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Volumn 7, Issue 3, 2010, Pages 182-189

The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease

Author keywords

Autoimmune disease; Cytokine; Regulatory T cell; T helper 17 cell

Indexed keywords

ADALIMUMAB; AMG 108; APILIMOD; ATACICEPT; BRIAKINUMAB; CD39 ANTIGEN; CD4 ANTIGEN; DACLIZUMAB; ETANERCEPT; GAMMA INTERFERON; INFLIXIMAB; INTERLEUKIN 1 ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 23 ANTIBODY; INTERLEUKIN 7; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TOCILIZUMAB; TRANSCRIPTION FACTOR FOXP3; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; USTEKINUMAB; CYTOKINE;

EID: 77953255484     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2010.22     Document Type: Review
Times cited : (186)

References (128)
  • 1
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • H2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-173. (Pubitemid 19138011)
    • (1989) Annual Review of Immunology , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 2
    • 33847667225 scopus 로고    scopus 로고
    • The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease
    • DOI 10.1111/j.1365-2249.2007.03356.x
    • Afzali B, Lombardi G, Lechler RI, Lord GM. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol 2007;148:32-46. (Pubitemid 46365005)
    • (2007) Clinical and Experimental Immunology , vol.148 , Issue.1 , pp. 32-46
    • Afzali, B.1    Lombardi, G.2    Lechler, R.I.3    Lord, G.M.4
  • 4
    • 2442484053 scopus 로고    scopus 로고
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • DOI 10.1146/annurev.immunol.21.120601.141122
    • + regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol 2004;22:531-562. (Pubitemid 38680433)
    • (2004) Annual Review of Immunology , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 7
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • DOI 10.1146/annurev.immunol.25.022106.141557
    • Weaver CT, Hatton RD, Mangan PR, Harrington LE. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu Rev Immunol 2007;25:821-852. (Pubitemid 46697925)
    • (2007) Annual Review of Immunology , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 8
    • 5644289875 scopus 로고    scopus 로고
    • IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB-and PI3-kinase/Akt-dependent pathways
    • Hwang SY, Kim JY, Kim KW, Park MK, Moon Y, Kim WU et al. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB-and PI3-kinase/Akt-dependent pathways. Arthritis Res Ther 2004;6: R120-R128.
    • (2004) Arthritis Res. Ther. , vol.6
    • Hwang, S.Y.1    Kim, J.Y.2    Kim, K.W.3    Park, M.K.4    Moon, Y.5    Kim, W.U.6
  • 9
    • 70049095101 scopus 로고    scopus 로고
    • How do regulatory T cells work?
    • Corthay A. How do regulatory T cells work? Scand J Immunol 2009;70:326-336.
    • (2009) Scand. J. Immunol. , vol.70 , pp. 326-336
    • Corthay, A.1
  • 10
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005;23:683-747. (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 11
    • 0023879766 scopus 로고
    • Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma
    • Billiau A, Heremans H, Vandekerckhove F, Dijkmans R, Sobis H, Meulepas E et al. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-gamma. J Immunol 1988;140:1506-1510.
    • (1988) J. Immunol. , vol.140 , pp. 1506-1510
    • Billiau, A.1    Heremans, H.2    Vandekerckhove, F.3    Dijkmans, R.4    Sobis, H.5    Meulepas, E.6
  • 15
    • 46949086111 scopus 로고    scopus 로고
    • A rush to judgment on Th17
    • DOI 10.1084/jem.20072066
    • Steinman L. A rush to judgment on Th17. J Exp Med 2008;205:1517-1522. (Pubitemid 351962013)
    • (2008) Journal of Experimental Medicine , vol.205 , Issue.7 , pp. 1517-1522
    • Steinman, L.1
  • 17
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jager A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol 2009;183:7169-7177.
    • (2009) J. Immunol. , vol.183 , pp. 7169-7177
    • Jager, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 18
    • 76249117009 scopus 로고    scopus 로고
    • Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease
    • Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB et al. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med 16:191-197.
    • Nat. Med. , vol.16 , pp. 191-197
    • Liu, X.1    Leung, S.2    Wang, C.3    Tan, Z.4    Wang, J.5    Guo, T.B.6
  • 19
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995;155:1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 20
    • 49649101595 scopus 로고    scopus 로고
    • Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells
    • Stummvoll GH, DiPaolo RJ, Huter EN, Davidson TS, Glass D, Ward JM et al. Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells. J Immunol 2008;181:1908-1916.
