Cell line specific modulation of connexin43 expression after exposure to ionizing radiation

Cell Communication and Adhesion

Volumn 12, Issue 5-6, 2005, Pages 249-259

  Banaz Yaşar, Ferya ^a   Tischka, Rabea ^a   Iliakis, George ^a   Winterhager, Elke ^a   Gellhaus, Alexandra ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

bEnd3; Connexin43; Gap junctions; Irradiation; Jeg3; Trophoblast

Indexed keywords

CONNEXIN 43;

ANIMAL CELL; ARTICLE; BYSTANDER EFFECT; CELL COMMUNICATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; GAP JUNCTION; HUMAN; HUMAN CELL; HYBRID CELL; IONIZING RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; TROPHOBLAST;

ANIMALS; BYSTANDER EFFECT; CELL LINE; CELL LINE, TUMOR; CONNEXIN 43; ENDOTHELIAL CELLS; GAP JUNCTIONS; GENE EXPRESSION REGULATION; HUMANS; MICE; RNA, MESSENGER; TRANSFECTION;

ANIMALIA;

EID: 33645004627     PISSN: 10615385     EISSN: 15435180     Source Type: Journal    
DOI: 10.1080/15419060500514101     Document Type: Article

References (46)

1. Azzam, E and de Toledo, S and Gooding, T and Little, J. (1998) Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles Radiat Res, 150, pp. 497 - 504. [PUBMED] [INFOTRIEVE] [CSA]
2. Azzam, E and de Toledo, S and Little, J. (2001) Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha particle irradiated to nonirradiated cells Proc Natl Acad Sci USA, 98, pp. 473 - 478. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
3. Bishayee, A and Hill, H and Stein, D and Rao, D and Howell, R. (2001) Free radical-initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model Radiat Res, 155, pp. 335 - 344. [PUBMED] [INFOTRIEVE] [CSA]
4. Nagasawa, H and Cremesti, A and Kolesnick, R and Fuks, Z and Little, J. (2002) Involvement of membrane signaling in the bystander effect in irradiated cells Cancer Res, 62, pp. 2531 - 2534. [PUBMED] [INFOTRIEVE] [CSA]
5. Shao, C and Furusawa, Y and Aoki, M and Ando, K. (2003) Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts Radiat Res, 160, pp. 318 - 323. [PUBMED] [INFOTRIEVE] [CSA]
6. Mitchell, S and Randers-Pehrson, G and Brenner, D and Hall, E. (2004) The bystander response in C3H 10T1/2 cells: The influence of cell-to-cell contact Radiat Res, 161, pp. 397 - 401. [PUBMED] [INFOTRIEVE] [CSA]
7. Sohl, G and Willecke, K. (2004) Gap junctions and the connexin protein family Cardiovasc Res, 62, pp. 228 - 232. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
8. Nagasawa, H and Little, J and Tsang, N and Saunders, E and Tesmer, J and Strniste, G. (1992) Effect of dose rate on the survival of irradiated human skin fibroblasts Radiat Res, 132, pp. 375 - 379. [PUBMED] [INFOTRIEVE] [CSA]
9. Singh, B and Arrand, J and Joiner, M. (1994) Hypersensitive response of normal human lung epithelial cells at low radiation doses Int J Radiat Biol, 65, pp. 457 - 464. [PUBMED] [INFOTRIEVE] [CSA]
10. Marples, B and Lambin, P and Skov, K and Joiner, M. (1997) Low dose hyper-radiosensitivity and increased radioresistance in mammalian cells Int J Radiat Biol, 71, pp. 721 - 735. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
11. Azzam, E and de Toledo, S and Little, J. (2003) Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect Oncogene, 22, pp. 7050 - 7057. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
12. Mothersill, C and Seymour, C. (2004) Radiation-induced bystander effects and adaptive responses- The Yin and Yang of low dose radiobiology? Mutat Res, 568, pp. 121 - 128. [PUBMED] [INFOTRIEVE] [CSA]
13. Mothersill, C and Seymour, C. (1997) Survival of human epithelial cells irradiated with cobalt 60 as microcolonies or single cells Int J Radiat Biol., 72(5), pp. 597 - 606. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
14. Mothersill, C and Seymour, C. (1998) Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium Radiat Res, 149, pp. 256 - 262. [PUBMED] [INFOTRIEVE] [CSA]
