Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro

Life Sciences

Volumn 82, Issue 25-26, 2008, Pages 1281-1287

  Kuhlmann, Christoph R W ^a   Gerigk, Marlis ^a   Bender, Bianca ^a   Closhen, Dorothea ^a   Lessmann, Volkmar ^a   Luhmann, Heiko J ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Blood brain barrier; Fluvastatin; Glutamate; Myosin light chain; NMDA receptor

Indexed keywords

1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; ADENOSINE TRIPHOSPHATASE (CALCIUM); APOCYNIN; DIZOCILPINE; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; FLUINDOSTATIN; FLUORESCENT DYE; GLUTAMIC ACID; MYOSIN LIGHT CHAIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N(G) METHYLARGININE; REACTIVE OXYGEN METABOLITE;

ARTICLE; BLOOD BRAIN BARRIER DISRUPTION; COCULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; GLIA CELL; IMMUNOHISTOCHEMISTRY; MEMBRANE DAMAGE; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; RAT; TIME;

ANIMALS; BLOOD-BRAIN BARRIER; CALCIUM; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; FATTY ACIDS, MONOUNSATURATED; GLUTAMIC ACID; INDOLES; INTRACELLULAR SPACE; MYOSIN LIGHT CHAINS; NITRIC OXIDE; OXIDATIVE STRESS; PHOSPHORYLATION; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, N-METHYL-D-ASPARTATE; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 44649187828     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2008.04.017     Document Type: Article

References (32)

