Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity

Nature Cell Biology

Volumn 11, Issue 3, 2009, Pages 320-327

  Shakya, Arvind ^a   Cooksey, Robert ^a   Cox, James E ^a   Wang, Victoria ^b   McClain, Donald A ^a   Tantin, Dean ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b HARVARD RADIATION ONCOLOGY PROGRAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUTAMIC ACID; LACTIC ACID; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 4; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE 4; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CANCER CELL; CARCINOGENICITY; CELL ACTIVITY; CELL METABOLISM; CITRIC ACID CYCLE; CONTROLLED STUDY; EMBRYO; FATTY ACID OXIDATION; FEMALE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENETIC REGULATION; GLUCOSE METABOLISM; MALE; METABOLIC RATE; METABOLIC REGULATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; OXIDATION; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; UPREGULATION;

AMINO ACIDS; ANIMALS; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLUCOSE; GLYCOLYSIS; HUMANS; METABOLOME; MICE; MITOCHONDRIA; NEOPLASMS; OCTAMER TRANSCRIPTION FACTOR-1; OXIDATION-REDUCTION;

ANIMALIA;

EID: 61849161672     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1840     Document Type: Article

References (36)

1. Kim, J. W. & Dang, C. V. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 66, 8927-8930 (2006).
2. Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100 57-70 (2000).
3. Warburg, O. On the origin of cancer cells. Science 123, 309-314 (1956).
4. + channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11, 37-51 (2007).
5. Christofk, H. R. et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452, 230-233 (2008).
6. Herr, W. & Cleary, M. A. The POU domain: Versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev. 9, 1679-1693 (1995).
7. Ryan, A. K. & Rosenfeld, M. G. POU domain family values: Flexibility, partnerships, and developmental codes. Genes Dev. 11, 1207-1225 (1997).
8. Sive, H. L. & Roeder, R. G. Interaction of a common factor with conserved promoter and enhancer sequences in histone H2B, immunoglobulin, and U2 small nuclear RNA (snRNA) genes. Proc. Natl Acad. Sci. USA 83, 6382-6386 (1986).
9. Fletcher, C., Heintz, N. & Roeder, R. G. Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene. Cell 51, 773-781 (1987).
10. Gunderson, S. I. et al. Binding of transcription factors to the promoter of the human U1 RNA gene studied by footprinting. J. Biol. Chem. 263, 17603-17610 (1988).
11. Bergman, Y., Rice, D., Grosschedl, R. & Baltimore, D. Two regulatory elements for immunoglobulin kappa light chain gene expression. Proc. Natl Acad. Sci. USA 81, 7041-7045 (1984).
12. Ephrussi, A., Church, G. M., Tonegawa, S. & Gilbert, W. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227, 134-140 (1985).
13. Gillies, S. D., Morrison, S. L., Oi, V. T. & Tonegawa, S. A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell 33 717-728 (1983).
14. Wang, V. E., Tantin, D., Chen, J. & Sharp, P. A. B cell development and immunoglobulin transcription in Oct-1-deficient mice. Proc. Natl Acad. Sci. USA 101, 2005-2010 (2004).
15. Wang, V. E., Schmidt, T., Chen, J., Sharp, P. A. & Tantin, D. Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Mol. Cell Biol. 24 1022-1032 (2004).
16. Almeida, R. et al. OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells. J. Pathol. 207, 396-401 (2005).
17. Jin, T. et al. Examination of POU homeobox gene expression in human breast cancer cells. Int. J. Cancer 81, 104-112 (1999).
18. Qin, X. F. et al. Transformation by homeobox genes can be mediated by selective transcriptional repression. EMBO J. 13, 5967-5976 (1994).
19. Reymann, S. & Borlak, J. Transcription profiling of lung adenocarcinomas of c-myc-transgenic mice: Identification of the c-myc regulatory gene network. BMC Syst. Biol. 2, 46 (2008).
20. Tantin, D., Schild-Poulter, C., Wang, V., Hache, R. J. & Sharp, P. A. The octamer binding transcription factor Oct-1 is a stress sensor. Cancer Res. 65, 10750-10758 (2005).
21. Sakai, K., Hasumi, K. & Endo, A. Inactivation of rabbit muscle glyceraldehyde-3-phosphate dehydrogenase by koningic acid. Biochim. Biophys. Acta 952, 297-303 (1988).
22. Stryer, L. Biochemistry (W. H. Freeman and Company, 2006).
23. Chen, X. et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133, 1106-1117 (2008).
24. Kondoh, H. et al. A high glycolytic flux supports the proliferative potential of murine embryonic stem cells. Antioxid. Redox Signal. 9, 293-299 (2007).
25. Glahn, F. et al. Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors. Arch. Toxicol. 82, 513-524 (2008).
26. Wu, Z. et al. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98 115-124 (1999).
27. Hicks, G. G., Egan, S. E., Greenberg, A. H. & Mowat, M. Mutant p53 tumour suppressor alleles release ras-induced cell cycle growth arrest. Mol. Cell. Biol. 11, 1344-1352 (1991).
28. Jacks, T. et al. Tumor spectrum analysis in p53-mutant mice. Curr. Biol. 4, 1-7 (1994).
29. Matoba, S. et al. p53 regulates mitochondrial respiration. Science 312, 1650-1653 (2006).
30. Debidda, M., Williams, D. A. & Zheng, Y. Rac1 GTPase regulates cell genomic stability and senescence. J. Biol. Chem. 281, 38519-38528 (2006).
31. Heiss, E. H., Schilder, Y. D. & Dirsch, V. M. Chronic Treatment with Resveratrol Induces Redox Stress- and Ataxia Telangiectasia-mutated (ATM)-dependent Senescence in p53-positive Cancer Cells. J. Biol. Chem. 282, 26759-26766 (2007).
32. Zheng, L., Roeder, R. G. & Luo, Y. S. phase activation of the histone H2B promoter by OCA-S., a coactivator complex that contains GAPDH as a key component. Cell 114, 255-266 (2003).
33. Hafstad, A. D., Solevag, G. H., Severson, D. L., Larsen, T. S. & Aasum, E. Perfused hearts from Type 2 diabetic (db/db) mice show metabolic responsiveness to insulin. Am. J. Physiol. Heart Circ. Physiol. 290, 1763-1769 (2006).
34. McClain, D. A., Hazel, M., Parker, G. & Cooksey, R. C. Adipocytes with increased hexosamine flux exhibit insulin resistance, increased glucose uptake, and increased synthesis and storage of lipid. Am. J. Physiol. Endocrinol. Metab. 288, 973-979 (2005).
35. Boyd, K. E. & Farnham, P. J. Coexamination of site-specific transcription factor binding and promoter activity in living cells. Mol. Cell Biol. 19, 8393-8399 (1999).
36. Melgar, S. et al. Mice with experimental colitis show an altered metabolism with decreased metabolic rate. Am. J. Physiol. Gastrointest. Liver Physiol. 292, 165-172 (2007).