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Volumn 62, Issue SUPPL. 2, 2003, Pages 86-89

Signal transduction networks in rheumatoid arthritis

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 0142156224     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.62.1.86     Document Type: Conference Paper
Times cited : (89)

References (36)
  • 1
    • 0035667907 scopus 로고    scopus 로고
    • Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
    • Shouda T, Yoshida T, Hanada T, Wakioka T, Oishi M, Miyoshi K, et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J Clin Invest 2001;108:1781-8.
    • (2001) J Clin Invest , vol.108 , pp. 1781-1788
    • Shouda, T.1    Yoshida, T.2    Hanada, T.3    Wakioka, T.4    Oishi, M.5    Miyoshi, K.6
  • 2
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 3
    • 0034746919 scopus 로고    scopus 로고
    • NF-κB: A key player in inflammatory diseases
    • Tak PP, Firestein GS. NF-κB: a key player in inflammatory diseases. J Clin Invest 2001;107:7-11.
    • (2001) J Clin Invest , vol.107 , pp. 7-11
    • Tak, P.P.1    Firestein, G.S.2
  • 4
    • 0031744967 scopus 로고    scopus 로고
    • Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA
    • Sioud M, Mellbye O, Forre O. Analysis of the NF-kappa B p65 subunit, Fas antigen, Fas ligand and Bcl-2-related proteins in the synovium of RA and polyarticular JRA. Clin Exp Rheumatol 1998;16:125-34.
    • (1998) Clin Exp Rheumatol , vol.16 , pp. 125-134
    • Sioud, M.1    Mellbye, O.2    Forre, O.3
  • 5
    • 0032428729 scopus 로고    scopus 로고
    • AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis
    • Han Z, Boyle DL, Manning AM, Firestein GS. AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998;28:197-208.
    • (1998) Autoimmunity , vol.28 , pp. 197-208
    • Han, Z.1    Boyle, D.L.2    Manning, A.M.3    Firestein, G.S.4
  • 6
    • 0033178749 scopus 로고    scopus 로고
    • Essential role of T cell NF-kappa B activation in collagen-induced arthritis
    • Seetharaman R, Mora AL, NaboznyG, Boothby M, Chen J. Essential role of T cell NF-kappa B activation in collagen-induced arthritis. J Immunol 1999;163:1577-83.
    • (1999) J Immunol , vol.163 , pp. 1577-1583
    • Seetharaman, R.1    Mora, A.L.2    Nabozny, G.3    Boothby, M.4    Chen, J.5
  • 7
    • 0035865090 scopus 로고    scopus 로고
    • NF-kappaB regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes
    • Aupperle K, Bennett B, Han Z, Boyle D, Manning A, Firestein G. NF-kappaB regulation by I kappa B kinase-2 in rheumatoid arthritis synoviocytes. J Immunol 2001;166:2705-11.
    • (2001) J Immunol , vol.166 , pp. 2705-2711
    • Aupperle, K.1    Bennett, B.2    Han, Z.3    Boyle, D.4    Manning, A.5    Firestein, G.6
  • 10
    • 0013536372 scopus 로고    scopus 로고
    • The small molecule IKK2 inhibitors SPC 839 is efficacious in an animal model of arthritis
    • Bhagwar S, Bennett BI, Satoh Y, O'Leary EC, Leisten J, Firestein GS, et al. The small molecule IKK2 inhibitors SPC 839 is efficacious in an animal model of arthritis [abstract]. Arthritis Rheum 2001;44(suppl):S213.
    • (2001) Arthritis Rheum , vol.44 , Issue.SUPPL.
    • Bhagwar, S.1    Bennett, B.I.2    Satoh, Y.3    O'Leary, E.C.4    Leisten, J.5    Firestein, G.S.6
  • 11
    • 17144449583 scopus 로고    scopus 로고
    • High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation
    • Lavon I, Goldberg I, Amit S, Landsman L, Jung S, Tsuberi BZ, et al. High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation. Nat Med 2000;6:573-7.
    • (2000) Nat Med , vol.6 , pp. 573-577
    • Lavon, I.1    Goldberg, I.2    Amit, S.3    Landsman, L.4    Jung, S.5    Tsuberi, B.Z.6
  • 12
    • 0033532386 scopus 로고    scopus 로고
    • The IKKbeta subunit of IkappaB Kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
    • Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, et al. The IKKbeta subunit of IkappaB Kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 1999;189:1839-45.