    • (2008) J. Immunol. , vol.181 , pp. 1908-1916
    • Stummvoll, G.H.1    DiPaolo, R.J.2    Huter, E.N.3    Davidson, T.S.4    Glass, D.5    Ward, J.M.6
  • 31
    • 17644384896 scopus 로고    scopus 로고
    • + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis
    • DOI 10.1111/j.1365-2249.2005.02754.x
    • + T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005;140:360-367. (Pubitemid 40559165)
    • (2005) Clinical and Experimental Immunology , vol.140 , Issue.2 , pp. 360-367
    • Mottonen, M.1    Heikkinen, J.2    Mustonen, L.3    Isomaki, P.4    Luukkainen, R.5    Lassila, O.6
  • 32
    • 4444300314 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells in rheumatoid arthritis: Differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    • DOI 10.1002/art.20499
    • + regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid. Arthritis Rheum 2004;50:2775-2785. (Pubitemid 39209514)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.9 , pp. 2775-2785
    • Van Amelsfort, J.M.R.1    Jacobs, K.M.G.2    Bijlsma, J.W.J.3    Lafeber, F.P.J.G.4    Taams, L.S.5
  • 34
    • 33744481749 scopus 로고    scopus 로고
    • H2 model: A personal perspective
    • DOI 10.1038/ni0606-539, PII N0606539
    • H2 model: a personal perspective. Nat Immunol 2006;7:539-541. (Pubitemid 43797329)
    • (2006) Nature Immunology , vol.7 , Issue.6 , pp. 539-541
    • Coffman, R.L.1
  • 35
  • 37
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-2357. (Pubitemid 16136806)
    • (1986) Journal of Immunology , vol.136 , Issue.7 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3
  • 38
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997;89:587-596. (Pubitemid 27511769)
    • (1997) Cell , vol.89 , Issue.4 , pp. 587-596
    • Zheng, W.-P.1    Flavell, R.A.2
  • 40
    • 44449136105 scopus 로고    scopus 로고
    • + T cells prevents development of experimental autoimmune diseases
    • + T cells prevents development of experimental autoimmune diseases. J Immunol 2008;180:6070-6076.
    • (2008) J. Immunol. , vol.180 , pp. 6070-6076
    • Liu, X.1    Lee, Y.S.2    Yu, C.R.3    Egwuagu, C.E.4
  • 41
    • 48249148236 scopus 로고    scopus 로고
    • IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis
    • Serada S, Fujimoto M, Mihara M, Koike N, Ohsugi Y, Nomura S et al. IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2008;105:9041-9046.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9041-9046
    • Serada, S.1    Fujimoto, M.2    Mihara, M.3    Koike, N.4    Ohsugi, Y.5    Nomura, S.6
  • 45
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • DOI 10.1074/jbc.M207577200
    • Aggarwal S, Ghilardi N, Xie MH, De Sauvage FJ, Gurney AL. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem 2003;278:1910-1914. (Pubitemid 36801431)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.3 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.-H.3    De Sauvage, F.J.4    Gurney, A.L.5
  • 49
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    • Chung Y, Chang SH, Martinez GJ, Yang XO, Nurieva R, Kang HS et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 2009;30:576-587.
    • (2009) Immunity , vol.30 , pp. 576-587
    • Chung, Y.1    Chang, S.H.2    Martinez, G.J.3    Yang, X.O.4    Nurieva, R.5    Kang, H.S.6
  • 50
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells
    • DOI 10.1038/ni1496, PII NI1496
    • Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007;8:942-949. (Pubitemid 47300008)
    • (2007) Nature Immunology , vol.8 , Issue.9 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 51
    • 0023243462 scopus 로고
    • Expression of interleukin 1 receptors on human peripheral T cells
    • Shirakawa F, Tanaka Y, Ota T, Suzuki H, Eto S, Yamashita U. Expression of interleukin 1 receptors on human peripheral T cells. J Immunol 1987;138:4243-4248. (Pubitemid 17090393)
    • (1987) Journal of Immunology , vol.138 , Issue.12 , pp. 4243-4248
    • Shirakawa, F.1    Tanaka, Y.2    Ota, T.3
  • 52
    • 58749105841 scopus 로고    scopus 로고
    • IL-23 promotes maintenance but not commitment to the Th17 lineage
    • Stritesky GL, Yeh N, Kaplan MH. IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol 2008;181:5948-5955.
