol.195 , Issue.1 , pp. 99-111
    • Termeer, C.1    Benedix, F.2    Sleeman, J.3
  • 10
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    • Leadbetter EA, Rifkin IR, Hohlbaum AM, et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002;416(6881):603-7
    • (2002) Nature , vol.416 , Issue.6881 , pp. 603-607
    • Leadbetter, E.A.1    Rifkin, I.R.2    Hohlbaum, A.M.3
  • 11
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 2001;167(5):2887-94
    • (2001) J. Immunol. , vol.167 , Issue.5 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 12
    • 0035971217 scopus 로고    scopus 로고
    • The extra domain A of fibronectin activates Toll-like receptor 4
    • Okamura Y, Watari M, Jerud ES, et al. The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 2001;276(13):10229-33
    • (2001) J. Biol. Chem. , vol.276 , Issue.13 , pp. 10229-10233
    • Okamura, Y.1    Watari, M.2    Jerud, E.S.3
  • 13
    • 67650502739 scopus 로고    scopus 로고
    • Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    • Midwood K, Sacre S, Piccinini AM, et al. Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease. Nat Med 2009;15(7):774-80
    • (2009) Nat. Med. , vol.15 , Issue.7 , pp. 774-780
    • Midwood, K.1    Sacre, S.2    Piccinini, A.M.3
  • 14
    • 46749136412 scopus 로고    scopus 로고
    • When signaling pathways collide: Positive and negative regulation of toll-like receptor signal transduction
    • O'Neill LA. When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. Immunity 2008;29(1):12-20
    • (2008) Immunity , vol.29 , Issue.1 , pp. 12-20
    • O'Neill, L.A.1
  • 15
    • 33748871187 scopus 로고    scopus 로고
    • The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
    • Carty M, Goodbody R, Schroder M, et al. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol 2006;7(10):1074-81
    • (2006) Nat. Immunol. , vol.7 , Issue.10 , pp. 1074-1081
    • Carty, M.1    Goodbody, R.2    Schroder, M.3
  • 16
    • 33646908228 scopus 로고    scopus 로고
    • Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
    • Kagan JC, Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 2006;125(5):943-55
    • (2006) Cell. , vol.125 , Issue.5 , pp. 943-955
    • Kagan, J.C.1    Medzhitov, R.2
  • 18
    • 0345991221 scopus 로고    scopus 로고
    • TIR-containing adapter molecule (TICAM) - 2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta
    • Oshiumi H, Sasai M, Shida K, et al. TIR-containing adapter molecule (TICAM) - 2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem 2003;278(50):49751-62
    • (2003) J. Biol. Chem. , vol.278 , Issue.50 , pp. 49751-49762
    • Oshiumi, H.1    Sasai, M.2    Shida, K.3
  • 19
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010;11(5):373-84
    • (2010) Nat. Immunol. , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 20
    • 67349182481 scopus 로고    scopus 로고
    • The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
    • Park BS, Song DH, Kim HM, et al. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 2009;458(7242):1191-5
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1191-1195
    • Park, B.S.1    Song, D.H.2    Kim, H.M.3
  • 21
    • 34547127890 scopus 로고    scopus 로고
    • Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2
    • Taylor KR, Yamasaki K, Radek KA, et al. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on Toll-like receptor 4, CD44, and MD-2. J Biol Chem 2007;282(25):18265-75
    • (2007) J. Biol. Chem. , vol.282 , Issue.25 , pp. 18265-18275
    • Taylor, K.R.1    Yamasaki, K.2    Radek, K.A.3
  • 22
    • 34548727522 scopus 로고    scopus 로고
    • Cutting edge: High molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells
    • Bollyky PL, Lord JD, Masewicz SA, et al. Cutting edge: high molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells. J Immunol 2007;179(2):744-7
    • (2007) J. Immunol. , vol.179 , Issue.2 , pp. 744-747
    • Bollyky, P.L.1    Lord, J.D.2    Masewicz, S.A.3
  • 23
    • 77955300229 scopus 로고    scopus 로고
    • Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium
    • Asari A, Kanemitsu T, Kurihara H. Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium. J Biol Chem 2010;285(32):24751-8
    • (2010) J. Biol. Chem. , vol.285 , Issue.32 , pp. 24751-24758
    • Asari, A.1    Kanemitsu, T.2    Kurihara, H.3
  • 24
    • 0142041982 scopus 로고    scopus 로고
    • Lasker clinical medical research award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases
    • Feldmann M, Maini RN. Lasker clinical medical research award. TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases. Nat Med 2003;9(10):1245-50
    • (2003) Nat. Med. , vol.9 , Issue.10 , pp. 1245-1250
    • Feldmann, M.1    Maini, R.N.2
  • 25
    • 0029900167 scopus 로고    scopus 로고
    • Potential infectious agents in the induction of arthritides
    • Krause A, Kamradt T, Burmester GR. Potential infectious agents in the induction of arthritides. Curr Opin Rheumatol 1996;8(3):203-9
    • (1996) Curr. Opin. Rheumatol. , vol.8 , Issue.3 , pp. 203-209
    • Krause, A.1    Kamradt, T.2    Burmester, G.R.3
  • 26
    • 63149158618 scopus 로고    scopus 로고
    • Antiviral immune responses: Triggers of or triggered by autoimmunity?
    • Munz C, Lunemann JD, Getts MT, Miller SD. Antiviral immune responses: triggers of or triggered by autoimmunity? Nat Rev 2009;9(4):246-58
    • (2009) Nat. Rev. , vol.9 , Issue.4 , pp. 246-258
    • Munz, C.1    Lunemann, J.D.2    Getts, M.T.3    Miller, S.D.4
  • 27
    • 0029583289 scopus 로고
    • Presence of bacterial flora-derived antigen in synovial tissue macrophages and dendritic cells
    • Melief MJ, Hoijer MA, Van Paassen HC, Hazenberg MP. Presence of bacterial flora-derived antigen in synovial tissue macrophages and dendritic cells. Br J Rheumatol 1995;34(12):1112-16
    • (1995) Br. J. Rheumatol. , vol.34 , Issue.12 , pp. 1112-1116
    • Melief, M.J.1    Hoijer, M.A.2    Van Paassen, H.C.3    Hazenberg, M.P.4
  • 28
    • 33846453283 scopus 로고    scopus 로고
    • Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs
    • Moen K, Brun JG, Valen M, et al. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol 2006;24(6):656-63
    • (2006) Clin. Exp. Rheumatol. , vol.24 , Issue.6 , pp. 656-663
    • Moen, K.1    Brun, J.G.2    Valen, M.3
  • 29
    • 0344483894 scopus 로고    scopus 로고
    • Chlamydia trachomatis nucleic acids can be found in the synovium of some asymptomatic subjects
    • Schumacher HR Jr, Arayssi T, Crane M, et al. Chlamydia trachomatis nucleic acids can be found in the synovium of some asymptomatic subjects. Arthritis Rheum 1999;42(6):1281-4
    • (1999) Arthritis Rheum. , vol.42 , Issue.6 , pp. 1281-1284
    • Schumacher Jr., H.R.1    Arayssi, T.2    Crane, M.3
  • 30
    • 23644449245 scopus 로고    scopus 로고
    • The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    • Roelofs MF, Joosten LA, Abdollahi-Roodsaz S, et al. The expression of toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 2005;52(8):2313-22
    • (2005) Arthritis Rheum. , vol.52 , Issue.8 , pp. 2313-2322
    • Roelofs, M.F.1    Joosten, L.A.2    Abdollahi-Roodsaz, S.3
  • 31
    • 33947545388 scopus 로고    scopus 로고
    • The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis
    • Sacre SM, Andreakos E, Kiriakidis S, et al. The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Am J Pathol 2007;170(2):518-25
