메뉴 건너뛰기




Volumn 117, Issue 2, 2009, Pages 111-124

Alzheimer disease macrophages shuttle amyloid-beta from neurons to vessels, contributing to amyloid angiopathy

Author keywords

Alzheimer; Amyloid beta; Angiopathy; Apoptosis; Congophillic; Macrophages

Indexed keywords

AMYLOID BETA PROTEIN;

EID: 59249103997     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-008-0481-0     Document Type: Article
Times cited : (94)

References (54)
  • 3
    • 40149099870 scopus 로고    scopus 로고
    • Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: Significance for cerebral amyloid angiopathy and neuroimmunology
    • doi: 10.1111/j.1365-2990.2007.00926.x
    • Carare RO, Bernardes-Silva M, Newman TA, Page AM, Nicoll JA, Perry VH, Weller RO (2008) Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: Significance for cerebral amyloid angiopathy and neuroimmunology. Neuropathol Appl Neurobiol 34:131-144. doi: 10.1111/j.1365-2990.2007.00926.x
    • (2008) Neuropathol Appl Neurobiol , vol.34 , pp. 131-144
    • Carare, R.O.1    Bernardes-Silva, M.2    Newman, T.A.3    Page, A.M.4    Nicoll, J.A.5    Perry, V.H.6    Weller, R.O.7
  • 4
    • 33645650780 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide
    • doi: 10.1074/jbc.M508125200
    • Chen K, Iribarren P, Hu J, Chen J, Gong W, Cho EH, Lockett S, Dunlop NM, Wang JM (2006) Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide. J Biol Chem 281:3651-3659. doi: 10.1074/jbc.M508125200
    • (2006) J Biol Chem , vol.281 , pp. 3651-3659
    • Chen, K.1    Iribarren, P.2    Hu, J.3    Chen, J.4    Gong, W.5    Cho, E.H.6    Lockett, S.7    Dunlop, N.M.8    Wang, J.M.9
  • 7
    • 34147115541 scopus 로고    scopus 로고
    • Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    • doi: 10.1038/nm1555
    • El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 13:432-438. doi: 10.1038/ nm1555
    • (2007) Nat Med , vol.13 , pp. 432-438
    • El Khoury, J.1    Toft, M.2    Hickman, S.E.3    Means, T.K.4    Terada, K.5    Geula, C.6    Luster, A.D.7
  • 10
    • 0002314983 scopus 로고    scopus 로고
    • Macrophages infiltrate the brain and express COX-2 and iNOS in Alzheimer's disease and AIDS
    • Fiala M, Liu NQ, Reddy S, Graves M (2001) Macrophages infiltrate the brain and express COX-2 and iNOS in Alzheimer's disease and AIDS. Alzheimers Rep 4:1-7
    • (2001) Alzheimers Rep , vol.4 , pp. 1-7
    • Fiala, M.1    Liu, N.Q.2    Reddy, S.3    Graves, M.4
  • 11
    • 0037000396 scopus 로고    scopus 로고
    • Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier
    • doi: 10.1046/j.1365-2362.2002.00994.x
    • Fiala M, Liu QN, Sayre J, Pop V, Brahmandam V, Graves MC, Vinters HV (2002) Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier. Eur J Clin Invest 32:360-371. doi: 10.1046/j.1365-2362.2002.00994.x
    • (2002) Eur J Clin Invest , vol.32 , pp. 360-371
    • Fiala, M.1    Liu, Q.N.2    Sayre, J.3    Pop, V.4    Brahmandam, V.5    Graves, M.C.6    Vinters, H.V.7
  • 14
    • 34447636918 scopus 로고    scopus 로고
    • Phagocytosis of amyloid-beta and inflammation: Two faces of innate immunity in Alzheimer's disease
    • Fiala M, Cribbs DH, Rosenthal M, Bernard G (2007) Phagocytosis of amyloid-beta and inflammation: Two faces of innate immunity in Alzheimer's disease. J Alzheimers Dis 11:457-463
    • (2007) J Alzheimers Dis , vol.11 , pp. 457-463
    • Fiala, M.1    Cribbs, D.H.2    Rosenthal, M.3    Bernard, G.4
  • 18
    • 25144501662 scopus 로고    scopus 로고
    • Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease
    • doi: 10.1016/j.neurobiolaging.2005.05.022
    • Gouras GK, Almeida CG, Takahashi RH (2005) Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging 26:1235-1244. doi: 10.1016/j.neurobiolaging.2005.05.022
    • (2005) Neurobiol Aging , vol.26 , pp. 1235-1244
