메뉴 건너뛰기




Volumn 56, Issue 9, 2007, Pages 2957-2967

Inhibition of toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CYTOKINE; INTERLEUKIN 1BETA; RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 4 ANTAGONIST; UNCLASSIFIED DRUG;

EID: 34848840994     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.22848     Document Type: Article
Times cited : (272)

References (47)
  • 2
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell 2006;124:783-801.
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 3
    • 0035813157 scopus 로고    scopus 로고
    • Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
    • Re F, Strominger JL. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J Biol Chem 2001; 276:37692-9.
    • (2001) J Biol Chem , vol.276 , pp. 37692-37699
    • Re, F.1    Strominger, J.L.2
  • 4
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004;4:499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 5
    • 0033784930 scopus 로고    scopus 로고
    • Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines
    • Schrijver IA, Melief MJ, Tak PP, Hazenberg MP, Laman JD. Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines. Arthritis Rheum 2000;43:2160-8.
    • (2000) Arthritis Rheum , vol.43 , pp. 2160-2168
    • Schrijver, I.A.1    Melief, M.J.2    Tak, P.P.3    Hazenberg, M.P.4    Laman, J.D.5
  • 6
    • 0034040746 scopus 로고    scopus 로고
    • Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides
    • Van der Heijden I, Wilbrink B, Tchetverikov I, Schrijver IA, Schouls LM, Hazenberg MP, et al. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthritis Rheum 2000;43:593-8.
    • (2000) Arthritis Rheum , vol.43 , pp. 593-598
    • Van der Heijden, I.1    Wilbrink, B.2    Tchetverikov, I.3    Schrijver, I.A.4    Schouls, L.M.5    Hazenberg, M.P.6
  • 7
    • 10744223444 scopus 로고    scopus 로고
    • Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: Critical role of myeloid differentiation factor 88
    • Joosten LA, Koenders MI, Smeets RL, Heuvelmans-Jacobs M, Helsen MM, Takeda K, et al. Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88. J Immunol 2003;171:6145-53.
    • (2003) J Immunol , vol.171 , pp. 6145-6153
    • Joosten, L.A.1    Koenders, M.I.2    Smeets, R.L.3    Heuvelmans-Jacobs, M.4    Helsen, M.M.5    Takeda, K.6
  • 9
    • 0033038486 scopus 로고    scopus 로고
    • Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis
    • Deng GM, Nilsson IM, Verdrengh M, Collins LV, Tarkowski A. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat Med 1999;5:702-5.
    • (1999) Nat Med , vol.5 , pp. 702-705
    • Deng, G.M.1    Nilsson, I.M.2    Verdrengh, M.3    Collins, L.V.4    Tarkowski, A.5
  • 10
    • 0029823508 scopus 로고    scopus 로고
    • Induction by chronic autoimmune arthritis in DBA/1 mice by oral administration of type II collagen and Escherichia coli lipopolysaccharidc
    • Terato K, Ye XJ, Miyahara H, Cremer MA, Griffiths MM. Induction by chronic autoimmune arthritis in DBA/1 mice by oral administration of type II collagen and Escherichia coli lipopolysaccharidc. Br J Rheumatol 1996;35:828-38.
    • (1996) Br J Rheumatol , vol.35 , pp. 828-838
    • Terato, K.1    Ye, X.J.2    Miyahara, H.3    Cremer, M.A.4    Griffiths, M.M.5
  • 11
    • 23844545868 scopus 로고    scopus 로고
    • Reactivation of antigen-induced arthritis in mice by oral administration of lipopolysaccharide
    • Yoshino S, Yamaki K, Taneda S, Yanagisawa R, Takano H. Reactivation of antigen-induced arthritis in mice by oral administration of lipopolysaccharide. Scand J Immunol 2005;62:117-22.