15. Lehnert, B and Goodwin, E and Deshpande, A. (1997) Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells Cancer Res, 57, pp. 2164 - 2171. [PUBMED] [INFOTRIEVE] [CSA]
16. Prise, K and Belyakov, O and Folkard, M and Michael, B. (1998) Studies of bystander effects in human fibroblasts using a charged particle microbeam Int J Radiat Biol, 74, pp. 793 - 798. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
17. Zhou, H and Randers-Pehrson, G and Waldren, C and Vannais, D and Hall, E and Hei, T. (2000) Induction of a bystander mutagenic effect of alpha particles in mammalian cells Proc Natl Acad Sci USA, 97, pp. 2099 - 2104. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
18. Iyer, R and Lehnert, B and Svensson, R. (2000) Factors underlying the cell growth-related bystander responses to alpha particles Cancer Res, 60, pp. 1290 - 1298. [PUBMED] [INFOTRIEVE] [CSA]
19. Mothersill, C and Stamato, T and Perez, M and Cummins, R and Mooney, R and Seymour, C. (2000) Involvement of energy metabolism in the production of "bystander effects" by radiation Br J Cancer, 82(10), pp. 1740 - 1746. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
20. Mothersill, C and Rea, D and Wright, E and Lorimore, S and Murphy, D and Seymour, C and O'Malley, K. (2001) Individual variation in the production of a "bystander signal" following irradiation of primary cultures of normal human urothelium Carcinogenesis, 22, pp. 1465 - 1471. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
21. Liu, K and Kasper, M and Bierhaus, A and Langer, S and Muller, M and Trott, K. (1997) Connexin 43 expression in normal and irradiated mouse skin Radiat Res, 147, pp. 437 - 441. [PUBMED] [INFOTRIEVE] [CSA]
22. Azzam, E and De Toledo, S and Spitz, D and Little, J. (2002) Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures Cancer Res, 62, pp. 5436 - 5442. [PUBMED] [INFOTRIEVE] [CSA]
23. Azzam, E and de Toledo, S and Little, J. (2003) Expression of CONNEXIN43 is highly sensitive to ionizing radiation and other environmental stresses Cancer Res, 63, pp. 7128 - 7135. [PUBMED] [INFOTRIEVE] [CSA]
24. Glover, D and Little, J and Lavin, M and Gueven, N. (2003) Low dose ionizing radiation-induced activation of connexin 43 expression Int J Radiat Biol, 79, pp. 955 - 964. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
25. Gaugler, M. (2005) A unifying system: Does the vascular endothelium have a role to play in multi-organ failure following radiation exposure? Br J Radiol, 27(Suppl.), pp. 100 - 105. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
26. Drukteinis, J and Medrano, T and Ablordeppey, E and Kitzman, J and Shiverick, K. (2005) Benzo[a]pyrene, but not 2,3,7,8-TCDD, induces G2/M cell cycle arrest, p21CIP1 and p53 phosphorylation in human choriocarcinoma JEG-3 cells: A distinct signaling pathway Placenta, 26(Suppl. A), pp. S87 - S95. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
27. Williams, R and Courtneidge, S and Wagner, E. (1988) Embryonic lethalities and endothelial tumors in chimeric mice expressing polyoma virus middle T oncogene Cell, 52, pp. 121 - 131. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
28. Gellhaus, A and Dong, X and Propson, S and Maass, K and Klein-Hitpass, L and Kibschull, M and Traub, O and Willecke, K and Perbal, B and Lye, S and Winterhager, E. (2004) Connexin43 interacts with NOV: A possible mechanism for negative regulation of cell growth in choriocarcinoma cells J Biol Chem, 279, pp. 36931 - 36942. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
29. Beyer, E and Paul, D and Goodenough, D. (1987) Connexin43: A protein from rat heart homologous to a gap junction protein from liver J Cell Biol, 105, pp. 2621 - 2629. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