    • Gouras, G.K.1    Almeida, C.G.2    Takahashi, R.H.3
  • 19
    • 0037076817 scopus 로고    scopus 로고
    • Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF)
    • doi: 10.1016/S0006-8993(02)02589-1 940:49-54. doi: 10.1016/ S0006-8993(02)02589-1
    • Hamilton JA, Whitty G, White AR, Jobling MF, Thompson A, Barrow CJ, Cappai R, Beyreuther K, Masters CL (2002) Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF). Brain Res 940:49-54. doi: 10.1016/S0006-8993(02)02589-1 940:49-54. doi: 10.1016/S0006-8993(02)02589-1
    • (2002) Brain Res , vol.940 , pp. 49-54
    • Hamilton, J.A.1    Whitty, G.2    White, A.R.3    Jobling, M.F.4    Thompson, A.5    Barrow, C.J.6    Cappai, R.7    Beyreuther, K.8    Masters, C.L.9
  • 20
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • doi: 10.1126/science.1072994
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356. doi: 10.1126/science.1072994
    • (2002) Science , vol.297 , pp. 353-356
    • Hardy, J.1    Se lkoe, D.J.2
  • 21
    • 0036847848 scopus 로고    scopus 로고
    • Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system
    • doi: 10.1002/glia.10148
    • Husemann J, Loike JD, Anankov R, Febbraio M, Silverstein SC (2002) Scavenger receptors in neurobiology and neuropathology: Their role on microglia and other cells of the nervous system. Glia 40:195-205. doi: 10.1002/glia.10148
    • (2002) Glia , vol.40 , pp. 195-205
    • Husemann, J.1    Loike, J.D.2    Anankov, R.3    Febbraio, M.4    Silverstein, S.C.5
  • 22
    • 0242668337 scopus 로고    scopus 로고
    • Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
    • doi: 10.1126/science.1079469
    • Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300:486-489. doi: 10.1126/ science.1079469
    • (2003) Science , vol.300 , pp. 486-489
    • Kayed, R.1    Head, E.2    Thompson, J.L.3    McIntire, T.M.4    Milton, S.C.5    Cotman, C.W.6    Glabe, C.G.7
  • 25
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-beta in Alzheimer's disease
    • doi: 10.1038/nrn2168
    • LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 8:499-509. doi: 10.1038/nrn2168
    • (2007) Nat Rev Neurosci , vol.8 , pp. 499-509
    • LaFerla, F.M.1    Green, K.N.2    Oddo, S.3
  • 26
    • 0036284366 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway
    • doi: 10.1128/JVI.76.13.6689-6700.2002
    • Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, Kriederman B, Roberts J, Pushkarsky T, Bukrinsky M, Witte M, Weinand M, Fiala M (2002) Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol 76:6689-6700. doi: 10.1128/ JVI.76.13.6689-6700.2002
    • (2002) J Virol , vol.76 , pp. 6689-6700
    • Liu, N.Q.1    Lossinsky, A.S.2    Popik, W.3    Li, X.4    Gujuluva, C.5    Kriederman, B.6    Roberts, J.7    Pushkarsky, T.8    Bukrinsky, M.9    Witte, M.10    Weinand, M.11    Fiala, M.12
  • 27
    • 0642311332 scopus 로고    scopus 로고
    • Studies of cerebral endothelium by scanning and high-voltage electron microscopy
    • In: Nag S (ed) Humana Press, Totawa
    • Lossinsky AS, Shivers RR (2003) Studies of cerebral endothelium by scanning and high-voltage electron microscopy. In: Nag S (ed) The blood-brain barrier: Biology and research protocols, vol 89. Humana Press, Totawa, pp 67-82
    • (2003) The Blood-brain Barrier: Biology and Research Protocols , vol.89 , pp. 67-82
    • Lossinsky, A.S.1    Shivers, R.R.2
  • 28
    • 40849105303 scopus 로고    scopus 로고
    • Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages
    • doi: 10.1016/j.neurobiolaging.2006.12.001
    • Majumdar A, Chung H, Dolios G, Wang R, Asamoah N, Lobel P, Maxfield FR (2008) Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages. Neurobiol Aging 29:707-715. doi: 10.1016/ j.neurobiolaging.2006.12.001
    • (2008) Neurobiol Aging , vol.29 , pp. 707-715
