Looking at the blood-brain barrier: Molecular anatomy and possible investigation approaches

Brain Research Reviews

Volumn 64, Issue 2, 2010, Pages 328-363

  Cardoso, Filipa Lourenço ^a   Brites, Dora ^a   Brito, Maria Alexandra ^a  

^a UNIVERSITY OF LISBON   (Portugal)

Author keywords

Blood brain barrier; Brain microvascular endothelial cell; Intercellular junction; Neurovascular unit; Signaling; Stem cell niche; Transport system

Indexed keywords

BETA CATENIN; CADHERIN; CALCIUM; CINGULIN; CLAUDIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANINE NUCLEOTIDE BINDING PROTEIN; JUNCTIONAL ADHESION MOLECULE A; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OCCLUDIN; PHOSPHOPROTEIN; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; PROTEIN ZO1; PROTEIN ZO2; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; WNT PROTEIN;

BASEMENT MEMBRANE; BLOOD BRAIN BARRIER; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN REGION; CELL CULTURE; CELL INTERACTION; CELL JUNCTION; CONFOCAL LASER MICROSCOPY; ELECTRON MICROSCOPY; ENDOTHELIUM CELL; FLUORESCENCE MICROSCOPY; GLIA CELL; HUMAN; MEMBRANE PERMEABILITY; NERVE CELL; NERVOUS SYSTEM FUNCTION; NEUROPROTECTION; NONHUMAN; PERICYTE; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD-BRAIN BARRIER; HUMANS; INTERCELLULAR JUNCTIONS; NEUROGLIA; NEURONS; SIGNAL TRANSDUCTION; TIGHT JUNCTIONS;

EID: 77956344034     PISSN: 01650173     EISSN: 18726321     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2010.05.003     Document Type: Review

References (357)

1. Abbott N.J. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell. Mol. Neurobiol. 2000, 20:131-147.
2. Abbott N.J. Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 2002, 200:629-638.
3. Abbott N.J., Ronnback L., Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 2006, 7:41-53.
4. Abulrob A., Brunette E., Slinn J., Baumann E., Stanimirovic D. Dynamic analysis of the blood-brain barrier disruption in experimental stroke using time domain in vivo fluorescence imaging. Mol. Imaging 2008, 7:248-262.
5. Adibhatla R.M., Hatcher J.F. Tissue plasminogen activator (tPA) and matrix metalloproteinases in the pathogenesis of stroke: therapeutic strategies. CNS Neurol. Disord. Drug Targets 2008, 7:243-253.
6. Afonso P.V., Ozden S., Cumont M.-C., Seilhean D., Cartier L., Rezaie P., Mason S., Lambert S., Huerre M., Gessain A., Couraud P.-O., Pique C., Ceccaldi P.-E., Romero I.A. Alteration of blood-brain barrier integrity by retroviral infection. PLoS Pathog. 2008, 4:e1000205.
7. Al Ahmad A., Gassmann M., Ogunshola O.O. Maintaining blood-brain barrier integrity: pericytes perform better than astrocytes during prolonged oxygen deprivation. J. Cell. Physiol. 2009, 218:612-622.
8. Alanne M.H., Pummi K., Heape A.M., Grènman R., Peltonen J., Peltonen S. Tight junction proteins in human Schwann cell autotypic junctions. J. Histochem. Cytochem. 2009, 57:523-529.
9. Allt G., Lawrenson J.G. Pericytes: cell biology and pathology. Cells Tissues Organs 2001, 169:1-11.
10. al-Obeidi F.A., Wu J.J., Lam K.S. Protein tyrosine kinases: structure, substrate specificity, and drug discovery. Biopolymers 1998, 47:197-223.
11. An P., Xue Y.X. Effects of preconditioning on tight junction and cell adhesion of cerebral endothelial cells. Brain Res. 2009, 1272:81-88.
12. Anderson R.G. Caveolae: where incoming and outgoing messengers meet. Proc. Natl. Acad. Sci. USA 1993, 90:10909-10913.
13. András I.E., Pu H., Tian J., Deli M.A., Nath A., Hennig B., Toborek M. Signaling mechanisms of HIV-1 Tat-induced alterations of claudin-5 expression in brain endothelial cells. J. Cereb. Blood Flow Metab. 2005, 25:1159-1170.
14. Argaw A.T., Gurfein B.T., Zhang Y., Zameer A., John G.R. VEGF-mediated disruption of endothelial CLN-5 promotes blood-brain barrier breakdown. Proc. Natl. Acad. Sci. USA 2009, 106:1977-1982.
15. Aronowski J., Labiche L.A. Perspectives on reperfusion-induced damage in rodent models of experimental focal ischemia and role of gamma-protein kinase C. ILAR J. 2003, 44:105-109.
16. Aschner M., Fitsanakis V.A., dos Santos A.P., Olivi L., Bressler J.P. Blood-brain barrier and cell-cell interactions: methods for establishing in vitro models of the blood-brain barrier and transport measurements. Methods Mol. Biol. 2006, 341:1-15.
17. Astradsson A., Jenkins B.G., Choi J.K., Hallett P.J., Levesque M.A., McDowell J.S., Brownell A.L., Spealman R.D., Isacson O. The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates-evidence from in vivo neuroimaging studies. Neurobiol. Dis. 2009, 35:348-351.
18. Aurrand-Lions M., Johnson-Leger C., Wong C., Du Pasquier L., Imhof B.A. Heterogeneity of endothelial junctions is reflected by differential expression and specific subcellular localization of the three JAM family members. Blood 2001, 98:3699-3707.
19. Avouac J., Wipff J., Goldman O., Ruiz B., Couraud P.O., Chiocchia G., Kahan A., Boileau C., Uzan G., Allanore Y. Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial growth factor receptor 1 in endothelial progenitor-derived cells under hypoxic conditions. Arthritis Rheum. 2008, 58:3550-3561.
20. Ay I., Francis J.W., Brown R.H.Jr. VEGF increases blood-brain barrier permeability to Evans blue dye and tetanus toxin fragment C but not adeno-associated virus in ALS mice. Brain Res. 2008, 1234:198-205.
21. Babakhanian K., Bendayan M., Bendayan R. Localization of P-glycoprotein at the nuclear envelope of rat brain cells. Biochem. Biophys. Res. Commun. 2007, 361:301-306.
22. Bagley R.G., Weber W., Rouleau C., Teicher B.A. Pericytes and endothelial precursor cells: cellular interactions and contributions to malignancy. Cancer Res. 2005, 65:9741-9750.
23. Bahbouhi B., Berthelot L., Pettré S., Michel L., Wiertlewski S., Weksler B., Romero I.A., Miller F., Couraud P.O., Brouard S., Laplaud D.A., Soulillou J.P. Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line. J. Leukoc. Biol. 2009, 86:1049-1063.
24. Ballabh P., Braun A., Nedergaard M. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol. Dis. 2004, 16:1-13.
25. Ballabh P., Hu F., Kumarasiri M., Braun A., Nedergaard M. Development of tight junction molecules in blood vessels of germinal matrix, cerebral cortex, and white matter. Pediatr. Res. 2005, 58:791-798.
26. Banaz-YaŞar F., Tischka R., Iliakis G., Winterhager E., Gellhaus A. Cell line specific modulation of connexin43 expression after exposure to ionizing radiation. Cell Commun. Adhes. 2005, 12:249-259.
27. Banks W.A. The blood-brain barrier as a regulatory interface in the gut-brain axes. Physiol. Behav. 2006, 89:472-476.
28. Banks W.A., Erickson M.A. The blood-brain barrier and immune function and dysfunction. Neurobiol. Dis. 2010, 37:26-32.
29. Banks W.A., Kastin A.J., Broadwell R.D. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 1995, 2:241-248.
30. Barakat S., Demeule M., Pilorget A., Regina A., Gingras D., Baggetto L.G., Beliveau R. Modulation of p-glycoprotein function by caveolin-1 phosphorylation. J. Neurochem. 2007, 101:1-8.
31. Bartels A.L., Willemsen A.T., Kortekaas R., de Jong B.M., de Vries R., de Klerk O., van Oostrom J.C., Portman A., Leenders K.L. Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA. J. Neural Transm. 2008, 115:1001-1009.
32. Baskin L., Urschel S., Eiberg B. A novel ex-vivo application of RNAi for neuroscience. Biotechniques 2008, 45:338-339.
33. Bauer A.T., Bürgers H.F., Rabie T., Marti H.H. Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement. J. Cereb. Blood Flow Metab. 2010, 30:837-848.
34. Beck D.W., Roberts R.L., Olson J.J. Glial cells influence membrane-associated enzyme activity at the blood-brain barrier. Brain Res. 1986, 381:131-137.
35. Bélanger M., Asashima T., Ohtsuki S., Yamaguchi H., Ito S., Terasaki T. Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro. Neurochem. Int. 2007, 50:95-101.
36. Bellavance M.A., Blanchette M., Fortin D. Recent advances in blood-brain barrier disruption as a CNS delivery strategy. AAPS J. 2008, 10:166-177.
37. Bendayan R., Ronaldson P.T., Gingras D., Bendayan M. In situ localization of P-glycoprotein (ABCB1) in human and rat brain. J. Histochem. Cytochem. 2006, 54:1159-1167.
38. Bernacki J., Dobrowolska A., Nierwinska K., Malecki A. Physiology and pharmacological role of the blood-brain barrier. Pharmacol. Rep. 2008, 60:600-622.
39. Bernas, M.J., Cardoso, F.L., Daley, S.K., Weinand, M.E., Campos, A.R., Ferreira, A.J.G., Hoying, J.B., Witte, M.H., Brites, D., Persidsky, Y., Ramirez, S.H., Brito, M.A., 2010. Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier. Nat. Protoc. 5, 1247-1254.