    • (2007) Am. J. Pathol. , vol.170 , Issue.2 , pp. 518-525
    • Sacre, S.M.1    Andreakos, E.2    Kiriakidis, S.3
  • 32
    • 25444443335 scopus 로고    scopus 로고
    • RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3
    • Brentano F, Schorr O, Gay RE, et al. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum 2005;52(9):2656-65
    • (2005) Arthritis Rheum. , vol.52 , Issue.9 , pp. 2656-2665
    • Brentano, F.1    Schorr, O.2    Gay, R.E.3
  • 33
    • 0031816053 scopus 로고    scopus 로고
    • Quantitative analysis of hyaluronan in the synovial tissues of patients with joint disorders
    • Itokazu M, Shinozaki M, Ohno T. Quantitative analysis of hyaluronan in the synovial tissues of patients with joint disorders. Clin Rheumatol 1998;17(3):261-2
    • (1998) Clin. Rheumatol. , vol.17 , Issue.3 , pp. 261-262
    • Itokazu, M.1    Shinozaki, M.2    Ohno, T.3
  • 34
    • 0019354902 scopus 로고
    • The distribution of fibronectin in the pannus in rheumatoid arthritis
    • Scott DL, Delamere JP, Walton KW. The distribution of fibronectin in the pannus in rheumatoid arthritis. Br J Exp Pathol 1981;62(4):362-8
    • (1981) Br. J. Exp. Pathol. , vol.62 , Issue.4 , pp. 362-368
    • Scott, D.L.1    Delamere, J.P.2    Walton, K.W.3
  • 35
    • 0030987868 scopus 로고    scopus 로고
    • Soluble oligonucleosomal complexes in synovial fluid from inflamed joints
    • Yu D, Rumore PM, Liu Q, Steinman CR. Soluble oligonucleosomal complexes in synovial fluid from inflamed joints. Arthritis Rheum 1997;40(4):648-54
    • (1997) Arthritis Rheum. , vol.40 , Issue.4 , pp. 648-654
    • Yu, D.1    Rumore, P.M.2    Liu, Q.3    Steinman, C.R.4
  • 36
    • 0037386810 scopus 로고    scopus 로고
    • High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine
    • Taniguchi N, Kawahara K, Yone K, et al. High mobility group box chromosomal protein 1 plays a role in the pathogenesis of rheumatoid arthritis as a novel cytokine. Arthritis Rheum 2003;48(4):971-81
    • (2003) Arthritis Rheum. , vol.48 , Issue.4 , pp. 971-981
    • Taniguchi, N.1    Kawahara, K.2    Yone, K.3
  • 37
    • 0027292352 scopus 로고
    • Tenascin is increased in cartilage and synovium from arthritic knees
    • Salter DM. Tenascin is increased in cartilage and synovium from arthritic knees. Br J Rheumatol 1993;32(9):780-6
    • (1993) Br. J. Rheumatol. , vol.32 , Issue.9 , pp. 780-786
    • Salter, D.M.1
  • 38
    • 0037333990 scopus 로고    scopus 로고
    • Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling
    • Kyburz D, Rethage J, Seibl R, et al. Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. Arthritis Rheum 2003;48(3):642-50
    • (2003) Arthritis Rheum. , vol.48 , Issue.3 , pp. 642-650
    • Kyburz, D.1    Rethage, J.2    Seibl, R.3
  • 39
    • 2342604896 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis
    • Iwahashi M, Yamamura M, Aita T, et al. Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum 2004;50(5):1457-67
    • (2004) Arthritis Rheum. , vol.50 , Issue.5 , pp. 1457-1467
    • Iwahashi, M.1    Yamamura, M.2    Aita, T.3
  • 40
    • 0037378466 scopus 로고    scopus 로고
    • Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium
    • Seibl R, Birchler T, Loeliger S, et al. Expression and regulation of Toll-like receptor 2 in rheumatoid arthritis synovium. Am J Pathol 2003;162(4):1221-7
    • (2003) Am. J. Pathol. , vol.162 , Issue.4 , pp. 1221-1227
    • Seibl, R.1    Birchler, T.2    Loeliger, S.3
  • 41
    • 10444278132 scopus 로고    scopus 로고
    • Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma
    • Radstake TR, Roelofs MF, Jenniskens YM, et al. Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum 2004;50(12):3856-65
    • (2004) Arthritis Rheum. , vol.50 , Issue.12 , pp. 3856-3865
    • Radstake, T.R.1    Roelofs, M.F.2    Jenniskens, Y.M.3
  • 42
    • 71849117626 scopus 로고    scopus 로고
    • Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures
    • Sacre SM, Lo A, Gregory B, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol 2008;181(11):8002-9
    • (2008) J. Immunol. , vol.181 , Issue.11 , pp. 8002-8009
    • Sacre, S.M.1    Lo, A.2    Gregory, B.3
  • 43
    • 57349192121 scopus 로고    scopus 로고
    • Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis
    • Ospelt C, Brentano F, Rengel Y, et al. Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. Arthritis Rheum 2008;58(12):3684-92
    • (2008) Arthritis Rheum. , vol.58 , Issue.12 , pp. 3684-3692
    • Ospelt, C.1    Brentano, F.2    Rengel, Y.3
  • 44
    • 77954478293 scopus 로고    scopus 로고
    • TBK1-targeted suppression of TRIF-dependent signaling pathway of toll-like receptor 3 by auranofin
    • Park SJ, Lee AN, Youn HS. TBK1-targeted suppression of TRIF-dependent signaling pathway of toll-like receptor 3 by auranofin. Arch Pharm Res 2010;33(6):939-45
    • (2010) Arch. Pharm. Res. , vol.33 , Issue.6 , pp. 939-945
    • Park, S.J.1    Lee, A.N.2    Youn, H.S.3
  • 45
    • 10744223444 scopus 로고    scopus 로고
    • Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: Critical role of myeloid differentiation factor 88
    • Joosten LA, Koenders MI, Smeets RL, et al. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J Immunol 2003;171(11):6145-53
    • (2003) J. Immunol. , vol.171 , Issue.11 , pp. 6145-6153
    • Joosten, L.A.1    Koenders, M.I.2    Smeets, R.L.3
  • 47
    • 34848840994 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
    • Abdollahi-Roodsaz S, Joosten LA, Roelofs MF, et al. Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 2007;56(9):2957-67
    • (2007) Arthritis Rheum. , vol.56 , Issue.9 , pp. 2957-2967
    • Abdollahi-Roodsaz, S.1    Joosten, L.A.2    Roelofs, M.F.3
  • 48
    • 0038681182 scopus 로고    scopus 로고
    • Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity
    • Kokkola R, Li J, Sundberg E, et al. Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity. Arthritis Rheum 2003;48(7):2052-8
    • (2003) Arthritis Rheum. , vol.48 , Issue.7 , pp. 2052-2058
    • Kokkola, R.1    Li, J.2    Sundberg, E.3
  • 49
    • 2942702125 scopus 로고    scopus 로고
    • A novel therapy of murine collagen-induced arthritis with soluble T1/ST2
    • Leung BP, Xu D, Culshaw S, et al. A novel therapy of murine collagen-induced arthritis with soluble T1/ST2. J Immunol 2004;173(1):145-50
    • (2004) J. Immunol. , vol.173 , Issue.1 , pp. 145-150
    • Leung, B.P.1    Xu, D.2    Culshaw, S.3
  • 50
    • 0037450737 scopus 로고    scopus 로고
    • Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling
    • Choe JY, Crain B, Wu SR, Corr M. Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling. J Exp Med 2003;197(4):537-42
    • (2003) J. Exp. Med. , vol.197 , Issue.4 , pp. 537-542
    • Choe, J.Y.1    Crain, B.2    Wu, S.R.3    Corr, M.4
  • 51
    • 77952483341 scopus 로고    scopus 로고
    • Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats
    • Meng L, Zhu W, Jiang C, et al. Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats. Arthritis Res Ther 2010;12(3):R103
    • (2010) Arthritis Res. Ther. , vol.12 , Issue.3
    • Meng, L.1    Zhu, W.2    Jiang, C.3
  • 52
    • 35649027495 scopus 로고    scopus 로고
    • Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue
    • Sacre SM, Drexler SK, Andreakos E, et al. Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue. Ann Rheum Dis 2007;66(Suppl 3): iii81-6
    • (2007) Ann. Rheum. Dis. , vol.66 , Issue.3 SUPPL.