1. Abbott N.J., Rönnbäck L., and Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nature Reviews. Neuroscience 7 (2006) 41-53
2. Andras I.E., Deli M.A., Veszelka S., Hayashi K., Hennig B., and Toborek M. The NMDA and AMPA/KA receptors are involved in glutamate-induced alteration of occludin expression and phosphorylation in brain endothelial cells. Journal of Cerebral Blood Flow and Metabolism 27 8 (2007) 1431-1443
3. Ballabh P., Braun A., and Nedergaard M. The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiology of Disease 16 1 (2004) 1-13
4. Chen H., Fitzgerald R., Brown A.T., Qureshi I., Breckenridge J., Kazi R., Wang Y., Wu Y., Zhang X., Mukunyadzi P., Eidt J., and Moursi M.M. Identification of a homocysteine receptor in the peripheral endothelium and its role in proliferation. Journal of Vascular Surgery 10 3 (2005) 215-223
5. Cull-Candy S., Brickley S., and Farrant M. NMDA receptor subunits: diversity, development and disease. Current Opinion in Neurobiology 11 3 (2001) 327-335
6. Doble A. The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacology and Therapeutics 81 (1998) 163-221
7. Elrod J.W., and Lefer D.J. The effects of statins on endothelium, inflammation and cardioprotection. Drug News and Perspectives 18 (2005) 229-236
8. Garcia-Garcia E., Andrieux K., Gil S., Kim H.R., Le Doan T., Desmaele D., d, ' Angelo J., Taran F., Georgin D., and Couvreur P. A methodology to study intracellular distribution of nanoparticles in brain endothelial cells. International Journal of Pharmaceutics 298 (2005) 310-314
9. Haorah J., Heilman D., Knipe B., Chrastil J., Leibhart J., Ghorpade A., Miller D.W., and Persidsky Y. Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise. Alcoholism, Clinical and Experimental Research 29 6 (2005) 999-1009
10. Haorah J., Knipe B., Leibhart J., Ghorpade A., and Persidsky Y. Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. Journal of Leukocyte Biology 78 6 (2005) 1223-1232
11. Haorah J., Knipe B., Gorantla S., Zheng J., and Persidsky Y. Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release. Journal of Neurochemistry 100 2 (2007) 324-336
12. Hillyard D.Z., Cameron A.J., McDonald K.J., Thomson J., MacIntyre A., Shields P.G., Panarelli M., and Jardine A.G. Simvastatin inhibits lymphocyte function in normal subjects and patients with cardiovascular disease. Atherosclerosis 175 (2004) 305-313
13. Jacobson J.R., Dudek S.M., Birukov K.G., Ye S.Q., Grigoryev D.N., Girgis R.E., and Garcia J.G. Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. American Journal of Respiratory Cell and Molecular Biology 30 (2004) 662-670
14. Jiang F., Roberts S.J., Datla S., and Dusting G.J. NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells. Hypertension 48 5 (2006) 950-957
15. Jiang J., Wang W., Sun Y.J., Hu M., Li F., and Zhu D.Y. Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage. European Journal of Pharmacology 561 (2007) 54-62
16. Krizbai I.A., Deli M.A., Pestenácz A., Siklos L., Szabo C.A., Andras I., and Joo F. Expression of glutamate receptors on cultured cerebral endothelial cells. Journal of Neuroscience Research 54 (1998) 814-819
17. Kuhlmann C.R.W., Lessmann V., and Luhmann H.J. Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains. Neuropharmacology 51 (2006) 907-913
18. Kuhlmann C.R.W., Tamaki R., Gamerdinger M., Lessmann V., Behl C., Kempski O.S., and Luhmann H.J. Inhibition of the myosin light chain kinase prevents hypoxia-induced blood brain barrier disruption. Journal of Neurochemistry 102 (2007) 501-507
19. Laufs U., La Fata V., Plutzky J., and Liao J.K. Upregulation of endothelial nitric oxide synthase by HMG-CoA reductase inhibitors. Circulation 97 (1998) 1129-1135
20. Lessmann V., and Heumann R. Modulation of unitary glutamatergic synapses by neurotrophin-4/5 or brain-derived neurotrophic factor in hippocampal microcultures: presynaptic enhancement depends on pre-established paired-pulse facilitation. Neuroscience 86 2 (1998) 399-413
21. Menge T., Hartung H.P., and Stuve O. Statins - a cure-all for the brain?. Nature Reviews. Neuroscience 6 (2005) 325-331
22. -/- mice. Arteriosclerosis, Thrombosis and Vascular Biology 26 (2006) 1753-1759
23. Qureshi A.I., Ali Z., Suri M.F., Shuaib A., Baker G., Todd K., Guterman L.R., and Hopkins L.N. Extracellular glutamate and other aminoacids in experimental intracerebral hemorrhage: an in vivo microdialysis study. Critical Care Medicine 31 5 (2003) 1482-1489
24. Schaefer C.A., Kuhlmann C.R., Gast C., Weitere S., Li F., Most A.K., Neumann T., Backenköhler U., Waldecker B., Erdogan A., and Wiecha J. Statins prevent oxidized low-density lipoprotein- and lysophosphatidylcholine-induced proliferation of human endothelial cells. Vascular Pharmacology 41 2 (2004) 67-73
25. Scott G.S., Bowman S.R., Smith T., Flower R.J., and Bolton C. Glutamate-stimulated peroxynitrite production in a brain-derived endothelial cell line is dependent on N-methyl-d-aspartate (NMDA) receptor activation. Biochemical Pharmacology 73 2 (2007) 228-236
26. Sharp D.C., Hines I., Houghton J., Warren A., Jackson IV T.H., Jawahar A., Nanda A., Elrod J.W., Long A., Chi A., Minagar A., and Alexander J.S. Glutamate causes a loss in cerebral endothelial barrier integrity through activation of NMDA receptor. American Journal of Physiology. Heart and Circulatory Physiology 285 (2003) H2592-H2598
27. Sharp C.D., Houghton J., Elrod J.W., Warren A., Jackson IV T.H., Jawahar A., Nanda A., Minagar A., and Alexander J.S. N-methyl-d-aspartate receptor activation in human cerebral endothelium promotes intracellular oxidant stress. American Journal of Physiology. Heart and Circulatory Physiology 288 (2005) H1893-H1899
28. Tan K.H., Dobbie M.S., Felix R.A., Barrand M.A., and Hurst R.D. A comparison of the induction of immortalized endothelial cell impermeability by astrocytes. NeuroReport 12 7 (2001) 1329-1334
29. Tan K.H., Harrington S., Purcell W.M., and Hurst R.D. Peroxynitrite mediates nitric oxide-induced blood-brain barrier damage. Neurochemical Research 29 (2004) 579-587
30. Undas A., Brummel K.E., Musial J., Mann K.G., and Szczeklik A. Simvastatin depresses blood clotting by inhibiting activation of prothrombin, factor V, and factor XIII and by enhancing factor Va inactivation. Circulation 103 (2001) 2248-2253
31. Utepbergenov D.I., Mertsch K., Sporbert A., Tenz K., Paul M., Haseloff R.F., and Blasig I.E. Nitric oxide protects blood-brain barrier in vitro from hypoxia/reoxygenation-mediated injury. FEBS Letters 424 3 (1998) 197-201
32. Yang G., Chan P.H., Chen S.F., Babuna O.A., Simon R.P., and Weinstein P.R. Reduction of vasogenic edema and infarction by MK-801 in rats after temporary focal cerebral ischemia. Neurosurgery 34 2 (1994) 339-345