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Volumn 183, Issue 10, 2009, Pages 6207-6216

Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CARDIOLIPIN ANTIBODY; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN G; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4;

EID: 77954237776     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803219     Document Type: Article
Times cited : (129)

References (70)
  • 1
    • 0029994333 scopus 로고    scopus 로고
    • Systemic lupus erythematosus
    • Kotzin, B. L. 1996. Systemic lupus erythematosus. Cell 85: 303-306.
    • (1996) Cell , vol.85 , pp. 303-306
    • Kotzin, B.L.1
  • 2
    • 0030850910 scopus 로고    scopus 로고
    • Lupus nephritis
    • Berden, J. H. 1997. Lupus nephritis. Kidney Int. 52: 538-558.
    • (1997) Kidney Int. , vol.52 , pp. 538-558
    • Berden, J.H.1
  • 3
    • 0025028745 scopus 로고
    • Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease
    • Klinman, D. M. 1990. Polyclonal B cell activation in lupus-prone mice precedes and predicts the development of autoimmune disease. J. Clin. Invest. 86: 1249-1254.
    • (1990) J. Clin. Invest. , vol.86 , pp. 1249-1254
    • Klinman, D.M.1
  • 4
    • 0031179651 scopus 로고    scopus 로고
    • Genetic Dissection of Systemic Lupus Erythematosu Pathogenesis: Sle2 on Murine Chromosome 4 Leads to B Cell Hyperactivity
    • Mohan, C., L. Morel, P. Yang, and E. K. Wakeland. 1997. Genetic dissection of systemic lupus erythematosus pathogenesis: Sle2 on murine chromosome 4 leads to B cell hyperactivity. J. Immunol. 159: 454-465. (Pubitemid 127493732)
    • (1997) Journal of Immunology , vol.159 , Issue.1 , pp. 454-465
    • Mohan, C.1    Morel, L.2    Yang, P.3    Wakeland, E.K.4
  • 6
    • 22144457050 scopus 로고    scopus 로고
    • T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells
    • Zhu, J., X. Liu, C. Xie, M. Yan, Y. Yu, E. S. Sobel, E. K. Wakeland, and C. Mohan. 2005. T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen-presenting cells. J. Clin. Invest. 115: 1869-1878.
    • (2005) J. Clin. Invest. , vol.115 , pp. 1869-1878
    • Zhu, J.1    Liu, X.2    Xie, C.3    Yan, M.4    Yu, Y.5    Sobel, E.S.6    Wakeland, E.K.7    Mohan, C.8
  • 7
    • 34249707811 scopus 로고    scopus 로고
    • TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
    • Baccala, R., K. Hoebe, D. H. Kono, B. Beutler, and A. N. Theofilopoulos. 2007. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat. Med. 13: 543-551.
    • (2007) Nat. Med. , vol.13 , pp. 543-551
    • Baccala, R.1    Hoebe, K.2    Kono, D.H.3    Beutler, B.4    Theofilopoulos, A.N.5
  • 8
    • 0034816964 scopus 로고    scopus 로고
    • Delineating the genetic basis of systemic lupus erythematosus
    • Wakeland, E. K., K. Liu, R. R. Graham, and T. W. Behrens. 2001. Delineating the genetic basis of systemic lupus erythematosus. Immunity 15: 397-408.
    • (2001) Immunity , vol.15 , pp. 397-408
    • Wakeland, E.K.1    Liu, K.2    Graham, R.R.3    Behrens, T.W.4
  • 9
    • 33745115404 scopus 로고    scopus 로고
    • Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus
    • Poole, B. D., R. H. Scofield, J. B. Harley, and J. A. James. 2006. Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity 39: 63-70.
    • (2006) Autoimmunity , vol.39 , pp. 63-70
    • Poole, B.D.1    Scofield, R.H.2    Harley, J.B.3    James, J.A.4
  • 11
    • 0025201081 scopus 로고
    • Lipopolysaccharide from Gram-negative bacteria enhances polyclonal B cell activation and exacerbates nephritis in MRL/lpr mice
    • Cavallo, T., and N. A. Granholm. 1990. Lipopolysaccharide from Gram-negative bacteria enhances polyclonal B cell activation and exacerbates nephritis in MRL/lpr mice. Clin. Exp. Immunol. 82: 515-521.
    • (1990) Clin. Exp. Immunol. , vol.82 , pp. 515-521
    • Cavallo, T.1    Granholm, N.A.2
  • 13
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 14
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V., S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, T. Giese, S. Endres, and G. Hartmann. 2002. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168: 4531-4537.
    • (2002) J. Immunol. , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 15
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
    • Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162: 3749-3752.
    • (1999) J. Immunol. , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 16
    • 0037450804 scopus 로고    scopus 로고
    • Egulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide
    • Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot. 2003. Regulatory T cells selectively express Toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197: 403-411.