    • (2005) Scand J Immunol , vol.62 , pp. 117-122
    • Yoshino, S.1    Yamaki, K.2    Taneda, S.3    Yanagisawa, R.4    Takano, H.5
  • 12
    • 0034063410 scopus 로고    scopus 로고
    • The role of lipopolysaccharide injected systemically in the reactivation of collagen-induced arthritis in mice
    • Yoshino S, Ohsawa M. The role of lipopolysaccharide injected systemically in the reactivation of collagen-induced arthritis in mice. Br J Pharmacol 2000;129:1309-14.
    • (2000) Br J Pharmacol , vol.129 , pp. 1309-1314
    • Yoshino, S.1    Ohsawa, M.2
  • 13
    • 0037450737 scopus 로고    scopus 로고
    • Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by Toll-like receptor 4 signaling
    • Choe JY, Crain B, Wu SR, Corr M. Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by Toll-like receptor 4 signaling. J Exp Med 2003;197:537-42.
    • (2003) J Exp Med , vol.197 , pp. 537-542
    • Choe, J.Y.1    Crain, B.2    Wu, S.R.3    Corr, M.4
  • 14
    • 0037094084 scopus 로고    scopus 로고
    • Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
    • Johnson GB, Brunn GJ, Kodaira Y, Platt JL. Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 2002;168:5233-9.
    • (2002) J Immunol , vol.168 , pp. 5233-5239
    • Johnson, G.B.1    Brunn, G.J.2    Kodaira, Y.3    Platt, J.L.4
  • 16
    • 23644456849 scopus 로고    scopus 로고
    • The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages
    • Schaefer L, Babelova A, Kiss E, Hausser HJ, Baliova M, Krzyzankova M, et al. The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest 2005;115:2223-33.
    • (2005) J Clin Invest , vol.115 , pp. 2223-2233
    • Schaefer, L.1    Babelova, A.2    Kiss, E.3    Hausser, H.J.4    Baliova, M.5    Krzyzankova, M.6
  • 17
    • 27744444832 scopus 로고    scopus 로고
    • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    • Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, et al. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J Exp Med 2005;202:1171-7.
    • (2005) J Exp Med , vol.202 , pp. 1171-1177
    • Lau, C.M.1    Broughton, C.2    Tabor, A.S.3    Akira, S.4    Flavell, R.A.5    Mamula, M.J.6
  • 19
    • 25444443335 scopus 로고    scopus 로고
    • RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3
    • Brentano F, Schorr O, Gay RE, Gay S, Kyburz D. RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3. Arthritis Rheum 2005;52:2656-65.
    • (2005) Arthritis Rheum , vol.52 , pp. 2656-2665
    • Brentano, F.1    Schorr, O.2    Gay, R.E.3    Gay, S.4    Kyburz, D.5
  • 20
    • 0019354902 scopus 로고
    • The distribution of fibronectin in the pannus in rheumatoid arthritis
    • Scott DL, Delamere JP, Walton KW. The distribution of fibronectin in the pannus in rheumatoid arthritis. Br J Exp Pathol 1981;62:362-8.
    • (1981) Br J Exp Pathol , vol.62 , pp. 362-368
    • Scott, D.L.1    Delamere, J.P.2    Walton, K.W.3
  • 21
    • 0025317565 scopus 로고
    • Cellular fibronectin in rheumatoid synovium and synovial fluid: A possible factor contributing to lymphocytic infiltration
    • Walle TK, Vartio T, Helve T, Virtanen I, Kurki P. Cellular fibronectin in rheumatoid synovium and synovial fluid: a possible factor contributing to lymphocytic infiltration. Scand J Immunol 1990;31:535-40.
    • (1990) Scand J Immunol , vol.31 , pp. 535-540
    • Walle, T.K.1    Vartio, T.2    Helve, T.3    Virtanen, I.4    Kurki, P.5
  • 22
    • 33646882893 scopus 로고    scopus 로고
    • Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    • Roelofs MF, Boelens WC, Joosten LA, Abdollahi-Roodsaz S, Geurts J, Wunderink LU, et al. Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 2006;176:7021-7.