    • (2008) J. Immunol. , vol.181 , pp. 5948-5955
    • Stritesky, G.L.1    Yeh, N.2    Kaplan, M.H.3
  • 53
    • 60749107176 scopus 로고    scopus 로고
    • The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
    • McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM et al. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 2009;10:314-324.
    • (2009) Nat. Immunol. , vol.10 , pp. 314-324
    • McGeachy, M.J.1    Chen, Y.2    Tato, C.M.3    Laurence, A.4    Joyce-Shaikh, B.5    Blumenschein, W.M.6
  • 54
    • 33645959483 scopus 로고    scopus 로고
    • STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
    • Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB et al. STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J Immunol 2006;176:5652-5661.
    • (2006) J. Immunol. , vol.176 , pp. 5652-5661
    • Cho, M.L.1    Kang, J.W.2    Moon, Y.M.3    Nam, H.J.4    Jhun, J.Y.5    Heo, S.B.6
  • 60
    • 76249117009 scopus 로고    scopus 로고
    • Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease
    • Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB et al. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med 2010;16:191-197.
    • (2010) Nat. Med. , vol.16 , pp. 191-197
    • Liu, X.1    Leung, S.2    Wang, C.3    Tan, Z.4    Wang, J.5    Guo, T.B.6
  • 61
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • DOI 10.1126/science.1079490
    • Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003;299:1057-1061. (Pubitemid 36222930)
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 68
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Wan YY, Flavell RA. Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc Natl Acad Sci USA 2005;102:5126-5131.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 69
    • 15244354286 scopus 로고    scopus 로고
    • Regulatory T cell lineage specification by the forkhead transcription factor Foxp3
    • DOI 10.1016/j.immuni.2005.01.016
    • Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG, Rudensky AY. Regulatory T cell lineage specification by the forkhead transcription factor foxp3. Immunity 2005;22:329-341. (Pubitemid 40387475)
    • (2005) Immunity , vol.22 , Issue.3 , pp. 329-341
    • Fontenot, J.D.1    Rasmussen, J.P.2    Williams, L.M.3    Dooley, J.L.4    Farr, A.G.5    Rudensky, A.Y.6
  • 72
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • DOI 10.1038/ni1160
    • Tai X, Cowan M, Feigenbaum L, Singer A. CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2. Nat Immunol 2005;6:152-162. (Pubitemid 40268196)
    • (2005) Nature Immunology , vol.6 , Issue.2 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 73
  • 74
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio CW, Hsieh CS. A two-step process for thymic regulatory T cell development. Immunity 2008;28:100-111.
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 78
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • DOI 10.1038/ni1263, PII N1263
    • Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005;6:1142-1151. (Pubitemid 41541792)
    • (2005) Nature Immunology , vol.6 , Issue.11 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 81
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008;29:44-56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3    Kang, H.S.4    Chung, Y.5    Pappu, B.P.6
  • 82
    • 65549123867 scopus 로고    scopus 로고
    • + regulatory T cells: More of the same or a division of labor?
    • + regulatory T cells: more of the same or a division of labor? Immunity 2009;30:626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto De Lafaille, M.A.1    Lafaille, J.J.2
  • 84
    • 34547769253 scopus 로고    scopus 로고
    • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation
    • DOI 10.1084/jem.20070719
    • Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-trans retinoic acid mediates enhanced Treg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 2007;204:1765-1774. (Pubitemid 47236315)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.8 , pp. 1765-1774
    • Benson, M.J.1    Pino-Lagos, K.2    Rosemblatt, M.3    Noelle, R.J.4
  • 88
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • DOI 10.1084/jem.20070602
    • Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007;204:1775-1785. (Pubitemid 47236316)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.8 , pp. 1775-1785
    • Sun, C.-M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6    Belkaid, Y.7
  • 90
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch MA, Tucker-Heard G, Perdue NR, Killebrew JR, Urdahl KB, Campbell DJ. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009;10:595-602.
