Critical role of actin in modulating BBB permeability

Brain Research Reviews

Volumn 50, Issue 1, 2005, Pages 7-13

  Lai, Char Huei ^a   Kuo, Kuo Hsing ^b,c   Leo, Joyce M ^c  

^a Advanced Peptide Medicine and Drug Delivery Research Laboratory   (United States)

^b UNIVERSITY OF NORTHERN BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Actin; Blood brain barrier; Cytochalasin; Cytoskeleton; Tight junction

Indexed keywords

ACTIN; CELL ADHESION MOLECULE; CLAUDIN; CYTOCHALASIN D; OCCLUDIN;

ACTIN FILAMENT; BLOOD BRAIN BARRIER; CYTOSKELETON; HUMAN; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; REVIEW; SPATIAL DISCRIMINATION; TIGHT JUNCTION;

ACTINS; ANIMALS; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CYTOSKELETON; MODELS, BIOLOGICAL; TIGHT JUNCTIONS;

EID: 27744464054     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2005.03.007     Document Type: Review

References (73)

1. J.M. Anderson, and C.M. Van Itallie Tight junctions and the molecular basis for regulation of paracellular permeability Am. J. Physiol. 269 1995 G467 G475
2. M.A. Aurrand-Lions, L. Duncan, L. Du Pasquier, and B.A. Imhof Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family? Curr. Top. Microbiol. Immunol. 251 2000 91 98
3. M.S. Balda, and K. Matter Transmembrane proteins of tight junctions Semin. Cell Dev. Biol. 11 2000 281 289
4. M.S. Balda, J.A. Whitney, C. Flores, S. Gonzalez, M. Cereijido, and K. Matter Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein J. Cell Biol. 134 1996 1031 1049
5. P. Ballabh, A. Braun, and M. Nedergaard The blood-brain barrier: an overview: structure, regulation, and clinical implications Neurobiol. Dis. 16 2004 1 13
6. G. Bazzoni, O.M. Martinez-Estrada, F. Orsenigo, M. Cordenonsi, S. Citi, and E. Dejana Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin J. Biol. Chem. 275 2000 20520 20526
7. C.J. Bentzel, B. Hainau, A. Edelman, T. Anagnostopoulos, and E.L. Benedetti Effect of plant cytokinins on microfilaments and tight junction permeability Nature 264 1976 666 668
8. J.W. Breslin, and S.Y. Yuan Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability Am. J. Physiol.: Heart Circ. Physiol. 286 2004 H1057 H1062
9. J.M. Bronstein, P. Popper, P.E. Micevych, and D.B. Farber Isolation and characterization of a novel oligodendrocyte-specific protein Neurology 47 1996 772 778
10. R.C. Brown, and T.P. Davis Hypoxia/aglycemia alters expression of occludin and actin in brain endothelial cells Biochem. Biophys. Res. Commun. 327 2005 1114 1123
11. Z. Chen, M. Zandonatti, D. Jakubowski, and H.S. Fox Brain capillary endothelial cells express MBEC1, a protein that is related to the Clostridium perfringens enterotoxin receptors Lab. Invest. 78 1998 353 363
12. C.C. Chio, T. Baba, and K.L. Black Selective blood-tumor barrier disruption by leukotrienes J. Neurosurg. 77 1992 407 410
13. M. Cordenonsi, F. D'Atri, E. Hammar, D.A. Parry, J. Kendrick-Jones, D. Shore, and S. Citi Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin J. Cell Biol. 147 1999 1569 1582
14. L.E. Crawford, E.E. Milliken, K. Irani, J.L. Zweier, L.C. Becker, T.M. Johnson, N.T. Eissa, R.G. Crystal, T. Finkel, and P.J. Goldschmidt-Clermont Superoxide-mediated actin response in post-hypoxic endothelial cells J. Biol. Chem. 271 1996 26863 26867
15. D.F. Emerich, R.L. Dean, C. Osborn, and R.T. Bartus The development of the bradykinin agonist labradimil as a means to increase the permeability of the blood-brain barrier: from concept to clinical evaluation Clin. Pharmacokinet. 40 2001 105 123
16. A.S. Fanning, L.L. Mitic, and J.M. Anderson Transmembrane proteins in the tight junction barrier J. Am. Soc. Nephrol. 10 1999 1337 1345
17. P. Florian, T. Schoneberg, J.D. Schulzke, M. Fromm, and A.H. Gitter Single-cell epithelial defects close rapidly by an actinomyosin purse string mechanism with functional tight junctions J. Physiol. 545 2002 485 499
18. G. Fricker, and D.S. Miller Modulation of drug transporters at the blood-brain barrier Pharmacology 70 2004 169 176
19. M. Furuse, T. Hirase, M. Itoh, A. Nagafuchi, S. Yonemura, and S. Tsukita Occludin: a novel integral membrane protein localizing at tight junctions J. Cell Biol. 123 1993 1777 1788
20. M. Furuse, K. Fujita, T. Hiiragi, K. Fujimoto, and S. Tsukita Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin J. Cell Biol. 141 1998 1539 1550