    • Sacre, S.M.1    Drexler, S.K.2    Andreakos, E.3
  • 53
    • 1642521633 scopus 로고    scopus 로고
    • Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus
    • Sanchez E, Orozco G, Lopez-Nevot MA, et al. Polymorphisms of toll-like receptor 2 and 4 genes in rheumatoid arthritis and systemic lupus erythematosus. Tissue Antigens 2004;63(1):54-7
    • (2004) Tissue Antigens , vol.63 , Issue.1 , pp. 54-57
    • Sanchez, E.1    Orozco, G.2    Lopez-Nevot, M.A.3
  • 54
    • 0037534428 scopus 로고    scopus 로고
    • A biologically important single nucleotide polymorphism within the toll-like receptor-4 gene is not associated with rheumatoid arthritis
    • Kilding R, Akil M, Till S, et al. A biologically important single nucleotide polymorphism within the toll-like receptor-4 gene is not associated with rheumatoid arthritis. Clin Exp Rheumatol 2003;21(3):340-2
    • (2003) Clin. Exp. Rheumatol. , vol.21 , Issue.3 , pp. 340-342
    • Kilding, R.1    Akil, M.2    Till, S.3
  • 55
    • 33747788749 scopus 로고    scopus 로고
    • Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis
    • Kuuliala K, Orpana A, Leirisalo-Repo M, et al. Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis. Ann Rheum Dis 2006;65(9):1241-3
    • (2006) Ann. Rheum. Dis. , vol.65 , Issue.9 , pp. 1241-1243
    • Kuuliala, K.1    Orpana, A.2    Leirisalo-Repo, M.3
  • 56
    • 46049104833 scopus 로고    scopus 로고
    • The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis
    • Sheedy FJ, Marinou I, O'Neill LA, Wilson AG. The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to, or severity of, rheumatoid arthritis. Ann Rheum Dis 2008;67(9):1328-31
    • (2008) Ann. Rheum. Dis. , vol.67 , Issue.9 , pp. 1328-1331
    • Sheedy, F.J.1    Marinou, I.2    O'Neill, L.A.3    Wilson, A.G.4
  • 57
    • 77951831491 scopus 로고    scopus 로고
    • Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: An association study in rheumatoid arthritis
    • Enevold C, Radstake TR, Coenen MJ, et al. Multiplex screening of 22 single-nucleotide polymorphisms in 7 Toll-like receptors: an association study in rheumatoid arthritis. J Rheumatol 2010;37(5):905-10
    • (2010) J. Rheumatol. , vol.37 , Issue.5 , pp. 905-910
    • Enevold, C.1    Radstake, T.R.2    Coenen, M.J.3
  • 58
    • 80054889306 scopus 로고    scopus 로고
    • The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients
    • Epub ahead of print; doi: 10.1007/s00296-010-1472-8
    • Etem EO, Elyas H, Ozgocmen S, et al. The investigation of toll-like receptor 3, 9 and 10 gene polymorphisms in Turkish rheumatoid arthritis patients. Rheumatol Int 2010. [Epub ahead of print; doi: 10.1007/s00296-010- 1472-8]
    • (2010) Rheumatol. Int.
    • Etem, E.O.1    Elyas, H.2    Ozgocmen, S.3
  • 59
    • 33748414196 scopus 로고    scopus 로고
    • Mode of action of hydroxychloroquine in RA-evidence of an inhibitory effect on toll-like receptor signaling
    • Kyburz D, Brentano F, Gay S. Mode of action of hydroxychloroquine in RA-evidence of an inhibitory effect on toll-like receptor signaling. Nat Clin Pract Rheumatol 2006;2(9):458-9
    • (2006) Nat. Clin. Pract. Rheumatol. , vol.2 , Issue.9 , pp. 458-459
    • Kyburz, D.1    Brentano, F.2    Gay, S.3
  • 60
    • 77649124410 scopus 로고    scopus 로고
    • Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors
    • Sacre S, Medghalchi M, Gregory B, et al. Fluoxetine and citalopram exhibit potent antiinflammatory activity in human and murine models of rheumatoid arthritis and inhibit toll-like receptors. Arthritis Rheum 2010;62(3):683-93
    • (2010) Arthritis Rheum. , vol.62 , Issue.3 , pp. 683-693
    • Sacre, S.1    Medghalchi, M.2    Gregory, B.3
  • 61
    • 34548024379 scopus 로고    scopus 로고
    • Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway
    • Peng G, Wang HY, Peng W, et al. Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway. Immunity 2007;27(2):334-48
    • (2007) Immunity , vol.27 , Issue.2 , pp. 334-348
    • Peng, G.1    Wang, H.Y.2    Peng, W.3
  • 62
    • 23944509107 scopus 로고    scopus 로고
    • Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function
    • Peng G, Guo Z, Kiniwa Y, et al. Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 2005;309(5739):1380-4
    • (2005) Science , vol.309 , Issue.5739 , pp. 1380-1384
    • Peng, G.1    Guo, Z.2    Kiniwa, Y.3
  • 63
    • 0347480224 scopus 로고    scopus 로고
    • Activation of autoreactive B cells by CpG dsDNA
    • Viglianti GA, Lau CM, Hanley TM, et al. Activation of autoreactive B cells by CpG dsDNA. Immunity 2003;19(6):837-47
    • (2003) Immunity , vol.19 , Issue.6 , pp. 837-847
    • Viglianti, G.A.1    Lau, C.M.2    Hanley, T.M.3
  • 64
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • Tian J, Avalos AM, Mao SY, et al. Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 2007;8(5):487-96
    • (2007) Nat. Immunol. , vol.8 , Issue.5 , pp. 487-496
    • Tian, J.1    Avalos, A.M.2    Mao, S.Y.3
  • 65
    • 17844383756 scopus 로고    scopus 로고
    • Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation
    • Duramad O, Fearon KL, Chang B, et al. Inhibitors of TLR-9 act on multiple cell subsets in mouse and man in vitro and prevent death in vivo from systemic inflammation. J Immunol 2005;174(9):5193-200
    • (2005) J. Immunol. , vol.174 , Issue.9 , pp. 5193-5200
    • Duramad, O.1    Fearon, K.L.2    Chang, B.3
  • 66
    • 2342491490 scopus 로고    scopus 로고
    • Suppressive oligonucleotides protect against collagen-induced arthritis in mice
    • Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum 2004;50(5):1686-9
    • (2004) Arthritis Rheum. , vol.50 , Issue.5 , pp. 1686-1689
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 67
    • 0036674998 scopus 로고    scopus 로고
    • Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides
    • Zeuner RA, Ishii KJ, Lizak MJ, et al. Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides. Arthritis Rheum 2002;46(8):2219-24
    • (2002) Arthritis Rheum. , vol.46 , Issue.8 , pp. 2219-2224
    • Zeuner, R.A.1    Ishii, K.J.2    Lizak, M.J.3
  • 68
    • 31344466165 scopus 로고    scopus 로고
    • The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
    • Tabeta K, Hoebe K, Janssen EM, et al. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9. Nat Immunol 2006;7(2):156-64
    • (2006) Nat. Immunol. , vol.7 , Issue.2 , pp. 156-164
    • Tabeta, K.1    Hoebe, K.2    Janssen, E.M.3
  • 69
    • 19344374510 scopus 로고    scopus 로고
    • Impaired early B cell tolerance in patients with rheumatoid arthritis
    • Samuels J, Ng YS, Coupillaud C, et al. Impaired early B cell tolerance in patients with rheumatoid arthritis. J Exp Med 2005;201(10):1659-67
    • (2005) J. Exp. Med. , vol.201 , Issue.10 , pp. 1659-1667
    • Samuels, J.1    Ng, Y.S.2    Coupillaud, C.3
  • 70
    • 15444365480 scopus 로고    scopus 로고
    • Defective B cell tolerance checkpoints in systemic lupus erythematosus
    • Yurasov S, Wardemann H, Hammersen J, et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med 2005;201(5):703-11
