Expression of nucleic acid binding Toll-like receptors in control, lupus and transplanted kidneys - a preliminary pilot study

Lupus

Volumn 17, Issue 6, 2008, Pages 580-585

  Ciferska, H ^a,e   Horak, P ^a   Konttinen, Y T ^b,c,d   Krejci, K ^a   Tichy, T ^a   Hermanova, Z ^a   Zadrazil, J ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c ORTON ORTHOPAEDIC HOSPITAL   (Finland)

^d Coxa Hospital for the Joint Replacement ^*  (Finland)

^e UNIVERSITY HOSPITAL OLOMOUC   (Czech Republic)

Author keywords

Lupus nephritis; TLR 3; TLR 7; TLR 8; TLR 9; Transplanted kidney

Indexed keywords

CYTOKINE; DNA; GLUCOCORTICOID; NUCLEIC ACID; SINGLE STRANDED RNA; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CHRONIC GRAFT REJECTION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE DURATION; DNA BINDING; FEMALE; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LUPUS ERYTHEMATOSUS NEPHRITIS; MICROSCOPY; PRIORITY JOURNAL; RNA BINDING; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; ANIMALS; HUMANS; KIDNEY TRANSPLANTATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MIDDLE AGED; NUCLEIC ACIDS; PROTEIN ISOFORMS; RABBITS; TOLL-LIKE RECEPTORS;

EID: 46849093204     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203307088130     Document Type: Article

References (31)

1. Means, TK, Latz, E, Hayashi, F, et al. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 2005; 115: 407-417.
2. Mostoslavsky, G, Fischel, R, Yachimovich, N, et al. Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur J Immunol 2001; 31: 1221-1227.
3. Lu, CY, Penfield, JG, Kielar, ML, et al. Hypothesis: is renal allograft rejection initiated by the response to injury sustained during the transplant process? Kidney Int 1999; 55: 2157-2168.
4. Medzhitov, R, Preston-Hurlburt, P, Janeway, CA. A human homo-logue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388: 394-397.
5. Ozinsky, A, Underhill, DM, Fontenot, JD, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc Natl Acad SciUSA 2000; 97: 13766-13771.
6. Xu, D, Liu, H, Komai-Koma, M. Direct and indirect role of Toll-like receptors in T cell mediated immunity. Cell Mol Immunol 2004; 1: 239-246.
7. Creagh, EM, O'Neill, LA. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006; 27: 352-357.
8. Hayashi, F, Means, TK, Luster, AD. Toll-like receptors stimulate human neutrophil function. Blood 2003; 102: 2660-2669.
9. Majewska, M, Szczepanik, M. The role of Toll-like receptors (TLR) in innate and adaptive immune responses and their function in immune response regulation. Postepy Hig Med Dosw 2006; 60: 52-63.
10. Martinon, F, Tschopp, J. NLRs join TLRs as innate sensors of pathogens. Trends Immunol 2005; 26: 447-454.
11. Pasare, C, Medzhitov, R. Toll-like receptors and acquired immunity. Semin Immunol 2004; 16: 23-26.
12. Leadbetter, EA, Rifkin, IR, Hohlbaum, AM, et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 2002; 416: 603-607.
13. Berland, R, Fernandez, L, Kari, E, et al. Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knocking mice. Immunity 2006; 25: 429-440.
14. Yu, P, Wellmann, U, Kunder, S, et al. Toll-like receptor 9-independent aggravation of glomerulonephritis in a novel model of SLE. Int Immunol 2006; 18: 1211-1219.
15. Lartigue, A, Courville, P, Auquit, I, et al. Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus. J Immunol 2006; 15: 1349-1354.
16. Weening, JJ, D'Agati, VD, Schwartz, MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 2004; 15: 241-250.
17. Patole, PS, Grone, HJ, Segerer, S, et al. Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells. J Am Soc Nephrol 2005; 16: 1326-1338.
18. Dieker, JW, van der Vlag, J, Berden, JH. Triggers for antichromatin autoantibody production in SLE. Lupus 2002; 11: 856-864.
19. Pawar, RD, Patole, PS, Ellwart, A, et al. Ligands to nucleic acid-specific toll-like receptors and the onset of lupus nephritis. J Am Soc Nephrol 2006; 17: 3365-3373.
20. Anders, HJ, Banas, B, Linde, Y, et al. CpG-DNA aggravates glomerulonephritis by TLR9-mediated expression of chemokines and che-mokine receptors. J Am Soc Nephrol 2003; 14: 317-326.
21. Diebold, SS, Kaisho, T, Hemmi, H, et al. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303: 1529-1531.
22. Armant, MA, Fenton, MJ. Toll-like receptors: a family of pattern-recognition receptors in mammals. Genome Biol 2002; 3.
23. Land, W, Schneeberger, H, Schleibner, S, et al. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation 1994; 57: 211-217.
24. Goldstein, DR, Tesar, BM, Akira, S, et al. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest 2003; 111: 1571-1578.
25. Bagavant, H, Deshmukh, US, Gaskin, F, et al. Lupus glomerulonephritis revisited 2004: autoimmunity and end-organ damage. Scand J Immunol 2004; 60: 52-63.
26. Christensen, SR, Shupe, J, Nickerson, K, et al. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006; 25: 417-428.
27. Wu, X, Peng, SL. Toll-like receptor 9 signaling protects against murine lupus. Arthritis Rheum 2006; 54: 336-342.
28. Anders, HJ, Banas, B, Schlondorff, D. Signaling danger: toll-like receptors and their potential roles in kidney disease. J Am Soc Nephrol 2004; 15: 854-867.
29. Jacob, L, Viard, JP. Anti-DNA antibodies and their relationships with anti-histone and anti-nucleosome specificities. Eur J Med 1992; 1:425-431.
30. Lefkowith, JB, Gilkeson, GS. Nephritogenic autoantibodies in lupus: current concepts and continuing controversies. Arthritis Rheum 1996; 39: 894-903.
31. Rekvig, OP, Kalaaji, M, Nossent, H. Anti-DNA antibody subpopu-lations and lupus nephritis. Autoimmun Rev 2004; 3: 1-6.