    • (2003) J. Exp. Med. , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 18
    • 0037436119 scopus 로고    scopus 로고
    • + T cell-mediated suppression by dendritic cells
    • + T cell-mediated suppression by dendritic cells. Science 299: 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 19
    • 33750369226 scopus 로고    scopus 로고
    • Toll-like receptors in systemic autoimmune disease
    • Marshak-Rothstein, A. 2006. Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6: 823-835.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 823-835
    • Marshak-Rothstein, A.1
  • 20
    • 33947656512 scopus 로고    scopus 로고
    • Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors
    • Christensen, S. R., and M. J. Shlomchik. 2007. Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Semin. Immunol. 19: 11-23.
    • (2007) Semin. Immunol. , vol.19 , pp. 11-23
    • Christensen, S.R.1    Shlomchik, M.J.2
  • 21
  • 23
    • 0037450737 scopus 로고    scopus 로고
    • Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by Toll-like receptor 4 signaling
    • Choe, J. Y., B. Crain, S. R. Wu, and M. Corr. 2003. Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by Toll-like receptor 4 signaling. J. Exp. Med. 197: 537-542.
    • (2003) J. Exp. Med. , vol.197 , pp. 537-542
    • Choe, J.Y.1    Crain, B.2    Wu, S.R.3    Corr, M.4
  • 24
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • Ohashi, K., V. Burkart, S. Flohe, and H. Kolb. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex. J. Immunol. 164: 558-561. (Pubitemid 30043672)
    • (2000) Journal of Immunology , vol.164 , Issue.2 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 26
    • 33750831778 scopus 로고    scopus 로고
    • TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease
    • Liu, B., Y. Yang, J. Dai, R. Medzhitov, M. A. Freudenberg, P. L. Zhang, and Z. Li. 2006. TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J. Immunol. 177: 6880-6888.
    • (2006) J. Immunol. , vol.177 , pp. 6880-6888
    • Liu, B.1    Yang, Y.2    Dai, J.3    Medzhitov, R.4    Freudenberg, M.A.5    Zhang, P.L.6    Li, Z.7
  • 27
    • 0025875259 scopus 로고
    • Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease
    • Cohen, P. L., and R. A. Eisenberg. 1991. lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease. Annu. Rev. Immunol. 9: 243-269.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 243-269
    • Cohen, P.L.1    Eisenberg, R.A.2
  • 28
    • 0037025942 scopus 로고    scopus 로고
    • Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lympho-proliferative autoimmunity
    • Shi, X., C. Xie, D. Kreska, J. A. Richardson, and C. Mohan. 2002. Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lympho-proliferative autoimmunity. J. Exp. Med. 196: 281-292.
    • (2002) J. Exp. Med. , vol.196 , pp. 281-292
    • Shi, X.1    Xie, C.2    Kreska, D.3    Richardson, J.A.4    Mohan, C.5
  • 32
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
    • Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11: 443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 33
    • 18944395146 scopus 로고    scopus 로고
    • Role of TLR in B cell development: Signaling through TLR4 promotes B cell maturation and is inhibited by TLR2
    • Hayashi, E. A., S. Akira, and A. Nobrega. 2005. Role of TLR in B cell development: signaling through TLR4 promotes B cell maturation and is inhibited by TLR2. J. Immunol. 174: 6639-6647.
    • (2005) J. Immunol. , vol.174 , pp. 6639-6647
    • Hayashi, E.A.1    Akira, S.2    Nobrega, A.3
  • 34
    • 0017704089 scopus 로고
    • Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: IdentificationofcirculatingDNAandrenallocalizationofDNA- anti-DNA complexes
    • Izui, S., P. H. Lambert, G. J. Fournie, H. Turler, and P. A. Miescher. 1977. Features of systemic lupus erythematosus in mice injected with bacterial lipopolysaccharides: identificationofcirculatingDNAandrenallocalizationofDNA- anti-DNA complexes. J. Exp. Med. 145: 1115-1130.
    • (1977) J. Exp. Med. , vol.145 , pp. 1115-1130
    • Izui, S.1    Lambert, P.H.2    Fournie, G.J.3    Turler, H.4    Miescher, P.A.5
  • 35
    • 0015094677 scopus 로고
    • The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response
    • Feldmann, M., and A. Easten. 1971. The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response. J. Exp. Med. 134: 103-119.
    • (1971) J. Exp. Med. , vol.134 , pp. 103-119
    • Feldmann, M.1    Easten, A.2
  • 36
    • 0025974745 scopus 로고
    • Dextranconjugated anti-Ig antibodies as a model for T cell-independent type 2 antigenmediated stimulation of Ig secretion in vitro: I. Lymphokine dependence
    • Pecanha, L. M., C. M. Snapper, F. D. Finkelman, and J. J. Mond. 1991. Dextranconjugated anti-Ig antibodies as a model for T cell-independent type 2 antigenmediated stimulation of Ig secretion in vitro: I. Lymphokine dependence. J. Immunol. 146: 833-839.