    • (2005) J. Exp. Med. , vol.201 , Issue.5 , pp. 703-711
    • Yurasov, S.1    Wardemann, H.2    Hammersen, J.3
  • 71
    • 55349142293 scopus 로고    scopus 로고
    • IRAK-4-and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans
    • Isnardi I, Ng YS, Srdanovic I, et al. IRAK-4-and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 2008;29(5):746-57
    • (2008) Immunity , vol.29 , Issue.5 , pp. 746-757
    • Isnardi, I.1    Ng, Y.S.2    Srdanovic, I.3
  • 72
    • 0035877190 scopus 로고    scopus 로고
    • Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice
    • Sun D, Whitaker JN, Huang Z, et al. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J Immunol 2001;166(12):7579-87
    • (2001) J. Immunol. , vol.166 , Issue.12 , pp. 7579-7587
    • Sun, D.1    Whitaker, J.N.2    Huang, Z.3
  • 73
    • 19944427519 scopus 로고    scopus 로고
    • Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease
    • Visser L, Jan de Heer H, Boven LA, et al. Proinflammatory bacterial peptidoglycan as a cofactor for the development of central nervous system autoimmune disease. J Immunol 2005;174(2):808-16
    • (2005) J. Immunol. , vol.174 , Issue.2 , pp. 808-816
    • Visser, L.1    Jan De Heer, H.2    Boven, L.A.3
  • 74
    • 0024603951 scopus 로고
    • LPS augments adoptive transfer of experimental allergic encephalomyelitis in the Lewis rat
    • Hamada T, Driscoll BF, Kies MW, Alvord EC Jr. LPS augments adoptive transfer of experimental allergic encephalomyelitis in the Lewis rat. Autoimmunity 1989;2(4):275-84
    • (1989) Autoimmunity , vol.2 , Issue.4 , pp. 275-284
    • Hamada, T.1    Driscoll, B.F.2    Kies, M.W.3    Alvord Jr., E.C.4
  • 75
    • 0034043957 scopus 로고    scopus 로고
    • CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
    • Segal BM, Chang JT, Shevach EM. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J Immunol 2000;164(11):5683-8
    • (2000) J. Immunol. , vol.164 , Issue.11 , pp. 5683-5688
    • Segal, B.M.1    Chang, J.T.2    Shevach, E.M.3
  • 76
    • 32444443739 scopus 로고    scopus 로고
    • Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis
    • Prinz M, Garbe F, Schmidt H, et al. Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis. J Clin Invest 2006;116(2):456-64
    • (2006) J. Clin. Invest. , vol.116 , Issue.2 , pp. 456-464
    • Prinz, M.1    Garbe, F.2    Schmidt, H.3
  • 77
    • 69949184869 scopus 로고    scopus 로고
    • Toll-like receptors in multiple sclerosis mouse experimental models
    • Marta M. Toll-like receptors in multiple sclerosis mouse experimental models. Ann NY Acad Sci 2009;1173:458-62
    • (2009) Ann. N.Y. Acad. Sci. , vol.1173 , pp. 458-462
    • Marta, M.1
  • 78
    • 42249109064 scopus 로고    scopus 로고
    • Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis
    • Marta M, Andersson A, Isaksson M, et al. Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur J Immunol 2008;38(2):565-75
    • (2008) Eur. J. Immunol. , vol.38 , Issue.2 , pp. 565-575
    • Marta, M.1    Andersson, A.2    Isaksson, M.3
  • 79
    • 33751571417 scopus 로고    scopus 로고
    • Cutting edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta
    • Touil T, Fitzgerald D, Zhang GX, et al. Cutting edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta. J Immunol 2006;177(11):7505-9
    • (2006) J. Immunol. , vol.177 , Issue.11 , pp. 7505-7509
    • Touil, T.1    Fitzgerald, D.2    Zhang, G.X.3
  • 80
    • 43049101640 scopus 로고    scopus 로고
    • The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    • Guo B, Chang EY, Cheng G. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 2008;118(5):1680-90
    • (2008) J. Clin. Invest. , vol.118 , Issue.5 , pp. 1680-1690
    • Guo, B.1    Chang, E.Y.2    Cheng, G.3
  • 81
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of Toll-like receptors in the human central nervous system
    • Bsibsi M, Ravid R, Gveric D, van Noort JM. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol 2002;61(11):1013-21
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , Issue.11 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    Van Noort, J.M.4
  • 82
    • 55549100952 scopus 로고    scopus 로고
    • Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis
    • Andersson A, Covacu R, Sunnemark D, et al. Pivotal advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis. J Leukoc Biol 2008;84(5):1248-55
    • (2008) J. Leukoc Biol. , vol.84 , Issue.5 , pp. 1248-1255
    • Andersson, A.1    Covacu, R.2    Sunnemark, D.3
  • 83
    • 77954893581 scopus 로고    scopus 로고
    • Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2
    • Sloane JA, Batt C, Ma Y, et al. Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2. Proc Natl Acad Sci USA 2010;107(25):11555-60
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , Issue.25 , pp. 11555-11560
    • Sloane, J.A.1    Batt, C.2    Ma, Y.3
  • 84
    • 24744468983 scopus 로고    scopus 로고
    • Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
    • Back SA, Tuohy TM, Chen H, et al. Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation. Nat Med 2005;11(9):966-72
    • (2005) Nat. Med. , vol.11 , Issue.9 , pp. 966-972
    • Back, S.A.1    Tuohy, T.M.2    Chen, H.3
  • 85
    • 77953622925 scopus 로고    scopus 로고
    • The microtubule regulator stathmin is an endogenous protein agonist for TLR3
    • Bsibsi M, Bajramovic JJ, Vogt MH, et al. The microtubule regulator stathmin is an endogenous protein agonist for TLR3. J Immunol 2010;184(12):6929-37
    • (2010) J. Immunol. , vol.184 , Issue.12 , pp. 6929-6937
    • Bsibsi, M.1    Bajramovic, J.J.2    Vogt, M.H.3
  • 86
    • 0023837047 scopus 로고
    • Effect of viral infection on experimental allergic encephalomyelitis in mice
    • Wu LX, Makela MJ, Roytta M, Salmi A. Effect of viral infection on experimental allergic encephalomyelitis in mice. J Neuroimmunol 1988;18(2):139-53
    • (1988) J. Neuroimmunol. , vol.18 , Issue.2 , pp. 139-153
    • Wu, L.X.1    Makela, M.J.2    Roytta, M.3    Salmi, A.4
  • 88
    • 33746595274 scopus 로고    scopus 로고
    • Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2
    • Herrmann I, Kellert M, Schmidt H, et al. Streptococcus pneumoniae Infection aggravates experimental autoimmune encephalomyelitis via Toll-like receptor 2. Infect Immun 2006;74(8):4841-8
    • (2006) Infect. Immun. , vol.74 , Issue.8 , pp. 4841-4848
    • Herrmann, I.1    Kellert, M.2    Schmidt, H.3
  • 89
    • 0034910692 scopus 로고    scopus 로고
    • Bacterial peptidoglycan and immune reactivity in the central nervous system in multiple sclerosis
    • Schrijver IA, van Meurs M, Melief MJ, et al. Bacterial peptidoglycan and immune reactivity in the central nervous system in multiple sclerosis. Brain 2001;124(Pt 8):1544-54
    • (2001) Brain , vol.124 , Issue.8 PT. , pp. 1544-1554
    • Schrijver, I.A.1    Van Meurs, M.2    Melief, M.J.3
  • 90
    • 0020436689 scopus 로고
    • The 1982 revised criteria for the classification of systemic lupus erythematosus
    • Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25(11):1271-7
    • (1982) Arthritis Rheum. , vol.25 , Issue.11 , pp. 1271-1277
    • Tan, E.M.1    Cohen, A.S.2    Fries, J.F.3
  • 91
    • 0020026322 scopus 로고
    • Serum interferon levels in patients with systemic lupus erythematosus
    • Ytterberg SR, Schnitzer TJ. Serum interferon levels in patients with systemic lupus erythematosus. Arthritis Rheum 1982;25(4):401-6
    • (1982) Arthritis Rheum. , vol.25 , Issue.4 , pp. 401-406
    • Ytterberg, S.R.1    Schnitzer, T.J.2
  • 92
    • 34548438559 scopus 로고    scopus 로고
    • High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus
    • Niewold TB, Hua J, Lehman TJ, et al. High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 2007;8(6):492-502
    • (2007) Genes Immun. , vol.8 , Issue.6 , pp. 492-502
    • Niewold, T.B.1    Hua, J.2    Lehman, T.J.3
  • 93
    • 17544373868 scopus 로고    scopus 로고
    • Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C
    • Niewold TB, Swedler WI. Systemic lupus erythematosus arising during interferon-alpha therapy for cryoglobulinemic vasculitis associated with hepatitis C. Clin Rheumatol 2005;24(2):178-81
    • (2005) Clin. Rheumatol. , vol.24 , Issue.2 , pp. 178-181
    • Niewold, T.B.1    Swedler, W.I.2
  • 94
    • 50449103533 scopus 로고    scopus 로고
    • Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    • Musone SL, Taylor KE, Lu TT, et al. Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet 2008;40(9):1062-4
    • (2008) Nat. Genet. , vol.40 , Issue.9 , pp. 1062-1064
    • Musone, S.L.1    Taylor, K.E.2    Lu, T.T.3
  • 95
    • 77955917771 scopus 로고    scopus 로고
    • The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity
    • Tavares RM, Turer EE, Liu CL, et al. The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity. Immunity 2010;33(2):181-91
    • (2010) Immunity , vol.33 , Issue.2 , pp. 181-191
    • Tavares, R.M.1    Turer, E.E.2    Liu, C.L.3
  • 96
    • 67849088550 scopus 로고    scopus 로고
    • Identification of new SLE-associated genes with a two-step Bayesian study design
    • Armstrong DL, Reiff A, Myones BL, et al. Identification of new SLE-associated genes with a two-step Bayesian study design. Genes Immun 2009;10(5):446-56
    • (2009) Genes Immun. , vol.10 , Issue.5 , pp. 446-456
    • Armstrong, D.L.1    Reiff, A.2    Myones, B.L.3
  • 97
    • 46749097334 scopus 로고    scopus 로고
    • TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus
    • Castiblanco J, Varela DC, Castano-Rodriguez N, et al. TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. Infect Genet Evol 2008;8(5):541-4
    • (2008) Infect. Genet. Evol. , vol.8 , Issue.5 , pp. 541-544
    • Castiblanco, J.1    Varela, D.C.2    Castano-Rodriguez, N.3
  • 98
    • 46849113681 scopus 로고    scopus 로고
    • Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus
    • Akahoshi M, Nakashima H, Sadanaga A, et al. Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus. Lupus 2008;17(6):568-74
    • (2008) Lupus , vol.17 , Issue.6 , pp. 568-574
    • Akahoshi, M.1    Nakashima, H.2    Sadanaga, A.3
  • 99
    • 65549124475 scopus 로고    scopus 로고
    • Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
    • Jacob CO, Zhu J, Armstrong DL, et al. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci USA 2009;106(15):6256-61
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , Issue.15 , pp. 6256-6261
    • Jacob, C.O.1    Zhu, J.2    Armstrong, D.L.3
  • 100
    • 0031838606 scopus 로고    scopus 로고
    • Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus
    • Herrmann M, Voll RE, Zoller OM, et al. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998;41(7):1241-50
    • (1998) Arthritis Rheum. , vol.41 , Issue.7 , pp. 1241-1250
    • Herrmann, M.1    Voll, R.E.2    Zoller, O.M.3
  • 101
    • 42449117483 scopus 로고    scopus 로고
    • Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis
    • Savarese E, Steinberg C, Pawar RD, et al. Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. Arthritis Rheum 2008;58(4):1107-15
    • (2008) Arthritis Rheum. , vol.58 , Issue.4 , pp. 1107-1115
    • Savarese, E.1    Steinberg, C.2    Pawar, R.D.3
  • 102
    • 33645076274 scopus 로고    scopus 로고
    • TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
    • Ehlers M, Fukuyama H, McGaha TL, et al. TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE. J Exp Med 2006;203(3):553-61
    • (2006) J. Exp. Med. , vol.203 , Issue.3 , pp. 553-561
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3
  • 103
    • 28544449709 scopus 로고    scopus 로고
    • Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
    • Vollmer J, Tluk S, Schmitz C, et al. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J Exp Med 2005;202(11):1575-85
    • (2005) J. Exp. Med. , vol.202 , Issue.11 , pp. 1575-1585
    • Vollmer, J.1    Tluk, S.2    Schmitz, C.3
  • 104
    • 77950521851 scopus 로고    scopus 로고
    • Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses
    • Khan N, Summers CW, Helbert MR, Arkwright PD. Effects of age, gender, and immunosuppressive agents on in vivo toll-like receptor pathway responses. Hum Immunol 2010;71(4):372-6
    • (2010) Hum. Immunol. , vol.71 , Issue.4 , pp. 372-376
    • Khan, N.1    Summers, C.W.2    Helbert, M.R.3    Arkwright, P.D.4
  • 105
    • 33745168605 scopus 로고    scopus 로고
    • Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    • Pisitkun P, Deane JA, Difilippantonio MJ, et al. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006;312(5780):1669-72
    • (2006) Science , vol.312 , Issue.5780 , pp. 1669-1672
    • Pisitkun, P.1    Deane, J.A.2    Difilippantonio, M.J.3
  • 106
    • 33745617886 scopus 로고    scopus 로고
    • A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
    • Subramanian S, Tus K, Li QZ, et al. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Proc Natl Acad Sci USA 2006;103(26):9970-5
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , Issue.26 , pp. 9970-9975
    • Subramanian, S.1    Tus, K.2    Li, Q.Z.3
  • 107
    • 77957673544 scopus 로고    scopus 로고
    • Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
    • Shen N, Fu Q, Deng Y, et al. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci USA 2010;107(36):15838-43
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , Issue.36 , pp. 15838-15843
    • Shen, N.1    Fu, Q.2    Deng, Y.3
  • 108
    • 27744444832 scopus 로고    scopus 로고
    • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    • Lau CM, Broughton C, Tabor AS, et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 2005;202(9):1171-7
    • (2005) J. Exp. Med. , vol.202 , Issue.9 , pp. 1171-1177
    • Lau, C.M.1    Broughton, C.2    Tabor, A.S.3
  • 109
    • 22944490869 scopus 로고    scopus 로고
    • Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
    • Christensen SR, Kashgarian M, Alexopoulou L, et al. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J Exp Med 2005;202(2):321-31