40. Bernoud N., Fenart L., Benistant C., Pageaux J.F., Dehouck M.P., Moliere P., Lagarde M., Cecchelli R., Lecerf J. Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood-brain barrier endothelial cells in vitro. J. Lipid Res. 1998, 39:1816-1824.
41. Betz A.L. An overview of the multiple functions of the blood-brain barrier. NIDA Res. Monogr. 1992, 120:54-72.
42. Betzen C., White R., Zehendner C.M., Pietrowski E., Bender B., Luhmann H.J., Kuhlmann C.R. Oxidative stress upregulates the NMDA receptor on cerebrovascular endothelium. Free Radic. Biol. Med. 2009, 47:1212-1220.
43. Birukov K.G., Csortos C., Marzilli L., Dudek S., Ma S.F., Bresnick A.R., Verin A.D., Cotter R.J., Garcia J.G. Differential regulation of alternatively spliced endothelial cell myosin light chain kinase isoforms by p60(Src). J. Biol. Chem. 2001, 276:8567-8573.
44. Boer K., Troost D., Jansen F., Nellist M., van den Ouweland A.M., Geurts J.J., Spliet W.G., Crino P., Aronica E. Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex. Neuropathology 2008, 28:577-590.
45. Bojanic D.D., Tarr P.T., Gale G.D., Smith D.J., Bok D., Chen B., Nusinowitz S., Lovgren-Sandblom A., Bjorkhem I., Edwards P.A. Differential expression and function of ABCG1 and ABCG4 during development and aging. J. Lipid Res. 2010, 51:169-181.
46. Boveri M., Kinsner A., Berezowski V., Lenfant A.M., Draing C., Cecchelli R., Dehouck M.P., Hartung T., Prieto P., Bal-Price A. Highly purified lipoteichoic acid from gram-positive bacteria induces in vitro blood-brain barrier disruption through glia activation: role of pro-inflammatory cytokines and nitric oxide. Neuroscience 2006, 137:1193-1209.
47. Bowman P.D., Ennis S.R., Rarey K.E., Betz A.L., Goldstein G.W. Brain microvessel endothelial cells in tissue culture: a model for study of blood-brain barrier permeability. Ann. Neurol. 1983, 14:396-402.
48. Braun A., Xu H., Hu F., Kocherlakota P., Siegel D., Chander P., Ungvari Z., Csiszar A., Nedergaard M., Ballabh P. Paucity of pericytes in germinal matrix vasculature of premature infants. J. Neurosci. 2007, 27:12012-12024.
49. Brown R.C., Davis T.P. Calcium modulation of adherens and tight junction function: a potential mechanism for blood-brain barrier disruption after stroke. Stroke 2002, 33:1706-1711.
50. Butt A.M. Effect of inflammatory agents on electrical resistance across the blood-brain barrier in pial microvessels of anaesthetized rats. Brain Res. 1995, 696:145-150.
51. Büttner A., Kroehling C., Mall G., Penning R., Weis S. Alterations of the vascular basal lamina in the cerebral cortex in drug abuse: a combined morphometric and immunohistochemical investigation. Drug Alcohol Depend. 2005, 79:63-70.
52. Calabria A.R., Shusta E.V. A genomic comparison of in vivo and in vitro brain microvascular endothelial cells. J. Cereb. Blood Flow Metab. 2008, 28:135-148.
53. Calabria A.R., Weidenfeller C., Jones A.R., de Vries H.E., Shusta E.V. Puromycin-purified rat brain microvascular endothelial cell cultures exhibit improved barrier properties in response to glucocorticoid induction. J. Neurochem. 2006, 97:922-933.
54. Carman C.V., Springer T.A. A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them. J. Cell Biol. 2004, 167:377-388.
55. Carvey P.M., Hendey B., Monahan A.J. The blood-brain barrier in neurodegenerative disease: a rhetorical perspective. J. Neurochem. 2009, 111:291-314.
56. Cattelino A., Liebner S., Gallini R., Zanetti A., Balconi G., Corsi A., Bianco P., Wolburg H., Moore R., Oreda B., Kemler R., Dejana E. The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J. Cell Biol. 2003, 162:1111-1122.
57. Cecchelli R., Berezowski V., Lundquist S., Culot M., Renftel M., Dehouck M.P., Fenart L. Modelling of the blood-brain barrier in drug discovery and development. Nat. Rev. Drug Discov. 2007, 6:650-661.
58. Cestelli A., Catania C., D'Agostino S., Di Liegro I., Licata L., Schiera G., Pitarresi G.L., Savettieri G., De Caro V., Giandalia G., Giannola L.I. Functional feature of a novel model of blood brain barrier: studies on permeation of test compounds. J. Control. Release 2001, 76:139-147.
59. Chaudhuri J.D. Blood brain barrier and infection. Med. Sci. Monit. 2000, 6:1213-1222.
60. Chen Y., Zhu Q.J., Pan J., Yang Y., Wu X.P. A prediction model for blood-brain barrier permeation and analysis on its parameter biologically. Comput. Meth. Programs Biomed. 2009, 95:280-287.
61. Chenn A. beta-catenin/β-catenin signaling in cerebral cortical development. Organogenesis 2008, 4:76-80.
62. Cho S., Wood A., Bowlby M.R. Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics. Curr. Neuropharmacol. 2007, 5:19-33.
63. Choi Y.K., Kim K.W. Blood-neural barrier: its diversity and coordinated cell-to-cell communication. BMB Rep. 2008, 41:345-352.
64. Cirino G., Fiorucci S., Sessa W.C. Endothelial nitric oxide synthase: the Cinderella of inflammation?. Trends Pharmacol. Sci. 2003, 24:91-95.
65. Cohen-Kashi Malina K.C., Cooper I., Teichberg V.I. Closing the gap between the in-vivo and in-vitro blood-brain barrier tightness. Brain Res. 2009, 1284:12-21.
66. Coisne C., Dehouck L., Faveeuw C., Delplace Y., Miller F., Landry C., Morissette C., Fenart L., Cecchelli R., Tremblay P., Dehouck B. Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium. Lab. Invest. 2005, 85:734-746.
67. Coisne C., Mao W., Engelhardt B. Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis. J. Immunol. 2009, 182:5909-5913.
68. Colgan O.C., Collins N.T., Ferguson G., Murphy R.P., Birney Y.A., Cahill P.A., Cummins P.M. Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function. Brain Res. 2008, 1193:84-92.
69. Collan Y., Hirsimäki P., Aho H., Wuorela M., Sundström J., Tertti R., Metsärinne K. Value of electron microscopy in kidney biopsy diagnosis. Ultrastruct. Pathol. 2005, 29:461-468.
70. Cook B.D., Ferrari G., Pintucci G., Mignatti P. TGF-β1 induces rearrangement of FLK-1-VE-cadherin-β-catenin complex at the adherens junction through VEGF-mediated signalling. J. Cell. Biochem. 2008, 105:1367-1373.
71. Cordenonsi M., D'Atri F., Hammar E., Parry D.A., Kendrick-Jones J., Shore D., Citi S. Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3 and myosin. J. Cell Biol. 1999, 147:1569-1582.
72. Cornford E.M., Hyman S. Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy. NeuroRx. 2005, 2:27-43.
73. Coureuil M., Mikaty G., Miller F., Lecuyer H., Bernard C., Bourdoulous S., Dumenil G., Mege R.M., Weksler B.B., Romero I.A., Couraud P.O., Nassif X. Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium. Science 2009, 325:83-87.
74. Cowan K.M., Easton A.S. Neutrophils block permeability increases induced by oxygen glucose deprivation in a culture model of the human model blood-brain barrier. Brain Res. 2010, 1332:20-31.
75. Crecelius A., Götz A., Arzberger T., Arnold G.J., Ferrer I., Kretzschmar H.A. Assessing quantitative post-mortem changes in the gray matter of the human frontal cortex proteome by 2-D DIGE. Proteomics 2008, 8:1276-1291.
76. Cross T.G., Scheel-Toellner D., Henriquez N.V., Deacon E., Salmon M., Lord J.M. Serine/threonine protein kinases and apoptosis. Exp. Cell Res. 2000, 256:34-41.
77. Cucullo L., Hossain M., Rapp E., Manders T., Marchi N., Janigro D. Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. Epilepsia 2007, 48:505-516.
78. Cucullo L., Couraud P.O., Weksler B., Romero I.A., Hossain M., Rapp E., Janigro D. Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J. Cereb. Blood Flow Metab. 2008, 28:312-328.
79. Cunningham L.A., Wetzel M., Rosenberg G.A. Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 2005, 50:329-339.
80. Cura A.J., Carruthers A. Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathway. J. Biol. Chem. 2010, 285:15430-15439.
81. D'Arcangelo D., Ambrosino V., Giannuzzo M., Gaetano C., Capogrossi M.C. Axl receptor activation mediates laminar shear stress anti-apoptotic effects in human endothelial cells. Cardiovasc. Res. 2006, 71:754-763.
82. de Boer A.G., Gaillard P.J. Blood-brain barrier dysfunction and recovery. J. Neural Transm. 2006, 113:455-462.
83. Deli M.A. Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery. Biochim. Biophys. Acta 2009, 1788:892-910.
84. Deli M.A., Ábrahám C.S., Kataoka Y., Niwa M. Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology. Cell. Mol. Neurobiol. 2005, 25:59-127.
85. Demel M.A., Schwaha R., Krämer O., Ettmayer P., Haaksma E.E.J., Ecker G.F. In silico prediction of substrate properties for ABC-multidrug transporters. Expert Opin. Drug Metab. Toxicol. 2008, 4:1167-1180.