30. Hanauer, A and Mandel, J. (1984) The glyceraldehyde 3 phosphate dehydrogenase gene family: Structure of a human cDNA and of an X chromosome linked pseudogene; amazing complexity of the gene family in mouse Embo J, 3, pp. 2627 - 2633. [PUBMED] [INFOTRIEVE] [CSA]
31. Doble, B and Ping, P and Kardami, E. (2000) The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation Circ Res, 86, pp. 293 - 301. [PUBMED] [INFOTRIEVE] [CSA]
32. Winterhager, E and Stutenkemper, R and Traub, O and Beyer, E and Willecke, K. (1991) Expression of different connexin genes in rat uterus during decidualization and at term Eur J Cell Biol, 55, pp. 133 - 142. [PUBMED] [INFOTRIEVE] [CSA]
33. Traub, O and Eckert, R and Lichtenberg-Frate, H and Elfgang, C and Bastide, B and Scheidtmann, K and Hulser, D and Willecke, K. (1994) Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells Eur J Cell Biol, 64, pp. 101 - 112. [PUBMED] [INFOTRIEVE] [CSA]
34. Czyz, J and Irmer, U and Schulz, G and Mindermann, A and Hulser, D. (2000) Gap-junctional coupling measured by flow cytometry Exp Cell Res, 255, pp. 40 - 46. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
35. Kwak, B and Pepper, M and Gros, D and Meda, P. (2001) Inhibition of endothelial wound repair by dominant negative connexin inhibitors Mol Biol Cell, 12, pp. 831 - 845. [PUBMED] [INFOTRIEVE] [CSA]
36. Hellmann, P and Winterhager, E and Spray, D. (1996) Properties of connexin40 gap junction channels endogenously expressed and exogenously overexpressed in human choriocarcinoma cell lines Pflugers Arch, 432, pp. 501 - 509. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
37. Trosko, J and Chang, C and Madhukar, B. (1990) Modulation of intercellular communication during radiation and chemical carcinogenesis Radiat Res, 123, pp. 241 - 251. [PUBMED] [INFOTRIEVE] [CSA]
38. Suzuki, M and Tsuruoka, C. (2004) Heavy charged particles produce a bystander effect via cell-cell junctions Biol Sci Space, 18, pp. 241 - 246. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
39. Suzuki, M and Zhou, H and Geard, C and Hei, T. (2004) Effect of medium on chromatin damage in bystander mammalian cells Radiat Res, 162, pp. 264 - 269. [PUBMED] [INFOTRIEVE] [CSA]
40. Lampe, P and Lau, A. (2000) Regulation of gap junctions by phosphorylation of connexins Arch Biochem Biophys, 384, pp. 205 - 215. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
41. Laird, D. (2005) Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation Biochim Biophys Acta, 1711, pp. 172 - 182. [PUBMED] [INFOTRIEVE] [CSA]
42. Kasper, M and Traub, O and Reimann, T and Bjermer, L and Grossmann, H and Muller, M and Wenzel, K. (1996) Upregulation of gap junction protein connexin43 in alveolar epithelial cells of rats with radiation-induced pulmonary fibrosis Histochem Cell Biol, 106, pp. 419 - 424. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
43. Provost, N and Moreau, M and Leturque, A and Nizard, C. (2003) Ultraviolet A radiation transiently disrupts gap junctional communication in human keratinocytes Am J Physiol Cell Physiol, 284, pp. C51 - C59. [PUBMED] [INFOTRIEVE] [CSA]
44. Echetebu, C and Ali, M and Izban, M and MacKay, L and Garfield, R. (1999) Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene Mol Hum Reprod, 5, pp. 757 - 766. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
45. Geimonen, E and Jiang, W and Ali, M and Fishman, G and Garfield, R and Andersen, J. (1996) Activation of protein kinase C in human uterine smooth muscle induces connexin-43 gene transcription through an AP-1 site in the promoter sequence J Biol Chem, 271, pp. 23667 - 23674. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]
46. Bailey, J and Phillips, R and Pollard, A and Gilmore, K and Robson, S and Europe-Finner, G. (2002) Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: Identification of a novel ATF2 species with potent transactivation properties J Clin Endocrinol Metab, 87, pp. 1717 - 1728. [PUBMED] [INFOTRIEVE] [CSA] [CROSSREF]