    • (1999) J Exp Med , vol.189 , pp. 1839-1845
    • Li, Z.W.1    Chu, W.2    Hu, Y.3    Delhase, M.4    Deerinck, T.5    Ellisman, M.6
  • 13
    • 0033557695 scopus 로고    scopus 로고
    • Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression
    • Manna SK, Aggarwal BB. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. J Immunol 1999;162:2095-102.
    • (1999) J Immunol , vol.162 , pp. 2095-2102
    • Manna, S.K.1    Aggarwal, B.B.2
  • 14
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta
    • Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature 1998;396:77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 15
    • 0032808084 scopus 로고    scopus 로고
    • IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases
    • Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, et al. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol 1999;11:1357-62.
    • (1999) Int Immunol , vol.11 , pp. 1357-1362
    • Shimada, T.1    Kawai, T.2    Takeda, K.3    Matsumoto, M.4    Inoue, J.5    Tatsumi, Y.6
  • 16
    • 0035950978 scopus 로고    scopus 로고
    • Expression and regulation of inducible I kappa B kinase (IKK-i) in human fibroblast-like synoviocytes
    • Aupperle KR, Bennett BL, Mercurio F, Boyle DL, Firestein GS. Expression and regulation of inducible I kappa B kinase (IKK-i) in human fibroblast-like synoviocytes. Cell Immunol 2001;214:54-9.
    • (2001) Cell Immunol , vol.214 , pp. 54-59
    • Aupperle, K.R.1    Bennett, B.L.2    Mercurio, F.3    Boyle, D.L.4    Firestein, G.S.5
  • 17
    • 0030898417 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways
    • Robinson MJ, Cobb MH. Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997;9:180-5.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 180-185
    • Robinson, M.J.1    Cobb, M.H.2
  • 18
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R, Krebs EG. The MAPK signaling cascade. FASEB J 1995;9:726-35.
    • (1995) FASEB J , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 19
    • 0031044561 scopus 로고    scopus 로고
    • MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: Upstream regulators of the c-Jun amino-terminal kinases?
    • Fanger GR, Gerwins P, Widmann C, Jarpe MB, Johnson GL. MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases? Curr Opin Genet Dev 1997;7:67-76.
    • (1997) Curr Opin Genet Dev , vol.7 , pp. 67-76
    • Fanger, G.R.1    Gerwins, P.2    Widmann, C.3    Jarpe, M.B.4    Johnson, G.L.5
  • 20
    • 0027423418 scopus 로고
    • Identification of an oncoprotein- and UV- responsive protein kinase that binds and potentiates the c-Jun activation domain
    • Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein- and UV- responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993;7:2149-60.
    • (1993) Genes Dev , vol.7 , pp. 2149-2160
    • Hibi, M.1    Lin, A.2    Smeal, T.3    Minden, A.4    Karin, M.5
  • 21
    • 0033758633 scopus 로고    scopus 로고
    • Activation, differentiatial localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis
    • Schett G, Tohidast-Akrad M, Smolen JS, Schmid BJ, Steiner CW, Bitzan P, et al. Activation, differentiatial localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum 2000;43:2501-12.
    • (2000) Arthritis Rheum , vol.43 , pp. 2501-2512
    • Schett, G.1    Tohidast-Akrad, M.2    Smolen, J.S.3    Schmid, B.J.4    Steiner, C.W.5    Bitzan, P.6
  • 23
  • 24
    • 0034813222 scopus 로고    scopus 로고
    • Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading
    • Feng Y, Schreiner GF, Chakravarty S, Liu DY, Joly AH. Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading. Atherosclerosis 2001;158:331-8.
    • (2001) Atherosclerosis , vol.158 , pp. 331-338
    • Feng, Y.1    Schreiner, G.F.2    Chakravarty, S.3    Liu, D.Y.4    Joly, A.H.5
  • 26
    • 0034121690 scopus 로고    scopus 로고
    • Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
    • Badger AM, Griswold DE, Kapadia R, Blake S, Swift BA, Hoffman SJ, et al. Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis. Arthritis Rheum 2000;43:175-83.