86. Demeule M., Jodoin J., Gingras D., Beliveau R. P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries. FEBS Lett. 2000, 466:219-224.
87. Dempsey E.C., Newton A.C., Mochly-Rosen D., Fields A.P., Reyland M.E., Insel P.A., Messing R.O. Protein kinase C isozymes and the regulation of diverse cell responses. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000, 279:L429-L438.
88. Ding G.R., Qiu L.B., Wang X.W., Li K.C., Zhou Y.C., Zhou Y., Zhang J., Zhou J.X., Li Y.R., Guo G.Z. EMP-induced alterations of tight junction protein expression and disruption of the blood-brain barrier. Toxicol. Lett. 2010, 196:154-160.
89. Dittmar S., Harms H., Runkler N., Maisner A., Kim K.S., Schneider-Schaulies J. Measles virus-induced block of transendothelial migration of T lymphocytes and infection-mediated virus spread across endothelial cell barriers. J. Virol. 2008, 82:11273-11282.
90. Doak S.H., Rogers D., Jones B., Francis L., Conlan R.S., Wright C. High-resolution imaging using a novel atomic force microscope and confocal laser scanning microscope hybrid instrument: essential sample preparation aspects. Histochem. Cell Biol. 2008, 130:909-916.
91. Dohgu S., Takata F., Yamauchi A., Nakagawa S., Egawa T., Naito M., Tsuruo T., Sawada Y., Niwa M., Kataoka Y. Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-β production. Brain Res. 2005, 1038:208-215.
92. Dore-Duffy P. Pericytes: pluripotent cells of the blood brain barrier. Curr. Pharm. Des. 2008, 14:1581-1593.
93. Dore-Duffy P., Katychev A., Wang X., Van Buren E. CNS microvascular pericytes exhibit multipotential stem cell activity. J. Cereb. Blood Flow Metab. 2006, 26:613-624.
94. Dörfel M.J., Westphal J.K., Huber O. Differential phosphorylation of occludin and tricellulin by CK2 and CK1. Ann. NY Acad. Sci. 2009, 165:69-73.
95. dos Santos A.P.M., Milatovic D., Au C., Yin Z., Batoreu M.C.C., Aschner M. Rat brain endothelial cells are a target of manganese toxicity. Brain Res. 2010, 1326:152-161.
96. Ebert A.D., Svendsen C.N. A new tool in the battle against Alzheimer's disease and aging: ex vivo gene therapy. Rejuvenation Res. 2005, 8:131-134.
97. Edelman D.A., Jiang Y., Tyburski J., Wilson R.F., Steffes C. Pericytes and their role in microvasculature homeostasis. J. Surg. Res. 2006, 135:305-311.
98. Ehrlich P. Das sauerstoff-bedürfnis des organismus. Eine Farbenanalytische Studie. Habilitation thesis, Berlin 1885.
99. Ehrlich P. Ueber die beziehungen von chemischer constitution, vertheilung, und pharmakologischen wirkung. Collected Studies on Immunity 1906, 404-442. Wiley, Berlin.
100. Ekins S., Mestres J., Testa B. In silico pharmacology for drug discovery: applications to targets and beyond. Br. J. Pharmacol. 2007, 152:21-37.
101. Eliceiri B.P., Paul R., Schwartzberg P.L., Hood J.D., Leng J., Cheresh D.A. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol. Cell 1999, 4:915-924.
102. Engelhardt B. PSGL-1-the hidden player in T cell trafficking into the brain in multiple sclerosis?. J. Leukoc. Biol. 2009, 86:1023-1025.
103. Erickson K.K., Sundstrom J.M., Antonetti D.A. Vascular permeability in ocular disease and the role of tight junctions. Angiogenesis 2007, 10:103-117.
104. Etienne-Manneville S., Hall A. Rho GTPases in cell biology. Nature 2002, 420:629-635.
105. Etienne-Manneville S., Manneville J.B., Adamson P., Wilbourn B., Greenwood J., Couraud P.O. ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines. J. Immunol. 2000, 165:3375-3383.
106. Faria A., Pestana D., Teixeira D., Azevedo J., De Freitas V., Mateus N., Calhau C. Flavonoid transport across RBE4 cells: a blood-brain barrier model. Cell. Mol. Biol. Lett. 2010, 15:234-241.
107. Farrall A.J., Wardlaw J.M. Blood-brain barrier: ageing and microvascular disease-systematic review and meta-analysis. Neurobiol. Aging 2009, 30:337-352.
108. Feng S.S., Mu L., Win K.Y., Huang G. Nanoparticles of biodegradable polymers for clinical administration of paclitaxel. Curr. Med. Chem. 2004, 11:413-424.
109. Filioreanu A.M., Popescu E., Cotrutz C., Cotrutz C.E. Immunohistochemical and transmission electron microscopy study regarding myofibroblasts in fibroinflammatory epulis and giant cell peripheral granuloma. Rom. J. Morphol. Embryol. 2009, 50:363-368.
110. Fischer S., Wiesnet M., Marti H.H., Renz D., Schaper W. Simultaneous activation of several second messengers in hypoxia-induced hyperpermeability of brain derived endothelial cells. J. Cell. Physiol. 2004, 198:359-369.
111. Fischer S., Wiesnet M., Renz D., Schaper W. H2O2 induces paracellular permeability of porcine brain-derived microvascular endothelial cells by activation of the p44/42 MAP kinase pathway. Eur. J. Cell Biol. 2005, 84:687-697.
112. Fleegal M.A., Hom S., Borg L.K., Davis T.P. Activation of PKC modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation. Am. J. Physiol. Heart Circ. Physiol. 2005, 289:H2012-H2019.
113. Fletcher N.F., Bexiga M.G., Brayden D.J., Brankin B., Willett B.J., Hosie M.J., Jacque J.M., Callanan J.J. Lymphocyte migration through the blood brain barrier (BBB) in feline immunodeficiency virus infection is significantly influenced by the pre-existence of virus and tumour necrosis factor (TNF)-Α within the central nervous system (CNS): studies using an in vitro feline BBB model. Neuropathol. Appl. Neurobiol. 2009, 35:592-602.
114. Förster C., Burek M., Romero I.A., Weksler B., Couraud P.O., Drenckhahn D. Differential effects of hydrocortisone and TNFβ on tight junction proteins in an in vitro model of the human blood-brain barrier. J. Physiol. 2008, 586:1937-1949.
115. Fottner C., Mettler E., Goetz M., Schirrmacher E., Anlauf M., Strand D., Schirrmacher R., Klöppel G., Delaney P., Schreckenberger M., Galle P.R., Neurath M.F., Kiesslich R., Weber M.M. In vivo molecular imaging of somatostatin receptors in pancreatic islet cells and neuroendocrine tumors by miniaturized confocal laser-scanning fluorescence microscopy. Endocrinology 2010, 151:2179-2188.
116. Francis K., van Beek J., Canova C., Neal J.W., Gasque P. Innate immunity and brain inflammation: the key role of complement. Expert Rev. Mol. Med. 2003, 5:1-19.
117. Furuse M. Knockout animals and natural mutations as experimental and diagnostic tool for studying tight junction functions in vivo. Biochim. Biophys. Acta 2009, 788:813-819.
118. Furuse M., Hirase T., Itoh M., Nagafuchi A., Yonemura S., Tsukita S., Tsukita S. Occludin: a novel integral membrane protein localizing at tight junctions. J. Cell Biol. 1993, 123:1777-1788.
119. Gaillard P.J., Voorwinden L.H., Nielsen J.L., Ivanov A., Atsumi R., Engman H., Ringbom C., de Boer A.G., Breimer D.D. Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. Eur. J. Pharm. Sci. 2001, 12:215-222.
120. Garcia J.G., Verin A.D., Schaphorst K., Siddiqui R., Patterson C.E., Csortos C., Natarajan V. Regulation of endothelial cell myosin light chain kinase by Rho, cortactin, and p60(src). Am. J. Physiol. 1999, 276:L989-L998.
121. Garg P., Verma J. In silico prediction of blood brain barrier permeability: an Artificial Neural Network model. J. Chem. Inf. Model. 2006, 46:289-297.
122. Gavard J., Gutkind J.S. VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin. Nat. Cell Biol. 2006, 8:1223-1234.
123. Gazzin S., Strazielle N., Schmitt C., Fevre-Montange M., Ostrow J.D., Tiribelli C., Ghersi-Egea J.F. Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. J. Comp. Neurol. 2008, 510:497-507.
124. Ge S., Song L., Pachter J.S. Where is the blood-brain barrier ... really?. J. Neurosci. Res. 2005, 79:421-427.
125. Ghazanfari F.A., Stewart R.R. Characteristics of endothelial cells derived from the blood-brain barrier and of astrocytes in culture. Brain Res. 2001, 890:49-65.
126. Goldberg J.S., Hirschi K.K. Diverse roles of the vasculature within the neural stem cell niche. Regen. Med. 2009, 4:879-897.
127. Goldmann E. Vitalfarbung am zentralnervensystem. Abhandl Konigl preuss Akad Wiss. 1913, 1:1-60.
128. González-Mariscal L., Betanzos A., Nava P., Jaramillo B.E. Tight junction proteins. Prog. Biophys. Mol. Biol. 2003, 81:1-44.
129. González-Mariscal L., Tapia R., Chamorro D. Crosstalk of tight junction components with signaling pathways. Biochim. Biophys. Acta 2008, 1778:729-756.