    • (1991) J. Immunol. , vol.146 , pp. 833-839
    • Pecanha, L.M.1    Snapper, C.M.2    Finkelman, F.D.3    Mond, J.J.4
  • 37
    • 0033822039 scopus 로고    scopus 로고
    • B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms
    • Vos, Q., A. Lees, Z. Q. Wu, C. M. Snapper, and J. J. Mond. 2000. B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms. Immunol. Rev. 176: 154-170.
    • (2000) Immunol. Rev. , vol.176 , pp. 154-170
    • Vos, Q.1    Lees, A.2    Wu, Z.Q.3    Snapper, C.M.4    Mond, J.J.5
  • 38
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: The virtues of a nonclonal system of recognition
    • Medzhitov, R., and C. A. Janeway, Jr. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91: 295-298.
    • (1997) Cell , vol.91 , pp. 295-298
    • Medzhitov, R.1    Janeway Jr., C.A.2
  • 39
    • 0023686940 scopus 로고
    • B cell memory to thymus-independent antigens type 1 and type 2: The role of lipopolysaccharide in B memory induction
    • Zhang, J., Y. J. Liu, I. C. MacLennan, D. Gray, and P. J. Lane. 1988. B cell memory to thymus-independent antigens type 1 and type 2: the role of lipopolysaccharide in B memory induction. Eur. J. Immunol. 18: 1417-1424.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 1417-1424
    • Zhang, J.1    Liu, Y.J.2    MacLennan, I.C.3    Gray, D.4    Lane, P.J.5
  • 41
    • 0031259951 scopus 로고    scopus 로고
    • The consequences of the intracellular retention of pathogen-derived T-cell-independent antigens on protein presentation to T cells
    • Leyva-Cobian, F., I. M. Outschoorn, E. Carrasco-Marin, and C. Alvarez- Dominguez. 1997. The consequences of the intracellular retention of pathogen-derived T-cell-independent antigens on protein presentation to T cells. Clin. Immunol. Immunopathol. 85: 1-15.
    • (1997) Clin. Immunol. Immunopathol. , vol.85 , pp. 1-15
    • Leyva-Cobian, F.1    Outschoorn, I.M.2    Carrasco-Marin, E.3    Alvarez-Dominguez, C.4
  • 42
    • 0027477318 scopus 로고
    • Nucleosome: A major immunogen for pathogenic autoantibody-inducing T cells of lupus
    • Mohan, C., S. Adams, V. Stanik, and S. K. Datta. 1993. Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus. J. Exp. Med. 177: 1367-1381.
    • (1993) J. Exp. Med. , vol.177 , pp. 1367-1381
    • Mohan, C.1    Adams, S.2    Stanik, V.3    Datta, S.K.4
  • 43
    • 0035013708 scopus 로고    scopus 로고
    • Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens
    • Martin, F., A. M. Oliver, and J. F. Kearney. 2001. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14: 617-629.
    • (2001) Immunity , vol.14 , pp. 617-629
    • Martin, F.1    Oliver, A.M.2    Kearney, J.F.3
  • 44
    • 0028789148 scopus 로고
    • Anatomy of autoantibody production: Dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice
    • Jacobson, B. A., D. J. Panka, K. A. Nguyen, J. Erikson, A. K. Abbas, and A. Marshak-Rothstein. 1995. Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice. Immunity 3: 509-519.
    • (1995) Immunity , vol.3 , pp. 509-519
    • Jacobson, B.A.1    Panka, D.J.2    Nguyen, K.A.3    Erikson, J.4    Abbas, A.K.5    Marshak-Rothstein, A.6
  • 45
    • 18944398750 scopus 로고    scopus 로고
    • Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: Differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center
    • William, J., C. Euler, and M. J. Shlomchik. 2005. Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center. J. Immunol. 174: 6879-6887. (Pubitemid 40705652)
    • (2005) Journal of Immunology , vol.174 , Issue.11 , pp. 6879-6887
    • William, J.1    Euler, C.2    Shlomchik, M.J.3
  • 46
    • 18944406639 scopus 로고    scopus 로고
    • Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity
    • William, J., C. Euler, E. Leadbetter, A. Marshak-Rothstein, and M. J. Shlomchik. 2005. Visualizing the onset and evolution of an autoantibody response in systemic autoimmunity. J. Immunol. 174: 6872-6878. (Pubitemid 40705651)
    • (2005) Journal of Immunology , vol.174 , Issue.11 , pp. 6872-6878
    • William, J.1    Euler, C.2    Leadbetter, E.3    Marshak-Rothstein, A.4    Shlomchik, M.J.5
  • 47
    • 0033526816 scopus 로고    scopus 로고
    • B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals
    • Loder, F., B. Mutschler, R. J. Ray, C. J. Paige, P. Sideras, R. Torres, M. C. Lamers, and R. Carsetti. 1999. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190: 75-89.
