A selective IKK-2 inhibitor blocks NF-κB-dependent gene expression in interleukin-1β-stimulated synovial fibroblasts

Journal of Biological Chemistry

Volumn 278, Issue 35, 2003, Pages 32861-32871

  Kishore, Nandini ^a   Sommers, Cindy ^a   Mathialagan, Sumathy ^a   Guzova, Julia ^a   Yao, Min ^a   Hauser, Scott ^a   Huynh, Khai ^a   Bonar, Sheri ^a   Mielke, Cindy ^a   Albee, Lee ^a   Weier, Richard ^a   Graneto, Matthew ^a   Hanau, Cathleen ^a   Perry, Thao ^a   Tripp, Catherine S ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; COMPLEXATION; DIMERS; DISEASE CONTROL; ENZYME KINETICS; SUBSTRATES;

INFLAMMATORY DISEASES;

GENES;

ENZYME INHIBITOR; I KAPPA B ALPHA; I KAPPA B KINASE; I KAPPA B KINASE 1; I KAPPA B KINASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; SC 514; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STIMULATION; CONCENTRATION RESPONSE; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN TRANSPORT; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; TRANSACTIVATION;

ACTIVE TRANSPORT, CELL NUCLEUS; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CELL ADHESION; CELL LINE; CELL NUCLEUS; CELLS, CULTURED; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC VECTORS; GLUTATHIONE TRANSFERASE; HUMANS; HYDROLYSIS; I-KAPPA B KINASE; INFLAMMATION; INHIBITORY CONCENTRATION 50; INTERLEUKIN-1; KINETICS; LIPOPOLYSACCHARIDES; MODELS, CHEMICAL; NF-KAPPA B; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; THIOPHENES; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC;

EUKARYOTA;

EID: 0041355495     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M211439200     Document Type: Article

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