    • Majumdar, A.1    Chung, H.2    Dolios, G.3    Wang, R.4    Asamoah, N.5    Lobel, P.6    Maxfield, F.R.7
  • 29
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34:939-944
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 31
    • 33645082486 scopus 로고    scopus 로고
    • Potential inflammatory biomarkers in Alzheimer's disease
    • Mrak RE, Griffin WS (2005) Potential inflammatory biomarkers in Alzheimer's disease. J Alzheimers Dis 8:369-375
    • (2005) J Alzheimers Dis , vol.8 , pp. 369-375
    • Mrak, R.E.1    Griffin, W.S.2
  • 32
    • 38349046973 scopus 로고    scopus 로고
    • Autophagy, amyloidogenesis and Alzheimer disease
    • doi: 10.1242/jcs.019265
    • Nixon RA (2007) Autophagy, amyloidogenesis and Alzheimer disease. J Cell Sci 120:4081-4091. doi: 10.1242/jcs.019265
    • (2007) J Cell Sci , vol.120 , pp. 4081-4091
    • Nixon, R.A.1
  • 33
    • 33144487701 scopus 로고    scopus 로고
    • Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology
    • doi: 10.1074/jbc.M507892200
    • Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM (2006) Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. J Biol Chem 281:1599-1604. doi: 10.1074/jbc.M507892200
    • (2006) J Biol Chem , vol.281 , pp. 1599-1604
    • Oddo, S.1    Caccamo, A.2    Tran, L.3    Lambert, M.P.4    Glabe, C.G.5    Klein, W.L.6    LaFerla, F.M.7
  • 34
    • 0030248270 scopus 로고    scopus 로고
    • Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
    • doi: 10.1016/S0896-6273(00)80187-7
    • Paresce DM, Ghosh RN, Maxfield FR (1996) Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron 17:553-565. doi: 10.1016/S0896-6273(00)80187-7
    • (1996) Neuron , vol.17 , pp. 553-565
    • Paresce, D.M.1    Ghosh, R.N.2    Maxfield, F.R.3
  • 36
    • 33645528251 scopus 로고    scopus 로고
    • Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease
    • doi: 10.1038/sj.mp.4001809
    • Simard AR, Rivest S (2006) Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer's disease. Mol Psychiatry 11:327-335. doi: 10.1038/sj.mp.4001809
    • (2006) Mol Psychiatry , vol.11 , pp. 327-335
    • Simard, A.R.1    Rivest, S.2
  • 37
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • doi: 10.1016/j.neuron.2006.01.022
    • Simard AR, Soulet D, Gowing G, Julien JP, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49:489-502. doi: 10.1016/ j.neuron.2006.01.022
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 38
    • 0036277146 scopus 로고    scopus 로고
    • Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes
    • doi: 10.1016/S0165-5728(02)00112-1
    • Smits HA, Rijsmus A, van Loon JH, Wat JW, Verhoef J, Boven LA, Nottet HS (2002) Amyloid-beta-induced chemokine production in primary human macrophages and astrocytes. J Neuroimmunol 127:160-168. doi: 10.1016/ S0165-5728(02)00112-1
    • (2002) J Neuroimmunol , vol.127 , pp. 160-168
    • Smits, H.A.1    Rijsmus, A.2    van Loon, J.H.3    Wat, J.W.4    Verhoef, J.5    Boven, L.A.6    Nottet, H.S.7
  • 39
    • 34047117766 scopus 로고    scopus 로고
    • Intravenous immunoglobulin and Alzheimer's disease immunotherapy
    • Solomon B (2007) Intravenous immunoglobulin and Alzheimer's disease immunotherapy. Curr Opin Mol Ther 9:79-85
    • (2007) Curr Opin Mol Ther , vol.9 , pp. 79-85
    • Solomon, B.1
  • 40
    • 0032937860 scopus 로고    scopus 로고
    • The role of microglia and macrophages in the pathophysiology of the CNS
    • doi: 10.1016/S0301-0082(98)00083-5
    • Stoll G, Jander S (1999) The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 58:233-247. doi: 10.1016/ S0301-0082(98)00083-5
    • (1999) Prog Neurobiol , vol.58 , pp. 233-247
    • Stoll, G.1    Jander, S.2
  • 42
    • 4444276735 scopus 로고    scopus 로고
    • Clearance of Alzheimer's Abeta peptide: The many roads to perdition