    • (2009) Nat. Immunol. , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 93
    • 0031821875 scopus 로고    scopus 로고
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • DOI 10.1084/jem.188.2.287
    • + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med 1998;188:287-296. (Pubitemid 28357757)
    • (1998) Journal of Experimental Medicine , vol.188 , Issue.2 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 96
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • DOI 10.1016/j.immuni.2004.09.002, PII S1074761304002729
    • Grossman WJ, Verbsky JW, Barchet W, Colonna M, Atkinson JP, Ley TJ. Human T regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity 2004;21:589-601. (Pubitemid 39370513)
    • (2004) Immunity , vol.21 , Issue.4 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3    Colonna, M.4    Atkinson, J.P.5    Ley, T.J.6
  • 101
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • Asseman C, Mauze S, Leach MW, Coffman RL, Powrie F. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med 1999;190:995-1004.
    • (1999) J. Exp. Med. , vol.190 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3    Coffman, R.L.4    Powrie, F.5
  • 104
    • 0032821774 scopus 로고    scopus 로고
    • Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
    • DOI 10.1093/intimm/11.10.1625
    • Burkhart C, Liu GY, Anderton SM, Metzler B, Wraith DC. Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10. Int Immunol 1999;11:1625-1634. (Pubitemid 29481729)
    • (1999) International Immunology , vol.11 , Issue.10 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Anderton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 108
    • 33846446041 scopus 로고    scopus 로고
    • Anti-TNF-α therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-β
    • DOI 10.1084/jem.20061531
    • Nadkarni S, Mauri C, Ehrenstein MR. Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. J Exp Med 2007;204:33-39. (Pubitemid 46148753)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.1 , pp. 33-39
    • Nadkarni, S.1    Mauri, C.2    Ehrenstein, M.R.3
  • 110
    • 64949203166 scopus 로고    scopus 로고
    • Tocilizumab: A review of its use in the management of rheumatoid arthritis
    • Oldfield V, Dhillon S, Plosker GL. Tocilizumab: a review of its use in the management of rheumatoid arthritis. Drugs 2009;69:609-632.
    • (2009) Drugs , vol.69 , pp. 609-632
    • Oldfield, V.1    Dhillon, S.2    Plosker, G.L.3
  • 111
    • 39749167232 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha antagonists and neuropathy
    • Stubgen JP. Tumor necrosis factor-alpha antagonists and neuropathy. Muscle Nerve 2008;37:281-292.
    • (2008) Muscle Nerve , vol.37 , pp. 281-292
    • Stubgen, J.P.1
  • 112
  • 113
    • 65249138318 scopus 로고    scopus 로고
    • Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis
    • Bielekova B, Howard T, Packer AN, Richert N, Blevins G, Ohayon J et al. Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis. Arch Neurol 2009;66:483-489.
    • (2009) Arch. Neurol. , vol.66 , pp. 483-489
    • Bielekova, B.1    Howard, T.2    Packer, A.N.3    Richert, N.4    Blevins, G.5    Ohayon, J.6
  • 115
    • 33846283803 scopus 로고    scopus 로고
    • Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells
    • DOI 10.1016/j.jim.2006.10.008, PII S0022175906002997
    • + regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods 2007;319:41-52. (Pubitemid 46110995)
    • (2007) Journal of Immunological Methods , vol.319 , Issue.1-2 , pp. 41-52
    • Hartigan-O'Connor, D.J.1    Poon, C.2    Sinclair, E.3    McCune, J.M.4
  • 116
    • 43449139402 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
    • DOI 10.1016/S0140-6736(08)60726-6, PII S0140673608607266
    • Papp KA, Langley RG, Lebwohl M, Krueger GG, Szapary P, Yeilding N et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebocontrolled trial (PHOENIX 2). Lancet 2008;371:1675-1684. (Pubitemid 351671884)
    • (2008) The Lancet , vol.371 , Issue.9625 , pp. 1675-1684
    • Papp, K.A.1    Langley, R.G.2    Lebwohl, M.3    Krueger, G.G.4    Szapary, P.5    Yeilding, N.6    Guzzo, C.7    Hsu, M.-C.8    Wang, Y.9    Li, S.10    Dooley, L.T.11    Reich, K.12
  • 117
    • 77949865934 scopus 로고    scopus 로고
    • The status of biologic therapies in the treatment of moderate to severe psoriasis
    • Menter A. The status of biologic therapies in the treatment of moderate to severe psoriasis. Cutis 2009;84:14-24.