130. González-Mariscal L., Tapia R., Huerta M., Lopez-Bayghen E. The tight junction protein ZO-2 blocks cell cycle progression and inhibits cyclin D1 expression. Ann. NY Acad. Sci. 2009, 1165:121-125.
131. Gosselin D., Rivest S. MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation. Mol. Psychiatry 2008, 13:480-497.
132. Gow A., Southwood C.M., Li J.S., Pariali M., Riordan G.P., Brodie S.E., Danias J., Bronstein J.M., Kachar B., Lazzarini R.A. CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell 1999, 99:649-659.
133. Greenwood J., Pryce G., Devine L., Male D.K., dos Santos W.L., Calder V.L., Adamson P. SV40 large T immortalised cell lines of the rat blood-brain and blood-retinal barriers retain their phenotypic and immunological characteristics. J. Neuroimmunol. 1996, 71:51-63.
134. Gumbleton M., Audus K.L. Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier. J. Pharm. Sci. 2001, 90:1681-1698.
135. Gupta I.R., Ryan A.K. Claudins: unlocking the code to tight junction function during embryogenesis and in disease. Clin. Genet. 2010, 77:314-325.
136. Hamabe W., Fujita R., Ueda H. Insulin receptor-protein kinase C-Γ signaling mediates inhibition of hypoxia-induced necrosis of cortical neurons. J. Pharmacol. Exp. Ther. 2005, 313:1027-1034.
137. Haorah J., Knipe B., Leibhart J., Ghorpade A., Persidsky Y. Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. J. Leukoc. Biol. 2005, 78:1223-1232.
138. Haorah J., Ramirez S.H., Schall K., Smith D., Pandya R., Persidsky Y. Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J. Neurochem. 2007, 101:566-576.
139. Haorah J., Knipe B., Gorantla S., Zheng J., Persidsky Y. Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1, 4, 5-triphosphate receptor (IP3R)-gated intracellular calcium release. J. Neurochem. 2007, 100:324-336.
140. Haorah J., Schall K., Ramirez S.H., Persidsky Y. Activation of protein tyrosine kinases and matrix metalloproteinases causes blood-brain barrier injury: novel mechanism for neurodegeneration associated with alcohol abuse. Glia 2008, 56:78-88.
141. Harhaj N.S., Felinski E.A., Wolpert E.B., Sundstrom J.M., Gardner T.W., Antonetti D.A. VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol. Vis. Sci. 2006, 47:5106-5115.
142. Harris L.W., Wayland M., Lan M., Ryan M., Giger T., Lockstone H., Wuethrich I., Mimmack M., Wang L., Kotter M., Craddock R., Bahn S. The cerebral microvasculature in schizophrenia: a laser capture microdissection study. PLoS ONE 2008, 3:e3964.
143. Hasselbalch S.G., Knudsen G.M., Capaldo B., Postiglione A., Paulson O.B. Blood-brain barrier transport and brain metabolism of glucose during acute hyperglycemia in humans. J. Clin. Endocrinol. Metab. 2001, 86:1986-1990.
144. Hawkins B.T., Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 2005, 57:173-185.
145. Hawkins B.T., Egleton R.D. Fluorescence imaging of blood-brain barrier disruption. J. Neurosci. Methods 2006, 151:262-267.
146. Hawkins R.A., Peterson D.R., Vina J.R. The complementary membranes forming the blood-brain barrier. IUBMB Life 2002, 54:101-107.
147. Hawkins R.A., O'Kane R.L., Simpson I.A., Vina J.R. Structure of the blood-brain barrier and its role in the transport of amino acids. J. Nutr. 2006, 136:218S-226S.
148. Hayashi Y., Nomura M., Yamagishi S., Harada S., Yamashita J., Yamamoto H. Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes. Glia 1997, 19:13-26.
149. Heuvelman G., Erdel F., Wachsmuth M., Rippe K. Analysis of protein mobilities and interactions in living cells by multifocal fluorescence fluctuation microscopy. Eur. Biophys. J. 2009, 38:813-828.
150. Hirase T., Staddon J.M., Saitou M., Ando-Akatsuka Y., Itoh M., Furuse M., Fujimoto K., Tsukita S., Rubin L.L. Occludin as a possible determinant of tight junction permeability in endothelial cells. J. Cell Sci. 1997, 110:1603-1613.
151. Hobbs A.J., Higgs A., Moncada S. Inhibition of nitric oxide synthase as a potential therapeutic target. Annu. Rev. Pharmacol. Toxicol. 1999, 39:191-220.
152. Hofmann J. The potential for isoenzyme-selective modulation of protein kinase C. FASEB J. 1997, 11:649-669.
153. Holland S.J., Powell M.J., Franci C., Chan E.W., Friera A.M., Atchison R.E., McLaughlin J., Swift S.E., Pali E.S., Yam G., Wong S., Lasaga J., Shen M.R., Yu S., Xu W., Hitoshi Y., Bogenberger J., Nör J.E., Payan D.G., Lorens J.B. Multiple roles for the receptor tyrosine kinase axl in tumor formation. Cancer Res. 2005, 65:9294-9303.
154. Holmes K., Roberts O.L., Thomas A.M., Cross M.J. Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell. Signal. 2007, 19:2003-2012.
155. Honda M., Nakagawa S., Hayashi K., Kitagawa N., Tsutsumi K., Nagata I., Niwa M. Adrenomedullin improves the blood-brain barrier function through the expression of claudin-5. Cell. Mol. Neurobiol. 2006, 26:109-118.
156. Huber J.D., Egleton R.D., Davis T.P. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci. 2001, 24:719-725.
157. Huber V.J., Tsujita M., Nakada T. Identification of aquaporin 4 inhibitors using in vitro and in silico methods. Bioorg. Med. Chem. 2009, 17:411-417.
158. Hynna K.M., Boahen K.A. Nonlinear influence of T-channels in an in silico relay neuron. IEEE Trans. Biomed. Eng. 2009, 56:1734-1743.
159. Ikenouchi J., Furuse M., Furuse K., Sasaki H., Tsukita S., Tsukita S. Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J. Cell Biol. 2005, 171:939-945.
160. Jacob A., Hack B., Chiang E., Garcia J.G., Quigg R.J., Alexander J.J. C5a alters blood-brain barrier integrity in experimental lupus. FASEB J. 2010, 24:1682-1688.
161. Janigro D., Leaman S.M., Stanness K.A. Dynamic modeling of the blood-brain barrier: a novel tool for studies of drug delivery to the brain. Pharm. Sci. Technol. Today 1999, 2:7-12.
162. Jeliazkova-Mecheva V.V., Bobilya D.J. A porcine astrocyte/endothelial cell co-culture model of the blood-brain barrier. Brain Res. Protoc. 2003, 12:91-98.
163. Jiang S., Khan M.I., Lu Y., Rathbone M.P. Acceleration of blood-brain barrier formation after transplantation of enteric glia into spinal cords of rats. Exp. Brain Res. 2005, 162:56-62.
164. Joó F., Karnushina I. A procedure for the isolation of capillaries from rat brain. Cytobios 1973, 8:41-48.
165. Kannan P., John C., Zoghbi S.S., Halldin C., Gottesman M.M., Innis R.B., Hall M.D. Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications. Clin. Pharmacol. Ther. 2009, 86:368-377.
166. Kaur C., Ling E.A. Blood brain barrier in hypoxic-ischemic conditions. Curr. Neurovasc. Res. 2008, 5:71-81.
167. Kelley C., D'Amore P., Hechtman H.B., Shepro D. Microvascular pericyte contractility in vitro: comparison with other cells of the vascular wall. J. Cell Biol. 1987, 104:483-490.
168. Kevil C.G., Okayama N., Alexander J.S. H2O2-mediated permeability II: importance of tyrosine phosphatase and kinase activity. Am. J. Physiol. Cell Physiol. 2001, 281:C1940-C1947.
169. Khan E. An examination of the blood-brain barrier in health and disease. Br. J. Nurs. 2005, 14:509-513.
170. Kierszenbaum A.L. Histology and Cell Biology: An Introduction to Pathology 2007, Mosby Elsevier, Canada.
171. Kim J.A., Tran N.D., Li Z., Yang F., Zhou W., Fisher M.J. Brain endothelial hemostasis regulation by pericytes. J. Cereb. Blood Flow Metab. 2006, 26:209-217.
172. Kim M.P., Park S.I., Kopetz S., Gallick G.E. Src family kinases as mediators of endothelial permeability: effects on inflammation and metastasis. Cell Tissue Res. 2009, 335:249-259.
173. Kim H.M., Hwang D.H., Lee J.E., Kim S.U., Kim B.G. Ex vivo VEGF delivery by neural stem cells enhances proliferation of glial progenitors, angiogenesis, and tissue sparing after spinal cord injury. PLoS ONE 2009, 4:e4987.
174. Kniesel U., Wolburg H. Tight junctions of the blood-brain barrier. Cell. Mol. Neurobiol. 2000, 20:57-76.
175. Kone B.C. Protein-protein interactions controlling nitric oxide synthases. Acta Physiol. Scand. 2000, 168:27-31.
176. Korshunov V.A., Daul M., Massett M.P., Berk B.C. Axl mediates vascular remodeling induced by deoxycorticosterone acetate salt hypertension. Hypertension 2007, 50:1057-1062.
177. Kovac A., Zilkova M., Deli M.A., Zilka N., Novak M. Human truncated tau is using a different mechanism from amyloid-beta to damage the blood-brain barrier. J. Alzheimers Dis. 2009, 18:897-906.
178. Kozler, P., Pokornỳ, J. 2003. Altered blood-brain barrier permeability and its effect on the distribution of Evans blue and sodium fluorescein in the rat brain applied by intracarotid injection. Physiol. Res. 52, 607-14.