    • (2005) J. Exp. Med. , vol.202 , Issue.2 , pp. 321-331
    • Christensen, S.R.1    Kashgarian, M.2    Alexopoulou, L.3
  • 110
    • 77954237776 scopus 로고    scopus 로고
    • Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus
    • Lartigue A, Colliou N, Calbo S, et al. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. J Immunol 2009;183(10):6207-16
    • (2009) J. Immunol. , vol.183 , Issue.10 , pp. 6207-6216
    • Lartigue, A.1    Colliou, N.2    Calbo, S.3
  • 111
    • 77953723966 scopus 로고    scopus 로고
    • TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
    • Guiducci C, Gong M, Xu Z, et al. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature 2010;465(7300):937-41
    • (2010) Nature , vol.465 , Issue.7300 , pp. 937-941
    • Guiducci, C.1    Gong, M.2    Xu, Z.3
  • 112
    • 77958151575 scopus 로고    scopus 로고
    • TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy
    • Summers SA, Hoi A, Steinmetz OM, et al. TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy. J Autoimmun 2010;35(4):291-8
    • (2010) J. Autoimmun , vol.35 , Issue.4 , pp. 291-298
    • Summers, S.A.1    Hoi, A.2    Steinmetz, O.M.3
  • 113
    • 77949903821 scopus 로고    scopus 로고
    • TLR9 regulates TLR7-and MyD88-dependent autoantibody production and disease in a murine model of lupus
    • Nickerson KM, Christensen SR, Shupe J, et al. TLR9 regulates TLR7-and MyD88-dependent autoantibody production and disease in a murine model of lupus. J Immunol 2010;184(4):1840-8
    • (2010) J. Immunol. , vol.184 , Issue.4 , pp. 1840-1848
    • Nickerson, K.M.1    Christensen, S.R.2    Shupe, J.3
  • 114
    • 77954339436 scopus 로고    scopus 로고
    • Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus
    • Jin O, Kavikondala S, Mok MY, et al. Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus. Arthritis Res Ther 2010;12(4):R137
    • (2010) Arthritis Res. Ther. , vol.12 , Issue.4
    • Jin, O.1    Kavikondala, S.2    Mok, M.Y.3
  • 115
    • 0025666735 scopus 로고
    • Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis
    • Richardson B, Scheinbart L, Strahler J, et al. Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 1990;33(11):1665-73
    • (1990) Arthritis Rheum. , vol.33 , Issue.11 , pp. 1665-1673
    • Richardson, B.1    Scheinbart, L.2    Strahler, J.3
  • 116
    • 0028235917 scopus 로고
    • 8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus
    • Lunec J, Herbert K, Blount S, et al. 8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus. FEBS Lett 1994;348(2):131-8
    • (1994) FEBS Lett. , vol.348 , Issue.2 , pp. 131-138
    • Lunec, J.1    Herbert, K.2    Blount, S.3
  • 117
    • 33845880868 scopus 로고    scopus 로고
    • Factors masking HMGB1 in human serum and plasma
    • Urbonaviciute V, Furnrohr BG, Weber C, et al. Factors masking HMGB1 in human serum and plasma. J Leukoc Biol 2007;81(1):67-74
    • (2007) J. Leukoc Biol. , vol.81 , Issue.1 , pp. 67-74
    • Urbonaviciute, V.1    Furnrohr, B.G.2    Weber, C.3
  • 118
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002;168(9):4531-7
    • (2002) J. Immunol. , vol.168 , Issue.9 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3
  • 119
    • 15444364398 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN
    • Bekeredjian-Ding IB, Wagner M, Hornung V, et al. Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN. J Immunol 2005;174(7):4043-50
    • (2005) J. Immunol. , vol.174 , Issue.7 , pp. 4043-4050
    • Bekeredjian-Ding, I.B.1    Wagner, M.2    Hornung, V.3
  • 120
    • 33847634336 scopus 로고    scopus 로고
    • Toll-like receptor expression in lupus peripheral blood mononuclear cells
    • Migita K, Miyashita T, Maeda Y, et al. Toll-like receptor expression in lupus peripheral blood mononuclear cells. J Rheumatol 2007;34(3):493-500
    • (2007) J. Rheumatol. , vol.34 , Issue.3 , pp. 493-500
    • Migita, K.1    Miyashita, T.2    Maeda, Y.3
  • 121
    • 43349094856 scopus 로고    scopus 로고
    • Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus
    • Komatsuda A, Wakui H, Iwamoto K, et al. Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus. Clin Exp Immunol 2008;152(3):482-7
    • (2008) Clin. Exp. Immunol. , vol.152 , Issue.3 , pp. 482-487
    • Komatsuda, A.1    Wakui, H.2    Iwamoto, K.3
  • 122
    • 33750953650 scopus 로고    scopus 로고
    • Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: Implications for the induction and maintenance of the autoimmune process
    • Papadimitraki ED, Choulaki C, Koutala E, et al. Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process. Arthritis Rheum 2006;54(11):3601-11
    • (2006) Arthritis Rheum. , vol.54 , Issue.11 , pp. 3601-3611
    • Papadimitraki, E.D.1    Choulaki, C.2    Koutala, E.3
  • 123
    • 67650600639 scopus 로고    scopus 로고
    • Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: Implications for the amplification of the inflammatory response
    • Papadimitraki ED, Tzardi M, Bertsias G, et al. Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response. Lupus 2009;18(9):831-5
    • (2009) Lupus , vol.18 , Issue.9 , pp. 831-835
    • Papadimitraki, E.D.1    Tzardi, M.2    Bertsias, G.3
  • 124
    • 46849093204 scopus 로고    scopus 로고
    • Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys-a preliminary pilot study
    • Ciferska H, Horak P, Konttinen YT, et al. Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys-a preliminary pilot study. Lupus 2008;17(6):580-5
    • (2008) Lupus , vol.17 , Issue.6 , pp. 580-585
    • Ciferska, H.1    Horak, P.2    Konttinen, Y.T.3
  • 125
    • 77949808406 scopus 로고    scopus 로고
    • Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders
    • Goldstein DM, Kuglstatter A, Lou Y, Soth MJ. Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. J Med Chem 2010;53(6):2345-53
    • (2010) J. Med. Chem. , vol.53 , Issue.6 , pp. 2345-2353
    • Goldstein, D.M.1    Kuglstatter, A.2    Lou, Y.3    Soth, M.J.4
  • 126
    • 33750355695 scopus 로고    scopus 로고
    • IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis
    • Schopf L, Savinainen A, Anderson K, et al. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum 2006;54(10):3163-73
    • (2006) Arthritis Rheum. , vol.54 , Issue.10 , pp. 3163-3173
    • Schopf, L.1    Savinainen, A.2    Anderson, K.3
  • 127
    • 33846200742 scopus 로고    scopus 로고
    • Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis
    • Izmailova ES, Paz N, Alencar H, et al. Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis. Arthritis Rheum 2007;56(1):117-28
    • (2007) Arthritis Rheum. , vol.56 , Issue.1 , pp. 117-128
    • Izmailova, E.S.1    Paz, N.2    Alencar, H.3
  • 129
    • 0041355495 scopus 로고    scopus 로고
    • A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts
    • Kishore N, Sommers C, Mathialagan S, et al. A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts. J Biol Chem 2003;278(35):32861-71
    • (2003) J. Biol. Chem. , vol.278 , Issue.35 , pp. 32861-32871
    • Kishore, N.1    Sommers, C.2    Mathialagan, S.3
  • 130
