Formation of the blood - Brain barrier: Wnt signaling seals the deal

Journal of Cell Biology

Volumn 183, Issue 3, 2008, Pages 371-373

  Polakis, Paul ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BETA CATENIN; CLAUDIN 3; CLAUDIN 5; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; OCCLUDIN; RHO KINASE; TAU PROTEIN; WNT PROTEIN; WNT3A PROTEIN;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; BRAIN CANCER; BRAIN CAPILLARY; BRAIN ISCHEMIA; DISEASE EXACERBATION; ENDOTHELIUM CELL; GENE OVEREXPRESSION; GENETIC POLYMORPHISM; MICROVASCULARIZATION; MOLECULAR RECOGNITION; NEUROMODULATION; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; NOTE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN SYNTHESIS REGULATION; SIGNAL TRANSDUCTION; STROKE; TIGHT JUNCTION; VITREORETINOPATHY; BRAIN CIRCULATION; CAPILLARY; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM DISEASE; DEGENERATIVE DISEASE; HUMAN; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

BLOOD-BRAIN BARRIER; CAPILLARIES; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM DISEASES; CEREBROVASCULAR CIRCULATION; ENDOTHELIUM, VASCULAR; HUMANS; NEURODEGENERATIVE DISEASES; NEURONS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 56149095723     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200810040     Document Type: Note

References (21)

1. Bhat, R.V., S.L. Budd Haeberlein, and J. Avila. 2004. Glycogen synthase kinase 3: a drug target for CNS therapies. J. Neurochem. 89:1313-1317.
2. Brembeck, F.H., M. Rosario, and W. Birchmeier. 2006. Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr. Opin. Genet. Dev. 16:51-59.
3. Caraci, F., C. Busceti, F. Biagioni, E. Aronica, F. Mastroiacovo, I. Cappuccio, G. Battaglia, V. Bruno, A. Caricasole, A. Copani, and F Nicoletti. 2008. The Wnt antagonist, Dickkopf-1, as a target for the treatment of neurodegenerative disorders. Neurochem. Res. doi:10.1007/s11064-008-9710- 0.
4. Cattelino, A., S. Liebner, R. Gallini, A. Zanetti, G. Balconi, A. Corsi, P. Bianco, H. Wolburg, R. Moore, B. Oreda, et al. 2003. The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J. Cell Biol. 162:1111-1122.
5. Cowper-Smith , C.D. , G.J. Anger , E. Magal , M.H. Norman , and G.S. Robertson . 2008 . Delayed administration of a potent cyclin dependent kinase and glycogen synthase kinase 3 beta inhibitor produces longterm neuroprotection in a hypoxia-ischemia model of brain injury. Neuroscience. 155:864-875.
6. De Ferrari, G.V., and R.T. Moon . 2006 . The ups and downs of Wnt signaling in prevalent neurological disorders. Oncogene. 25:7545-7553.
7. De Ferrari, G.V., A. Papassotiropoulos, T. Biechele, F. Wavrant De-Vrieze, M.E. Avila, M.B. Major , A. Myers, K. Saez, J.P. Henriquez, A. Zhao, et al. 2007 . Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer ' s disease. Proc. Natl. Acad. Sci. USA. 104:9434-9439.
8. Haines, J.L., N. Schnetz-Boutaud, S. Schmidt, W.K. Scott, A. Agarwal, E.A. Postel, L. Olson, S.J. Kenealy, M. Hauser, J.R. Gilbert, and M.A. Pericak- Vance . 2006 . Functional candidate genes in age-related macular degeneration: signif cant association with VEGF, VLDLR, and LRP6. Invest. Ophthalmol. Vis. Sci. 47:329-335.
9. Hawkins, B.T., and T.P. Davis . 2005 . The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57:173-185.
10. Hooper, C. , R. Killick , and S. Lovestone. 2008. The GSK3 hypothesis of Alzheimer's disease. J. Neurochem. 104:1433-1439.
11. Jiao, X., V. Ventruto, M.T. Trese, B.S. Shastry, and J.F. Hejtmancik. 2004. Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5. Am. J. Hum. Genet. 75:878-884.
12. Kim, K.A., M. Kakitani, J. Zhao, T. Oshima, T. Tang, M. Binnerts, Y. Liu, B. Boyle, E. Park, P. Emtage, et al. 2005. Mitogenic inf uence of human R-spondin1 on the intestinal epithelium. Science. 309:1256-1259.
13. Liebner , S., M. Corada, T. Bangsow, J. Babbage, A. Taddei, C.J. Czupalla, M. Reis, A. Felici, H. Wolburg, M. Fruttiger, et al. 2008. Wnt/b-catenin signaling controls development of the blood -brain barrier. J. Cell Biol. 183:409-417.
14. Magdesian, M.H., M.M. Carvalho, F.A. Mendes, L.M. Saraiva, M.A. Juliano, L. Juliano, J. Garcia-Abreu, and S.T. Ferreira. 2008. Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/betacatenin signaling. J. Biol. Chem. 283:9359-9368.
15. Nitta, T., M. Hata, S. Gotoh,Y. Seo, H. Sasaki, N. Hashimoto, M. Furuse, and S. Tsukita . 2003 . Size-selective loosening of the blood-brain barrier in claudin-5-def cient mice. J. Cell Biol. 161:653-660.
16. Persidsky, Y., S.H. Ramirez, J. Haorah, and G.D. Kanmogne. 2006. Bloodbrain barrier: structural components and function under physiologic and pathologic conditions. J. Neuroimmune Pharmacol. 1:223-236.
17. Robitaille, J., M.L. MacDonald, A. Kaykas, L.C. Sheldahl, J. Zeisler , M.P. Dube, L.H. Zhang, R.R. Singaraja, D.L. Guernsey, B. Zheng, et al. 2002. Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy. Nat. Genet. 32:326-330.
18. Wolburg, H., K. Wolburg-Buchholz, J. Kraus, G. Rascher-Eggstein, S. Liebner, S. Hamm, F. Duffner, E.H. Grote, W. Risau, and B. Engelhardt. 2003. Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme. Acta Neuropathol. (Berl.). 105:586-592.
19. Xu, Q., Y. Wang, A. Dabdoub, P.M. Smallwood, J. Williams, C. Woods, M.W. Kelley, L. Jiang, W. Tasman, K. Zhang, and J. Nathans. 2004. Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-aff nity ligand-receptor pair. Cell. 116:883-895.
20. Zerlin, M., M.A. Julius , and J. Kitajewski. 2008. Wnt/Frizzled signaling in angiogenesis. Angiogenesis. 11:63-69.
21. Zlokovic, B.V. 2008 . The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 57:178-201.