21. M. Furuse, H. Sasaki, and S. Tsukita Manner of interaction of heterogeneous claudin species within and between tight junction strands J. Cell Biol. 147 1999 891 903
22. S.M. Gloor, M. Wachtel, M.F. Bolliger, H. Ishihara, R. Landmann, and K. Frei Molecular and cellular permeability control at the blood-brain barrier Brain Res. Brain Res. Rev. 36 2001 258 264
23. A. Hall Rho GTPases and the actin cytoskeleton Science 279 1998 509 514
24. S. Hamm, B. Dehouck, J. Kraus, K. Wolburg-Buchholz, H. Wolburg, W. Risau, R. Cecchelli, B. Engelhardt, and M.P. Dehouck Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts Cell Tissue Res. 315 2004 157 166
25. J. Haskins, L. Gu, E.S. Wittchen, J. Hibbard, and B.R. Stevenson ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin J. Cell Biol. 141 1998 199 208
26. B.T. Hawkins, T.J. Abbruscato, R.D. Egleton, R.C. Brown, J.D. Huber, C.R. Campos, and T.P. Davis Nicotine increases in vivo blood-brain barrier permeability and alters cerebral microvascular tight junction protein distribution Brain Res. 1027 2004 48 58
27. T. Hirase, J.M. Staddon, M. Saitou, Y. Ando-Akatsuka, M. Itoh, M. Furuse, K. Fujimoto, S. Tsukita, and L.L. Rubin Occludin as a possible determinant of tight junction permeability in endothelial cells J. Cell Sci. 110 1997 1603 1613
28. T. Hirase, S. Kawashima, E.Y. Wong, T. Ueyama, Y. Rikitake, S. Tsukita, M. Yokoyama, and J.M. Staddon Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms J. Biol. Chem. 276 2001 10423 10431
29. N. Hirokawa, and L.G. Tilney Interactions between actin filaments and between actin filaments and membranes in quick-frozen and deeply etched hair cells of the chick ear J. Cell Biol. 95 1982 249 261
30. J.D. Huber, R.D. Egleton, and T.P. Davis Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier Trends Neurosci. 24 2001 719 725
31. D.E. Ingber, D. Prusty, Z. Sun, H. Betensky, and N. Wang Cell shape, cytoskeletal mechanics, and cell cycle control in angiogenesis J. Biomech. 28 1995 1471 1484
32. M. Itoh, M. Furuse, K. Morita, K. Kubota, M. Saitou, and S. Tsukita Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins J. Cell Biol. 147 1999 1351 1363
33. T.S. Jou, E.E. Schneeberger, and W.J. Nelson Structural and functional regulation of tight junctions by RhoA and Rac1 small GTPases J. Cell Biol. 142 1998 101 115
34. J. Katahira, H. Sugiyama, N. Inoue, Y. Horiguchi, M. Matsuda, and N. Sugimoto Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo J. Biol. Chem. 272 1997 26652 26658
35. T. Korkiamaki, H. Yla-Outinen, J. Koivunen, and J. Peltonen An intact actin-containing cytoskeleton is required for capacitative calcium entry, but not for ATP-induced calcium-mediated cell signaling in cultured human keratinocytes Med. Sci. Monit. 9 2003 199 207
36. M. Laposata, D.K. Dovnarsky, and H.S. Shin Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro Blood 62 1983 549 556
37. S. Liebner, A. Fischmann, G. Rascher, F. Duffner, E.H. Grote, H. Kalbacher, and H. Wolburg Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme Acta Neuropathol. (Berl) 100 2000 323 331
38. Y. Liu, A. Nusrat, F.J. Schnell, T.A. Reaves, S. Walsh, M. Pochet, and C.A. Parkos Human junction adhesion molecule regulates tight junction resealing in epithelia J. Cell Sci. 113 Pt 13 2000 2363 2374
39. L.M. Machesky, and A. Hall Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization J. Cell Biol. 138 1997 913 926
40. J.L. Madara Intestinal absorptive cell tight junctions are linked to cytoskeleton Am. J. Physiol. 253 1987 C171 C175
41. J.L. Madara Regulation of the movement of solutes across tight junctions Annu. Rev. Physiol. 60 1998 143 159
42. J.L. Madara, and J. Stafford Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers J. Clin. Invest. 83 1989 724 727
43. J.L. Madara, D. Barenberg, and S. Carlson Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity J. Cell Biol. 102 1986 2125 2136
44. R. Maddala, V.N. Reddy, D.L. Epstein, and V. Rao Growth factor induced activation of Rho and Rac GTPase and actin cytoskeletal reorganization in human lens epithelial cells Mol. Vision 17 2003 329 336
45. K.S. Mark, and T.P. Davis Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation Am. J. Physiol.: Heart Circ. Physiol. 282 2002 H1485 H1494
