Modulation of p-glycoprotein function by caveolin-1 phosphorylation

Journal of Neurochemistry

Volumn 101, Issue 1, 2007, Pages 1-8

  Barakat, Stéphane ^a,b   Demeule, Michel ^a   Pilorget, Anthony ^a   Régina, Anthony ^a   Gingras, Denis ^a   Baggetto, Loris G ^b   Béliveau, Richard ^a  

^a UNIVERSITÉ DU QUÉBEC À MONTRÉAL   (Canada)

^b INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

Author keywords

Blood brain barrier; Caveolin 1; Endothelial cells; P glycoprotein; Phosphorylation; Sarcoma

Indexed keywords

CAVEOLIN 1; GLYCOPROTEIN P; HOE 33342; PACLITAXEL; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; TRITIUM; VINBLASTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CAVEOLA; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; CAVEOLIN 1; CELL LINE, TRANSFORMED; DOWN-REGULATION; ENDOTHELIAL CELLS; P-GLYCOPROTEIN; PACLITAXEL; PHOSPHORYLATION; PROTEIN TRANSPORT; RATS; RNA, SMALL INTERFERING; SRC-FAMILY KINASES; VINBLASTINE;

RATTUS;

EID: 33947279373     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04410.x     Document Type: Article

References (29)