    • (2009) Cutis , vol.84 , pp. 14-24
    • Menter, A.1
  • 118
    • 43549087865 scopus 로고    scopus 로고
    • ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseases
    • Ding C, Xu J, Li J. ABT-874, a fully human monoclonal anti-IL-12/IL-23 antibody for the potential treatment of autoimmune diseases. Curr Opin Investig Drugs 2008;9:515-522. (Pubitemid 351677906)
    • (2008) Current Opinion in Investigational Drugs , vol.9 , Issue.5 , pp. 515-522
    • Ding, C.1    Xu, J.2    Li, J.3
  • 119
    • 77953693548 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease
    • in press
    • Sands BE, Jacobson EW, Sylwestrowicz T, Younes Z, Dryden G, Fedorak R et al. Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn's disease. Inflamm Bowel Dis 2009; in press.
    • (2009) Inflamm. Bowel Dis.
    • Sands, B.E.1    Jacobson, E.W.2    Sylwestrowicz, T.3    Younes, Z.4    Dryden, G.5    Fedorak, R.6
  • 120
    • 33947319314 scopus 로고    scopus 로고
    • Drug evaluation: Apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency
    • Billich A. Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency. IDrugs 2007;10:53-59. (Pubitemid 46438284)
    • (2007) IDrugs , vol.10 , Issue.1 , pp. 53-59
    • Billich, A.1
  • 121
    • 22344454672 scopus 로고    scopus 로고
    • Anakinra: A review of its use in the management of rheumatoid arthritis
    • Waugh J, Perry CM. Anakinra: a review of its use in the management of rheumatoid arthritis. BioDrugs 2005;19:189-202.
    • (2005) BioDrugs , vol.19 , pp. 189-202
    • Waugh, J.1    Perry, C.M.2
  • 122
    • 74049134371 scopus 로고    scopus 로고
    • Mixed results with modulation of TH-17 cells in human autoimmune diseases
    • Steinman L. Mixed results with modulation of TH-17 cells in human autoimmune diseases. Nat Immunol; 11:41-44.
    • Nat. Immunol. , vol.11 , pp. 41-44
    • Steinman, L.1
  • 123
    • 70349968220 scopus 로고    scopus 로고
    • IL-17 as a future therapeutic target for rheumatoid arthritis
    • van den Berg WB, Miossec P. IL-17 as a future therapeutic target for rheumatoid arthritis. Nat Rev Rheumatol 2009;5:549-553.
    • (2009) Nat. Rev. Rheumatol. , vol.5 , pp. 549-553
    • Van Den Berg, W.B.1    Miossec, P.2
  • 124
    • 34250025930 scopus 로고    scopus 로고
    • Etanercept: A review of its use in the management of rheumatoid arthritis
    • DOI 10.2165/00003495-200767080-00011
    • Dhillon S, Lyseng-Williamson KA, Scott LJ. Etanercept: a review of its use in the management of rheumatoid arthritis. Drugs 2007;67:1211-1241. (Pubitemid 46880983)
    • (2007) Drugs , vol.67 , Issue.8 , pp. 1211-1241
    • Dhillon, S.1    Lyseng-Williamson, K.A.2    Scott, L.J.3
  • 127
    • 37149023520 scopus 로고    scopus 로고
    • Humanized anti-CD25 antibody treatment with daclizumab in multiple sclerosis
    • DOI 10.1159/000109934
    • Martin R. Humanized anti-CD25 antibody treatment with daclizumab in multiple sclerosis. Neurodegener Dis 2008;5:23-26. (Pubitemid 350261812)
    • (2008) Neurodegenerative Diseases , vol.5 , Issue.1 , pp. 23-26
    • Martin, R.1
  • 128
    • 54949118810 scopus 로고    scopus 로고
    • Atacicept, a homodimeric fusion protein for the potential treatment of diseases triggered by plasma cells
    • Gatto B. Atacicept, a homodimeric fusion protein for the potential treatment of diseases triggered by plasma cells. Curr Opin Investig Drugs 2008;9:1216-1227.
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 1216-1227
    • Gatto, B.1


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