    • (2006) J Immunol , vol.176 , pp. 7021-7027
    • Roelofs, M.F.1    Boelens, W.C.2    Joosten, L.A.3    Abdollahi-Roodsaz, S.4    Geurts, J.5    Wunderink, L.U.6
  • 23
    • 0028906093 scopus 로고
    • EDA-containing fibronectin is synthesized from rheumatoid synovial fibroblast-like cells
    • Hino K, Shiozawa S, Kuroki Y, Ishikawa H, Shiozawa K, Sekiguchi K, et al. EDA-containing fibronectin is synthesized from rheumatoid synovial fibroblast-like cells. Arthritis Rheum 1995;38:678-83.
    • (1995) Arthritis Rheum , vol.38 , pp. 678-683
    • Hino, K.1    Shiozawa, S.2    Kuroki, Y.3    Ishikawa, H.4    Shiozawa, K.5    Sekiguchi, K.6
  • 24
    • 23644449245 scopus 로고    scopus 로고
    • The expression of Toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of Toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells
    • Roelofs MF, Joosten LA, Abdollahi-Roodsaz S, van Lieshout AW, Sprang T, van den Hoogen FH, et al. The expression of Toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of Toll-like receptors 3, 4, and 7/8 results in synergistic cytokine production by dendritic cells. Arthritis Rheum 2005;52:2313-22.
    • (2005) Arthritis Rheum , vol.52 , pp. 2313-2322
    • Roelofs, M.F.1    Joosten, L.A.2    Abdollahi-Roodsaz, S.3    van Lieshout, A.W.4    Sprang, T.5    van den Hoogen, F.H.6
  • 26
    • 0034677123 scopus 로고    scopus 로고
    • Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice
    • Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J Exp Med 2000;191:313-20.
    • (2000) J Exp Med , vol.191 , pp. 313-320
    • Horai, R.1    Saijo, S.2    Tanioka, H.3    Nakae, S.4    Sudo, K.5    Okahara, A.6
  • 27
    • 85047693264 scopus 로고    scopus 로고
    • TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice
    • Horai R, Nakajima A, Habiro K, Kotani M, Nakae S, Matsuki T, et al. TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest 2004;114:1603-11.
    • (2004) J Clin Invest , vol.114 , pp. 1603-1611
    • Horai, R.1    Nakajima, A.2    Habiro, K.3    Kotani, M.4    Nakae, S.5    Matsuki, T.6
  • 28
    • 0027995345 scopus 로고
    • Elimination of trace endotoxin protein from rough chemotype LPS
    • Manthey CL, Vogel SN. Elimination of trace endotoxin protein from rough chemotype LPS. J Endotoxin Res 1994;1:84-91.
    • (1994) J Endotoxin Res , vol.1 , pp. 84-91
    • Manthey, C.L.1    Vogel, S.N.2
  • 29
    • 0029875804 scopus 로고    scopus 로고
    • Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNFα, anti-IL-1α/β and IL-1Ra
    • Joosten LA, Helsen MM, van de Loo FA, van den Berg WB. Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFα, anti-IL-1α/β and IL-1Ra. Arthritis Rheum 1996;39:797-809.
    • (1996) Arthritis Rheum , vol.39 , pp. 797-809
    • Joosten, L.A.1    Helsen, M.M.2    van de Loo, F.A.3    van den Berg, W.B.4
  • 30
    • 0032752705 scopus 로고    scopus 로고
    • IL-1αβ blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-α blockade only ameliorates joint inflammation
    • Joosten LA, Helsen MM, Saxne T, van de Loo FA, Heinegard D, van den Berg WB. IL-1αβ blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-α blockade only ameliorates joint inflammation. J Immunol 1999;163:5049-55.