179. Krause G., Winkler L., Mueller S.L., Haseloff R.F., Piontek J., Blasig I.E. Structure and function of claudins. Biochim. Biophys. Acta 2008, 1778:631-645.
180. Krizbai I.A., Deli M.A. Signalling pathways regulating the tight junction permeability in the blood-brain barrier. Cell Mol. Biol. 2003, 49:23-31.
181. Krizbai I.A., Bauer H., Bresgen N., Eckl P.M., Farkas A., Szatmári E., Traweger A., Wejksza K., Bauer H.C. Effect of oxidative stress on the junctional proteins of cultured cerebral endothelial cells. Cell. Mol. Neurobiol. 2005, 25:129-139.
182. Krug S.M., Amasheh S., Richter J.F., Milatz S., Günzel D., Westphal J.K., Huber O., Schulzke J.D., Fromm M. Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol. Biol. Cell 2009, 20:3713-3724.
183. Kuhlmann C.R.W., Gerigk M., Bender B., Closhen D., Lessman V., Luhmann H.J. Fluvastatin prevents glutamate-induced blood-brain barrier disruption in vitro. Life Sci. 2008, 82:1281-1287.
184. Kumar P., Shen Q., Pivetti C.D., Lee E.S., Wu M.H., Yuan S.Y. Molecular mechanisms of endothelial hyperpermeability: implications in inflammation. Expert Rev. Mol. Med. 2009, 30:11:e19.
185. Lai C.H., Kuo K.H. The critical component to establish in vitro BBB model: pericyte. Brain Res. Brain Res. Rev. 2005, 50:258-265.
186. Lai C.H., Kuo K.H., Leo J.M. Critical role of actin in modulating BBB permeability. Brain Res. Brain Res. Rev. 2005, 50:7-13.
187. Lee S.J., Benveniste E.N. Adhesion molecule expression and regulation on cells of the central nervous system. J. Neuroimmunol. 1999, 98:77-88.
188. Lee H.S., Namkoong K., Kim D.H., Kim K.J., Cheong Y.H., Kim S.S., Lee W.B., Kim K.Y. Hydrogen peroxide-induced alterations of tight junction proteins in bovine brain microvascular endothelial cells. Microvasc. Res. 2004, 68:231-238.
189. Lee S.W., Kim W.J., Park J.A., Choi Y.K., Kwon Y.W., Kim K.W. Blood-brain barrier interfaces and brain tumors. Arch. Pharm. Res. 2006, 29:265-275.
190. Lewandowsky M. Zur lehre von der cerebrospinalflussigkeit. Z. Klin. Med. 1900, 40:480-494.
191. Li G., Simon M.J., Cancel L.M., Ji X., Tarbell J.M., Morrison B., Fu B.M. Permeability of endothelial and astrocyte cocultures: in vitro blood-brain barrier models for drug delivery studies. Ann. Biomed. Eng. 2010, 38:2499-2511.
192. Liebner S., Corada M., Bangsow T., Babbage J., Taddei A., Czupalla C.J., Reis M., Felici A., Wolburg H., Fruttiger M., Taketo M.M., von Melchner H., Plate K.H., Gerhardt H., Dejana E. Wnt/ccc-catenin signaling controls development of the blood-brain barrier. J. Cell Biol. 2008, 183:409-417.
193. Lim J.C., Kania K.D., Wijesuriya H., Chawla S., Sethi J.K., Pulaski L., Romero I.A., Couraud P.O., Weksler B.B., Hladky S.B., Barrand M.A. Activation of β-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J. Neurochem. 2008, 106:1855-1865.
194. Lippoldt A., Kniesel U., Liebner S., Kalbacher H., Kirsch T., Wolburg H., Haller H. Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res. 2000, 885:251-261.
195. Liu T., DeCostanzo A.J., Liu X., Wang H., Hallagan S., Moon R.T., Malbon C.C. G protein signaling from activated rat frizzled-1 to the β-catenin-Lef-Tcf pathway. Science 2001, 292:1718-1722.
196. Liu N.Q., Lossinsky A.S., Popik W., Li X., Gujuluva C., Kriederman B., Roberts J., Pushkarsky T., Bukrinsky M., Witte M., Weinand M., Fiala M. Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J. Virol. 2002, 76:6689-6700.
197. Liu J., Johnson T.V., Lin J., Ramirez S.H., Bronich T.K., Caplan S., Persidsky Y., Gendelman H.E., Kipnis J. T cell independent mechanism for copolymer-1-induced neuroprotection. Eur. J. Immunol. 2007, 37:3143-3154.
198. Lossi L., Alasia S., Salio C., Merighi A. Cell death and proliferation in acute slices and organotypic cultures of mammalian CNS. Prog. Neurobiol. 2009, 88:221-245.
199. Lossinsky A.S., Jong A., Fiala M., Mukhtar M., Buttle K.F., Ingram M. The histopathology of Candida albicans invasion in neonatal rat tissues and in the human blood-brain barrier in culture revealed by light, scanning, transmission and immunoelectron microscopy. Histol. Histopathol. 2006, 21:1029-1041.
200. Lu D.Y., Yu W.H., Yeh W.L., Tang C.H., Leung Y.M., Wong K.L., Chen Y.F., Lai C.H., Fu W.M. Hypoxia-induced matrix metalloproteinase-13 expression in astrocytes enhances permeability of brain endothelial cells. J. Cell. Physiol. 2009, 220:163-173.
201. Ma T.Y., Tran D., Hoa N., Nguyen D., Merryfield M., Tarnawski A. Mechanism of extracellular calcium regulation of intestinal epithelial tight junction permeability: role of cytoskeletal involvement. Microsc. Res. Tech. 2000, 51:156-168.
202. Mahajan S.D., Aalinkeel R., Sykes D.E., Reynolds J.L., Bindukumar B., Adal A., Qi M., Toh J., Xu G., Prasad P.N., Schwartz S.A. Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: implication for HIV-1 neuropathogenesis in the context of drug abuse. Brain Res. 2008, 1203:133-148.
203. Man S., Ubogu E.E., Ransohoff R.M. Inflammatory cell migration into the central nervous system: a few new twists on an old tale. Brain Pathol. 2007, 17:243-250.
204. Man S., Tucky B., Bagheri N., Li X., Kochar R., Ransohoff R.M. α4 Integrin/FN-CS1 mediated leukocyte adhesion to brain microvascular endothelial cells under flow conditions. J. Neuroimmunol. 2009, 210:92-99.
205. Mano Y., Higuchi S., Kamimura H. Investigation of the high partition of YM992, a novel antidepressant, in rat brain - in vitro and in vivo evidence for the high binding in brain and the high permeability at the BBB. Biopharm. Drug Dispos. 2002, 23:351-360.
206. Marchi N., Cavaglia M., Fazio V., Bhudia S., Hallene K., Janigro D. Peripheral markers of blood-brain barrier damage. Clin. Chim. Acta 2004, 342:1-12.
207. Marreilha dos Santos A.P., Santos D., Au C., Milatovic D., Aschner M., Batoréu M.C. Antioxidants prevent the cytotoxicity of manganese in RBE4 cells. Brain Res. 2008, 1236:200-205.
208. Maruszak A., Safranow K., Gustaw K., Kijanowska-Haładyna B., Jakubowska K., Olszewska M., Styczyłska M., Berdyłski M., Tysarowski A., Chlubek D., Siedlecki J., Barcikowska M., Zekanowski C. PIN1 gene variants in Alzheimer's disease. BMC Med. Genet. 2009, 10:115. 10.1186/1471-2350-10-115.
209. Mayhan W.G. Disruption of the blood-brain barrier in open and closed cranial window preparations in rats. Stroke 1991, 22:1059-1063.
210. Mayhan W.G. Nitric oxide donor-induced increase in permeability of the blood-brain barrier. Brain Res. 2000, 866:101-108.
211. Megard I., Garrigues A., Orlowski S., Jorajuria S., Clayette P., Ezan E., Mabondzo A. A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation. Brain Res. 2002, 927:153-167.
212. Mehdipour A.R., Hamidi M. Brain drug targeting: a computational approach for overcoming blood-brain barrier. Drug Discov. Today 2009, 14:1030-1036.
213. Mensch J., Oyarzabal J., Mackie C., Augustijns P. In vivo, in vitro and in silico methods for small molecule transfer across the BBB. J. Pharm. Sci. 2009, 98:4429-4468.
214. Miller F., Fenart L., Landry V., Coisne C., Cecchelli R., Dehouck M.P., Buée-Scherrer V. The MAP kinase pathway mediates transcytosis induced by TNF-Α in an in vitro blood-brain barrier model. Eur. J. Neurosci. 2005, 22:835-844.
215. Mironov A.A., Polishchuk R.S., Beznoussenko G.V. Combined video fluorescence and 3D electron microscopy. Methods Cell Biol. 2008, 88:83-95.
216. Mitic L.L., Anderson J.M. Molecular architecture of tight junctions. Annu. Rev. Physiol. 1998, 60:121-142.
217. Mkrtchyan H., Scheler S., Klein I., Fahr A., Couraud P.O., Romero I.A., Weksler B., Liehr T. Molecular cytogenetic characterization of the human cerebral microvessel endothelial cell line hCMEC/D3. Cytogenet. Genome Res. 2009, 126:313-317.
218. Mobley A.K., Tchaicha J.H., Shin J., Hossain M.G., McCarty J.H. β8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain. J. Cell Sci. 2009, 122:1842-1851.
219. Moon, R.T. 2005. Wnt/beta-catenin pathway. Sci STKE. 2005, cm1.
220. Mooradian D.L., Diglio C.A. Production of a transforming growth factor-beta-like growth factor by RSV-transformed rat cerebral microvascular endothelial cells. Tumour Biol. 1991, 12:171-183.
