Pitavastatin strengthens the barrier integrity in primary cultures of rat brain endothelial cells

Cellular and Molecular Neurobiology

Volumn 30, Issue 5, 2010, Pages 727-735

  Morofuji, Yoichi ^a   Nakagawa, Shinsuke ^a,b   So, Gohei ^a   Hiu, Takeshi ^a   Horai, Shoji ^a   Hayashi, Kentaro ^a   Tanaka, Kunihiko ^a   Suyama, Kazuhiko ^a   Deli, Maria A ^b,c   Nagata, Izumi ^a   Niwa, Masami ^a,b  

^a NAGASAKI UNIVERSITY   (Japan)

^b PharmaCo Cell Co Ltd   (Japan)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Blood brain barrier; Brain endothelial cells (rat); Claudin 5; Geranyl geranylation; Pitavastatin; Statins; Tight junctions; Transendothelial electrical resistance

Indexed keywords

CLAUDIN 5; FARNESYL DIPHOSPHATE; FLUORESCEIN SODIUM; GERANYLGERANYL PYROPHOSPHATE; ISOPRENOID GERANYLGERANYL PYROPHOSPHATE; PITAVASTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BLOOD BRAIN BARRIER; CAPILLARY ENDOTHELIUM; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; IMMUNOCYTOCHEMISTRY; MODEL; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; TIGHT JUNCTION; TRANSENDOTHELIAL ELECTRIC RESISTANCE; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL MARKERS; BLOOD-BRAIN BARRIER; BRAIN; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CLAUDINS; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; POLYISOPRENYL PHOSPHATES; QUINOLINES; RATS; RNA, MESSENGER; SESQUITERPENES; TIGHT JUNCTIONS;

RATTUS;

EID: 77956263165     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-010-9497-9     Document Type: Article

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