    • (1999) J Immunol , vol.163 , pp. 5049-5055
    • Joosten, L.A.1    Helsen, M.M.2    Saxne, T.3    van de Loo, F.A.4    Heinegard, D.5    van den Berg, W.B.6
  • 31
    • 3042521641 scopus 로고    scopus 로고
    • Deficient host-bacteria interactions in inflammatory bowel disease? The Toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis
    • Franchimont D, Vermeire S, El Housni H, Pierik M, Van Steen K, Gustot T, et al. Deficient host-bacteria interactions in inflammatory bowel disease? The Toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn's disease and ulcerative colitis. Gut 2004;53:987-92.
    • (2004) Gut , vol.53 , pp. 987-992
    • Franchimont, D.1    Vermeire, S.2    El Housni, H.3    Pierik, M.4    Van Steen, K.5    Gustot, T.6
  • 32
    • 20844463064 scopus 로고    scopus 로고
    • A synthetic TLR4 antagonist has antiinflammatory effects in two murine models of inflammatory bowel disease
    • Fort MM, Mozaffarian A, Stover AG, Correia JS, Johnson DA, Crane RT, et al. A synthetic TLR4 antagonist has antiinflammatory effects in two murine models of inflammatory bowel disease. J Immunol 2005;174:6416-23.
    • (2005) J Immunol , vol.174 , pp. 6416-6423
    • Fort, M.M.1    Mozaffarian, A.2    Stover, A.G.3    Correia, J.S.4    Johnson, D.A.5    Crane, R.T.6
  • 33
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger P. The danger model: a renewed sense of self. Science 2002;296:301-5.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 34
    • 1242336786 scopus 로고    scopus 로고
    • Reduced myocardial ischemia-reperfusion injury in Toll-like receptor 4-deficient mice
    • Oyama J, Biais C Jr, Liu X, Pu M, Kobzik L, Kelly RA, et al. Reduced myocardial ischemia-reperfusion injury in Toll-like receptor 4-deficient mice. Circulation 2004;109:784-9.
    • (2004) Circulation , vol.109 , pp. 784-789
    • Oyama, J.1    Biais Jr, C.2    Liu, X.3    Pu, M.4    Kobzik, L.5    Kelly, R.A.6
  • 35
    • 28244489599 scopus 로고    scopus 로고
    • Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells
    • Tsung A, Hoffman RA, Izuishi K, Critchlow ND, Nakao A, Chan MH, et al. Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchymal cells. J Immunol 2005;175: 7661-8.
    • (2005) J Immunol , vol.175 , pp. 7661-7668
    • Tsung, A.1    Hoffman, R.A.2    Izuishi, K.3    Critchlow, N.D.4    Nakao, A.5    Chan, M.H.6
  • 36
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    • Jiang D, Liang J, Fan J, Yu S, Chen S, Luo Y, et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med 2005;11:1173-9.
    • (2005) Nat Med , vol.11 , pp. 1173-1179
    • Jiang, D.1    Liang, J.2    Fan, J.3    Yu, S.4    Chen, S.5    Luo, Y.6
  • 37
    • 10444278132 scopus 로고    scopus 로고
    • Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-γ
    • Radstake TR, Roelofs MF, Jenniskens YM, Oppers-Walgreen B, van Riel PL, Barrera P, et al. Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-γ. Arthritis Rheum 2004;50:3856-65.
    • (2004) Arthritis Rheum , vol.50 , pp. 3856-3865
    • Radstake, T.R.1    Roelofs, M.F.2    Jenniskens, Y.M.3    Oppers-Walgreen, B.4    van Riel, P.L.5    Barrera, P.6
  • 38
    • 2442651352 scopus 로고    scopus 로고
    • Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T
    • Zahringer U, Lindner B, Knirel YA, van den Akker WM, Hiestand R, Heine H, et al. Structure and biological activity of the short-chain lipopolysaccharide from Bartonella henselae ATCC 49882T. J Biol Chem 2004;279:21046-54.