221. Morofuji Y., Nakagawa S., So G., Hiu T., Horai S., Hayashi K., Tanaka K., Suyama K., Deli M.A., Nagata I., Niwa M. Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells. Cell. Mol. Neurobiol. 2010, 30:727-735.
222. Mullier A., Bouret S.G., Prevot V., Dehouck B. Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain. J. Comp. Neurol. 2010, 518:943-962.
223. Nabi I.R., Le P.U. Caveolae/raft-dependent endocytosis. J. Cell Biol. 2003, 161:673-677.
224. Nakagawa S., Deli M.A., Nakao S., Honda M., Hayashi K., Nakaoke R., Kataoka Y., Niwa M. Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells. Cell. Mol. Neurobiol. 2007, 27:687-694.
225. Nakagawa S., Deli M.A., Kawaguchi H., Shimizudani T., Shimono T., Kittel A., Tanaka K., Niwa M. A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. Neurochem. Int. 2009, 54:253-263.
226. Nakashima I., Kato M., Akhand A.A., Suzuki H., Takeda K., Hossain K., Kawamoto Y. Redox-linked signal transduction pathways for protein tyrosine kinase activation. Antioxid. Redox Signal. 2002, 4:517-531.
227. Navarro P., Ruco L., Dejana E. Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J. Cell Biol. 1998, 140:1475-1484.
228. Neuhaus W., Lauer R., Oelzant S., Fringeli U.P., Ecker G.F., Noe C.R. A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2. J. Biotechnol. 2006, 125:127-141.
229. Neuhaus W., Wirth M., Plattner V.E., Germann B., Gabor F., Noe C.R. Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media. Neurosci. Lett. 2008, 446:59-64.
230. Nishioku T., Dohgu S., Takata F., Eto T., Ishikawa N., Kodama K.B., Nakagawa S., Yamauchi A., Kataoka Y. Detachment of brain pericytes from the basal lamina is involved in disruption of the blood-brain barrier caused by lipopolysaccharide-induced sepsis in mice. Cell. Mol. Neurobiol. 2009, 29:309-316.
231. Nitta T., Hata M., Gotoh S., Seo Y., Sasaki H., Hashimoto N., Furuse M., Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J. Cell Biol. 2003, 161:653-660.
232. Norsted E., Gomuc B., Meister B. Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus. J. Chem. Neuroanat. 2008, 36:107-121.
233. Numaguchi K., Shimokawa H., Nakaike R., Egashira K., Takeshita A. PKC inhibitors prevent endothelial dysfunction after myocardial ischemia-reperfusion in rats. Am. J. Physiol. 1996, 270:H1634-H1639.
234. Nwariaku F.E., Liu Z., Zhu X., Turnage R.H., Sarosi G.A., Terada L.S. Tyrosine phosphorylation of vascular endothelial cadherin and the regulation of microvascular permeability. Surgery 2002, 132:180-185.
235. Obataya I., Nakamura C., Han S., Nakamura N., Miyake J. Nanoscale operation of a living cell using an atomic force microscope with a nanoneedle. Nano Lett. 2005, 5:27-30.
236. Ogasawara N., Kojima T., Go M., Fuchimoto J., Kamekura R., Koizumi J., Ohkuni T., Masaki T., Murata M., Tanaka S., Ichimiya S., Himi T., Sawada N. Induction of JAM-A during differentiation of human THP-1 dendritic cells. Biochem. Biophys. Res. Commun. 2009, 389:543-549.
237. Pan W., Kastin A.J. TNFαtransport across the blood-brain barrier is abolished in receptor knockout mice. Exp. Neurol. 2002, 174:193-200.
238. Pan W., Kastin A.J., Daniel J., Yu C., Baryshnikova L.M., von Bartheld C.S. TNFα trafficking in cerebral vascular endothelial cells. J. Neuroimmunol. 2007, 185:47-56.
239. Pardridge W.M. Blood-brain barrier biology and methodology. J. Neurovirol. 1999, 5:556-569.
240. Peng Y.J., Nanduri J., Yuan G., Wang N., Deneris E., Pendyala S., Natarajan V., Kumar G.K., Prabhakar N.R. NADPH oxidase is required for the sensory plasticity of the carotid body by chronic intermittent hypoxia. J. Neurosci. 2009, 29:4903-4910.
241. Peppiatt C.M., Howarth C., Mobbs P., Attwell D. Bidirectional control of CNS capillary diameter by pericytes. Nature 2006, 443:700-704.
242. Perez-Moreno M., Davis M.A., Wong E., Pasolli H.A., Reynolds A.B., Fuchs E. p120-catenin mediates inflammatory responses in the skin. Cell 2006, 124:631-644.
243. Perloff M.D., von Moltke L.L., Fahey J.M., Greenblatt D.J. Induction of P-glycoprotein expression and activity by ritonavir in bovine brain microvessel endothelial cells. J. Pharm. Pharmacol. 2007, 59:947-953.
244. Perrière N., Yousif S., Cazaubon S., Chaverot N., Bourasset F., Cisternino S., Declèves X., Hori S., Terasaki T., Deli M., Scherrmann J.M., Temsamani J., Roux F., Couraud P.O. A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters. Brain Res. 2007, 1150:1-13.
245. Persidsky Y., Ramirez S.H., Haorah J., Kanmogne G.D. Blood-brain barrier: structural components and function under physiologic and pathologic conditions. J. Neuroimmune Pharmacol. 2006, 1:223-236.
246. Persidsky Y., Heilman D., Haorah J., Zelivyanskaya M., Persidsky R., Weber G.A., Shimokawa H., Kaibuchi K., Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood 2006, 107:4770-4780.
247. Petty M.A., Lo E.H. Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation. Prog. Neurobiol. 2002, 68:311-323.
248. Piotrowski P.L., Sumpter B.G., Malling H.V., Wassom J.S., Lu P.Y., Brothers R.A., Sega G.A., Martin S.A., Parang M. A toxicity evaluation and predictive system based on neural networks and wavelets. J. Chem. Inf. Model. 2007, 47:676-685.
249. Polakis P. Formation of the blood-brain barrier: Wnt signaling seals the deal. J. Cell Biol. 2008, 183:371-373.
250. Poller B., Drewe J., Krahenbuhl S., Huwyler J., Gutmann H. Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier. Cell. Mol. Neurobiol. 2010, 30:63-70.
251. Poole A.W., Pula G., Hers I., Crosby D., Jones M.L. PKC-interacting proteins: from function to pharmacology. Trends Pharmacol. Sci. 2004, 25:528-535.
252. Prudhomme J.G., Sherman I.W., Land K.M., Moses A.V., Stenglein S., Nelson J.A. Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells. Int. J. Parasitol. 1996, 26:647-655.
253. Quan N. Immune-to-brain signaling: how important are the blood-brain barrier-independent pathways?. Mol. Neurobiol. 2008, 37:142-152.
254. Radisavljevic Z., Avraham H., Avraham S. Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric oxide pathway and modulates migration of brain microvascular endothelial cells. J. Biol. Chem. 2000, 275:20770-20774.
255. Ramirez S.H., Heilman D., Morsey B., Potula R., Haorah J., Persidsky Y. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. J. Immunol. 2008, 180:1854-1865.
256. Ramirez S.H., Potula R., Fan S., Eidem T., Papugani A., Reichenbach N., Dykstra H., Weksler B.B., Romero I.A., Couraud P.O., Persidsky Y. Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells. J. Cereb. Blood Flow Metab. 2009, 29:1933-1945.
257. Ramírez-Castillejo C., Sánchez-Sánchez F., Andreu-Agulló C., Férron S.R., Aroca-Aguilar J.D., Sanchéz P., Mira H., Escribano J., Fariñas I. Pigment epithelium-derived factor is a niche signal for neural stem cell renewal. Nat. Neurosci. 2006, 9:331-339.
258. Ramsauer M., Krause D., Dermietzel R. Angiogenesis of the blood-brain barrier in vitro and the function of cerebral pericytes. FASEB J. 2002, 16:1274-1276.
259. Ranganath S.H., Kee I., Krantz W.B., Chow P.K., Wang C.H. Hydrogel matrix entrapping PLGA-paclitaxel microspheres: drug delivery with near zero-order release and implantability advantages for malignant brain tumour chemotherapy. Pharm. Res. 2009, 26:2101-2114.
260. Ransohoff R.M., Perry V.H. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 2009, 27:119-145.
261. Reese T.S., Karnovsky M.J. Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol. 1967, 34:207-217.
262. Reinhard M., Hetzel A., Krüger S., Talazko J., Ziyeh S., Weber J., Els T. Blood-brain barrier disruption by low-frequency ultrasound. Stroke 2006, 37:1546-1548.
263. Revest P.A., Jones H.C., Abbott N.J. Transendothelial electrical potential across pial vessels in anaesthetised rats: a study of ion permeability and transport at the blood-brain barrier. Brain Res. 1994, 652:76-82.
264. Ricardo-Dukelow M., Kadiu I., Rozek W., Schlautman J., Persidsky Y., Ciborowski P., Kanmogne G.D., Gendelman H.E. HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia. J. Neuroimmunol. 2007, 185:37-46.
265. Rigau V., Morin M., Rousset M.C., de Bock F., Lebrun A., Coubes P., Picot M.C., Baldy-Moulinier M., Bockaert J., Crespel A., Lerner-Natoli M. Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. Brain 2007, 130:1942-1956.