    • 48749109290 scopus 로고    scopus 로고
    • Pyogenic bacterial infections in humans with MyD88 deficiency
    • von Bernuth H, Picard C, Jin Z, et al. Pyogenic bacterial infections in humans with MyD88 deficiency. Science 2008;321(5889):691-6
    • (2008) Science , vol.321 , Issue.5889 , pp. 691-696
    • Von Bernuth, H.1    Picard, C.2    Jin, Z.3
  • 131
    • 0034595833 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide
    • Iyer S, Kontoyiannis D, Chevrier D, et al. Inhibition of tumor necrosis factor mRNA translation by a rationally designed immunomodulatory peptide. J Biol Chem 2000;275(22):17051-7
    • (2000) J. Biol. Chem. , vol.275 , Issue.22 , pp. 17051-17057
    • Iyer, S.1    Kontoyiannis, D.2    Chevrier, D.3
  • 132
    • 3042610075 scopus 로고    scopus 로고
    • RDP58, a novel immunomodulatory peptide, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalomyelitis
    • DeVry CG, Valdez M, Gao L, et al. RDP58, a novel immunomodulatory peptide, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalomyelitis. J Neuroimmunol 2004;152(1-2): 33-43
    • (2004) J. Neuroimmunol. , vol.152 , Issue.1-2 , pp. 33-43
    • DeVry, C.G.1    Valdez, M.2    Gao, L.3
  • 133
    • 24644495105 scopus 로고    scopus 로고
    • RDP58 is a novel and potentially effective oral therapy for ulcerative colitis
    • Travis S, Yap LM, Hawkey C, et al. RDP58 is a novel and potentially effective oral therapy for ulcerative colitis. Inflamm Bowel Dis 2005;11(8):713-19
    • (2005) Inflamm. Bowel Dis. , vol.11 , Issue.8 , pp. 713-719
    • Travis, S.1    Yap, L.M.2    Hawkey, C.3
  • 134
    • 34548415806 scopus 로고    scopus 로고
    • Pivotal advance: Inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound
    • Loiarro M, Capolunghi F, Fanto N, et al. Pivotal advance: inhibition of MyD88 dimerization and recruitment of IRAK1 and IRAK4 by a novel peptidomimetic compound. J Leukoc Biol 2007;82(4):801-10
    • (2007) J. Leukoc Biol. , vol.82 , Issue.4 , pp. 801-810
    • Loiarro, M.1    Capolunghi, F.2    Fanto, N.3
  • 135
    • 78249238729 scopus 로고    scopus 로고
    • Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients
    • Epub ahead of print. doi: 10.1093/rheumatology/keq226
    • Capolunghi F, Rosado MM, Cascioli S, et al. Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients. Rheumatology (Oxford) 2010. [Epub ahead of print. doi: 10.1093/rheumatology/keq226]
    • (2010) Rheumatology (Oxford)
    • Capolunghi, F.1    Rosado, M.M.2    Cascioli, S.3
  • 136
    • 23844478190 scopus 로고    scopus 로고
    • Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: Molecular targets are TBK1 and RIP1 in TRIF complex
    • Youn HS, Lee JY, Fitzgerald KA, et al. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. J Immunol 2005;175(5):3339-46
    • (2005) J. Immunol. , vol.175 , Issue.5 , pp. 3339-3346
    • Youn, H.S.1    Lee, J.Y.2    Fitzgerald, K.A.3
  • 137
    • 33748189399 scopus 로고    scopus 로고
    • Suppression of MyD88-and TRIF-dependent signaling pathways of Toll-like receptor by (-) - epigallocatechin-3-gallate, a polyphenol component of green tea
    • Youn HS, Lee JY, Saitoh SI, et al. Suppression of MyD88-and TRIF-dependent signaling pathways of Toll-like receptor by (-) - epigallocatechin-3-gallate, a polyphenol component of green tea. Biochem Pharmacol 2006;72(7):850-9
    • (2006) Biochem. Pharmacol. , vol.72 , Issue.7 , pp. 850-859
    • Youn, H.S.1    Lee, J.Y.2    Saitoh, S.I.3
  • 138
    • 68649096651 scopus 로고    scopus 로고
    • TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger
    • Park SJ, Lee MY, Son BS, Youn HS. TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger. Biosci Biotechnol Biochem 2009;73(7):1474-8
    • (2009) Biosci. Biotechnol. Biochem. , vol.73 , Issue.7 , pp. 1474-1478
    • Park, S.J.1    Lee, M.Y.2    Son, B.S.3    Youn, H.S.4
  • 139
    • 77953735417 scopus 로고    scopus 로고
    • Zingiber officinale protects HaCaT cells and C57BL/6 mice from ultraviolet B-induced inflammation
    • Guahk GH, Ha SK, Jung HS, et al. Zingiber officinale protects HaCaT cells and C57BL/6 mice from ultraviolet B-induced inflammation. J Med Food 2010;13(3):673-80
    • (2010) J. Med. Food , vol.13 , Issue.3 , pp. 673-680
    • Guahk, G.H.1    Ha, S.K.2    Jung, H.S.3
  • 140
    • 77957995258 scopus 로고    scopus 로고
    • A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer
    • Rossi JF, Negrier S, James ND, et al. A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer. Br J Cancer 2010;103(8):1154-62
    • (2010) Br. J. Cancer , vol.103 , Issue.8 , pp. 1154-1162
    • Rossi, J.F.1    Negrier, S.2    James, N.D.3
  • 141
    • 33747881274 scopus 로고    scopus 로고
    • Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: A double-blind randomised trial
    • Vanags D, Williams B, Johnson B, et al. Therapeutic efficacy and safety of chaperonin 10 in patients with rheumatoid arthritis: a double-blind randomised trial. Lancet 2006;368(9538):855-63
    • (2006) Lancet , vol.368 , Issue.9538 , pp. 855-863
    • Vanags, D.1    Williams, B.2    Johnson, B.3
  • 142
    • 61849150375 scopus 로고    scopus 로고
    • Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis
    • Broadley SA, Vanags D, Williams B, et al. Results of a phase IIa clinical trial of an anti-inflammatory molecule, chaperonin 10, in multiple sclerosis. Mult Scler 2009;15(3):329-36
    • (2009) Mult Scler , vol.15 , Issue.3 , pp. 329-336
    • Broadley, S.A.1    Vanags, D.2    Williams, B.3
  • 143
    • 3242670505 scopus 로고    scopus 로고
    • Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells
    • Kumar MV, Nagineni CN, Chin MS, et al. Innate immunity in the retina: toll-like receptor (TLR) signaling in human retinal pigment epithelial cells. J Neuroimmunol 2004;153(1-2): 7-15
    • (2004) J. Neuroimmunol. , vol.153 , Issue.1-2 , pp. 7-15
    • Kumar, M.V.1    Nagineni, C.N.2    Chin, M.S.3
  • 144
    • 25444493823 scopus 로고    scopus 로고
    • Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2-and CD14-dependent mechanism
    • Elass E, Aubry L, Masson M, et al. Mycobacterial lipomannan induces matrix metalloproteinase-9 expression in human macrophagic cells through a Toll-like receptor 1 (TLR1)/TLR2-and CD14-dependent mechanism. Infect Immun 2005;73(10):7064-8
    • (2005) Infect. Immun. , vol.73 , Issue.10 , pp. 7064-7068
    • Elass, E.1    Aubry, L.2    Masson, M.3
  • 145
    • 33845562049 scopus 로고    scopus 로고
    • Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2
    • Erridge C, Spickett CM, Webb DJ. Non-enterobacterial endotoxins stimulate human coronary artery but not venous endothelial cell activation via Toll-like receptor 2. Cardiovasc Res 2007;73(1):181-9
    • (2007) Cardiovasc. Res. , vol.73 , Issue.1 , pp. 181-189
    • Erridge, C.1    Spickett, C.M.2    Webb, D.J.3
  • 146
    • 67049095880 scopus 로고    scopus 로고
    • A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis
    • Ungaro R, Fukata M, Hsu D, et al. A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis. Am J Physiol Gastrointest Liver Physiol 2009;296(6):G1167-79
    • (2009) Am. J. Physiol. Gastrointest Liver Physiol. , vol.296 , Issue.6
    • Ungaro, R.1    Fukata, M.2    Hsu, D.3
  • 147
    • 60549101332 scopus 로고    scopus 로고
    • Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4
    • Roger T, Froidevaux C, Le Roy D, et al. Protection from lethal gram-negative bacterial sepsis by targeting Toll-like receptor 4. Proc Natl Acad Sci USA 2009;106(7):2348-52
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , Issue.7 , pp. 2348-2352
    • Roger, T.1    Froidevaux, C.2    Le Roy, D.3
  • 148
    • 47049114564 scopus 로고    scopus 로고
    • Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3
    • Ranjith-Kumar CT, Duffy KE, Jordan JL, et al. Single-stranded oligonucleotides can inhibit cytokine production induced by human toll-like receptor 3. Mol Cell Biol 2008;28(14):4507-19
    • (2008) Mol. Cell. Biol. , vol.28 , Issue.14 , pp. 4507-4519
    • Ranjith-Kumar, C.T.1    Duffy, K.E.2    Jordan, J.L.3
  • 149
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat FJ, Meeker T, Gregorio J, et al. Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J Exp Med 2005;202(8):1131-9
    • (2005) J. Exp. Med. , vol.202 , Issue.8 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3
  • 150
    • 13444302229 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice
    • Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice. Arthritis Rheum 2005;52(2):651-8
    • (2005) Arthritis Rheum. , vol.52 , Issue.2 , pp. 651-658
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 151
    • 34250698370 scopus 로고    scopus 로고
    • Ligand-induced conformational changes allosterically activate Toll-like receptor 9
    • Latz E, Verma A, Visintin A, et al. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat Immunol 2007;8(7):772-9
    • (2007) Nat. Immunol. , vol.8 , Issue.7 , pp. 772-779
    • Latz, E.1    Verma, A.2    Visintin, A.3
  • 152
    • 50949094940 scopus 로고    scopus 로고
    • Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis
    • Boivin N, Sergerie Y, Rivest S, Boivin G. Effect of pretreatment with toll-like receptor agonists in a mouse model of herpes simplex virus type 1 encephalitis. J Infect Dis 2008;198(5):664-72
    • (2008) J. Infect. Dis. , vol.198 , Issue.5 , pp. 664-672
    • Boivin, N.1    Sergerie, Y.2    Rivest, S.3    Boivin, G.4
  • 153
    • 75149143628 scopus 로고    scopus 로고
    • Therapy: Hydroxychloroquine in SLE: Old drug, new perspectives
    • Dorner T. Therapy: hydroxychloroquine in SLE: old drug, new perspectives. Nat Rev Rheumatol 2010;6(1):10-11
    • (2010) Nat. Rev. Rheumatol. , vol.6 , Issue.1 , pp. 10-11
    • Dorner, T.1
  • 154
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator of type-I interferon-dependent immune responses
    • Honda K, Yanai H, Negishi H, et al. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 2005;434(7034):772-7
    • (2005) Nature , vol.434 , Issue.7034 , pp. 772-777
    • Honda, K.1    Yanai, H.2    Negishi, H.3
  • 155
    • 58149279347 scopus 로고    scopus 로고
    • Sequence independent interferon-alpha induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells
    • Haas T, Schmitz F, Heit A, Wagner H. Sequence independent interferon-alpha induction by multimerized phosphodiester DNA depends on spatial regulation of Toll-like receptor-9 activation in plasmacytoid dendritic cells. Immunology 2009;126(2):290-8
    • (2009) Immunology , vol.126 , Issue.2 , pp. 290-298
    • Haas, T.1    Schmitz, F.2    Heit, A.3    Wagner, H.4
  • 156
    • 74049125175 scopus 로고    scopus 로고
    • Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis
    • Tidswell M, Tillis W, Larosa SP, et al. Phase 2 trial of eritoran tetrasodium (E5564), a toll-like receptor 4 antagonist, in patients with severe sepsis. Crit Care Med 2010;38(1):72-83
    • (2010) Crit. Care Med. , vol.38 , Issue.1 , pp. 72-83
    • Tidswell, M.1    Tillis, W.2    Larosa, S.P.3
  • 157
    • 34547582255 scopus 로고    scopus 로고
    • Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice
    • Nakamura M, Shimizu Y, Sato Y, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol 2007;569(3):237-43
    • (2007) Eur. J. Pharmacol. , vol.569 , Issue.3 , pp. 237-243
    • Nakamura, M.1    Shimizu, Y.2    Sato, Y.3
  • 158
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • Suntharalingam G, Perry MR, Ward S, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006;355(10):1018-28
    • (2006) N. Engl. J. Med. , vol.355 , Issue.10 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3
  • 159
    • 77958151921 scopus 로고    scopus 로고
    • Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1-and Th-17-polarizing capability
    • Dzopalic T, Dragicevic A, Vasilijic S, et al. Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1-and Th-17-polarizing capability. Int Immunopharmacol 2010;10(11):1428-33
    • (2010) Int. Immunopharmacol , vol.10 , Issue.11 , pp. 1428-1433
    • Dzopalic, T.1    Dragicevic, A.2    Vasilijic, S.3
  • 160
    • 70350441863 scopus 로고    scopus 로고
    • Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
    • Barbalat R, Lau L, Locksley RM, Barton GM. Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands. Nat Immunol 2009;10(11):1200-7
    • (2009) Nat. Immunol. , vol.10 , Issue.11 , pp. 1200-1207
    • Barbalat, R.1    Lau, L.2    Locksley, R.M.3    Barton, G.M.4
  • 161
    • 33750016788 scopus 로고    scopus 로고
    • Herpes simplex virus encephalitis in human UNC-93B deficiency
    • Casrouge A, Zhang SY, Eidenschenk C, et al. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 2006;314(5797):308-12
    • (2006) Science , vol.314 , Issue.5797 , pp. 308-312
    • Casrouge, A.1    Zhang, S.Y.2    Eidenschenk, C.3
  • 162
    • 0032528185 scopus 로고    scopus 로고
    • Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs
    • Schett G, Redlich K, Xu Q, et al. Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor 1 (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J Clin Invest 1998;102(2):302-11
    • (1998) J. Clin. Invest. , vol.102 , Issue.2 , pp. 302-311
    • Schett, G.1    Redlich, K.2    Xu, Q.3
  • 163
    • 20844463064 scopus 로고    scopus 로고
    • A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease
    • Fort MM, Mozaffarian A, Stover AG, et al. A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J Immunol 2005;174(10):6416-23
    • (2005) J. Immunol. , vol.174 , Issue.10 , pp. 6416-6423
    • Fort, M.M.1    Mozaffarian, A.2    Stover, A.G.3
  • 164
    • 77749285660 scopus 로고    scopus 로고
    • CD14-independent responses induced by a synthetic lipid A mimetic
    • Legat A, Thomas S, Hermand P, et al. CD14-independent responses induced by a synthetic lipid A mimetic. Eur J Immunol 2010;40(3):797-80
    • (2010) Eur. J. Immunol. , vol.40 , Issue.3 , pp. 797-780
    • Legat, A.1    Thomas, S.2    Hermand, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.