46. I. Martin-Padura, S. Lostaglio, M. Schneemann, L. Williams, M. Romano, P. Fruscella, C. Panzeri, A. Stoppacciaro, L. Ruco, A. Villa, D. Simmons, and E. Dejana Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration J. Cell Biol. 142 1998 117 127
47. K. Matter, and M.S. Balda Holey barrier: claudins and the regulation of brain endothelial permeability J. Cell Biol. 161 2003 459 460
48. K. Matter, and M.S. Balda Signalling to and from tight junctions Nat. Rev., Mol. Cell Biol. 4 2003 225 236
49. I. Meza, G. Ibarra, M. Sabanero, A. Martinez-Palomo, and M. Cereijido Occluding junctions and cytoskeletal components in a cultured transporting epithelium J. Cell Biol. 87 1980 746 754
50. A. Misra, S. Ganesh, A. Shahiwala, and S.P. Shah Drug delivery to the central nervous system: a review J. Pharm. Pharm. Sci. 6 2003 252 273
51. L.L. Mitic, C.M. Van Itallie, and J.M. Anderson Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins Am. J. Physiol.: Gastrointest Liver Physiol. 279 2000 G250 G254
52. K. Morita, M. Furuse, K. Fujimoto, and S. Tsukita Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands Proc. Natl. Acad. Sci. U. S. A. 96 1999 511 516
53. K. Morita, H. Sasaki, K. Fujimoto, M. Furuse, and S. Tsukita Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis J. Cell Biol. 145 1999 579 588
54. S. Nag Morphology and molecular properties of cellular components of normal cerebral vessels Methods Mol. Med. 89 2003 3 36
55. T. Nitta, M. Hata, S. Gotoh, Y. Seo, H. Sasaki, N. Hashimoto, M. Furuse, and S. Tsukita Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice J. Cell Biol. 161 2003 653 660
56. C.D. Nobes, and A. Hall Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia Cell 81 1995 53 62
57. A. Nusrat, M. Giry, J.R. Turner, S.P. Colgan, C.A. Parkos, D. Carnes, E. Lemichez, P. Boquet, and J.L. Madara Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia Proc. Natl. Acad. Sci. U. S. A. 92 1995 10629 10633
58. D. Palmeri, A. van Zante, C.C. Huang, S. Hemmerich, and S.D. Rosen Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells J. Biol. Chem. 275 2000 19139 19145
59. A.J. Ridley, and A. Hall The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors Cell 70 1992 389 399
60. J.P. Rodriguez, M. Gonzalez, S. Rios, and V. Cambiazo Cytoskeletal organization of human mesenchymal stem cells (MSC) changes during their osteogenic differentiation J. Cell. Biochem. 93 2004 721 731
61. M.K. Saitou, K. Fujimoto, Y. Doi, M. Itoh, T. Fujimoto, M. Furuse, H. Takano, T. Noda, and S. Tsukita Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions J. Cell Biol. 141 1998 397 408
62. H. Steuer, A. Jaworski, D. Stoll, and B. Schlosshauer In vitro model of the outer blood-retina barrier Brain Res. Brain Res. Protoc. 13 2004 26 36
63. B.R. Stevenson, and D.A. Begg Concentration-dependent effects of cytochalasin D on tight junctions and actin filaments in MDCK epithelial cells J. Cell Sci. 107 1994 367 375
64. I. Tamai, and A. Tsuji Transporter-mediated permeation of drugs across the blood-brain barrier J. Pharm. Sci. 89 2000 1371 1388
65. S. Tsukita, and M. Furuse Occludin and claudins in tight-junction strands: leading or supporting players? Trends Cell Biol. 9 1999 268 273
66. S. Tsukita, M. Furuse, and M. Itoh Multifunctional strands in tight junctions Nat. Rev. Mol. Cell Biol. 2 2001 285 293
67. A.W. Vorbrodt, and D.H. Dobrogowska Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view Brain Res. Brain Res. Rev. 42 2003 221 242
68. A.W. Vorbrodt, and D.H. Dobrogowska Molecular anatomy of interendothelial junctions in human blood-brain barrier microvessels Folia Histochem. Cytobiol. 42 2004 67 75
69. P.D. Ward, H. Ouyang, and D.R. Thakker Role of phospholipase C-beta in the modulation of epithelial tight junction permeability J. Pharmacol. Exp. Ther. 304 2003 689 698
70. E.S. Wittchen, J. Haskins, and B.R. Stevenson Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3 J. Biol. Chem. 274 1999 35179 35185
71. B. Wojciak-Stothard, S. Potempa, T. Eichholtz, and A.J. Ridley Rho and Rac but not Cdc42 regulate endothelial cell permeability J. Cell Sci. 114 2001 1343 1355
72. H. Wolburg, and A. Lippoldt Tight junctions of the blood-brain barrier: development, composition and regulation Vascul. Pharmacol. 38 2002 323 337
73. A. Youakim, and M. Ahdieh Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin Am. J. Physiol. 276 1999 G1279 G1288