266. Romanitan M.O., Popescu B.O., Spulber S., Bajenaru O., Popescu L.M., Winblad B., Bogdanovic N. Altered expression of claudin family proteins in Alzheimer's disease and vascular dementia brains. J. Cell. Mol. Med. 2009, 14:1088-1100.
267. Rosell A., Ortega-Aznar A., Alvarez-Sabin J., Fernandez-Cadenas I., Ribo M., Molina C.A., Lo E.H., Montaner J. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke 2006, 37:1399-1406.
268. Rosenberg G.A., Yang Y. Vasogenic edema due to tight junction disruption by matrix metalloproteinases in cerebral ischemia. Neurosurg. Focus 2007, 22:E4.
269. Roura S., Miravet S., Piedra J., García de Herreros A., Duñach M. Regulation of E-cadherin/catenin association by tyrosine phosphorylation. J. Biol. Chem. 1999, 274:36734-36740.
270. Roux F., Durieu-Trautmann O., Chaverot N., Claire M., Mailly P., Bourre J.M., Strosberg A.D., Couraud P.O. Regulation of gamma-glutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J. Cell. Physiol. 1994, 159:101-113.
271. Sandoval K.E., Witt K.A. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol. Dis. 2008, 32:200-219.
272. Sandoval R., Malik A.B., Minshall R.D., Kouklis P., Ellis C.A., Tiruppathi C. Ca2+ signalling and PKCα activate increased endothelial permeability by disassembly of VE-cadherin junctions. J. Physiol. 2001, 533:433-445.
273. Santaguida S., Janigro D., Hossain M., Oby E., Rapp E., Cucullo L. Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: a permeability study. Brain Res. 2006, 1109:1-13.
274. Sawada N., Liao J.K. Targeting eNOS and beyond: emerging heterogeneity of the role of endothelial Rho proteins in stroke protection. Expert Rev. Neurother. 2009, 9:1171-1186.
275. Scherrmann J.M. Drug delivery to brain via the blood-brain barrier. Vascul. Pharmacol. 2002, 38:349-354.
276. Schiera G., Sala S., Gallo A., Raffa M.P., Pitarresi G.L., Savettieri G., Di Liegro I. Permeability properties of a three-cell type in vitro model of blood-brain barrier. J. Cell. Mol. Med. 2005, 9:373-379.
277. Schreibelt G., Kooij G., Reijerkerk A., van Doorn R., Gringhuis S.I., van der Pol S., Weksler B.B., Romero I.A., Couraud P.O., Piontek J., Blasig I.E., Dijkstra C.D., Ronken E., de Vries H.E. Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling. FASEB J. 2007, 21:3666-3676.
278. Schüller U., Rowitch D.H. β-catenin function is required for cerebellar morphogenesis. Brain Res. 2007, 1140:161-169.
279. Shasby D.M., Ries D.R., Shasby S.S., Winter M.C. Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin. Am. J. Physiol. Lung Cell. Mol. Physiol. 2002, 282:L1330-L1338.
280. Shen Q., Goderie S.K., Jin L., Karanth N., Sun Y., Abramova N., Vincent P., Pumiglia K., Temple S. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science 2004, 304:1338-1340.
281. Shepro D., Morel N.M.L. Pericyte physiology. FASEB J. 1993, 7:1031-1038.
282. Shimizu F., Sano Y., Maeda T., Abe M.A., Nakayama H., Takahashi R., Ueda M., Ohtsuki S., Terasaki T., Obinata M., Kanda T. Peripheral nerve pericytes originating from the blood-nerve barrier expresses tight junctional molecules and transporters as barrier-forming cells. J. Cell. Physiol. 2008, 217:388-399.
283. Shukla A., Dikshit M., Srimal R.C. Nitric oxide-dependent blood-brain barrier permeability alteration in the rat brain. Experientia 1996, 52:136-140.
284. Siddharthan V., Kim Y.V., Liu S., Kim K.S. Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells. Brain Res. 2007, 1147:39-50.
285. Silva R.F.M., Falcão A.S., Fernandes A., Gordo A.C., Brito M.A., Brites D. Dissociated primary nerve cell cultures as models for assessment of neurotoxicity. Toxicol. Lett. 2006, 163:1-9.
286. Silwedel C., Förster C. Differential susceptibility of cerebral and cerebellar murine brain microvascular endothelial cells to loss of barrier properties in response to inflammatory stimuli. J. Neuroimmunol. 2006, 179:37-45.
287. Simionescu M., Gafencu A., Antohe F. Transcytosis of plasma macromolecules in endothelial cells: a cell biological survey. Microsc. Res. Tech. 2002, 57:269-288.
288. Singh A.K., Jiang Y., Gupta S., Benlhabib E. Effects of chronic ethanol drinking on the blood brain barrier and ensuing neuronal toxicity in alcohol-preferring rats subjected to intraperitoneal LPS injection. Alcohol Alcohol. 2007, 42:385-399.
289. Slusarski D.C., Corces V.G., Moon R.T. Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 1997, 390:410-413.
290. Smith M.W., Gumbleton M. Endocytosis at the blood-brain barrier: from basic understanding to drug delivery strategies. J. Drug Target. 2006, 14:191-214.
291. Smith M., Omidi Y., Gumbleton M. Primary porcine brain microvascular endothelial cells: biochemical and functional characterisation as a model for drug transport and targeting. J. Drug Target. 2007, 15:253-268.
292. Somanath P.R., Razorenova O.V., Chen J., Byzova T.V. Akt1 in endothelial cell and angiogenesis. Cell Cycle 2006, 5:512-518.
293. Song L., Ge S., Pachter J.S. Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells. Blood 2007, 109:1515-1523.
294. Song Y., Xue Y., Liu X., Wang P., Liu L. Effects of acute exposure to aluminum on blood-brain barrier and the protection of zinc. Neurosci. Lett. 2008, 445:42-46.
295. Spranger J., Verma S., Göhring I., Bobbert T., Seifert J., Sindler A.L., Pfeiffer A., Hileman S.M., Tschöp M., Banks W.A. Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes 2006, 55:141-147.
296. Sprenger R.R., Fontijn R.D., van Marle J., Pannekoek H., Horrevoets A.J. Spatial segregation of transport and signalling functions between human endothelial caveolae and lipid raft proteomes. Biochem. J. 2006, 400:401-410.
297. Staehelin L.A. Further observations on the fine structure of freeze-cleaved tight junctions. J. Cell Sci. 1973, 13:763-786.
298. Stamatovic S.M., Keep R.F., Andjelkovic A.V. Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr. Neuropharmacol. 2008, 6:179-192.
299. Stamatovic S.M., Keep R.F., Wang M.M., Jankovic I., Andjelkovic A.V. Caveolae-mediated internalization of occludin and claudin-5 during CCL2-induced tight junction remodeling in brain endothelial cells. J. Biol. Chem. 2009, 284:19053-19066.
300. Stanness K.A., Guatteo E., Janigro D. A dynamic model of the blood-brain barrier "in vitro". Neurotoxicology 1996, 17:481-496.
301. Stanness K.A., Westrum L.E., Fornaciari E., Mascagni P., Nelson J.A., Stenglein S.G., Myers T., Janigro D. Morphological and functional characterization of an in vitro blood-brain barrier model. Brain Res. 1997, 771:329-342.
302. Stevenson B.R., Anderson J.M., Braun I.D., Mooseker M.S. Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance. Biochem. J. 1989, 263:597-599.
303. Stins M.F., Prasadarao N.V., Zhou J., Arditi M., Kim K.S. Bovine brain microvascular endothelial cells transfected with SV40-large T antigen: development of an immortalized cell line to study pathophysiology of CNS disease. In Vitro Cell. Dev. Biol. Anim. 1997, 33:243-247.
304. Stins M.F., Badger J., Kim K.S. Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells. Microb. Pathog. 2001, 30:19-28.
305. Sulik A., Chyczewski L. Immunohistochemical analysis of MMP-9, MMP-2 and TIMP-1, TIMP-2 expression in the central nervous system following infection with viral and bacterial meningitis. Folia Histochem. Cytobiol. 2008, 46:437-442.
306. Sumi N., Nishioku T., Takata F., Matsumoto J., Watanabe T., Shuto H., Yamauchi A., Dohgu S., Kataoka Y. Lipopolysaccharide-activated microglia induce dysfunction of the blood-brain barrier in rat microvascular endothelial cells co-cultured with microglia. Cell. Mol. Neurobiol. 2010, 30:247-253.
307. Tähti H., Vaalavirta L., Toimela T. In vitro methods as a tool in neurotoxicity studies. Altern. Lab. Anim. 1995, 23:491-496.
308. Tai L.M., Reddy P.S., Lopez-Ramirez M.A., Davies H.A., Male D.K., Loughlin A.J., Romero I.A. Polarized P-glycoprotein expression by the immortalised human brain endothelial cell line, hCMEC/D3, restricts apical-to-basolateral permeability to rhodamine 123. Brain Res. 2009, 1292:14-24.
309. Tao Y.S., Edwards R.A., Tubb B., Wang S., Bryan J., McCrea P.D. β-Catenin associates with the actin-bundling protein fascin in a noncadherin complex. J. Cell Biol. 1996, 134:1271-1281.
310. Tavazoie M., Van derVeken L., Silva-Vargas V., Louissaint M., Colonna L., Zaidi B., Garcia-Verdugo J.M., Doetsch F. A specialized vascular niche for adult neural stem cells. Cell Stem Cell 2008, 3:279-288.
311. Teng C.H., Tseng Y.T., Maruvada R., Pearce D., Xie Y., Paul-Satyaseela M., Kim K.S. NlpI contributes to Escherichia coli K1 strain RS218 interaction with human brain microvascular endothelial cells. Infect. Immun. 2010, 78:3090-3096.