    • Tanzi RE, Moir RD, Wagner SL (2004) Clearance of Alzheimer's Abeta peptide: The many roads to perdition. Neuron 43:605-608
    • (2004) Neuron , vol.43 , pp. 605-608
    • Tanzi, R.E.1    Moir, R.D.2    Wagner, S.L.3
  • 43
    • 51449096696 scopus 로고    scopus 로고
    • Abeta inhibits the proteasome and enhances amyloid and tau accumulation
    • doi: 10.1016/j.neurobiolaging.2007.04.014
    • Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM (2008) Abeta inhibits the proteasome and enhances amyloid and tau accumulation. Neurobiol Aging 29:1607-1618. doi: 10.1016/j.neurobiolaging.2007.04.014
    • (2008) Neurobiol Aging , vol.29 , pp. 1607-1618
    • Tseng, B.P.1    Green, K.N.2    Chan, J.L.3    Blurton-Jones, M.4    LaFerla, F.M.5
  • 45
    • 0034050540 scopus 로고    scopus 로고
    • Complement component C1q modulates the phagocytosis of Abeta by microglia
    • doi: 10.1006/exnr.1999.7260
    • Webster SD, Yang AJ, Margol L, Garzon-Rodriguez W, Glabe CG, Tenner AJ (2000) Complement component C1q modulates the phagocytosis of Abeta by microglia. Exp Neurol 161:127-138. doi: 10.1006/exnr.1999.7260
    • (2000) Exp Neurol , vol.161 , pp. 127-138
    • Webster, S.D.1    Yang, A.J.2    Margol, L.3    Garzon-Rodriguez, W.4    Glabe, C.G.5    Tenner, A.J.6
  • 46
    • 0035877075 scopus 로고    scopus 로고
    • Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q
    • Webster SD, Galvan MD, Ferran E, Garzon-Rodriguez W, Glabe CG, Tenner AJ (2001) Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. J Immunol 166:7496-7503
    • (2001) J Immunol , vol.166 , pp. 7496-7503
    • Webster, S.D.1    Galvan, M.D.2    Ferran, E.3    Garzon-Rodriguez, W.4    Glabe, C.G.5    Tenner, A.J.6
  • 48
    • 33646384419 scopus 로고    scopus 로고
    • Immunology and immunotherapy of Alzheimer's disease
    • doi: 10.1038/nri1843
    • Weiner HL, Frenkel D (2006) Immunology and immunotherapy of Alzheimer's disease. Nat Rev Immunol 6:404-416. doi: 10.1038/nri1843
    • (2006) Nat Rev Immunol , vol.6 , pp. 404-416
    • Weiner, H.L.1    Frenkel, D.2
  • 49
    • 0042888860 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy: Pathogenesis and effects on the ageing and Alzheimer brain
    • doi: 10.1179/016164103101202057
    • Weller RO, Nicoll JA (2003) Cerebral amyloid angiopathy: Pathogenesis and effects on the ageing and Alzheimer brain. Neurol Res 25:611-616. doi: 10.1179/016164103101202057
    • (2003) Neurol Res , vol.25 , pp. 611-616
    • Weller, R.O.1    Nicoll, J.A.2
  • 50
    • 0037531198 scopus 로고    scopus 로고
    • Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation
    • Wilcock DM, DiCarlo G, Henderson D, Jackson J, Clarke K, Ugen KE, Gordon MN, Morgan D (2003) Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation. J Neurosci 23:3745-3751
    • (2003) J Neurosci , vol.23 , pp. 3745-3751
    • Wilcock, D.M.1    DiCarlo, G.2    Henderson, D.3    Jackson, J.4    Clarke, K.5    Ugen, K.E.6    Gordon, M.N.7    Morgan, D.8
  • 51
    • 0028180541 scopus 로고
    • Beta-amyloid formation by myocytes of leptomeningeal vessels
    • doi: 10.1007/BF00296738
    • Wisniewski HM, Wegiel J (1994) Beta-amyloid formation by myocytes of leptomeningeal vessels. Acta Neuropathol 87:233-241. doi: 10.1007/ BF00296738
    • (1994) Acta Neuropathol , vol.87 , pp. 233-241
    • Wisniewski, H.M.1    Wegiel, J.2
  • 52
    • 0026685656 scopus 로고
    • Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease
    • doi: 10.1007/BF00311383
    • Wisniewski HM, Wegiel J, Wang KC, Lach B (1992) Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease. Acta Neuropathol 84:117-127. doi: 10.1007/BF00311383
    • (1992) Acta Neuropathol , vol.84 , pp. 117-127
    • Wisniewski, H.M.1    Wegiel, J.2    Wang, K.C.3    Lach, B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.