Suppression of MyD88- and TRIF-dependent signaling pathways of toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea

Biochemical Pharmacology

Volumn 72, Issue 7, 2006, Pages 850-859

  Youn, Hyung S ^a   Lee, Joo Y ^b   Saitoh, Shin I ^c   Miyake, Kensuke ^c   Kang, Keon W ^d   Choi, Yong J ^b   Hwang, Daniel H ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b Gwangju Institute of Science and Technology (GIST)   (South Korea)

^c UNIVERSITY OF TOKYO   (Japan)

^d Chosun University   (South Korea)

Author keywords

EGCG; Flavonoid; MyD88; TBK1; Toll like receptor; TRIF

Indexed keywords

ADAPTOR PROTEIN; CATECHIN; EPIGALLOCATECHIN GALLATE; FLAVONOID; GREEN TEA EXTRACT; INTERFERON REGULATORY FACTOR 3; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; POLYINOSINIC POLYCYTIDYLIC ACID; POLYPHENOL; PROTEIN KINASE; TANK BINDING KINASE 1; TIR DOMAIN CONTAINING ADAPTER INDUCING INTERFERON BETA PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TEA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CATECHIN; CELL LINE; CYCLOOXYGENASE 2; FLAVONOIDS; GENE EXPRESSION; HUMANS; I-KAPPA B KINASE; INTERFERON TYPE II; LUCIFERASES; MICE; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; PHENOLS; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TEA; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRANSFECTION;

EID: 33748189399     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.021     Document Type: Article

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