    • (2004) J Biol Chem , vol.279 , pp. 21046-21054
    • Zahringer, U.1    Lindner, B.2    Knirel, Y.A.3    van den Akker, W.M.4    Hiestand, R.5    Heine, H.6
  • 40
    • 0025188131 scopus 로고
    • Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS
    • Loppnow H, Libby P, Freudenberg M, Krauss JH, Weckesser J, Mayer H. Cytokine induction by lipopolysaccharide (LPS) corresponds to lethal toxicity and is inhibited by nontoxic Rhodobacter capsulatus LPS. Infect Immun 1990;58:3743-50.
    • (1990) Infect Immun , vol.58 , pp. 3743-3750
    • Loppnow, H.1    Libby, P.2    Freudenberg, M.3    Krauss, J.H.4    Weckesser, J.5    Mayer, H.6
  • 41
    • 0037372661 scopus 로고    scopus 로고
    • Inhibition of endotoxin response by E5564, a novel Toll-like receptor 4-directed endotoxin antagonist
    • Mullarkey M, Rose JR, Bristol J, Kawata T, Kimura A, Kobayashi S, et al. Inhibition of endotoxin response by E5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J Pharmacol Exp Ther 2003;304:1093-102.
    • (2003) J Pharmacol Exp Ther , vol.304 , pp. 1093-1102
    • Mullarkey, M.1    Rose, J.R.2    Bristol, J.3    Kawata, T.4    Kimura, A.5    Kobayashi, S.6
  • 42
    • 27744497439 scopus 로고    scopus 로고
    • Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity
    • Su SB, Silver PB, Grajewski RS, Agarwal RK, Tang J, Chan CC, et al. Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol 2005;175:6303-10.
    • (2005) J Immunol , vol.175 , pp. 6303-6310
    • Su, S.B.1    Silver, P.B.2    Grajewski, R.S.3    Agarwal, R.K.4    Tang, J.5    Chan, C.C.6
  • 43
    • 34848894127 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 during experimental arthritis mediated by skewed T cell balance
    • Submitted for publication
    • Abdollahi-Roodsaz S, Joosten LA, Koenders MI, Devesa I, Roelofs MF, Radstake TR, et al. Differential roles of TLR2 and TLR4 during experimental arthritis mediated by skewed T cell balance. Submitted for publication.
    • Abdollahi-Roodsaz, S.1    Joosten, L.A.2    Koenders, M.I.3    Devesa, I.4    Roelofs, M.F.5    Radstake, T.R.6
  • 44
    • 0025016233 scopus 로고
    • Macrophages cultured in vitro release leukotriene B4 and neutrophil attractant/activation protein (interleukin 8) sequentially in response to stimulation with lipopolysaccharide and zymosan
    • Rankin JA, Sylvester I, Smith S, Yoshimura T, Leonard EJ. Macrophages cultured in vitro release leukotriene B4 and neutrophil attractant/activation protein (interleukin 8) sequentially in response to stimulation with lipopolysaccharide and zymosan. J Clin Invest 1990;86:1556-64.
    • (1990) J Clin Invest , vol.86 , pp. 1556-1564
    • Rankin, J.A.1    Sylvester, I.2    Smith, S.3    Yoshimura, T.4    Leonard, E.J.5
  • 46
    • 0031058029 scopus 로고    scopus 로고
    • Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures
    • Winzler C, Rovere P, Rescigno M, Granucci F, Penna G, Adorini L, et al. Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med 1997;185:317-28.
    • (1997) J Exp Med , vol.185 , pp. 317-328
    • Winzler, C.1    Rovere, P.2    Rescigno, M.3    Granucci, F.4    Penna, G.5    Adorini, L.6
  • 47
    • 0033178828 scopus 로고    scopus 로고
    • Reis e Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999;11:392-9.
    • Reis e Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol 1999;11:392-9.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.