1. Ahmed S. N., Brown D. A. and London E. (1997) On the origin of sphingolipid/cholesterol-rich detergent-insoluble cell membranes: physiological concentrations of cholesterol and sphingolipid induce formation of a detergent-insoluble, liquid-ordered lipid phase in model membranes. Biochemistry 36, 10 944-10 953.
2. Arnal J. F., Dinh-Xuan A. T., Pueyo M., Darblade B. and Rami J. (1999) Endothelium-derived nitric oxide and vascular physiology and pathology. Cell. Mol. Life Sci. 55, 1078-1087.
3. Beaulieu E., Demeule M., Ghitescu L. and Beliveau R. (1997) P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. Biochem. J. 326 (pt 2), 539-544.
4. Belanger M. M., Gaudreau M., Roussel E. and Couet J. (2004) Role of caveolin-1 in etoposide resistance development in A549 lung cancer cells. Cancer Biol. Ther. 3, 954-959.
5. Cai C. and Chen J. (2004) Overexpression of caveolin-1 induces alteration of multidrug resistance in Hs578T breast adenocarcinoma cells. Int. J. Cancer 111, 522-529.
6. Cao H., Courchesne W. E. and Mastick C. C. (2002) A phosphotyrosine- dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase. J. Biol. Chem. 277, 8771-8774.
7. Cohen A. W., Hnasko R., Schubert W. and Lisanti M. P. (2004) Role of caveolae and caveolins in health and disease. Physiol. Rev. 84, 1341-1379.
8. Demeule M., Jodoin J., Gingras D. and Beliveau R. (2000) P-glycoprotein is localized in caveolae in resistant cells and in brain capillaries. FEBS Lett. 466, 219-224.
9. Fielding P. E. and Fielding C. J. (1995) Plasma membrane caveolae mediate the efflux of cellular free cholesterol. Biochemistry 34, 14 288-14 292.
10. Fiucci G., Ravid D., Reich R. and Liscovitch M. (2002) Caveolin-1 inhibits anchorage-independent growth, anoikis and invasiveness in MCF-7 human breast cancer cells. Oncogene 21, 2365-2375.
11. Gaus K., Rodriguez M., Ruberu K. R., Gelissen I., Sloane T. M., Kritharides L. and Jessup W. (2005) Domain-specific lipid distribution in macrophage plasma membranes. J. Lipid Res. 46, 1526-1538.
12. Gayet L., Dayan G., Barakat S., Labialle S., Michaud M., Cogne S., Mazane A., Coleman A. W., Rigal D. and Baggetto L. G. (2005) Control of P-glycoprotein activity by membrane cholesterol amounts and their relation to multidrug resistance in human CEM leukemia cells. Biochemistry 44, 4499-4509.
13. Gottesman M. M., Fojo T. and Bates S. E. (2002) Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer 2, 48-58.
14. Hinrichs J. W., Klappe K., Hummel I. and Kok J. W. (2004) ATP-binding cassette transporters are enriched in non-caveolar detergent-insoluble glycosphingolipid-enriched membrane domains (DIGs) in human multidrug-resistant cancer cells. J. Biol. Chem. 279, 5734-5738.
15. Jodoin J., Demeule M., Fenart L., Cecchelli R., Farmer S., Linton K. J., Higgins C. F. and Beliveau R. (2003) P-glycoprotein in bloodbrain barrier endothelial cells: interaction and oligomerization with caveolins. J. Neurochem. 87, 1010-1023.
16. Krajewska W. M. and Maslowska I. (2004) Caveolins: structure and function in signal transduction. Cell. Mol. Biol. Lett. 9, 195-220.
17. Labrecque L., Nyalendo C., Langlois S., Durocher Y., Roghi C., Murphy G., Gingras D. and Beliveau R. (2004) Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinase. J. Biol. Chem. 279, 52 132-52 140.
18. Lavie Y., Fiucci G. and Liscovitch M. (1998) Up-regulation of caveolae and caveolar constituents in multidrug-resistant cancer cells. J. Biol. Chem. 273, 32 380-32 383.
19. Li S., Couet J. and Lisanti M. P. (1996) Src tyrosine kinases, Galpha subunits, and H-Ras share a common membrane-anchored scaffolding protein, caveolin. Caveolin binding negatively regulates the auto-activation of Src tyrosine kinases. J. Biol. Chem. 271, 29 182-29 190.
20. Liu P. and Anderson R. G. (1995) Compartmentalized production of ceramide at the cell surface. J. Biol. Chem. 270, 27 179-27 185.
21. Radeva G. and Sharom F. J. (2004) Isolation and characterization of lipid rafts with different properties from RBL-2H3 (rat basophilic leukaemia) cells. Biochem. J. 380, 219-230.
22. Radeva G., Perabo J. and Sharom F. J. (2005) P-Glycoprotein is localized in intermediate-density membrane microdomains distinct from classical lipid rafts and caveolar domains. FEBS J. 272, 4924-4937.
23. Regina A., Romero I. A., Greenwood J., Adamson P., Bourre J. M., Couraud P. O. and Roux F. (1999) Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT. J. Neurochem. 73, 1954-1963.
24. Ronaldson P. T., Bendayan M., Gingras D., Piquette-Miller M. and Bendayan R. (2004) Cellular localization and functional expression of P-glycoprotein in rat astrocyte cultures. J. Neurochem. 89, 788-800.
25. Schinkel A. H., Wagenaar E., Mol C. A. and van Deemter L. (1996) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J. Clin. Invest. 97, 2517-2524.
26. Smart E. J., Ying Y. S., Mineo C. and Anderson R. G. (1995) A detergent-free method for purifying caveolae membrane from tissue culture cells. Proc. Natl Acad. Sci. USA 92, 10 104-10 108.
27. Virgintino D., Robertson D., Errede M., Benagiano V., Girolamo F., Maiorano E., Roncali L. and Bertossi M. (2002) Expression of P-glycoprotein in human cerebral cortex microvessels. J. Histochem. Cytochem. 50, 1671-1676.
28. Wiechen K., Sers C., Agoulnik A., Arlt K., Dietel M., Schlag P. M. and Schneider U. (2001) Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas. Am. J. Pathol. 158, 833-839.
29. Yamamoto M., Toya Y., Jensen R. A. and Ishikawa Y. (1999) Caveolin is an inhibitor of platelet-derived growth factor receptor signaling. Exp. Cell Res. 247, 380-388.