312. Terry S., Nie M., Matter K., Balda M.S. Rho signaling and tight junction functions. Physiology 2010, 25:16-26.
313. Thiel V.E., Audus K.L. Nitric oxide and blood-brain barrier integrity. Antioxid. Redox Signal. 2001, 3:273-278.
314. Tosi G., Costantino L., Ruozi B., Forni F., Vandelli M.A. Polymeric nanoparticles for the drug delivery to the central nervous system. Expert Opin. Drug Deliv. 2008, 5:155-174.
315. Tsukita S., Furuse M., Itoh M. Multifunctional strands in tight junctions. Nat. Rev. Mol. Cell Biol. 2001, 2:285-293.
316. Tweedie D., Luo W., Short R.G., Brossi A., Holloway H.W., Li Y., Yu Q.S., Greig N.H. A cellular model of inflammation for identifying TNF-α synthesis inhibitors. J. Neurosci. Methods 2009, 183:182-187.
317. Ueno M. Molecular anatomy of the brain endothelial barrier: an overview of the distributional features. Curr. Med. Chem. 2007, 14:1199-1206.
318. van Hinsbergh V.W., van Nieuw Amerongen G.P. Intracellular signalling involved in modulating human endothelial barrier function. J. Anat. 2002, 200:549-560.
319. van Vliet E.A., da Costa Araújo S., Redeker S., van Schaik R., Aronica E., Gorter J.A. Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain 2007, 130:521-534.
320. van Vliet E.A., van Schaik R., Edelbroek P.M., Voskuyl R.A., Redeker S., Aronica E., Wadman W.J., Gorter J.A. Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats. J. Pharmacol. Exp. Ther. 2007, 322:141-147.
321. Vastag M., Keseru G.M. Current In Vitro and In Silico Models of the Blood-Brain Barrier Penetration: A Practical View. Curr. Opin. Drug Discov. Devel. 2009, 12:115-125.
322. Vichalkovski A., Gresko E., Hess D., Restuccia D.F., Hemmings B.A. PKB/AKT phosphorylation of the transcription factor Twist-1 at Ser42 inhibits p53 activity in response to DNA damage. Oncogene. 2010, 29:3554-3565.
323. Virgintino D., Robertson D., Errede M., Benagiano V., Tauer U., Roncali L., Bertossi M. Expression of caveolin-1 in human brain microvessels. Neuroscience 2002, 115:145-152.
324. Vogel C., Bauer A., Wiesnet M., Preissner K.T., Schaper W., Marti H.H., Fischer S. Flt-1, but not Flk-1 mediates hyperpermeability through activation of the PI3-K/Akt pathway. J. Cell. Physiol. 2007, 212:236-243.
325. von Wedel-Parlow M., Wölte P., Galla H.J. Regulation of major efflux transporters under inflammatory conditions at the blood-brain barrier in vitro. J. Neurochem. 2009, 111:111-118.
326. Vorbrodt A.W., Dobrogowska D.H. Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view. Brain Res. Brain Res. Rev. 2003, 42:221-242.
327. Vorbrodt A.W., Li S., Brown W.T., Ramakrishna N. Increased expression of β-catenin in brain microvessels of a segmentally trisomic (Ts65Dn) mouse model of Down syndrome. Brain Cell Biol. 2008, 36:203-211.
328. Wade J.B., Karnovsky M.J. The structure of the zonula occludens. A single fibril model based on freeze-fracture. J. Cell Biol. 1974, 60:168-180.
329. Warren M.S., Zerangue N., Woodford K., Roberts L.M., Tate E.H., Feng B., Li C., Feuerstein T.J., Gibbs J., Smith B., de Morais S.M., Dower W.J., Koller K.J. Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human. Pharmacol. Res. 2009, 59:404-413.
330. Waschke J., Burger S., Curry F.R., Drenckhahn D., Adamson R.H. Activation of Rac-1 and Cdc42 stabilizes the microvascular endothelial barrier. Histochem. Cell Biol. 2006, 125:397-406.
331. Weinger J.G., Gohari P., Yan Y., Backer J.M., Varnum B., Shafit-Zagardo B. In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. J. Neurochem. 2008, 106:134-146.
332. Weis S.M. Vascular permeability in cardiovascular disease and cancer. Curr. Opin. Hematol. 2008, 15:243-249.
333. Weiss N., Miller F., Cazaubon S., Couraud P.O. The blood-brain barrier in brain homeostasis and neurological diseases. Biochim. Biophys. Acta 2009, 1788:842-857.
334. Weksler B.B., Subileau E.A., Perrière N., Charneau P., Holloway K., Leveque M., Tricoire-Leignel H., Nicotra A., Bourdoulous S., Turowski P., Male D.K., Roux F., Greenwood J., Romero I.A., Couraud P.O. Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J. 2005, 19:1872-1874.
335. Wilhelm I., Nagyöszi P., Farkas A.E., Courad P.O., Romero I.A., Weksler B., Fasakas C., Dung N.T.K., Bottka S., Bauer H., Bauer H.C., Krizbai I.A. Hyperosmotic stress induces Axl activation and cleavage in cerebral endothelial cells. J. Neurochem. 2008, 107:116-126.
336. Williams R.L., Risau W., Zerwes H.G., Drexler H., Aguzzi A., Wagner E.F. Endothelioma cells expressing the polyoma middle T oncogene induce hemangiomas by host cell recruitment. Cell 1989, 57:1053-1063.
337. Willis C.L., Nolan C.C., Reith S.N., Lister T., Prior M.J., Guerin C.J., Mavroudis G., Ray D.E. Focal astrocyte loss is followed by microvascular damage, with subsequent repair of the blood-brain barrier in the apparent absence of direct astrocytic contact. Glia 2004, 45:325-337.
338. Wilson B., Samanta M.K., Santhi K., Sampath Kumar K.P., Ramasamy M., Suresh B. Significant delivery of tacrine into the brain using magnetic chitosan microparticles for treating Alzheimer's disease. J. Neurosci. Methods 2009, 177:427-433.
339. Wojciak-Stothard B., Tsang L.Y., Haworth S.G. Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 2005, 288:L749-L760.
340. Wolburg H., Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul. Pharmacol. 2002, 38:323-337.
341. Wolburg H., Noell S., Mack A., Wolburg-Buchholz K., Fallier-Becker P. Brain endothelial cells and the glio-vascular complex. Cell Tissue Res. 2009, 335:75-96.
342. Wong D., Dorovini-Zis K., Vincent S.R. Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood-brain barrier. Exp. Neurol. 2004, 190:446-455.
343. Yamagata K., Tagami M., Nara Y., Mitani M., Kubota A., Fujino H., Numano F., Kato T., Yamori Y. Astrocyte-conditioned medium induces blood-brain barrier properties in endothelial cells. Clin. Exp. Pharmacol. Physiol. 1997, 24:710-713.
344. Yamagata K., Tagami M., Takenaga F., Yamori Y., Itoh S. Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide. Neurobiol. Dis. 2004, 17:491-499.
345. Yamamoto M., Ramirez S.H., Sato S., Kiyota T., Cerny R.L., Kaibuchi K., Persidsky Y., Ikezu T. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. Am. J. Pathol. 2008, 172:521-533.
346. Yamauchi A., Dohgu S., Nishioku T., Shuto H., Naito M., Tsuruo T., Sawada Y., Kataoka Y. An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function. Cell Mol. Neurobiol. 2007, 27:263-270.
347. Yuan S.Y. Protein kinase signaling in the modulation of microvascular permeability. Vascul. Pharmacol. 2003, 39:213-223.
348. Zaghi J., Goldenson B., Inayathullah M., Lossinsky A.S., Masoumi A., Avagyan H., Mahanian M., Bernas M., Weinand M., Rosenthal M.J., Espinosa-Jeffrey A., de Vellis J., Teplow D.B., Fiala M. Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy. Acta Neuropathol. 2009, 117:111-124.
349. Zenker D., Begley D., Bratzke H., Rübsamen-Waigmann H., von Briesen H. Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells. J. Physiol. 2003, 551:1023-1032.
350. Zerlin M., Julius M.A., Kitajewski J. Wnt/Frizzled signaling in angiogenesis. Angiogenesis 2008, 11:63-69.
351. Zhang Y., Li C.S., Ye Y., Johnson K., Poe J., Johnson S., Bobrowski W., Garrido R., Madhu C. Porcine brain microvessel endothelial cells as an in vitro model to predict in vivo blood-brain barrier permeability. Drug Metab. Dispos. 2006, 34:1935-1943.
352. Zhang X., Alakhova D.Y., Batrakova E.V., Li S., Yang Z., Li Y., Kabanov A.V. Effect of pluronic p85 on amino acid transport in bovine brain microvessel endothelial cells. J. Neuroimmune Pharmacol. 2009, 4:35-46.
353. Zhang Z., Xia C., Xue Y., Liu Y. Synergistic effect of low-frequency ultrasound and low-dose bradykinin on increasing permeability of the blood-tumor barrier by opening tight junction. J. Neurosci. Res. 2009, 87:2282-2289.
354. Zheng W., Aschner M., Ghersi-Egea J.F. Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol. Appl. Pharmacol. 2003, 192:1-11.
355. Zhong Y., Smart E.J., Weksler B., Couraud P.O., Henning B., Toborek M. Caveolin-1 regulates HIV-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling. J. Neurosci. 2008, 28:7788-7796.
356. Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.
357. Zozulya A., Weidenfeller C., Galla H.J. Pericyte-endothelial cell interaction increases MMP-9 secretion at the blood-brain barrier in vitro. Brain Res. 2008, 1189:1-11.