Hydrogel matrix entrapping PLGA-paclitaxel microspheres: Drug delivery with near zero-order release and implantability advantages for malignant brain tumour chemotherapy

Pharmaceutical Research

Volumn 26, Issue 9, 2009, Pages 2101-2114

  Ranganath, Sudhir Hulikal ^a   Kee, Irene ^b   Krantz, William B ^a   Chow, Pierce Kah Hoe ^b,c   Wang, Chi Hwa ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Chemotherapy; Electrohydrodynamic atomization; Glioma; Hydrogel; Microspheres; PLGA paclitaxel

Indexed keywords

CALCIUM ION; CASPASE 3; MICROSPHERE; PACLITAXEL; PLACEBO; POLYGLACTIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER MODEL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULARY; DRUG FORMULATION; DRUG IMPLANT; DRUG RELEASE; ELECTROSPRAY; ENZYME ACTIVITY; GEL; GELATION; GLIOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEL; IC 50; MALE; MOUSE; NEBULIZATION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SCANNING ELECTRON MICROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BRAIN NEOPLASMS; CALORIMETRY, DIFFERENTIAL SCANNING; CELL LINE, TUMOR; HYDROGELS; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PACLITAXEL; POLYGLYCOLIC ACID; RATS;

EID: 68149161773     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9922-2     Document Type: Article

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