Increased expression of β-catenin in brain microvessels of a segmentally trisomic (Ts65Dn) mouse model of Down syndrome

Brain Cell Biology

Volumn 36, Issue 5-6, 2008, Pages 203-211

  Vorbrodt, Andrzej W ^a   Li, Shuyun ^a   Brown, W Ted ^a   Ramakrishna, Narayan ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; SERUM ALBUMIN;

ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CELL JUNCTION; CELL NUCLEUS; CONTROL GROUP; CONTROLLED STUDY; CYTOPLASM; DOWN SYNDROME; ENDOTHELIUM CELL; FEMALE; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULATURE; MOUSE; NEUROPIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRISOMY;

ALBUMINS; ANALYSIS OF VARIANCE; ANIMALS; BETA CATENIN; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CELL NUCLEUS; CEREBRAL CORTEX; CYTOPLASM; DISEASE MODELS, ANIMAL; DOWN SYNDROME; ENDOTHELIUM, VASCULAR; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; MICROVESSELS; TRISOMY;

MUS;

EID: 64949140956     PISSN: 15597105     EISSN: 15597113     Source Type: Journal    
DOI: 10.1007/s11068-008-9038-3     Document Type: Article

References (23)

1. P. Z. Anastasiadis A. B. Reynolds 2000 The p120 catenin family: complex roles in adhesion, signaling and cancer J. Cell Sci. 113 1319 1334
2. S. E. Antonarkis R. Lyle E. T. Dermitzakis A. Reymond S. Deutsch 2004 Chromosome 21 and Down syndrome: from genomics to pathophysiology Nat. Rev. Genet. 5 725 738
3. S. Barolo 2006 Transgenic Wnt/TCF pathway reports: all you need is Lef? Oncogene 25 7505 7511
4. S. J. Bolton D. C. Anthony V. H. Perry 1998 Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo Neuroscience 86 1245 1257
5. M. Capelli-Bigazzi G. Santoro C. Battaglia M. T. Palladino M. Carozza M. G. Russo G. Pacielo R. Calabro 2004 Endothelial cell function in patients with Down syndrome Am. J. Cardiol. 94 392 395
6. M. T. Davisson C. Schmidt R. H. Reeves N. G. Irving E. C. Akeson B. S. Harris R. T. Bronson 1993 Segmental trisomy as a mouse model for Down syndrome Prog. Clin. Biol. Res. 384 117 133
7. D. H. Dobrogowska A. W. Vorbrodt 2004 Immunogold localization of tight junctional proteins in normal and osmotically-affected rat blood-brain barrier J. Mol. Hist. 35 529 539
8. M. D. Gordon R. Nurse 2006 Wnt signaling: multiple pathways, multiple receptors and multiple transcription factors J. Biol. Chem. 281 22429 22433
9. B. M. Gumbiner 1996 Cell adhesion: the molecular basis of tissue architecture and morphogenesis Cell 84 345 357
10. S. Kaga L. Zhan E. Altaf N. Maulik 2006 Glycogen synthase kinase-3 beta-catenin promotes angiogenic and antiapoptotic signaling through the induction of VEGF, Bcl-2 and Survivin expression in rat ischemic preconditioned myocardium J. Mol. Cell. Cardiol. 40 138 147
11. D. E. Kang S Soriano M. P. Frosch T. Collins S. Naruse S. S. Sisodia G. Leibovitz F. Levine E. H. Koo 1999 Presenilin 1 facilitates the constitutive turnover of β-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the β-catenin signaling pathway J. Neurosci. 19 4229 4237
12. P. I. Morin 1999 Beta-catenin signaling and cancer Bioessays 21 1021 1030
13. A. Novak S. Dedhar 1999 Signalling through beta-catenin and Lef/Tcf cell Mol. Life Sci. 56 523 537
14. N. Ramakrishna 2007 Upregulation of beta-catenin expression in Down syndrome model Ts65Dn mouse brain and human Down syndrome brain FASEB J. 21 A649 A650
15. Ramakrishna, N., Meeker, H. C., Li, S., and El Idrissi, A. (2008). Regulation of β-catenin in Down syndrome (submitted for publication)
16. N. Ramakrishna H. C. Meeker S. Li E. C. Jenkins J. R. Currie M. Flory B. Lee M. S. Liu D. L. Miller 2005 Polymerase chain reaction method to identify Down syndrome model segmentally trisomic mice Anal. Biochem. 340 213 219
17. C. H. Schulze A. Firth 1993 Immunohistochemical localization of adherens junction components in blood-brain barrier microvessels of the rat J. Cell Sci. 104 773 782
18. K. I. Takemaru R. T. Moon 2000 The transcriptional coactivator CBP interacts with β-catenin to activate gene expression J. Cell Biol. 149 249 254
19. A. W. Vorbrodt D. H. Dobrogowska 2003 Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view Brain Res. Rev. 42 221 242
20. A. W. Vorbrodt D. H. Dobrogowska 2004 Molecular anatomy of interendothelial junctions in human blood-brain barrier microvessels Folia Histochem. Cytobiol. 42 67 75
21. A. W. Vorbrodt D. H. Dobrogowska M. Tarnawski A. S. Lossinsky 1994 A quantitative immunocytochemical study of the osmotic opening of the blood-brain barrier to endogenous albumin J. Neurocytol. 23 792 800
22. A. W. Vorbrodt D. H. Dobrogowska M. Tarnawski H. C. Meeker R. I. Carp 2006 Immunogold study of altered expression of some interendothelial junctional molecules in the brain blood microvessels of diabetic scrapie-infected mice J. Mol. Hist. 37 27 35
23. A. S. Yap R. Briehr B. M. Gumbiner 1997 Molecular and functional analysis of cadherin-based adherens junctions Annu. Rev. Cell Dev. Biol. 13 119 146