    • (1999) J. Exp. Med. , vol.190 , pp. 75-89
    • Loder, F.1    Mutschler, B.2    Ray, R.J.3    Paige, C.J.4    Sideras, P.5    Torres, R.6    Lamers, M.C.7    Carsetti, R.8
  • 50
    • 34249796982 scopus 로고    scopus 로고
    • Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes
    • Debnath, I., K. M. Roundy, J. J. Weis, and J. H. Weis. 2007. Defining in vivo transcription factor complexes of the murine CD21 and CD23 genes. J. Immunol. 178: 7139-7150. (Pubitemid 46847440)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 7139-7150
    • Debnath, I.1    Roundy, K.M.2    Weis, J.J.3    Weis, J.H.4
  • 57
    • 17644368573 scopus 로고    scopus 로고
    • Interleukin-6: From basic science to medicine: 40 years in immunology
    • Kishimoto, T. 2005. Interleukin-6: from basic science to medicine: 40 years in immunology. Annu. Rev. Immunol. 23: 1-21.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 1-21
    • Kishimoto, T.1
  • 58
    • 20344381320 scopus 로고    scopus 로고
    • The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody
    • Mihara, M., N. Nishimoto, and Y. Ohsugi. 2005. The therapy of autoimmune diseases by anti-interleukin-6 receptor antibody. Expert Opin. Biol. Ther. 5: 683-690.
    • (2005) Expert Opin. Biol. Ther. , vol.5 , pp. 683-690
    • Mihara, M.1    Nishimoto, N.2    Ohsugi, Y.3
  • 60
    • 33750011260 scopus 로고    scopus 로고
    • Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus
    • Liang, B., D. B. Gardner, D. E. Griswold, P. J. Bugelski, and X. Y. Song. 2006. Anti-interleukin-6 monoclonal antibody inhibits autoimmune responses in a murine model of systemic lupus erythematosus. Immunology 119: 296-305.
    • (2006) Immunology , vol.119 , pp. 296-305
    • Liang, B.1    Gardner, D.B.2    Griswold, D.E.3    Bugelski, P.J.4    Song, X.Y.5
  • 61
    • 0030953632 scopus 로고    scopus 로고
    • Roles of interferon-γ and interleukin-4 in murine lupus
    • Peng, S. L., J. Moslehi, and J. Craft. 1997. Roles of interferon-γ and interleukin-4 in murine lupus. J. Clin. Invest. 99: 1936-1946.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1936-1946
    • Peng, S.L.1    Moslehi, J.2    Craft, J.3
  • 62
    • 0036620643 scopus 로고    scopus 로고
    • Promotion of lupus in NZB x NZWF1 mice by plasmids encoding interferon (IFN)-κ but not by those encoding interleukin (IL)-4
    • Hasegawa, K., T. Hayashi, and K. Maeda. 2002. Promotion of lupus in NZB x NZWF1 mice by plasmids encoding interferon (IFN)-κ but not by those encoding interleukin (IL)-4. J. Comp. Pathol. 127: 1-6.
    • (2002) J. Comp. Pathol. , vol.127 , pp. 1-6
    • Hasegawa, K.1    Hayashi, T.2    Maeda, K.3
  • 65
    • 34250192856 scopus 로고    scopus 로고
    • TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses
    • Genestier, L., M. Taillardet, P. Mondiere, H. Gheit, C. Bella, and T. Defrance. 2007. TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. J. Immunol. 178: 7779-7786.
    • (2007) J. Immunol. , vol.178 , pp. 7779-7786
    • Genestier, L.1    Taillardet, M.2    Mondiere, P.3    Gheit, H.4    Bella, C.5    Defrance, T.6
  • 66
    • 0035903158 scopus 로고    scopus 로고
    • Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells
    • Vabulas, R. M., P. Ahmad-Nejad, C. da Costa, T. Miethke, C. J. Kirschning, H. Hacker, and H. Wagner. 2001. Endocytosed HSP60s use Toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J. Biol. Chem. 276: 31332-31339.
    • (2001) J. Biol. Chem. , vol.276 , pp. 31332-31339
    • Vabulas, R.M.1    Ahmad-Nejad, P.2    Da Costa, C.3    Miethke, T.4    Kirschning, C.J.5    Hacker, H.6    Wagner, H.7
  • 70
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park, J. S., D. Svetkauskaite, Q. He, J. Y. Kim, D. Strassheim, A. Ishizaka, and E. Abraham. 2004. Involvement of Toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 279: 7370-7377.
    • (2004) J. Biol. Chem. , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6    Abraham, E.7


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