    • (2000) Arthritis Rheum , vol.43 , pp. 175-183
    • Badger, A.M.1    Griswold, D.E.2    Kapadia, R.3    Blake, S.4    Swift, B.A.5    Hoffman, S.J.6
  • 27
    • 0035000643 scopus 로고    scopus 로고
    • Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers
    • Fijen JW, Zijlstra JG, De Boer P, Spanjersberg R, Cohen Tervaert JW, Van Der Werf TS, et al. Suppression of the clinical and cytokine response to endotoxin by RWJ-67657, a p38 mitogen-activated protein-kinase inhibitor, in healthy human volunteers. Clin Exp Immunol 2001;124:16-20.
    • (2001) Clin Exp Immunol , vol.124 , pp. 16-20
    • Fijen, J.W.1    Zijlstra, J.G.2    De Boer, P.3    Spanjersberg, R.4    Cohen Tervaert, J.W.5    Van Der Werf, T.S.6
  • 28
    • 0028988138 scopus 로고
    • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
    • Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, Gallagher TF, et al. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 1995;364:229-33.
    • (1995) FEBS Lett , vol.364 , pp. 229-233
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3    Meier, R.4    Cohen, P.5    Gallagher, T.F.6
  • 29
    • 0034931503 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    • Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, et al. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 2001;108:73-81.
    • (2001) J Clin Invest , vol.108 , pp. 73-81
    • Han, Z.1    Boyle, D.L.2    Chang, L.3    Bennett, B.4    Karin, M.5    Yang, L.6
  • 30
    • 0036188479 scopus 로고    scopus 로고
    • Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis
    • Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS. Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis Rheum 2002;46:818-23.
    • (2002) Arthritis Rheum , vol.46 , pp. 818-823
    • Han, Z.1    Chang, L.2    Yamanishi, Y.3    Karin, M.4    Firestein, G.S.5
  • 31
    • 0034668860 scopus 로고    scopus 로고
    • Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7
    • Fleming Y, Armstrong CG, Morrice N, Paterson A, Goedert M, Cohen P. Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. Biochem J 2000;352(Pt 1):145-54.
    • (2000) Biochem J , vol.352 , Issue.1 PART , pp. 145-154
    • Fleming, Y.1    Armstrong, C.G.2    Morrice, N.3    Paterson, A.4    Goedert, M.5    Cohen, P.6
  • 32
    • 0032585615 scopus 로고    scopus 로고
    • Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro
    • Lawler S, Fleming Y, Goedert M, Cohen P. Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro. Curr Biol 1998;8:1387-90.
    • (1998) Curr Biol , vol.8 , pp. 1387-1390
    • Lawler, S.1    Fleming, Y.2    Goedert, M.3    Cohen, P.4
  • 33
    • 0032508714 scopus 로고    scopus 로고
    • A mammalian scaffold complex that selectively mediates MAP kinase activation
    • Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 1998;281:1671-4.
    • (1998) Science , vol.281 , pp. 1671-1674
    • Whitmarsh, A.J.1    Cavanagh, J.2    Tournier, C.3    Yasuda, J.4    Davis, R.J.5
  • 34
    • 0032508538 scopus 로고    scopus 로고
    • MP1: A MEK binding partner that enhances enzymatic activation of the MAP kinase cascade
    • Schaeffer HJ, Catling AD, Eblen ST, Collier LS, Krauss A, Weber MJ. MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 1998;281:1668-71.
    • (1998) Science , vol.281 , pp. 1668-1671
    • Schaeffer, H.J.1    Catling, A.D.2    Eblen, S.T.3    Collier, L.S.4    Krauss, A.5    Weber, M.J.6
  • 35
    • 0141676444 scopus 로고    scopus 로고
    • Expression and regulation of the MAP kinase kinases, MKK4 and MKK7, in rheumatoid arthritis
    • Sundarrajan M, Boyle DL, Chabaud M, Hammaker D, Firestein GS. Expression and regulation of the MAP kinase kinases, MKK4 and MKK7, in rheumatoid arthritis. Arthritis Rheum 2003;48:2450-60.
    • (2003) Arthritis Rheum , vol.48 , pp. 2450-2460
    • Sundarrajan, M.1    Boyle, D.L.2    Chabaud, M.3    Hammaker, D.4    Firestein, G.S.5
  • 36
    • 0037032817 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    • Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002;298:1911-12.
    • (2002) Science , vol.298 , pp. 1911-1912
    • Johnson, G.L.1    Lapadat, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.